A randomized, double-blind, placebo-controlled study to investigate the safety, tolerability, and pharmacokinetics of single enantiomer (+)-mefloquine compared with racemic mefloquine in healthy persons.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  American Journal of Tropical Medicine and Hygiene

• Publication date

  2010-12-06

• Fields of study

  Medicine

• Identifiers
  DOI 10.4269/ajtmh.2010.10-0228PMID 21118921PMCID PMC2990031
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Guidelines for the treatment of malaria

  2010cited by this paper
• Efficacy and safety of pyronaridine/artesunate fixed-dose combination compared with mefloquine plus artesunate in patients with acute uncomplicated Plasmodium falciparum malaria: results of a pivotal phase III trial

  2009cited by this paper
• Adenosine A2A receptors and Parkinson's disease.

  2009cited by this paper
• Intermittent treatment for the prevention of malaria during pregnancy in Benin: a randomized, open-label equivalence trial comparing sulfadoxine-pyrimethamine with mefloquine.

  2009cited by this paper
• Relative tolerability of Alzheimer's disease treatments.

  2008cited by this paper
• Mefloquine for preventing malaria in non-immune adult travellers.

  2008cited by this paper
• Effectiveness of antimalarial drugs.

  2005cited by this paper
• The leeds sleep evaluation questionnaire in psychopharmacological investigations—a review

  2004cited by this paper
• Tolerability of malaria chemoprophylaxis in non-immune travellers to sub-Saharan Africa: multicentre, randomised, double blind, four arm study

  2003cited by this paper
• Randomized trial of the adenosine A2A receptor antagonist istradefylline in advanced PD

  2003cited by this paper
• Pharmacokinetic Interactions of Antimalarial Agents

  2001cited by this paper
• Mefloquine for preventing malaria in non-immune adult travellers.

  2000cited by this paper
• Mefloquine for preventing malaria in non-immune adult travellers.

  2000cited by this paper
• Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP

  1999cited by this paper
• Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia.

  1997cited by this paper
• Tolerance of mefloquine by SwissAir trainee pilots.

  1997cited by this paper
• Women may be more susceptible to adverse events

  1996cited by this paper
• Adverse events associated with mefloquine. Study in returned travellers confirms authors' findings.

  1996cited by this paper
• Adverse events associated with mefloquine

  1996cited by this paper
• Comparison of adverse events associated with use of mefloquine and combination of chloroquine and proguanil as antimalarial prophylaxis: postal and telephone survey of travellers

  1996cited by this paper
• Pharmacology of adenosine A2A receptors.

  1996cited by this paper
• Pharmacokinetics of mefloquine when given as a single and two divided-dose regimens.

  1995cited by this paper
• Stereoselective pharmacokinetics of mefloquine in healthy Caucasians after multiple doses.

  1994cited by this paper
• Plasmodium falciparum: role of absolute stereochemistry in the antimalarial activity of synthetic amino alcohol antimalarial agents.

  1993cited by this paper
• Mefloquine compared with other malaria chemoprophylactic regimens in tourists visiting east Africa.

  1993cited by this paper
• Long-term malaria prophylaxis with weekly mefloquine.

  1993cited by this paper
• Adenosine-dopamine interactions in the brain.

  1992cited by this paper
• In vitro activity of the enantiomers of mefloquine, halofantrine and enpiroline against Plasmodium falciparum.

  1992cited by this paper
• Mefloquine therapy for Plasmodium falciparum malaria in children under 5 years of age in Malawi: in vivo/in vitro efficacy and correlation of drug concentration with parasitological outcome.

  1990cited by this paper
• Mefloquine kinetics in cured and recrudescent patients with acute falciparum malaria and in healthy volunteers

  1990cited by this paper
• Stereospecific inhibition of cholinesterases by mefloquine enantiomers.

  1987cited by this paper

• Synthesis and Antifungal Activity of Stereoisomers of Mefloquine Analogs.

  2024cites this paper
• An In Silico and In Vitro Assessment of the Neurotoxicity of Mefloquine

  2024cites this paper
• The gender-related variability in the pharmacokinetics and antiplasmodial activity of naphthoquine in rodents

  2020cites this paper
• Current scenario of artemisinin and its analogues for antimalarial activity.

  2019cites this paper
• Adverse effects of mefloquine for the treatment of uncomplicated malaria in Thailand: A pooled analysis of 19, 850 individual patients

  2017cites this paper
• Parasite physiology: No longer lost in translation

  2017cites this paper
• Mefloquine for preventing malaria during travel to endemic areas

  2017cites this paper
• Advances in Malaria Research

  2016cites this paper
• Alternatives to currently used antimalarial drugs: in search of a magic bullet

  2016cites this paper
• Adverse neuropsychiatric effects of antimalarial drugs

  2016cites this paper
• Development of medicines for the control and elimination of malaria

  2016cites this paper
• Role of Plasmodium falciparum transporters in drug resistance

  2016cites this paper
• Antimalarial Chemotherapy: Natural Product Inspired Development of Preclinical and Clinical Candidates with Diverse Mechanisms of Action.

  2016cites this paper
• NEURO-PSYCHIATRIC ILLNESS, BRAIN INJURY, NEUROTOXIC DRUGS AND MORAL INJURY IN AUSTRALIAN DEFENCE FORCE VETERANS Submission the Inquiry into the Mental Health of Australian Defence Force Personnel

  2015cites this paper
• Malaria medicines: a glass half full?

  2015cites this paper
• From medicinal chemistry optimisation of antimalarial 2-aryl quinolones to synthesis and application of endoperoxide activity-based protein profiling probes

  2014cites this paper
• Case Study of Small Molecules As Antimalarials: 2-Amino-1-phenylethanol (APE) Derivatives.

  2014cites this paper
• Idiosyncratic quinoline central nervous system toxicity: Historical insights into the chronic neurological sequelae of mefloquine☆

  2014cites this paper
• Creative solutions to extraordinary challenges in clinical trials: methodology of a phase III trial of azithromycin and chloroquine fixed-dose combination in pregnant women in Africa

  2013cites this paper
• Antimalarial drug discovery: recent progress and future directions.

  2013cites this paper
• The global pipeline of new medicines for the control and elimination of malaria

  2012cites this paper
• A high performance liquid chromatographic assay of Mefloquine in saliva after a single oral dose in healthy adult Africans

  2012cites this paper
• Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy

  2011cites this paper