Overexpression of human hepatic lipase and ApoE in transgenic rabbits attenuates response to dietary cholesterol and alters lipoprotein subclass distributions.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Arteriosclerosis, Thrombosis and Vascular Biology

• Publication date

  1999-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1161/01.ATV.19.3.625PMID 10073966
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma.

  1998cited by this paper
• Development and application of a multicompartmental model to study very low density lipoprotein subfraction metabolism.

  1995cited by this paper
• Triglyceride lipases and atherosclerosis.

  1995cited by this paper
• Triglyceride lpases and atherosclerosis

  1995cited by this paper
• Chylomicron Metabolism in Normal, Cholesterol-fed, and Watanabe Heritable Hyperlipidemic Rabbits

  1995cited by this paper
• Mild Dyslipidemia in Mice following Targeted Inactivation of the Hepatic Lipase Gene (*)

  1995cited by this paper
• Effects of particle size on cell uptake of model triglyceride-rich particles with and without apoprotein E.

  1994cited by this paper
• Hepatic lipase may act as a ligand in the uptake of artificial chylomicron remnant-like particles by isolated rat hepatocytes.

  1994cited by this paper
• Heterogeneity of plasma low‐density lipoproteins and atherosclerosis risk

  1994cited by this paper
• Overexpression of hepatic lipase in transgenic rabbits leads to a marked reduction of plasma high density lipoproteins and intermediate density lipoproteins.

  1994cited by this paper
• Overexpression of human apolipoprotein C-III in transgenic mice results in an accumulation of apolipoprotein B48 remnants that is corrected by excess apolipoprotein E.

  1994cited by this paper
• Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans.

  1994cited by this paper
• Enhanced binding and uptake of remnant lipoproteins by hepatic lipase-secreting hepatoma cells in culture.

  1994cited by this paper
• Role of heparan sulfate proteoglycans in the binding and uptake of apolipoprotein E-enriched remnant lipoproteins by cultured cells.

  1993cited by this paper
• Hepatic lipase function and the accumulation of beta-very-low-density lipoproteins in the plasma of cholesterol-fed rabbits.

  1993cited by this paper
• Reduced lipolysis of large apo E-poor very-low-density lipoprotein subfractions from type IV hypertriglyceridemic subjects in vitro and in vivo.

  1993cited by this paper
• Hepatic lipase treatment of chylomicron remnants increases exposure of apolipoprotein E.

  1993cited by this paper
• Effect of hepatic lipase on LDL in normal men and those with coronary artery disease.

  1993cited by this paper
• Hepatic lipase deficiency. Clinical, biochemical, and molecular genetic characteristics.

  1993cited by this paper
• Composition of human low density lipoprotein: effects of postprandial triglyceride-rich lipoproteins, lipoprotein lipase, hepatic lipase and cholesteryl ester transfer protein.

  1993cited by this paper
• In vivo model systems: the choice of the experimental animal model for analysis of lipoproteins and atherosclerosis

  1992cited by this paper
• A study of the chylomicron metabolism in WHHL rabbits after fat loading. Discrepancy between results based on measurement of apoprotein B-48 or retinyl palmitate.

  1992cited by this paper
• Production of polyacrylamide gradient gels for the electrophoretic resolution of lipoproteins.

  1992cited by this paper
• Metabolism of high density lipoprotein lipids by the rat liver: evidence for participation of hepatic lipase in the uptake of cholesteryl ester.

  1992cited by this paper
• Detection and quantitation of LDL subfractions

  1992cited by this paper
• Lipoprotein lipase and hepatic lipase

  1991cited by this paper
• Chylomicron and chylomicron remnant catabolism

  1991cited by this paper
• Differences in carbohydrate content of low density lipoproteins associated with low density lipoprotein subclass patterns.

  1990cited by this paper
• Inhibition of hepatic lipase activity impairs chylomicron remnant-removal in rats.

  1990cited by this paper
• Increased hepatic lipase activity and increased direct removal of very-low-density lipoprotein remnants in Watanabe heritable hyperlipidaemic (WHHL) rabbits treated with ethinyl oestradiol.

  1990cited by this paper
• Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.

