Carbohydrate moieties on the procofactor factor V, but not the derived cofactor factor Va, regulate its inactivation by activated protein C.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Biochemistry

• Publication date

  2002-01-03

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI011304GPMID 11814362
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Partial glycosylation at asparagine-2181 of the second C-type domain of human factor V modulates assembly of the prothrombinase complex.

  1999cited by this paper
• Partial glycosylation of Asn2181 in human factor V as a cause of molecular and functional heterogeneity. Modulation of glycosylation efficiency by mutagenesis of the consensus sequence for N-linked glycosylation.

  1999cited by this paper
• Platelet-derived factor Va/Va Leiden cofactor activities are sustained on the surface of activated platelets despite the presence of activated protein C.

  1998cited by this paper
• Secretable human platelet-derived factor V originates from the plasma pool.

  1998cited by this paper
• Factor VLeiden and thrombophilia.

  1997cited by this paper
• The carbohydrate moiety of factor V modulates inactivation by activated protein C.

  1997cited by this paper
• Human factor Va1 and factor Va2: properties in the procoagulant and anticoagulant pathways.

  1997cited by this paper
• Coagulation Factor V: An Old Star Shines Again

  1997cited by this paper
• The effect of Arg306 → Ala and Arg506 → Gln substitutions in the inactivation of recombinant human factor Va by activated protein C and protein S

  1997cited by this paper
• Phenotyping and Genotyping of Coagulation Factor V Leiden

  1996cited by this paper
• Factor V Enhances the Cofactor Function of Protein S in the APC-Mediated Inactivation of Factor VIII: Influence of the Factor VR506Q Mutation

  1996cited by this paper
• Peptide Bond Cleavages and Loss of Functional Activity during Inactivation of Factor Va and Factor VaR506Q by Activated Protein C (*)

  1995cited by this paper
• The Mechanism of Inactivation of Human Platelet Factor Va from Normal and Activated Protein C-resistant Individuals (*)

  1995cited by this paper
• Activated protein C resistance: molecular mechanisms based on studies using purified Gln506-factor V.

  1995cited by this paper
• Characterization of the Molecular Defect in Factor VR506A(*)

  1995cited by this paper
• Thrombin-catalyzed activation of recombinant human factor V.

  1995cited by this paper
• Posttranslational sulfation of factor V is required for efficient thrombin cleavage and activation and for full procoagulant activity.

  1994cited by this paper
• Factor Va-membrane interaction is mediated by two regions located on the light chain of the cofactor.

  1994cited by this paper
• Mutation in blood coagulation factor V associated with resistance to activated protein C

  1994cited by this paper
• Post-translational requirements for functional factor V and factor VIII secretion in mammalian cells.

  1994cited by this paper
• Association of idiopathic venous thromboembolism with single point-mutation at Arg506 of factor V.

  1994cited by this paper
• Inherited resistance to activated protein C is corrected by anticoagulant cofactor activity found to be a property of factor V.

  1994cited by this paper
• The mechanism of inactivation of human factor V and human factor Va by activated protein C.

  1994cited by this paper
• Resistance to activated protein C as a basis for venous thrombosis.

  1994cited by this paper
• Modified APC resistance assay for patients on oral anticoagulants.

  1994cited by this paper
• Frequency of a defective response to activated protein C in patients with a history of venous thrombosis.

  1994cited by this paper
• Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis.

  1994cited by this paper
• Blood coagulation factor Va abnormality associated with resistance to activated protein C in venous thrombophilia.

  1994cited by this paper
• Modified test for activated protein C resistance.

  1994cited by this paper
• Anticoagulant protein C pathway defective in majority of thrombophilic patients.

  1993cited by this paper
• Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden Thrombophilia Study.

  1993cited by this paper
• Characterization of two forms of human factor Va with different cofactor activities.

  1993cited by this paper
• Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C.

  1993cited by this paper
• Role of the membrane in the inactivation of factor Va by activated protein C.

  1993cited by this paper
• Functional characterization of human platelet-released factor V and its activation by factor Xa and thrombin.

