Pharmacologic interaction of furosemide and phenylbutazone in horses.

The effect of premedication with phenylbutazone on systemic hemodynamic and diuretic effects of furosemide was examined in 6 healthy, conscious, mares. Mares were instrumented for measurement of systemic hemodynamics, including cardiac output and pulmonary arterial, systemic arterial, and intracardiac pressures, and urine flow. Each of 3 treatments was administered in a randomized, blinded study; furosemide (1 mg/kg of body weight, IV) only, phenylbutazone (8.8 mg/kg, PO, at 24 hours and 4.4 mg/kg, IV, 30 minutes before furosemide) and furosemide, or 0.9% NaCl. Phenylbutazone administration significantly attenuated, but did not abolish, the diuretic effect of furosemide. Phenylbutazone completely inhibited the immediate effect of furosemide on cardiac output, stroke volume, total peripheral resistance, and right ventricular peak pressure. Premedication with phenylbutazone did not inhibit equally the diuretic and hemodynamic effects of furosemide, indicating that some of furosemide's hemodynamic effects are mediated by an extrarenal activity of furosemide.

• Publication year

  1995

• Venue

  American Journal of Veterinary Research

• Publication date

  1995-09-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2460/ajvr.1995.56.09.1206PMID 7486400
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Effect of furosemide on angiotensin II-mediated prostaglandin I2 production in hypertensive subjects

  2004cited by this paper
• Effect of phenylbutazone on the haemodynamic, acid-base and eicosanoid responses of horses to sustained submaximal exertion.

  1994cited by this paper
• Pulmonary vascular pressures of strenuously exercising thoroughbreds after administration of flunixin meglumine and furosemide.

  1994cited by this paper
• Effect of furosemide on plasma atrial natriuretic peptide and aldosterone concentrations and renin activity in running horses.

  1994cited by this paper
• Pulmonary haemodynamics in the exercising horse and their relationship to exercise-induced pulmonary haemorrhage.

  1993cited by this paper
• Furosemide magnifies the exercise-induced elevation of plasma vasopressin concentration in horses.

  1993cited by this paper
• Influence of cyclooxygenase inhibitors on furosemide-induced hemodynamic effects during exercise in horses.

  1992cited by this paper
• Influence of furosemide on hemodynamic responses during exercise in horses.

  1992cited by this paper
• Furosemide-induced changes in plasma and blood volume of horses.

  1991cited by this paper
• Effect of inhibitors of prostaglandin synthesis on the furosemide action in the loop Henle of rat kidney

  1988cited by this paper
• Effect of cyclooxygenase inhibition on the pulmonary vasodilator response to furosemide.

  1988cited by this paper
• Influence of furosemide treatment on fluid and electrolyte balance in horses.

  1988cited by this paper
• ENDOTHELIUM‐DEPENDENT INHIBITION OF SYMPATHETIC VASOCONSTRICTION BY FRUSEMIDE ADMINISTRATION TO RATS

  1988cited by this paper
• The effect of furosemide on vascular smooth muscle is influenced by plasma protein.

  1988cited by this paper
• Influence of furosemide on rubidium-86 uptake and alpha-adrenergic responsiveness of arterial smooth muscle.

  1987cited by this paper
• Negative Inotropic Effects of Furosemide in the Isolated Rabbit Heart: A Prostaglandin‐Mediated Event

  1987cited by this paper
• Serum thromboxane in the horse and its inhibition by aspirin, phenylbutazone and flunixin.

  1987cited by this paper
• Indomethacin antagonizes furosemide's intratubular effects during loop segment microperfusion.

  1987cited by this paper
• Pressures in the right side of the heart and esophagus (pleura) in ponies during exercise before and after furosemide administration.

  1986cited by this paper
• Effects of flunixin meglumine, phenylbutazone and a selective thromboxane synthetase inhibitor (UK-38,485) on thromboxane and prostacyclin production in healthy horses.

  1986cited by this paper
• FRUSEMIDE INHIBITION OF SYMPATHETIC VASOCONSTRICTION IN THE RAT IN SITU BLOOD PERFUSED MESENTERY

  1986cited by this paper
• Effect of furosemide administration on systemic circulation of ponies during severe exercise.

  1986cited by this paper
• Acute vasoconstrictor response to intravenous furosemide in patients with chronic congestive heart failure. Activation of the neurohumoral axis.

  1985cited by this paper
• Prostaglandin inhibitors alter loop segment chloride uptake during furosemide diuresis.

  1985cited by this paper
• Inhibition of vasoconstriction by frusemide in the rat

  1984cited by this paper
• Factors modifying the early nondiuretic vascular effects of furosemide in man. The possible role of renal prostaglandins.

  1983cited by this paper
• Pharmacokinetics of phenylbutazone and its metabolites in the horse.

  1981cited by this paper
• Pharmacokinetic-dynamic analysis of the indomethacin-furosemide interaction in man.

  1980cited by this paper
• Effects of furosemide on cardiovascular function and performance when given prior to simulated races: a double-blind study.

  1980cited by this paper
• Effects of furosemide on plasma volume and extracellular fluid volume in horses.

  1978cited by this paper
• The role of the kidney in the early nondiuretic action of furosemide to reduce elevated left atrial pressure in the hypervolemic dog.

  1977cited by this paper
• Acute hemodynamic effects of furosemide administered intravenously in the horse.

  1976cited by this paper
• Renal and extrarenal hemodynamic effects of furosemide in congestive heart failure after acute myocardial infarction.

  1973cited by this paper

• Effects of phenylbutazone, firocoxib, and dipyrone on the diuretic response to furosemide in horses

  2023cites this paper
• Exercise-induced pulmonary haemorrhage in Thoroughbred racehorses: an investigation of risk factors, the association with race day performance and a longitudinal study

  2018cites this paper
• Horse of a different color: Peculiarities of equine pharmacology

  2015cites this paper
• horses during brief intense exertion Furosemide reduces accumulated oxygen deficit in

  2015cites this paper
• Horse of a different color

  2014cites this paper
• Horse of a different color : Peculiarities of equine pharmacology

  2014cites this paper
• Efeito da associação de furosemida e fenilbutazona sobre variáveis hidroeletrolíticas de cavalos antes e após a corrida

  2011cites this paper
• Right ventricular pressure dynamics during exercise: relationship to stress echocardiography.

  2010cites this paper
• Analysis of the right ventricular function in the exercising horse: use of the Fourier Transform.

  2010cites this paper
• Ureteral ligation prevents the haemodynamic effect of frusemide in pentobarbitol anaesthetised horses.

  2010cites this paper
• Hevosdoping. Kirjallisuuskatsaus ja vaikutusten arviointi.

  2010influential citation
• Adverse drug reactions and interactions in the horse.

  2001cites this paper
• Effect of furosemide on performance of Thoroughbreds racing in the United States and Canada.

  1999cites this paper
• Attenuation by phenylbutazone of the renal effects and excretion of frusemide in horses.

  1999cites this paper
• Effects of furosemide on athletic performance and exercise-induced pulmonary hemorrhage in horses.

  1999cites this paper
• Treatments affecting fluid and electrolyte status during exercise.

  1998cites this paper
• Effect of exercise on fluid balance and renal function in horses.

  1998cites this paper
• Review of furosemide in horse racing: its effects and regulation.

  1998cites this paper
• Fluid administration attenuates the haemodynamic effect of frusemide in running horses.

  1998cites this paper
• Effect of furosemide and subsequent intravenous fluid administration on right atrial pressure of splenectomized horses.

  1997cites this paper
• Furosemide reduces accumulated oxygen deficit in horses during brief intense exertion.

  1996cites this paper