Influence of silymarin and its flavonolignans on doxorubicin‐iron induced lipid peroxidation in rat heart microsomes and mitochondria in comparison with quercetin

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Phytotherapy Research

• Publication date

  2002-03-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1002/ptr.811PMID 11933142
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Activities of silymarin and its flavonolignans upon low density lipoprotein oxidizability in vitro

  1999cited by this paper
• Milk Thistle (Silybum marianum) for the Therapy of Liver Disease

  1998cited by this paper
• Cytoprotective agents for anthracyclines.

  1996cited by this paper
• Structural aspects of antioxidant activity of flavonoids.

  1996influential reference
• Silybum marianum (Carduus marianus)

  1995cited by this paper
• DNA Topoisomerases and Their Inhibition by Anthracyclines

  1994cited by this paper
• Role of Reactive-Oxygen Metabolism in Cardiac Toxicity of Anthracycline Antibiotics

  1994cited by this paper
• Diastereomeric Separation of Free and Conjugated Silibinin in Plasma by Reversed Phase HPLC After Specific Extraction

  1993cited by this paper
• Free radical formation by antitumor quinones.

  1989cited by this paper
• Adriamycin-dependent peroxidation of rat liver and heart microsomes catalysed by iron chelates and ferritin. Maximum peroxidation at low oxygen partial pressures.

  1988cited by this paper
• Lipid peroxidation and possible hydroxyl radical formation stimulated by the self-reduction of a doxorubicin-iron (III) complex.

  1984cited by this paper
• The anthracycline antineoplastic drugs.

  1981cited by this paper
• Microsomal lipid peroxidation.

  1978influential reference
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• [Relationship between essential fatty acids and tissue antioxidant levels in mice].

  1970influential reference

• Silymarin-Based Nanosheets Efficiently Protect Mitochondria against Oxidative Damage Mediated by α-Synuclein Amyloid Aggregates.

  2025cites this paper
• Mechanistic Insights into Flavonoid Subclasses as Cardioprotective Agents Against Doxorubicin-Induced Cardiotoxicity: A Comprehensive Review

  2025cites this paper
• The effect of flavonoids on the doxorubicin efficacy in cancer treatment

  2025influential citation
• Natural Products for Preventing and Managing Anthracycline-Induced Cardiotoxicity: A Comprehensive Review

  2024cites this paper
• A systematic review of the protective effects of silymarin/silibinin against doxorubicin-induced cardiotoxicity

  2023influential citation
• Silymarin as a preventive or therapeutic measure for chemotherapy and radiotherapy-induced adverse reactions: a comprehensive review of preclinical and clinical data

  2022cites this paper
• Role of Silymarin in Cancer Treatment: Facts, Hypotheses, and Questions

  2022cites this paper
• The Natural Estrogen Receptor Beta Agonist Silibinin as a Promising Therapeutic Tool in Diffuse Large B-cell Lymphoma

  2022cites this paper
• A Comprehensive Review of the Cardiovascular Protective Properties of Silibinin/Silymarin: A New Kid on the Block

  2022cites this paper
• Efficient Euphorbia hirta Phytosomes for in vitro Antiasthmatic Activity

  2022cites this paper
• The Role of Nutrition in Primary and Secondary Prevention of Cardiovascular Damage in Childhood Cancer Survivors

  2022cites this paper
• Silymarin mitigates bile duct obstruction-induced cholemic nephropathy

  2021cites this paper
• Natural flavonolignans as potential therapeutic agents against common diseases.

  2021cites this paper
• Phytosome-Nanosuspensions for Silybin-Phospholipid Complex with Increased Bioavailability and Hepatoprotection Efficacy.

  2020cites this paper
• Effects of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker use on cancer therapy-related cardiac dysfunction: a meta-analysis of randomized controlled trials

  2020cites this paper
• A pilot study of the UVA-photoprotective potential of dehydrosilybin, isosilybin, silychristin, and silydianin on human dermal fibroblasts

  2019cites this paper
• Ethnobotanical Approaches of Traditional Medicinal Plants Used in the Management of Asthma in Iran

  2019cites this paper
• Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and anti-oxidant activity

  2019cites this paper
• Protective and toxicogenetic aspects of Piper betle

  2019cites this paper
• Protective Effect of Boswellic Acids against Doxorubicin-Induced Hepatotoxicity: Impact on Nrf2/HO-1 Defense Pathway

  2018cites this paper
• DEEPER INSIGHTS INTO IMPACT OF ANTIOXIDANTS ON ANTICANCER DRUG- INDUCED LIPID PEROXIDATION: AYE AND NEY

  2018cites this paper
• Recent progress in doxorubicin-induced cardiotoxicity and protective potential of natural products.

  2018cites this paper
• The protective effect of quercetin against hepatotoxicity induced by doxorubicin in male rats

  2018cites this paper
• Silymarin decreases the expression of VEGF-A , iNOS and caspase-3 and preserves the ultrastructure of cardiac cells in doxorubicin induced cardiotoxicity in rats : a possible protective role

  2017cites this paper
• Effective Agents Targeting the Mitochondria and Apoptosis to Protect the Heart.

  2017cites this paper
• Hyperglycemia-induced oxidative stress and heart disease-cardioprotective effects of rooibos flavonoids and phenylpyruvic acid-2-O-β-D-glucoside

  2017cites this paper
• Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity.

  2016cites this paper
• Quercetin Impacts Expression of Metabolism- and Obesity-Associated Genes in SGBS Adipocytes

  2016cites this paper
• Protective effect of silymarin against chemical-induced cardiotoxicity

  2016influential citation
• Anti-proliferative activity of epigallocatechin-3-gallate and silibinin on soft tissue sarcoma cells

  2016cites this paper
• Quercetin and the mitochondria: A mechanistic view.

