Group I metabotropic glutamate receptors reduce excitotoxic injury and may facilitate neurogenesis.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Neuropharmacology

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.NEUROPHARM.2005.04.029PMID 16023152
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Antisense oligonucleotide against GTPase Rab5b inhibits metabotropic agonist DHPG-induced neuroprotection.

  2004cited by this paper
• Changes in hippocampal gene expression after neuroprotective activation of group I metabotropic glutamate receptors.

  2003cited by this paper
• The distinct role of mGlu1 receptors in post-ischemic neuronal death.

  2003cited by this paper
• Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents.

  2003cited by this paper
• Group I mGluRs increase excitability of hippocampal CA1 pyramidal neurons by a PLC-independent mechanism.

  2002cited by this paper
• Neurogenesis in Adult Subventricular Zone

  2002cited by this paper
• Effect of chronic imipramine or electroconvulsive shock on the expression of mGluR1a and mGluR5a immunoreactivity in rat brain hippocampus.

  2002cited by this paper
• Regulation of phosphoinositide-specific phospholipase C.

  2001cited by this paper
• Internalization of ionotropic glutamate receptors in response to mGluR activation

  2001cited by this paper
• Cell culture: Progenitor cells from human brain after death

  2001cited by this paper
• Cell culture. Progenitor cells from human brain after death.

  2001cited by this paper
• NMDA receptor antagonist treatment induces a long‐lasting increase in the number of proliferating cells, PSA‐NCAM‐immunoreactive granule neurons and radial glia in the adult rat dentate gyrus

  2001cited by this paper
• Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells.

  2001cited by this paper
• Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus

  2001cited by this paper
• Metabotropic glutamate receptor activation causes a rapid redistribution of AMPA receptors.

  2001influential reference
• Group I and Group III metabotropic glutamate receptor subtypes provide enhanced neuroprotection

  2000cited by this paper
• Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus

  2000cited by this paper
• Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus

  2000cited by this paper
• Inhibitors of phospholipase C prevent glutamate neurotoxicity in primary cultures of cerebellar neurons.

  2000cited by this paper
• Activation of group I metabotropic glutamate receptors reduces neuronal apoptosis but increases necrotic cell death in vitro

  2000cited by this paper
• Neuroprotective action of group I metabotropic glutamate receptor agonists against oxygen-glucose deprivation-induced neuronal death.

  2000cited by this paper
• Structure, function, and control of phosphoinositide-specific phospholipase C.

  2000cited by this paper
• Activation of group I metabotropic glutamate receptors induces long-term depression at sensory synapses in superficial spinal dorsal horn.

  2000cited by this paper
• Insulin-Like Growth Factor-I Promotes Neurogenesis and Synaptogenesis in the Hippocampal Dentate Gyrus during Postnatal Development

  2000cited by this paper
• Glutamate-mediated neuroprotection against N-methyl-D-aspartate toxicity: a role for metabotropic glutamate receptors.

  2000cited by this paper
• A family of proteins implicated in axon guidance and outgrowth.

  1999cited by this paper
• Protective effect of group I metabotropic glutamate receptor activation against hypoxic/hypoglycemic injury in rat hippocampal slices: timing and involvement of protein kinase C.

  1999cited by this paper
• Group-I metabotropic glutamate receptors: hypotheses to explain their dual role in neurotoxicity and neuroprotection.

  1999cited by this paper
• Two compounds commonly used for phospholipase C inhibition activate the nuclear estrogen receptors.

  1999cited by this paper
• Phosphoinositide hydrolysis in vivo with group I metabotropic glutamate receptor agonists.

  1999cited by this paper
• Induction of LTD by activation of group I mGluR in the dentate gyrus in vitro.

  1999cited by this paper
• Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias.

  1999cited by this paper
• Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat.

  1998cited by this paper
• Multipotent progenitor cells in the adult dentate gyrus.

  1998cited by this paper
• Neurogenesis in the adult human hippocampus

  1998cited by this paper
• Differential expression of rat brain phospholipase C isozymes in development and aging.

