Responses of glomus cells to hypoxia and acidosis are uncoupled, reciprocal and linked to ASIC3 expression: selectivity of chemosensory transduction

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Physiology

• Publication date

  2013-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1113/jphysiol.2012.247189PMID 23165770PMCID PMC3591706
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Acid sensing ion channels regulate neuronal excitability by inhibiting BK potassium channels.

  2012cited by this paper
• Effects of chemostimuli on [Ca2+]i responses of rat aortic body type I cells and endogenous local neurons: comparison with carotid body cells

  2012cited by this paper
• Peripheral chemoreceptors: function and plasticity of the carotid body.

  2012influential reference
• Expressing acid-sensing ion channel 3 in the brain alters acid-evoked currents and impairs fear conditioning

  2011cited by this paper
• Chronic hypoxia-induced acid-sensitive ion channel expression in chemoafferent neurons contributes to chemoreceptor hypersensitivity.

  2011cited by this paper
• Multifocal animated imaging of changes in cellular oxygen and calcium concentrations and membrane potential within the intact adult mouse carotid body ex vivo.

  2011cited by this paper
• Mechanisms for acute oxygen sensing in the carotid body.

  2010influential reference
• Chemoreceptor Hypersensitivity, Sympathetic Excitation, and Overexpression of ASIC and TASK Channels Before the Onset of Hypertension in SHR

  2010cited by this paper
• H2S mediates O2 sensing in the carotid body

  2010cited by this paper
• Systemic effects resulting from carotid body stimulation-invited article.

  2009cited by this paper
• Acid-sensing ion channels interact with and inhibit BK K+ channels

  2008cited by this paper
• Acid-Sensing Ion Channels Contribute to Transduction of Extracellular Acidosis in Rat Carotid Body Glomus Cells

  2007cited by this paper
• TASK-like potassium channels and oxygen sensing in the carotid body.

  2007influential reference
• The TASK background K2P channels: chemo- and nutrient sensors.

  2007cited by this paper
• Pituitary adenylate cyclase‐activating polypeptide (PACAP) stimulates the oxygen sensing type I (glomus) cells of rat carotid bodies via reduction of a background TASK‐like K+ current

  2007cited by this paper
• O2 sensing at the mammalian carotid body: why multiple O2 sensors and multiple transmitters?

  2006cited by this paper
• Oxygen sensing in the body.

  2006cited by this paper
• Neurotransmission and neuromodulation in the chemosensory carotid body.

  2005influential reference
• Cell biology. Oxygen sensing: it's a gas!

  2004cited by this paper
• Peripheral chemoreceptors in health and disease.

  2004cited by this paper
• Oxygen Sensing: It's a Gas!

  2004cited by this paper
• The effect of mitochondrial inhibitors on membrane currents in isolated neonatal rat carotid body type I cells

  2004influential reference
• Acid‐sensing ion channels ASIC2 and ASIC3 do not contribute to mechanically activated currents in mammalian sensory neurones

  2004cited by this paper
• Effects of hypoxia and putative transmitters on [Ca2+]i of rat glomus cells.

  2004cited by this paper
• Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells

  2003cited by this paper
• Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells

  2003cited by this paper
• ATP Triggers Intracellular Ca2+ Release in Type II Cells of the Rat Carotid Body

  2003influential reference
• HIGHLIGHTED TOPIC Oxygen Sensing in Health and Disease Acetylcholine release from the carotid body by hypoxia: evidence for the involvement of autoinhibitory receptors

  2003cited by this paper
• CO2/H(+) sensing: peripheral and central chemoreception.

  2003cited by this paper
• CO(2) and pH independently modulate L-type Ca(2+) current in rabbit carotid body glomus cells.

  2002cited by this paper
• Electrical properties of chemoreceptor elements in the carotid body

  2002cited by this paper
• Behavior of junction channels between rat glomus cells during normoxia and hypoxia.

  2002influential reference
• Expression of P2X2 and P2X3 receptor subunits in rat carotid body afferent neurones: role in chemosensory signalling

  2001cited by this paper
• Molecular physiology of oxygen-sensitive potassium channels.

  2001cited by this paper
• Intracellular Ca(2+) stores in chemoreceptor cells of the rabbit carotid body: significance for chemoreception.

  2000cited by this paper
• HERG-Like potassium current regulates the resting membrane potential in glomus cells of the rabbit carotid body.

  2000cited by this paper
• Timing of Ca2+ Release from Intracellular Stores and the Electrical Response of Limulus Ventral Photoreceptors to Dim Flashes

  2000cited by this paper
• Interactions between hypoxia and hypercapnic acidosis on calcium signaling in carotid body type I cells.

  2000cited by this paper
• An oxygen‐, acid‐ and anaesthetic‐sensitive TASK‐like background potassium channel in rat arterial chemoreceptor cells

  2000cited by this paper
• Postnatal maturation of carotid body and type I cell chemoreception in the rat.

  1999cited by this paper
• Postnatal maturation of carotid body and type I cell chemoreception in the rat.

  1999cited by this paper
• Properties of ionic currents from isolated adult rat carotid body chemoreceptor cells: effect of hypoxia.

  1997influential reference
• Depolarization is a critical event in hypoxia-induced glomus cell secretion.

  1996cited by this paper
• Heterogeneity in cytosolic calcium responses to hypoxia in carotid body cells.

  1996cited by this paper
• Protein and acidosis alter calcium-binding and fluorescence spectra of the calcium indicator indo-1.

  1994cited by this paper
• Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells.

