Virtual-tissue computer simulations define the roles of cell adhesion and proliferation in the onset of kidney cystic disease

Virtual-tissue modeling is used to model emergent cyst growth in polycystic kidney disease. Model predictions, confirmed experimentally, show that decreased cell adhesion is necessary to produce stalk cysts, and loss of contact inhibition causes saccular cysts. Virtual-tissue modeling can be used to fully explore cell- and tissue-based behaviors.

• Publication year

  2016

• Venue

  Molecular Biology of the Cell

• Publication date

  2016-11-07

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1091/mbc.E16-01-0059PMID 27193300PMCID 5221598
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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