  1989cited by this paper
• Increased clearance of plasma cholesterol after injection of apolipoprotein E into Watanabe heritable hyperlipidemic rabbits.

  1989cited by this paper
• The rabbit as an animal model of hepatic lipase deficiency.

  1989cited by this paper
• Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits.

  1989cited by this paper
• Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.

  1988cited by this paper
• Metabolism of Human Intermediate and Very Low Density Lipoprotein Subtractions from Normal and Dysbetalipoproteinemic Plasma: In Vivo Studies in the Rat

  1987cited by this paper
• Synthesis of hepatic lipase in liver and extrahepatic tissues.

  1987cited by this paper
• Presence of Multiple Subpopulations of Lipoproteins of Intermediate Density in Normal Subjects

  1986cited by this paper
• Metabolism of lipoproteins containing apolipoprotein B-100 in blood plasma of rabbits: heterogeneity related to the presence of apolipoprotein E.

  1986cited by this paper
• Nondenaturing polyacrylamide gradient gel electrophoresis.

  1986cited by this paper
• Apolipoprotein E-mediated binding of hypertriglyceridemic very low density lipoproteins to isolated low density lipoprotein receptors detected by ligand blotting.

  1986cited by this paper
• Comparison of improved precipitation methods for quantification of high-density lipoprotein cholesterol.

  1985cited by this paper
• Obligatory role of cholesterol and apolipoprotein E in the formation of large cholesterol-enriched and receptor-active high density lipoproteins.

  1985cited by this paper
• Roles of apolipoproteins B and E in the cellular binding of very low density lipoproteins.

  1985cited by this paper
• Enzymology and physiological role of hepatic lipase.

  1985cited by this paper
• Reagent for the Enzymatic Determination of Serum Total Triglycerides with Improved Lipolytic Efficiency

  1984cited by this paper
• Plasma triglyceride determines structure-composition in low and high density lipoproteins.

  1984cited by this paper
• Lipoprotein receptors and cholesterol homeostasis.

  1983cited by this paper
• Identification of multiple subclasses of plasma low density lipoproteins in normal humans.

  1982cited by this paper
• Composition, concentration, and size of low density lipoproteins and of subfractions of very low density lipoproteins from serum of normal men and women.

  1982cited by this paper
• Accumulation of intermediate density lipoprotein in plasma after intravenous administration of hepatic triglyceride lipase antibody in rats.

  1981cited by this paper
• Heterogeneity of serum low density lipoproteins in normal human subjects.

  1981cited by this paper
• Atherogenesis: a postprandial phenomenon.

  1979cited by this paper
• Lipoprotein substrates of lipoprotein lipase and hepatic triacylglycerol lipase from human post-heparin plasma.

  1979cited by this paper
• Localization of the heparin-releasable lipase in situ in the rat liver.

  1979cited by this paper
• A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples.

  1978cited by this paper
• Isolation of subfractions of human very low density lipoproteins by zonal ultracentrifugation.

  1978cited by this paper
• The determination of total cholesterol in serum by gas-liquid chromatography compared with two other methods.

  1977cited by this paper
• Enzymatic determination of total serum cholesterol.

  1974cited by this paper
• On the metabolic conversion of human plasma very low density lipoprotein to low density lipoprotein.

  1973cited by this paper
• Blood lipids and lipoproteins; quantitation, composition and metabolism

  1973cited by this paper
• Blood Constituents. (Book Reviews: Blood Lipids and Lipoproteins. Quantitation, Composition, and Metabolism)

  1972cited by this paper
• Phosphorus assay in column chromatography.

  1959cited by this paper

• Genetically modified rabbit models for cardiovascular medicine.

  2022cites this paper
• Transgenic Rabbit Models: Now and the Future

  2020cites this paper
• Hepatic Lipase: a Comprehensive View of its Role on Plasma Lipid and Lipoprotein Metabolism.

  2015cites this paper
• Heparin induces an accumulation of atherogenic lipoproteins during hemodialysis in normolipidemic end‐stage renal disease patients

  2015cites this paper
• HDL quality and functionality: what can proteins and genes predict?

  2014cites this paper
• The diameter of liver sinusoidal fenestrae is not a major determinant of lipoprotein levels and atherosclerosis in cholesterol-fed rabbits.

