Cell cycle regulation in the inner ear sensory epithelia: role of cyclin D1 and cyclin-dependent kinase inhibitors.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Developmental Biology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ydbio.2009.10.027PMID 19854167
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• CDK inhibitors: cell cycle regulators and beyond.

  2008cited by this paper
• Prox1 interacts with Atoh1 and Gfi1, and regulates cellular differentiation in the inner ear sensory epithelia.

  2008cited by this paper
• Cyclin D1 in excitatory neurons of the adult brain enhances kainate-induced neurotoxicity.

  2008cited by this paper
• Notch signaling regulates growth and differentiation in the mammalian lens.

  2008cited by this paper
• The influence of glycogen synthase kinase 3 in limiting cell addition in the mammalian ear

  2008cited by this paper
• p19Ink4d and p21Cip1 Collaborate to Maintain the Postmitotic State of Auditory Hair Cells, Their Codeletion Leading to DNA Damage and p53-Mediated Apoptosis

  2007cited by this paper
• Proliferative responses to growth factors decline rapidly during postnatal maturation of mammalian hair cell epithelia

  2007cited by this paper
• Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?

  2007cited by this paper
• Regulation of cell fate in the sensory epithelia of the inner ear

  2007cited by this paper
• Regulation of cell fate in the sensory epithelia of the inner ear

  2006cited by this paper
• A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development

  2006cited by this paper
• Wnt/beta-catenin signaling in development and disease.

  2006cited by this paper
• Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis.

  2006cited by this paper
• Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells

  2006cited by this paper
• Post-translational protein modification as the substrate for long-lasting memory.

  2005cited by this paper
• The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear

  2005cited by this paper
• Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors

  2003cited by this paper
• GSK-3-selective inhibitors derived from Tyrian purple indirubins.

  2003cited by this paper
• Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d

  2003cited by this paper
• Development of mice expressing a single D-type cyclin.

  2002cited by this paper
• Intracellular Signals That Control Cell Proliferation in Mammalian Balance Epithelia: Key Roles for Phosphatidylinositol-3 Kinase, Mammalian Target of Rapamycin, and S6 Kinases in Preference to Calcium, Protein Kinase C, and Mitogen-Activated Protein Kinase

  2001cited by this paper
• Cyclin-Dependent Kinase 4 and Cyclin D1 Are Required for Excitotoxin-Induced Neuronal Cell Death In Vivo

  2001cited by this paper
• Brief Treatments with Forskolin Enhance S-Phase Entry in Balance Epithelia from the Ears of Rats

  2001cited by this paper
• Liver regeneration.

  2000cited by this paper
• Predictors of morbidity and mortality after the first episode of upper gastrointestinal bleeding in liver cirrhosis.

  2000cited by this paper
• p57(Kip2) regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina.

  2000cited by this paper
• Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells.

  1999cited by this paper
• β-Catenin regulates expression of cyclin D1 in colon carcinoma cells

  1999cited by this paper
• The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.

  1999cited by this paper
• Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation.

  1999cited by this paper
• Cyclin D1 promotes mitogen-independent cell cycle progression in hepatocytes.

  1999cited by this paper
• Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti.

  1999cited by this paper
• p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti.

  1999cited by this paper
• Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development.

  1998cited by this paper
• Unconventional Myosins in Inner-Ear Sensory Epithelia

  1997cited by this paper
• Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.

  1997cited by this paper
• Ototoxicity in developing mammals.

  1995cited by this paper
• Mice lacking cyclin D1 are small and show defects in eye and mammary gland development.

  1995cited by this paper
• Cyclin D1 is a nuclear protein required for cell cycle progression in G1.

  1993cited by this paper
• Regenerative proliferation in inner ear sensory epithelia from adult guinea pigs and humans.

  1993cited by this paper
• Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle.

  1991cited by this paper
• Regeneration of sensory hair cells after acoustic trauma.

  1988cited by this paper
• Hair cell regeneration after acoustic trauma in adult Coturnix quail.

  1988cited by this paper
• Development of the inner ear of the mouse: a radioautographic study of terminal mitoses.

  1967cited by this paper

• Regeneration of sensory hair cells in mature mammals.

  2025cites this paper
• Integrated scRNAseq analyses of mouse cochlear supporting cells reveal the involvement of Ezh2 in hair cell regeneration

  2024cites this paper
• Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

  2022cites this paper
• Neuroprotective role of insulin-like growth factor 1 in auditory and other nervous systems.

