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In-vivo anthelmintic evaluation of a processed herbal drug from Entada leptostachya (Harms) and Prosopis juliflora (Sw.) (DC) against gastrointestinal nematodes in sheep

J. Mutembei,P. Kareru,F. Njonge,G. Peter,H. Kutima,J. Karanja,D. Kimani

Published 2015 in Unknown venue

ABSTRACT

In vivo anthelmintic activity of a herbal drug processed through spray-drying from Prosopis juliflora (Sw.) DC) and Entada leptostachya (Harms) against gastrointestinal nematodes of sheep is described and reported for the first time in this work. Maximum percent egg count reduction (%ECR) of 80.95% in egg per gram of faeces (EPG) on day 11 post-treatment (PT) was recorded in sheep treated with a dose of 250 mg/kg b.w. of the herbal drug mixture. This was followed by a reduction (P≤0.05) of the same dose treatment (59.80%) on day 8 PT. The positive control exhibited the highest egg count reduction (P˂0.01) with an EPG of 88.31% on day 14 PT (P≤0.05). It was found that the herbal drug had a comparable anthelmintic activity with the conventional anthelmintic drug, Nilzan (1.5% Levamisole HCl). Although the herbal drug had a far much higher concentration than 1.5% Levamisole HCl (5.0 mg/Kg b.w.), the difference in activity could be attributed to high purity of Levamisole. Phytochemical analysis of the herbal drug revealed the presence of alkaloids, steroids, phenolic compounds and tannins, flavonoids and saponins. It was concluded that the processed herbal drug mixture had appreciable anthelmintic activity and could therefore be used as an alternative dewormer in livestock.

PUBLICATION RECORD

  • Publication year

    2015

  • Venue

    Unknown venue

  • Publication date

    Unknown publication date

  • Fields of study

    Agricultural and Food Sciences, Medicine

  • Identifiers

    No identifiers available.

  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

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