  2011cites this paper
• The triglyceride to high-density lipoprotein-cholesterol ratio in adolescence and subsequent weight gain predict nuclear magnetic resonance-measured lipoprotein subclasses in adulthood.

  2011cites this paper
• Genetic aspects of type 2 diabetes and related traits - The past, present and future

  2009cites this paper
• The -250G>A promoter variant in hepatic lipase associates with elevated fasting serum high-density lipoprotein cholesterol modulated by interaction with physical activity in a study of 16,156 Danish subjects.

  2008cites this paper
• Molecular Mechanisms of Atherosclerosis

  2007cites this paper
• Lipolytic and ligand-binding functions of hepatic lipase protect against atherosclerosis in LDL receptor-deficient mices⃞ Published, JLR Papers in Press, October 27, 2006.

  2007cites this paper
• HDL elevation and lipid lowering therapy: current scenario and future perspectives.

  2007cites this paper
• Accumulation of apoE-enriched triglyceride-rich lipoproteins in patients with coronary artery disease.

  2006cites this paper
• Vascular lipases, inflammation and atherosclerosis.

  2006cites this paper
• Reciprocal hemizygosity analysis of mouse hepatic lipase reveals influence on obesity.

  2004cites this paper
• Endothelial Lipase Promotes the Catabolism of ApoB-Containing Lipoproteins

  2004cites this paper
• HDL: the metabolism, function, and therapeutic importance.

  2004cites this paper
• ApoE polymorphism in a small Mediterranean island: Relationships with plasma lipids, lipoproteins and LDL particle size

  2004cites this paper
• The Ligand-binding Function of Hepatic Lipase Modulates the Development of Atherosclerosis in Transgenic Mice*

  2004cites this paper
• Investigation into the mechanism and treatment of atherogenic dyslipidemia in HIV + patients with HIV metabolic syndrome

  2004cites this paper
• Hepatic lipase, lipoprotein metabolism, and atherogenesis.

  2004cites this paper
• EFFETTI “BEYOND CHOLESTEROL” DELLE STATINE

  2004cites this paper
• Effects on Lipoprotein Subclasses of Combined Expression of Human Hepatic Lipase and Human apoB in Transgenic Rabbits

  2003cites this paper
• Regulation of reverse cholesterol transport and clinical implications.

  2003cites this paper
• Low‐density‐lipoprotein peak particle size in a Mediterranean population

  2003cites this paper
• The Transgenic Rabbit as Model for Human Diseases and as a Source of Biologically Active Recombinant Proteins

  2003cites this paper
• Transgenic rabbits as therapeutic protein bioreactors and human disease models.

  2003cites this paper
• HDL: a molecular view of the "classic" antiatherogenic lipoprotein

  2002cites this paper
• Lipases and HDL metabolism.

  2002cites this paper
• Changes in plasma lipids and low-density lipoprotein peak particle size during and after acute myocardial infarction.

  2002cites this paper
• Metabolism of ApoA-I as Lipid-Free Protein or as Component of Discoidal and Spherical Reconstituted HDLs: Studies in Wild-Type and Hepatic Lipase Transgenic Rabbits

  2002cites this paper
• Antioxidant vitamins and lipid therapy: end of a long romance?

  2002cites this paper
• Antioxidant Vitamins and Lipid Therapy

  2002cites this paper
• Changes in Plasma Lipids and Low-Density Lipoprotein Peak Particle Size During and After Acute Myocardial Infarction

  2002cites this paper
• Hepatic lipase and HDL metabolism.

  2000cites this paper
• Role of hepatic and lipoprotein lipase in lipoprotein metabolism and atherosclerosis: studies in transgenic and knockout animal models and somatic gene transfer.

  2000cites this paper
• Bimonthly update. Lipid metabolism.

  2000cites this paper
• In vivo evidence of a role for hepatic lipase in human apoB-containing lipoprotein metabolism, independent of its lipolytic activity.

  2000cites this paper
• In-vivo and in-vitro nutrient-gene interactions.

  2000cites this paper
• Transgenic rabbit models for biomedical research: Current status, basic methods and future perspectives

  1999cites this paper
• Hepatic lipase.

  1998cites this paper