  2022cites this paper
• Insulin-like Growth Factor 1 Signaling in Mammalian Hearing

  2021cites this paper
• Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal

  2020cites this paper
• LIN28B controls the regenerative capacity of neonatal murine auditory supporting cells through activation of mTOR signaling

  2020cites this paper
• Characterizing Adult Cochlear Supporting Cell Transcriptional Diversity Using Single-Cell RNA-Seq: Validation in the Adult Mouse and Translational Implications for the Adult Human Cochlea

  2020cites this paper
• Spatiotemporally controlled overexpression of cyclin D1 triggers generation of supernumerary cells in the postnatal mouse inner ear.

  2020cites this paper
• Correction: Transcriptomic analysis of the developing and adult mouse cochlear sensory epithelia

  2020cites this paper
• Gene therapy for hair cell regeneration: Review and new data.

  2020cites this paper
• Characterizing Adult cochlear supporting cell transcriptional diversity using single-cell RNA-Seq: Validation in the adult mouse and translational implications for the adult human cochlea

  2019cites this paper
• Novel insights into inner ear development and regeneration for targeted hearing loss therapies.

  2019cites this paper
• Gata3 is required for the functional maturation of inner hair cells and their innervation in the mouse cochlea

  2019cites this paper
• Applications of Lgr5-Positive Cochlear Progenitors (LCPs) to the Study of Hair Cell Differentiation

  2019cites this paper
• Telomerase reverse transcriptase induced thyroid carcinoma cell proliferation through PTEN/AKT signaling pathway

  2018cites this paper
• Pluripotent stem cell-derived cochlear cells: a challenge in constant progress

  2018cites this paper
• Evaluation of 14-3-3 sigma as a potential partner of p16 in quiescence and differentiation

  2018cites this paper
• Characterization of Wnt and Notch-Responsive Lgr5+ Hair Cell Progenitors in the Striolar Region of the Neonatal Mouse Utricle

  2018influential citation
• Characterization of Lgr5+ Progenitor Cell Transcriptomes after Neomycin Injury in the Neonatal Mouse Cochlea

  2017influential citation
• Development and regeneration of vestibular hair cells in mammals.

  2017cites this paper
• Postmitotic state of a cell as a challenge for regeneration: inner ear as a model

  2017influential citation
• Elastic force restricts growth of the murine utricle

  2017cites this paper
• LGR4 and LGR5 Regulate Hair Cell Differentiation in the Sensory Epithelium of the Developing Mouse Cochlea

  2016cites this paper
• Regeneration of hair cells in the mammalian vestibular system

  2016cites this paper
• Identification of Adeno-Associated Viral Vectors That Target Neonatal and Adult Mammalian Inner Ear Cell Subtypes

  2016cites this paper
• Seminars in Cell and Developmental Biology Insights into inner ear-specific gene regulation: epigenetics and non-coding RNAs in inner ear development and regeneration

  2016cites this paper
• Insulin-like growth factor 1: A novel treatment for the protection or regeneration of cochlear hair cells.

  2015cites this paper
• The Wnt and Notch signalling pathways in the developing cochlea: Formation of hair cells and induction of regenerative potential

  2015influential citation
• The RNA-binding protein LIN28B regulates developmental timing in the mammalian cochlea

  2015cites this paper
• Characterisation of cello : an ENU-induced mouse model of early-onset hearing loss

  2015cites this paper
• Toward Translating Molecular Ear Development to Generate Hair Cells from Stem Cells

  2014cites this paper
• C-MYC Transcriptionally Amplifies SOX2 Target Genes to Regulate Self-Renewal in Multipotent Otic Progenitor Cells

  2014cites this paper
• DNA damage signaling regulates age-dependent proliferative capacity of quiescent inner ear supporting cells

  2014cites this paper
• Adult Stem Cells

  2014cites this paper
• Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear.

  2014cites this paper
• 3D mouse embryonic stem cell culture for generating inner ear organoids

  2014cites this paper
• Auditory Hair Cell-Specific Deletion of p27Kip1 in Postnatal Mice Promotes Cell-Autonomous Generation of New Hair Cells and Normal Hearing

  2014cites this paper
• Insulin-like growth factor 1 inhibits hair cell apoptosis and promotes the cell cycle of supporting cells by activating different downstream cascades after pharmacological hair cell injury in neonatal mice.