  1990cited by this paper
• Identification and characterization of a phospholipid-binding site of bovine factor Va.

  1990cited by this paper
• Surface-dependent reactions of the vitamin K-dependent enzyme complexes.

  1990cited by this paper
• The reassociation of factor Va from its isolated subunits.

  1989cited by this paper
• Cofactor proteins in the assembly and expression of blood clotting enzyme complexes.

  1988cited by this paper
• Blood coagulation factors V and VIII: structural and functional similarities and their relationship to hemorrhagic and thrombotic disorders.

  1988cited by this paper
• Kinetics of inactivation of membrane-bound factor Va by activated protein C. Protein S modulates factor Xa protection.

  1988cited by this paper
• The isolation of human platelet factor V.

  1987cited by this paper
• Complete cDNA and derived amino acid sequence of human factor V.

  1987cited by this paper
• The function of the human factor V carbohydrate moiety in blood coagulation.

  1987cited by this paper
• Cloning of cDNAs coding for the heavy chain region and connecting region of human factor V, a blood coagulation factor with four types of internal repeats.

  1987cited by this paper
• Proteolysis of factor Va by factor Xa and activated protein C.

  1987cited by this paper
• Cloning of a cDNA coding for human factor V, a blood coagulation factor homologous to factor VIII and ceruloplasmin.

  1986cited by this paper
• The interaction of bovine factor V and factor V-derived peptides with phospholipid vesicles.

  1983cited by this paper
• The factor Xa-catalyzed activation of factor V.

  1983cited by this paper
• Inactivation of human coagulation factor V by activated protein C.

  1983cited by this paper
• Radioimmunoassay of factor V in human plasma and platelets.

  1982cited by this paper
• Thrombin-catalyzed activation of human coagulation factor V.

  1982cited by this paper
• Mechanism of action of human activated protein C, a thrombin-dependent anticoagulant enzyme.

  1982cited by this paper
• Factor V.

  1981cited by this paper
• Purification and characterization of human coagulation factor V.

  1981cited by this paper
• A simplified procedure for purification of human prothrombin, factor IX and factor X.

  1981cited by this paper
• A rapid sensitive silver stain for polypeptides in polyacrylamide gels.

  1981cited by this paper
• Isolation of functional human coagulation factor V by using a hybridoma antibody.

  1981cited by this paper
• The contribution of bovine Factor V and Factor Va to the activity of prothrombinase.

  1979cited by this paper
• Human plasma protein C: isolation, characterization, and mechanism of activation by alpha-thrombin.

  1979cited by this paper
• The subunit structure of thrombin-activated factor V. Isolation of activated factor V, separation of subunits, and reconstitution of biological activity.

  1979cited by this paper
• Thrombin-catalyzed activation of single chain bovine factor V.

  1979cited by this paper
• Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

  1979cited by this paper
• A simple method for the preparation of homogeneous phospholipid vesicles.

  1977cited by this paper
• Prothrombin.

  1976cited by this paper
• Factor V.

  1976cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970cited by this paper

• Comprehensive N‐ and O‐glycosylation mapping of human coagulation factor V

  2020cites this paper
• The anticoagulant function of coagulation factor

  2017cites this paper
• α(1,3)-Fucosyltransferases FUT4 and FUT7 control murine susceptibility to thrombosis.

  2013cites this paper
• Identification of the Regions in Factor V Mediating its Edocytosis by Megakaryocytes to Form the Unique Platelet-Derived Cofactor Molecule

  2013cites this paper
• The anticoagulant function of coagulation factor V

  2011cites this paper
• Inactivation of coagulation factors Va and VIIIa by activated protein C

  2011cites this paper
• Carbohydrates and Activity of Natural and Recombinant Tissue Factor*

  2009cites this paper
• Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis.

  2008cites this paper
• Identification of the N-linked glycosylation sites of vitamin K-dependent carboxylase and effect of glycosylation on carboxylase function.

  2006cites this paper
• Elucidation of N-Glycosylation Sites on Human Platelet Proteins

  2006cites this paper
• Post‐translational modifications in proteins involved in blood coagulation

  2005cites this paper