  1998cited by this paper
• Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain

  1997cited by this paper
• Phospholipase C inhibitor, U73122, releases intracellular Ca2+, potentiates Ins(1,4,5)P3-mediated Ca2+ release and directly activates ion channels in mouse pancreatic acinar cells.

  1997cited by this paper
• Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation

  1997cited by this paper
• Suppression of phospholipase C beta, gamma, and delta families alters cell growth and phosphatidylinositol 4,5-bisphosphate levels.

  1997cited by this paper
• Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus

  1997cited by this paper
• Altered expression of group I metabotropic glutamate receptors in the hippocampus of amygdala-kindled rats.

  1996cited by this paper
• Early postmitotic neurons transiently express TOAD‐64, a neural specific protein

  1995cited by this paper
• TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth

  1995cited by this paper
• Activation of metabotropic glutamate receptors coupled to inositol phospholipid hydrolysis amplifies NMDA-induced neuronal degeneration in cultured cortical cells.

  1995cited by this paper
• Neurogenesis persists in the subependymal layer of the adult mouse brain.

  1993cited by this paper
• Activation of metabotropic receptors has a neuroprotective effect in a rodent model of focal ischaemia.

  1992cited by this paper
• A simple method for organotypic cultures of nervous tissue.

  1991cited by this paper
• Activation of the metabotropic glutamate receptor attenuates N-methyl-D-aspartate neurotoxicity in cortical cultures.

  1991cited by this paper

• Neuroglia in epilepsy.

  2025cites this paper
• Metabotropic glutamate receptors—guardians and gatekeepers in neonatal hypoxic-ischemic brain injury

  2024cites this paper
• Transcriptome analysis reveals genes associated with stem cell activation by physical exercise in the dentate gyrus of aged p16Ink4a knockout mice

  2023cites this paper
• mGluR1α expression in the hippocampus, subiculum, entorhinal cortex and superior temporal gyrus in Alzheimer’s disease

  2022influential citation
• Secondary Intracranial Hypertension After Ciprofloxacin Treatment: A Case Report

  2021cites this paper
• Role of Optineurin In Metabotropic Glutamate Receptor 5-Regulated Autophagy

  2020cites this paper
• Location-dependent role of phospholipase C signaling in the brain: Physiology and pathology.

  2020cites this paper
• Improvement of impaired electrical activity in NPC1 mutant cortical neurons upon DHPG stimulation detected by micro-electrode array.

  2018cites this paper
• The Role of Metabotropic Glutamate Receptor 1 Dependent Signaling in Glioma Viability

  2018cites this paper
• The Akt pathway in oncology therapy and beyond (Review)

  2018influential citation
• The role of ADHD associated genes in neurodevelopment.

  2018cites this paper
• Meet Our Editorial Board Member

  2018cites this paper
• Gender‐specific desensitization of group I metabotropic glutamate receptors after maternal l‐glutamate intake during lactation

  2018influential citation
• Functional changes of AMPA responses in human induced pluripotent stem cell–derived neural progenitors in fragile X syndrome

  2018cites this paper
• Metabotropic glutamate receptors and neurodegenerative diseases.

  2017cites this paper
• Metabotropic glutamate receptor 5 responses dictate differentiation of neural progenitors to NMDA‐responsive cells in fragile X syndrome

  2017cites this paper
• Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington’s disease

  2017cites this paper
• The Role of Metabotropic Glutamate Receptor 1 (MGLU1) Dependent Signaling in Glioma Cell Line Viability

  2017cites this paper
• Crosstalk of metabolic factors and neurogenic signaling in adult neurogenesis: Implication of metabolic regulation for mental and neurological diseases.

