Upregulation of microRNA‐135b and microRNA‐182 promotes chemoresistance of colorectal cancer by targeting ST6GALNAC2 via PI3K/AKT pathway

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Molecular Carcinogenesis

• Publication date

  2017-08-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/mc.22710PMID 28767179
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2015cited by this paper
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  2015cited by this paper
• MicroRNA‑135b regulates the stability of PTEN and promotes glycolysis by targeting USP13 in human colorectal cancers.

  2015cited by this paper
• SATB1 and 2 in colorectal cancer.

  2015cited by this paper
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  2014cited by this paper
• Sp1-mediated microRNA-182 expression regulates lung cancer progression

  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
• Cancer statistics, 2014

  2014cited by this paper
• Increased expression of miRNA-182 in colorectal carcinoma: an independent and tissue-specific prognostic factor.

  2014cited by this paper
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  2014cited by this paper
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  2014cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
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  2013cited by this paper
• Up-regulation of miR-182 expression in colorectal cancer tissues and its prognostic value

  2013influential reference
• Association between the expression of four upregulated miRNAs and extrathyroidal invasion in papillary thyroid carcinoma

  2013cited by this paper
• Altered mRNA expressions of sialyltransferases in human gastric cancer tissues

  2012cited by this paper
• microRNA involvement in human cancer.

  2012cited by this paper
• MicroRNA-182 downregulates metastasis suppressor 1 and contributes to metastasis of hepatocellular carcinoma

  2012cited by this paper
• Dysregulation of microRNA-34a expression causes drug-resistance to 5-FU in human colon cancer DLD-1 cells.

  2011cited by this paper
• MicroRNAs: Target Recognition and Regulatory Functions

  2009cited by this paper
• Inhibition of class I phosphoinositide 3-kinase activity impairs proliferation and triggers apoptosis in acute promyelocytic leukemia without affecting atra-induced differentiation.

  2009cited by this paper
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  2009cited by this paper
• alpha 2-6-Linked sialic acids on N-glycans modulate carcinoma differentiation in vivo.

  2008cited by this paper
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  2008cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2002cited by this paper
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  2001cited by this paper
• Cancer statistics

  1989cited by this paper

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• Charge matters: how flanking substrate charge modulates O-glycan Core elongation.

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  2024cites this paper
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  2024cites this paper
• MicroRNA-135b mainly functions as an oncogene during tumor progression.

  2024cites this paper
• Sialylation in the gut: From mucosal protection to disease pathogenesis.

  2024cites this paper
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  2024cites this paper
• Drug resistance and new therapies in gallbladder cancer.

  2023cites this paper
• MicroRNA-183 cluster: a promising biomarker and therapeutic target in gastrointestinal malignancies.

  2023cites this paper
• Revolutionizing colorectal cancer treatment: unleashing the potential of miRNAs in targeting cancer stem cells.

  2023cites this paper
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  2023cites this paper
• A comprehension of signaling pathways and drug resistance; an insight into the correlation between microRNAs and cancer.

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  2023cites this paper
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  2023cites this paper
• Rebound increase in microRNA levels at the end of 5-FU-based therapy in colorectal cancer patients

  2023cites this paper
• The Critical Function of microRNAs in Developing Resistance against 5-Fluorouracil in Cancer Cells.

  2023cites this paper
• Recent advances microRNAs and metabolic reprogramming in colorectal cancer research

  2023cites this paper
• The emerging role of MicroRNA-182 in tumorigenesis; a promising therapeutic target

  2023cites this paper
• The miR-183 Cluster: Biogenesis, Functions, and Cell Communication via Exosomes in Cancer

  2023cites this paper
• Cancer stem cells in colorectal cancer: signaling pathways involved in stemness and therapy resistance.

  2023cites this paper
• Novel strategies to reverse chemoresistance in colorectal cancer

  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
• Reposition of the anti-inflammatory drug diacerein in an in-vivo colorectal cancer model

  2021cites this paper
• Dissecting miRNA signature in colorectal cancer progression and metastasis.

  2020cites this paper
• The role of miRNAs in colorectal cancer progression and chemoradiotherapy.

  2020cites this paper
• LOC441178 Overexpression Inhibits the Proliferation and Migration of Esophageal Carcinoma Cells via Methylation of miR-182

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• MicroRNA expression profiling in the colorectal normal-adenoma-carcinoma transition.

  2019cites this paper
• PI3K/ Akt/ mTOR pathway as a therapeutic target for colorectal cancer: A review of preclinical and clinical evidence.

  2019cites this paper
• A panel of serum exosomal microRNAs as predictive markers for chemoresistance in advanced colorectal cancer

  2019cites this paper
• Interactions among lncRNAs, miRNAs and mRNA in colorectal cancer.

  2019cites this paper
• Targeted delivery of anti-miR-155 by functionalized mesoporous silica nanoparticles for colorectal cancer therapy

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• The role of microRNAs in 5‐FU resistance of colorectal cancer: Possible mechanisms

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• Current understanding and clinical utility of miRNAs regulation of colon cancer stem cells.

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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