Role of Mitochondrial Aldehyde Dehydrogenase in Nitroglycerin-Induced Vasodilation of Coronary and Systemic Vessels: An Intact Canine Model

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Circulation

• Publication date

  2004-08-10

• Fields of study

  Medicine

• Identifiers
  DOI 10.1161/01.CIR.0000138105.17864.6BPMID 15289380
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance.

  2004cited by this paper
• Does Nitric Oxide Mediate the Vasodilator Activity of Nitroglycerin?

  2003cited by this paper
• Nitric Oxide Modulates Myocardial Oxygen Consumption in the Failing Heart

  2002cited by this paper
• Identification of the enzymatic mechanism of nitroglycerin bioactivation

  2002cited by this paper
• Relaxant properties mediated by nitroglycerin in aortic coarctation hypertensive rats

  2002cited by this paper
• Does nitroglycerin therapy hit the endothelium?

  2001cited by this paper
• Endothelial Dysfunction, Oxidative Stress, and Risk of Cardiovascular Events in Patients With Coronary Artery Disease

  2001cited by this paper
• In vitro activation of soluble guanylyl cyclase and nitric oxide release: a comparison of NO donors and NO mimetics.

  2001cited by this paper
• Evidence supporting abnormalities in nitric oxide synthase function induced by nitroglycerin in humans.

  2001cited by this paper
• Long-term nitrate use may be deleterious in ischemic heart disease: A study using the databases from two large-scale postinfarction studies. Multicenter Myocardial Ischemia Research Group.

  1999cited by this paper
• Nitrate therapy for stable angina pectoris.

  1999cited by this paper
• Nitric oxide inhibits vascular bioactivation of glyceryl trinitrate: a novel mechanism to explain preferential venodilation of organic nitrates.

  1998cited by this paper
• Nitric oxide and nitrovasodilators: similarities, differences, and interactions.

  1996cited by this paper
• Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle

  1994cited by this paper
• Heterogeneous effects of nitroglycerin on the conductance and resistance coronary arterial vasculature.

  1993cited by this paper
• A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

  1993cited by this paper
• Effects of High Arterial Oxygen Tension on Function, Blood Flow Distribution, and Metabolism in Ischemic Myocardium

  1992cited by this paper
• Biotransformation of organic nitrates to nitric oxide by vascular smooth muscle and endothelial cells.

  1991cited by this paper
• Goodman and Gilman's The Pharmacological Basis of Therapeutics

  1991cited by this paper
• Mechanisms responsible for the heterogeneous coronary microvascular response to nitroglycerin.

  1991cited by this paper
• Influence of vessel size on the sensitivity of porcine coronary microvessels to nitroglycerin.

  1990cited by this paper
• A reappraisal of nitrate therapy.

  1988cited by this paper
• In vivo induction and reversal of nitroglycerin tolerance in human coronary arteries.

  1987cited by this paper
• Incidence of early tolerance to hemodynamic effects of continuous infusion of nitroglycerin in patients with coronary artery disease and heart failure.

  1987cited by this paper
• Biotransformation of glyceryl trinitrate occurs concurrently with relaxation of rabbit aorta.

  1986cited by this paper
• Goodman and Gilman's the Pharmacological Basis of Therapeutics

  1986cited by this paper
• Hemodynamic effects of nitroglycerin and long-acting nitrates.

  1985cited by this paper
• Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation

  1983cited by this paper
• Relationship between cyclic guanosine 3':5'-monophosphate formation and relaxation of coronary arterial smooth muscle by glyceryl trinitrate, nitroprusside, nitrite and nitric oxide: effects of methylene blue and methemoglobin.

  1981cited by this paper
• Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as active intermediates.

  1981cited by this paper
• Biochemistry and pharmacology of ethanol

  1979cited by this paper
• Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerin and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylamine.

  1977cited by this paper
• Inhibition of aldehyde dehydrogenase in brain and liver by cyanamide.

  1976cited by this paper
• Preparation and standardization of nitroglycerin injection.

  1975cited by this paper
• Identification and assay of isomeric 14C-glyceryl nitrates

  1968cited by this paper

• Nitroglycerin: a comprehensive review in cancer therapy

  2023cites this paper
• The effect of vitamin C on nitroglycerin‐mediated vasodilation in individuals with and without the aldehyde dehydrogenase 2 polymorphism

  2023cites this paper
• Calcium Channel Blockers with and without Nitrates for the Prognosis of Patients with Coronary Vasospastic Angina: A Meta-Analysis

  2022cites this paper
• Nitric Oxide as a Central Molecule in Hypertension: Focus on the Vasorelaxant Activity of New Nitric Oxide Donors

  2021cites this paper
• Impact of ALDH2 Gene Polymorphism on Coronary Artery lesions in Ethnic Hakka Population with Acute Myocardial Infarction

  2020cites this paper
• Comparative analysis of cost-effectiveness between isosorbide-5-mononitrate and isosorbide: a retrospective real-world evaluation.

  2020cites this paper
• Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology: Developments on a Three-Gas Respiratory Cycle.

  2020cites this paper
• Nitroglycerin as a comparative experimental model of migraine pain: From animal to human and back

  2019cites this paper
• Role of Mitochondrial Aldehyde Dehydrogenase in Nitroglycerin-Mediated Vasodilation: Observations Concerning the Dose-Response Relationship.

  2019cites this paper
• Don't just say no: Differential pathways and pharmacological responses to diverse nitric oxide donors.