  1994cited by this paper
• Effects of hypercapnia on membrane potential and intracellular calcium in rat carotid body type I cells.

  1994cited by this paper
• Response of cytosolic Ca2+ to hypercapnic acidosis in cultured glomus cells of the adult rabbit carotid body.

  1994cited by this paper
• Hypoxia affects differently the intracellular pH of clustered and isolated glomus cells of the rat carotid body.

  1993cited by this paper
• Norepinephrine-containing glomus cells in the rabbit carotid body. II. Immunocytochemical evidence of dopamine-β-hydroxylase and norepinephrine

  1992cited by this paper
• Different effects of hypoxia on the membrane potential and input resistance of isolated and clustered carotid body glomus cells.

  1992cited by this paper
• Response of cytosolic calcium to anoxia and cyanide in cultured glomus cells of newborn rabbit carotid body.

  1991influential reference
• Potassium currents recorded in type I carotid body cells from the neonatal rat and their modulation by chemoexcitatory agents.

  1990cited by this paper
• Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans.

  1989cited by this paper
• Chemotransduction in the carotid body: K+ current modulated by PO2 in type I chemoreceptor cells.

  1988influential reference
• The mammalian carotid body.

  1987cited by this paper
• The Mammalian Carotid Body

  1987influential reference
• A new generation of Ca2+ indicators with greatly improved fluorescence properties.

  1985cited by this paper
• Aortic and carotid chemoreceptor responses to metabolic acidosis in the cat.

  1983cited by this paper
• Transduction mechanisms in carotid body: glomus cells, putative neurotransmitters, and nerve endings.

  1980cited by this paper
• Stimulus interaction in the responses of carotid body chemoreceptor single afferent fibers.

  1975cited by this paper
• The innervation of glomus cells, ganglion cells and blood vessels in the rat carotid body: A quantitative ultrastructural analysis

  1975cited by this paper
• Morphometric studies of dense-cored vesicles in Type I cells of rat carotid body

  1975influential reference
• The frequency of nerve impulses in single carotid body chemoreceptor afferent fibres recorded in vivo with intact circulation

  1970influential reference
• Four types of main cells in the carotid body of the cat.

  1969influential reference

• Acid-sensing ion channels: structure, function, pharmacology and clinical significance.

  2025cites this paper
• Chemoreflex function in pulmonary diseases – A review

  2025influential citation
• Mechanisms underpinning peripheral chemoreceptor modulation of hypertension.

  2025cites this paper
• Translating physiology of the arterial chemoreflex into novel therapeutic interventions targeting carotid bodies in cardiometabolic disorders

  2025cites this paper
• Short-term sustained hypoxia distinctly affects subpopulations of carotid body glomus cells from rats.

  2025cites this paper
• Carotid body interoception in health and disease.

  2024cites this paper
• Acid-Sensing Ion Channels’ Immunoreactivity in Nerve Profiles and Glomus Cells of the Human Carotid Body

  2023cites this paper
• TASK inhibition by mild acidosis increases Ca2+ oscillations to mediate pH sensing in rat carotid body chemoreceptor cells.

  2023cites this paper
• Acid-sensing ion channel 1a activates IKCa/SKCa channels and contributes to endothelium-dependent dilation

  2022cites this paper
• Tissue-specific mitochondrial HIGD1C promotes oxygen sensitivity in carotid body chemoreceptors

  2022cites this paper
• Understanding mechanoreflex and metaboreflex interactions – a great challenge

  2021cites this paper
• A mitochondrial electron transport chain with atypical subunit composition confers oxygen sensitivity to a mammalian chemoreceptor

  2021cites this paper
• Carotid Body Chemoreceptors: Physiology, Pathology, and Implications for Health and Disease.

  2021cites this paper
• The role of carotid bodies in the generation of active inspiratory and expiratory responses to exercise in rats

  2020cites this paper
• Acid-Sensing Ion Channels in Sensory Signaling.

  2020cites this paper
• Fail‐safe aspects of oxygen supply

  2020cites this paper
• TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons.

  2019cites this paper
• A New Neuropathologic Mechanism of Blood pH Irregularities After Neck Trauma: Importance of Carotid Body-Glossopharyngeal Nerve Network Degeneration.

  2019cites this paper
• The Logic of Carotid Body Connectivity to the Brain.

  2019cites this paper
• Role of acid-sensing ion channels in hypoxia- and hypercapnia-induced ventilatory responses

  2018cites this paper
• Novel Insights into Acid-Sensing Ion Channels: Implications for Degenerative Diseases.

  2016cites this paper
• Integration of Central and Peripheral Respiratory Chemoreflexes.

  2016cites this paper
• Étude de la régulation pharmacologique des canaux ioniques ASIC par des toxines animales

  2016cites this paper
• Extracellular H+ induces Ca2+ signals in respiratory chemoreceptors of zebrafish

  2015cites this paper
• ASICs and cardiovascular homeostasis.

  2015influential citation
• Arterial Chemoreceptors in Physiology and Pathophysiology

  2015cites this paper
• Role of the Carotid Body Chemoreflex in the Pathophysiology of Heart Failure: A Perspective from Animal Studies.

  2015cites this paper
• Enhanced non-eupneic breathing following hypoxic, hypercapnic or hypoxic-hypercapnic gas challenges in conscious mice.

  2014influential citation
• Responses of glomus cells to hypoxia and acidosis

  2013cites this paper
• Revelations About Carotid Body Function Through its Pathological Role in Resistant Hypertension

  2013cites this paper
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