  2016cites this paper
• The Protective Role of Phenolic Compounds Against Doxorubicin-induced Cardiotoxicity: A Comprehensive Review

  2016influential citation
• Evaluating the Safety and Efficacy of Silymarin in β-Thalassemia Patients: A Review

  2015cites this paper
• Silymarin and its constituents in cardiac preconditioning.

  2014cites this paper
• Dependence of DPPH radical scavenging activity of dietary flavonoid quercetin on reaction environment.

  2014cites this paper
• Research Article EFFECT OF FERMENTED PAPAYA PREPARATION ON DOXORUBICIN INDUCED MYOCARDIAL TOXICITY

  2014cites this paper
• Silymarin induces cell cycle arrest and apoptosis in ovarian cancer cells.

  2014cites this paper
• Silibinin meglumine, a water-soluble form of milk thistle silymarin, is an orally active anti-cancer agent that impedes the epithelial-to-mesenchymal transition (EMT) in EGFR-mutant non-small-cell lung carcinoma cells.

  2013cites this paper
• The Cardioprotection of Silymarin in Coronary Artery Bypass Grafting Surgery

  2013cites this paper
• The role of milk thistle extract in breast carcinoma cell line (MCF-7) apoptosis with doxorubicin.

  2013cites this paper
• Application of numerical modeling for optimization of selective hot water extraction of taxifolin from ‘milk thistle’ seeds

  2013cites this paper
• Antioxidant Capacity and Radical Scavenging Activity of Silybum marianum and Ceratonia siliqua

  2012cites this paper
• Treatment of chemotherapy-induced oral mucositis by silymarin

  2012cites this paper
• Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies.

  2011cites this paper
• The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats

  2011influential citation
• Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II).

  2011cites this paper
• Polyphenol compounds as antioxidants for disease prevention: Reactive oxygen species scavenging, enzyme regulation, and metal chelation mechanisms in E. coli and human cells

  2011cites this paper
• Protective effects of silymarin against doxorubicin-induced toxicity.

  2011cites this paper
• Silymarin Ascending Multiple Oral Dosing Phase I Study in Noncirrhotic Patients With Chronic Hepatitis C

  2010cites this paper
• Augalinio vaistinio preparato kiekybinio stabilumo pagrindimas efektyviosios skysčių chromatografijos metodu

  2010cites this paper
• New advances in molecular mechanisms and the prevention of adriamycin toxicity by antioxidant nutrients.

  2010cites this paper
• The effect of silybin on passive avoidance learning and pathological changes in hippocampal CA1 and DG regions in male Wistar rats offspring

  2009cites this paper
• Silybum marianum (L.) Gaertn: the Source of Silymarin

  2008cites this paper
• Investigation of hypoxia and hyperglycaemia mediated DNA damage in human endothelial cells

  2008cites this paper
• The Pharmacokinetics of Silymarin Is Altered in Patients with Hepatitis C Virus and Nonalcoholic Fatty Liver Disease and Correlates with Plasma Caspase-3/7 Activity

  2008influential citation
• Polyphenol Extract of Greens+™ Nutritional Supplement Stimulates Bone Formation in Cultures of Human Osteoblast-like SaOS-2 Cells

  2008cites this paper
• Attenuation of UVA-induced damage to human keratinocytes by silymarin.

  2007cites this paper
• Clinical Applications of Silybum marianum in Oncology

  2007cites this paper
• Toward the Definition of the Mechanism of Action of Silymarin: Activities Related to Cellular Protection From Toxic Damage Induced by Chemotherapy

  2007cites this paper
• Flavonolignans from Silybum marianum moderate UVA-induced oxidative damage to HaCaT keratinocytes.

  2007cites this paper
• Silybin and silymarin--new and emerging applications in medicine.

  2007cites this paper
• Anticancer potential of silymarin: from bench to bed side.

  2006cites this paper
• The in vitro biological activity of Lepidium meyenii extracts

  2006influential citation
• Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts.

  2006cites this paper
• Protective effect of selected flavonoids on in vitro daunorubicin‐induced cardiotoxicity

  2006cites this paper
• Serum total creatine phosphokinase ( CPK ) activity was determined according to the method of Swanson and Wilkinson

  2006cites this paper
• Silybin and silymarin--new effects and applications.

  2005cites this paper
• Abatement by naringenin of doxorubicin-induced cardiac toxicity in rats.

  2005cites this paper
• Chemosensitization and Radiosensitization of Tumors by Plant Polyphenols

  2005cites this paper
• Lipoic acid ameliorates adriamycin-induced testicular mitochondriopathy.

  2005cites this paper
• Chemoprotective effect of plant phenolics against anthracycline‐induced toxicity on rat cardiomyocytes. Part I. Silymarin and its flavonolignans

  2004cites this paper
• Chemoprotective effect of plant phenolics against anthracycline‐induced toxicity on rat cardiomyocytes. Part III. Apigenin, baicalelin, kaempherol, luteolin and quercetin

  2004cites this paper
• The Many Faces of Silybum marianum (Milk Thistle): Part 1 - Treating Cancer and Hyperlipidemia and Restoring Kidney Function

  2003cites this paper
• Effects of Flavonoids on the Resistance of Microsomes to Lipid Peroxidation In Vitro and Ex Vivo

  2003cites this paper
• Ameliorative Effect of Carvedilol and N-acetylcysteine on Doxorubicin-induced Cardiotoxicity in Rats, Possible Role of SIRT 1.

  year unknowncites this paper