Notch Receptor‐Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Stem Cells

• Publication date

  2015-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/stem.2031PMID 25851125PMCID PMC4478168
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow

  2015cited by this paper
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• Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-κB-dependent manner.

  2014cited by this paper
• An Evolutionary-Conserved Function of Mammalian Notch Family Members as Cell Adhesion Molecules

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• Deltex-1 Activates Mitotic Signaling and Proliferation and Increases the Clonogenic and Invasive Potential of U373 and LN18 Glioblastoma Cells and Correlates with Patient Survival

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• Klf5 controls bone marrow homing of stem cells and progenitors through Rab5-mediated β1/β2-integrin trafficking

  2013cited by this paper
• Regional localization within the bone marrow influences the functional capacity of human HSCs.

  2013cited by this paper
• Dynamic Imaging of Marrow-Resident Granulocytes Interacting with Human Mesenchymal Stem Cells upon Systemic Lipopolysaccharide Challenge

  2013cited by this paper
• Haematopoietic stem cells and early lymphoid progenitors occupy distinct bone marrow niches

  2013cited by this paper
• Arteriolar niches maintain haematopoietic stem cell quiescence

  2013cited by this paper
• CXCL12 Production by Early Mesenchymal Progenitors is Required for Hematopoietic Stem Cell Maintenance

  2012cited by this paper
• Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration.

  2012cited by this paper
• Endothelial and perivascular cells maintain haematopoietic stem cells

  2011cited by this paper
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  2011cited by this paper
• Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche

  2011cited by this paper
• Genome-wide Analysis of Simultaneous GATA1/2, RUNX1, FLI1, and SCL Binding in Megakaryocytes Identifies Hematopoietic Regulators

  2011cited by this paper
• Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions.

  2011cited by this paper
• Notch2 governs the rate of generation of mouse long- and short-term repopulating stem cells.

  2011cited by this paper
• Fucose‐deficient hematopoietic stem cells have decreased self‐renewal and aberrant marrow niche occupancy

  2010cited by this paper
• Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells.

  2010cited by this paper
• Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

  2010cited by this paper
• Chronic DLL4 blockade induces vascular neoplasms

  2010cited by this paper
• A Notch Ligand, Delta-Like 1 Functions As an Adhesion Molecule for Mast Cells

  2010cited by this paper
• Positioning of bone marrow hematopoietic and stromal cells relative to blood flow in vivo: serially reconstituting hematopoietic stem cells reside in distinct nonperfused niches.

  2010cited by this paper
• Biophysical Determinants of Notch Signaling.

  2009cited by this paper
• Functional Heterogeneity of the Bone Marrow Vascular Niche

  2009cited by this paper
• Notch-dependent control of myelopoiesis is regulated by fucosylation.

  2008cited by this paper
• Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation

  2008cited by this paper
• In vivo consequences of deleting EGF repeats 8–12 including the ligand binding domain of mouse Notch1

  2008cited by this paper
• The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development

  2008cited by this paper
• The transcription factor EGR1 controls both the proliferation and localization of hematopoietic stem cells.

  2008cited by this paper
• Pofut1 is required for the proper localization of the Notch receptor during mouse development.

  2008cited by this paper
• Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment.

  2007cited by this paper
• Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow

  2007cited by this paper
• Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization.

  2007cited by this paper
• Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches

  2007cited by this paper
• Parathyroid hormone stimulates expression of the Notch ligand Jagged1 in osteoblastic cells.

  2006cited by this paper
• PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

  2006cited by this paper
• Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis

  2006cited by this paper
• Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis

  2006cited by this paper
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  2006cited by this paper
• Bone-marrow haematopoietic-stem-cell niches

  2006cited by this paper
• Maintenance of the hematopoietic stem cell pool by CXCL12-CXCR4 chemokine signaling in bone marrow stromal cell niches.

  2006cited by this paper
• Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis.

  2006cited by this paper
• Dominance of SOX9 function over RUNX2 during skeletogenesis

  2006cited by this paper
• Material For : Chaperone Activity of Protein O-fucosyltransferase 1 Promotes Notch Receptor Folding

  2005cited by this paper
• O-Fucosylation of Notch Occurs in the Endoplasmic Reticulum*

  2005cited by this paper
• Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist

  2005cited by this paper
• G-CSF potently inhibits osteoblast activity and CXCL12 mRNA expression in the bone marrow.

  2005cited by this paper
• Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche.

  2004cited by this paper
• Circulation and Chemotaxis of Fetal Hematopoietic Stem Cells

  2004cited by this paper
• Modulation of Notch-Ligand Binding by Protein O-Fucosyltransferase 1 and Fringe*

  2003cited by this paper
• Identification of the haematopoietic stem cell niche and control of the niche size

  2003cited by this paper
• Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways

  2003cited by this paper
• Osteoblastic cells regulate the haematopoietic stem cell niche

  2003cited by this paper
• Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation.

  2002cited by this paper
• Activated Notch4 Inhibits Angiogenesis: Role of β1-Integrin Activation

  2002cited by this paper
• Regulation of notch signaling by o-linked fucose.

  2002cited by this paper
• Synergistic mobilization of hemopoietic progenitor cells using concurrent beta1 and beta2 integrin blockade or beta2-deficient mice.

  2001cited by this paper
• Synergistic mobilization of hemopoietic progenitor cells using concurrent β1 and β2 integrin blockade or β2-deficient mice

  2001cited by this paper
• Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis

  2001cited by this paper
• Modification of epidermal growth factor-like repeats with O-fucose. Molecular cloning and expression of a novel GDP-fucose protein O-fucosyltransferase.

  2001cited by this paper
• The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells

  2000cited by this paper
• Hematopoietic stem cell quiescence maintained by p21cip1/waf1.

  2000cited by this paper
• All-trans retinoic acid enhances the long-term repopulating activity of cultured hematopoietic stem cells.

  2000cited by this paper
• Adhesion molecules in haemopoiesis.

  1997cited by this paper
• Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor.

  1991cited by this paper
• Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila.

  1990cited by this paper
• Hematopoietic Stem Cell Quiescence Maintained by p 21 cip 1 / waf 1

  year unknowncited by this paper

• Targeting Endothelial PERK Accelerates Lymphoid Regeneration by Enhancing DLL4-NOTCH3 Signaling at the Pre-B Niche

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• ‘Nomadic’ Hematopoietic Stem Cells Navigate the Embryonic Landscape

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• Jag1 insufficiency alters liver fibrosis via T cell and hepatocyte differentiation defects

  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
• Ex Vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells.

  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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• Understanding the “SMART” features of hematopoietic stem cells and beyond

  2021cites this paper
• The Role of Bone Stem Cell Niches in Bone Metastasis

  2020cites this paper
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  2020influential citation
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• A modifier in the 129S2/SvPasCrl genome is responsible for the viability of Notch1[12f/12f] mice

  2019cites this paper
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  2018cites this paper
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  2018cites this paper
• Investigating the mechanism of bone marrow failure observed in patients with acute myeloid leukaemia

  2018cites this paper
• Multiple roles for O‐glycans in Notch signalling

  2018cites this paper
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