  2017cites this paper
• Selective inhibition of metabotropic glutamate type 1 alpha receptor (mGluR1α) reduces cell proliferation and migration following status epilepticus in early development

  2016cites this paper
• Maternal exposure to hexachlorophene targets intermediate‐stage progenitor cells in the hippocampal neurogenesis involving myelin vacuolation of cholinergic and glutamatergic inputs in mice

  2016cites this paper
• The Effects of Jodeungsan Pharmacopuncture at GB20 on Cognitive Impairment Induced by Focal Brain Injury in Rats

  2016cites this paper
• The dose makes the poison: from glutamate-mediated neurogenesis to neuronal atrophy and depression

  2016cites this paper
• Metabotropic glutamate receptor 1 promotes cementoblast proliferation via MAP kinase signaling pathways

  2016cites this paper
• Glutamate promotes neural stem cell proliferation by increasing the expression of vascular endothelial growth factor of astrocytes in vitro.

  2015cites this paper
• Transient Receptor Potential Channels and Their Role in Modulating Radial Glial–Neuronal Interaction: A Signaling Pathway Involving mGluR5

  2015cites this paper
• Hypobaric Preconditioning Modifies Group I mGluRs Signaling in Brain Cortex

  2015cites this paper
• Up-regulation of DRP-3 long isoform during the induction of neural progenitor cells by glutamate treatment in the ex vivo rat retina.

  2015cites this paper
• [General anesthetics as a factor of effective neuroprotection in ischemic stroke models].

  2015cites this paper
• mGluR5 protect astrocytes from ischemic damage in postnatal CNS white matter

  2015cites this paper
• HD iPSC-derived neural progenitors accumulate in culture and are susceptible to BDNF withdrawal due to glutamate toxicity.

  2015cites this paper
• VGF (TLQP-62)-induced neurogenesis targets early phase neural progenitor cells in the adult hippocampus and requires glutamate and BDNF signaling.

  2014cites this paper
• mGluR5: a potential target for the treatment of Huntington's disease

  2014cites this paper
• The role of glutamate and its receptors in the proliferation, migration, differentiation and survival of neural progenitor cells

  2014cites this paper
• Metabotropic glutamate receptor 5 as a potential therapeutic target in Huntington’s disease

  2014influential citation
• Metabotropic glutamate receptors in oligodendrocytes and astrocytes in white and grey matter brain regions

  2014cites this paper
• Role of metabotropic glutamate receptor 5 signaling and homer in oxygen glucose deprivation-mediated astrocyte apoptosis

  2013cites this paper
• Effect of glutamate receptor antagonists on migrating neural progenitor cells

  2013cites this paper
• Metabotropic glutamate receptor 5 (mGluR5) regulates proliferation and differentiation of neuronal progenitors in the developmental hippocampus.

  2013cites this paper
• Neural progenitor cell differentiation and migration : Role of glutamate signaling, brain-derived neurotrophic factor, and hypoxia/acidosis

  2013cites this paper
• Metabotropic glutamate receptor 5 positive allosteric modulators are neuroprotective in a mouse model of Huntington's disease

  2013cites this paper
• G-Protein-Coupled Receptors in Adult Neurogenesis

  2012influential citation
• Phosphoinositide pathway and the signal transduction network in neural development

  2012cites this paper
• Glutamate in CNS neurodegeneration and cognition and its regulation by GCPII inhibition.

  2012cites this paper
• Altered expression of metabotropic glutamate receptor 1 alpha after acute diffuse brain injury

  2012cites this paper
• Neuroprotective effect of Buyang Huanwu decoction against focal cerebral ischemia/reperfusion injury in rats--time window and mechanism.

  2012cites this paper
• Excitatory amino acids in neurological and neurodegenerative disorders.

  2012cites this paper
• GROUP I METABOTROPIC GLUTAMATE RECEPTORS ON SELECTIVE CELLULAR SUBTYPES IN EPILEPTOGENIC MALFORMED CORTEX

  2012cites this paper
• Phosphoinositide pathway and the signal transduction network in neural development

  2012cites this paper
• Brain-derived neurotrophic factor increases the motility of a particular N-methyl-D-aspartate /GABA-responsive subset of neural progenitor cells.

  2012cites this paper
• Efecto de la administración de glicina en la función motora de la rata después de lesión traumática de la médula espinal

  2011cites this paper
• Altered PLCβ-1 expression in the gerbil hippocampal complex following spontaneous seizure.