  2018cites this paper
• Pharmacology of Nitrovasodilators

  2017cites this paper
• Aldehyde dehydrogenase 2 protects human umbilical vein endothelial cells against oxidative damage and increases endothelial nitric oxide production to reverse nitroglycerin tolerance.

  2016cites this paper
• Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress

  2015cites this paper
• The Glu504Lys polymorphism of aldehyde dehydrogenase 2 contributes to development of coronary artery disease.

  2014cites this paper
• Organic nitrates: update on mechanisms underlying vasodilation, tolerance and endothelial dysfunction.

  2014cites this paper
• Therapeutics targeting of dysregulated redox equilibrium and endothelial dysfunction.

  2013cites this paper
• Effects of cyanamide, an aldehyde dehydrogenase type 2 inhibitor, on glyceryl trinitrate- and isosorbide dinitrate-induced vasodilation in rabbit excised aorta and in anesthetized whole animal.

  2013cites this paper
• Chapter 7 – Pharmacologic Options for Treatment of Ischemic Disease

  2013cites this paper
• Investigating Organic Nitrate Tolerance and Alzheimer's Disease: Roles for Aldehyde Dehydrogenase 2 and 4-Hydroxynonenal

  2013cites this paper
• Nitroglycerin drives endothelial nitric oxide synthase activation via the phosphatidylinositol 3-kinase/protein kinase B pathway.

  2012cites this paper
• Nitroglycerin use in myocardial infarction patients.

  2012cites this paper
• Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome

  2011cites this paper
• New Aspects Concerning Molecular Action and Tolerance

  2011cites this paper
• Differential effects of organic nitrates on arterial diameter among healthy Japanese participants with different mitochondrial aldehyde dehydrogenase 2 genotypes: randomised crossover trial

  2011cites this paper
• Nitrate therapy: new aspects concerning molecular action and tolerance.

  2011cites this paper
• Contemporary Reviews in Cardiovascular Medicine Nitrate Therapy New Aspects Concerning Molecular Action and Tolerance

  2011cites this paper
• Nitroglycerin Use in Myocardial Infarction Patients – Risks and Benefits –

  2011cites this paper
• Organic nitrates and nitrate tolerance--state of the art and future developments.

  2010cites this paper
• Mechanisms of nitrite reduction in ischemia in the cardiovascular system: therapeutic potential

  2010cites this paper
• Contemporary Reviews in Cardiovascular Medicine

  2010cites this paper
• Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat.

  2010cites this paper
• Mitochondrial aldehyde dehydrogenase and cardiac diseases

  2010cites this paper
• Demethylbellidifolin Prevents Nitroglycerin Tolerance via Improved Aldehyde Dehydrogenase 2 Activity

  2009cites this paper
• Vascular responses to nitrite are mediated by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase in the rat.

  2009cites this paper
• Novel options for the pharmacological treatment of chronic anal fissure--role of botulin toxin.

  2009cites this paper
• Exploiting cGMP-based therapies for the prevention of left ventricular hypertrophy: NO* and beyond.

  2009cites this paper
• Nitroglycerin-mediated S-nitrosylation of proteins: a field comes full cycle.

  2008cites this paper
• Bioactivation of Nitroglycerin by Purified Mitochondrial and Cytosolic Aldehyde Dehydrogenases*

  2008cites this paper
• Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins

  2008cites this paper
• The enigma of nitroglycerin bioactivation and nitrate tolerance: news, views and troubles

  2008cites this paper
• Chapter 5 – Pharmacologic Options for Treatment of Ischemic Disease

  2007cites this paper
• Oxidative inhibition of the mitochondrial aldehyde dehydrogenase promotes nitroglycerin tolerance in human blood vessels.

  2007cites this paper
• Radicals for life : the various forms of nitric oxide

  2007cites this paper
• Organic nitrates and nitrites as stores of NO bioactivity

  2007cites this paper
• Recent developments in nitric oxide donor drugs

  2007cites this paper
• Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase.

  2006cites this paper
• Mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism contributes to the variation in efficacy of sublingual nitroglycerin.

  2006cites this paper
• Effects of Nitroglycerin on Erythrocyte Rheology and Oxygen Unloading: Novel Role of S-Nitrosohemoglobin in Relieving Myocardial Ischemia

  2006cites this paper
• Heterozygous Deficiency of Manganese Superoxide Dismutase in Mice (Mn-SOD+/-): A Novel Approach to Assess the Role of Oxidative Stress for the Development of Nitrate Tolerance

  2005cites this paper
• Heterozygous Deficiency of Manganese Superoxide Dismutase in Mice (Mn-SOD (cid:1) / (cid:2) ): A Novel Approach to Assess the Role of Oxidative Stress for the Development of Nitrate Tolerance

  2005cites this paper
• Aldehyde Dehydrogenase 2 Plays a Role in the Bioactivation of Nitroglycerin in Humans

  2005cites this paper
• An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation.

  2005cites this paper
• Contribution of aldehyde dehydrogenase to mitochondrial bioactivation of nitroglycerin: evidence for the activation of purified soluble guanylate cyclase through direct formation of nitric oxide.

  2005cites this paper
• cGMP-dependent protein kinases in drug discovery.

  2005cites this paper
• Low-Potency Pathway for Bioactivation of GTN

  2005cites this paper
• Explaining the phenomenon of nitrate tolerance.

  2005cites this paper
• Modulation de la biodisponibilité du monoxyde d'azote (no) en physiopathologie vasculaire : intérêt des stocks mobilisables de no et des antioxydants naturels

  2004cites this paper