  2013cites this paper
• Ectopic Expression of Activated Notch or SOX2 Reveals Similar and Unique Roles in the Development of the Sensory Cell Progenitors in the Mammalian Inner Ear

  2013influential citation
• A brief history of hair cell regeneration research and speculations on the future.

  2013cites this paper
• Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA.

  2013cites this paper
• Optical analogues of the Newton–Schrödinger equation and boson star evolution

  2013cites this paper
• Coupling the cell cycle to development and regeneration of the inner ear.

  2013cites this paper
• A historical to present-day account of efforts to answer the question: "what puts the brakes on mammalian hair cell regeneration?".

  2013cites this paper
• Changes in the adult vertebrate auditory sensory epithelium after trauma.

  2013cites this paper
• Development and characterization of pro-apoptotic drug candidates for anticancer drug discovery

  2013cites this paper
• Scratch2 Prevents Cell Cycle Re-Entry by Repressing miR-25 in Postmitotic Primary Neurons

  2013cites this paper
• Inner ear supporting cells: rethinking the silent majority.

  2013cites this paper
• Lack of Rbl1/p107 Effects on Cell Proliferation and Maturation in the Inner Ear

  2013cites this paper
• Cdc42-dependent structural development of auditory supporting cells is required for wound healing at adulthood

  2012cites this paper
• Regulationofp27 Kip1 bySox2MaintainsQuiescenceofInner PillarCellsintheMurineAuditorySensoryEpithelium

  2012cites this paper
• Regulation of p27Kip1 by Sox2 Maintains Quiescence of Inner Pillar Cells in the Murine Auditory Sensory Epithelium

  2012cites this paper
• Over Half the Hair Cells in the Mouse Utricle First Appear After Birth, with Significant Numbers Originating from Early Postnatal Mitotic Production in Peripheral and Striolar Growth Zones

  2012cites this paper
• MYC Gene Delivery to Adult Mouse Utricles Stimulates Proliferation of Postmitotic Supporting Cells In Vitro

  2012cites this paper
• Stem Cell Therapy for the Inner Ear

  2012cites this paper
• A dual function for canonical Wnt/β-catenin signaling in the developing mammalian cochlea

  2012cites this paper
• Transcriptional mechanisms of developmental cell cycle arrest: problems and models.

  2012cites this paper
• In Vivo Proliferative Regeneration of Balance Hair Cells in Newborn Mice

  2012influential citation
• Transcriptomic Analysis of the Developing and Adult Mouse Cochlear Sensory Epithelia

  2012cites this paper
• The MYC Road to Hearing Restoration

  2012cites this paper
• Arrêt de la prolifération cellulaire pendant le développement embryonnaire : étude transcriptionnelle de gènes suppresseurs de tumeurs au cours de la croissance du système nerveux central chez le poisson médaka Oryzias latipes

  2012cites this paper
• Dynamics of Wnt/β-catenin signalling during cerebellum development

  2012cites this paper
• The Cyclin Dependent Kinase Inhibitor p27 Kip1 Maintains Terminal Differentiation in the Mouse Organ of Corti

  2011cites this paper
• Expression of candidate markers for stem/progenitor cells in the inner ears of developing and adult GFAP and nestin promoter-GFP transgenic mice.

  2011cites this paper
• p27Kip1 is required to maintain proliferative quiescence in the adult cochlea and pituitary

  2011cites this paper
• The Cyclin-Dependent Kinase Inhibitor and Tumor Suppressor Locus p16/INK4Ap14ARF and Regulation of the Transition Into and Out of the Cell Cycle

  2011influential citation
• Restrictions in Cell Cycle Progression of Adult Vestibular Supporting Cells in Response to Ectopic Cyclin D1 Expression

  2011influential citation
• Variations in Shape-Sensitive Restriction Points Mirror Differences in the Regeneration Capacities of Avian and Mammalian Ears

  2011cites this paper
• Characterization of the Key Mouse Cochlear Developmental Genes for Auditory Hair Cell Regeneration

  2011cites this paper
• N-myc Controls Proliferation, Morphogenesis, and Patterning of the Inner Ear

  2011influential citation
• Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research.

  2011cites this paper
• Regulated reprogramming in the regeneration of sensory receptor cells.

  2011cites this paper
• Stem Cell Replacement Therapy for the Mammalian Inner Ear: A Systematic Literature Review

  2011cites this paper
• The Volta Review

  2010cites this paper
• In Vivo Proliferation of Postmitotic Cochlear Supporting Cells by Acute Ablation of the Retinoblastoma Protein in Neonatal Mice

  2010cites this paper