  2011cites this paper
• Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors.

  2010cites this paper
• The PDZ domain protein CAL interacts with mGluR5a and modulates receptor expression

  2010influential citation
• Treadmill pre-training suppresses the release of glutamate resulting from cerebral ischemia in rats

  2010cites this paper
• Glutamate Differently Modulates Metabotropic Glutamate Receptors in Neuronal and Glial Cells

  2010cites this paper
• Interneuron subtype specific activation of mGluR1/5 during epileptiform activity in hippocampus

  2010cites this paper
• Metabotropic Glutamate Receptor-Mediated Cell Signaling Pathways Are Altered in a Mouse Model of Huntington's Disease

  2010cites this paper
• A hypothesized role for dendritic remodeling in the etiology of mood and anxiety disorders.

  2010cites this paper
• Neurotransmitter responsiveness during early maturation of neural progenitor cells.

  2009cites this paper
• Molecular mechanisms underlying glutamatergic dysfunction in schizophrenia: therapeutic implications

  2009cites this paper
• Modulation de l’expression du transporteur vésiculaire du glutamate : implication dans la plasticité des neurones dopaminergiques

  2009cites this paper
• Alterations in gene expression of glutamate receptors and exocytosis-related factors by a hydroxylated-polychlorinated biphenyl in the developing rat brain.

  2009cites this paper
• mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice.

  2008cites this paper
• Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats.

  2008cites this paper
• Group I metabotropic glutamate receptors control proliferation, survival and differentiation of cultured neural progenitor cells isolated from the subventricular zone of adult mice.

  2008cites this paper
• Synaptic plasticity in mice (Mus musculus L., 1758) deficient in cell adhesion or extracellular matrix molecules: in vivo and in vitro electrophysiological analysis

  2008cites this paper
• Insensitivity to glutamate neurotoxicity mediated by NMDA receptors in association with delayed mitochondrial membrane potential disruption in cultured rat cortical neurons

  2008cites this paper
• Developmental lead exposure alters gene expression of metabotropic glutamate receptors in rat hippocampal neurons.

  2007cites this paper
• Metabotropic glutamate receptors in stem/progenitor cells.

  2007cites this paper
• Adult neurogenesis and schizophrenia: a window on abnormal early brain development?

  2007cites this paper
• Hydrogen peroxide increases GABAergic mIPSC through presynaptic release of calcium from IP3 receptor‐sensitive stores in spinal cord substantia gelatinosa neurons

  2007cites this paper
• Metabotropic glutamate receptors as drug targets.

  2007cites this paper
• Group I mGluR5 metabotropic glutamate receptors regulate proliferation of neuronal progenitors in specific forebrain developmental domains

  2007cites this paper
• Calpain-Mediated mGluR1α Truncation: A Key Step in Excitotoxicity

  2007cites this paper
• Rab‐Mediated Endocytosis

  2007cites this paper
• Metabotropic glutamate receptors: new targets for the control of tumor growth?

  2007cites this paper
• Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity.

  2007cites this paper
• Glutamate as a modulator of embryonic and adult neurogenesis.

  2006cites this paper
• Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c‐Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells

  2006cites this paper
• Glutamate‐mediated excitotoxicity in neonatal hippocampal neurons is mediated by mGluR‐induced release of Ca++ from intracellular stores and is prevented by estradiol

  2006cites this paper
• Protective effect of metabotropic glutamate receptor inhibition on amyotrophic lateral sclerosis-cerebrospinal fluid toxicity in vitro.

  2006cites this paper
• Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.

  2006cites this paper
• Emerging novel treatments for severe mood disorders involving cellular plasticity cascades

  2006cites this paper
• Trophic effect of glutamate.

  2006cites this paper
• Context-dependent regulation of embryonic stem cell differentiation by mGlu4 metabotropic glutamate receptors.

  2006cites this paper
• The role of excitotoxicity in neurodegeneration.

  2006cites this paper
• K252a, an inhibitor of Trk, disturbs path¢nding of hippocampal mossy ¢bers

  2005cites this paper