Clozapine-Induced Hypersalivation: A Review of Treatment Strategies

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Canadian journal of psychiatry. Revue canadienne de psychiatrie

• Publication date

  2007-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1177/070674370705200607PMID 17696024
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Guanfacine treatment of clozapine-induced sialorrhea.

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• Clozapine-induced sialorrhea treated with sublingual ipratropium spray: a case series.

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• Botulinum toxin as an effective treatment of clozapine-induced hypersalivation

  2004cited by this paper
• Scolpolamine patch for clozapine-induced sialorrhea.

  2004cited by this paper
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  2003cited by this paper
• A randomized trial of botulinum toxin A for treatment of drooling

  2003cited by this paper
• Biperiden for excessive sweating from clozapine.

  2001cited by this paper
• Clozapine and sialorrhea: update.

  2001cited by this paper
• Therapeutic Effect of Pirenzepine for Clozapine-Induced Hypersalivation: A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study

  2001cited by this paper
• Hyoscine patches in clozapine-induced hypersalivation

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  2001cited by this paper
• Botulinum toxin A as treatment for drooling saliva in PD

  2000cited by this paper
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  2000cited by this paper
• Treatment of sialorrhea with glycopyrrolate: A double-blind, dose-ranging study.

  2000cited by this paper
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  2000cited by this paper
• Potential use of ipatropium bromide for the treatment of clozapine‐induced hypersalivation: a preliminary report

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• Colon perforation and peritonitis associated with clozapine.

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  1999cited by this paper
• Clozapine and sialorrhea: a new intervention for this bothersome and potentially dangerous side effect.

  1999cited by this paper
• Hypersalivation coincident with olanzapine treatment.

  1998cited by this paper
• Clozapine treatment for neuroleptic-induced tardive dyskinesia, parkinsonism, and chronic akathisia in schizophrenic patients.

  1997cited by this paper
• Trihexyphenidyl treatment of clozapine‐induced hypersalivation

  1997cited by this paper
• Improvement of clozapine-induced sialorrhea after septoplasty.

  1996cited by this paper
• Salivary flow-rate and composition in schizophrenic patients on clozapine: subjective reports and laboratory data.

  1996influential reference
• Aspiration pneumonia possibly secondary to clozapine-induced sialorrhea.

  1996cited by this paper
• The effect of clozapine on saliva flow rate: a pilot study.

  1996cited by this paper
• Treatment of clozapine-induced parotid gland swelling.

  1996cited by this paper
• Effects of the clozapine national registry system on incidence of deaths related to agranulocytosis.

  1996cited by this paper
• Pirenzepine for clozapine-induced hypersalivation.

  1995cited by this paper
• Clozapine-induced hypersalivation and the alpha2 adrenoceptor

  1995cited by this paper
• Possible association of parotitis with clozapine.

  1995cited by this paper
• Clozapine is a potent and selective muscarinic M4 receptor agonist.

  1994cited by this paper
• The involvement of muscarinic receptor subtypes in the mediation of hypothermia, tremor, and salivation in male mice.

  1994cited by this paper
• Clozapine, nocturnal sialorrhea, and choking.

  1994cited by this paper
• Esophageal dysfunction in two patients after clozapine treatment.

  1994cited by this paper
• Principles of Saliva Secretion

  1993cited by this paper
• Clonidine treatment of clozapine-induced hypersalivation.

  1992cited by this paper
• Pharmacological prospects for alpha 2-adrenoceptor antagonist therapy.

  1992cited by this paper
• Pharmacological prospects for α2-adrenoceptor antagonist therapy

  1992cited by this paper
• Amitriptyline in clozapine-induced sialorrhoea

  1991cited by this paper
• Hypersalivation and clozapine.

  1991cited by this paper
• Update on the clinical efficacy and side effects of clozapine.

  1991influential reference
• Clozapine. A novel antipsychotic agent.

  1991cited by this paper
• The Effects of Clozapine on Tardive Dyskinesia

  1991cited by this paper
• EFFICACY OF BENZTROPINE THERAPY FOR DROOLING

  1989cited by this paper
• Evaluation of the systemic anticholinergic activity of nasally administered ipratropium bromide.

  1988cited by this paper
• Clozapine for the treatment-resistant schizophrenic. A double-blind comparison with chlorpromazine.

  1988cited by this paper
• Comparative study of the effects of 9 antidepressants on several physiological parameters in healthy volunteers.

  1987cited by this paper

• Amisulpride from the standpoint of efficacy and safety

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• Complete resolution of clozapine-induced sialorrhea with low dose trihexyphenidyl.

  2025cites this paper
• Ptyalism gravidarum

  2024cites this paper
• Clozapine-Associated Sialorrhea

  2024cites this paper
• Second to none: rationale, timing, and clinical management of clozapine use in schizophrenia

  2023cites this paper
• Treatment of Clozapine-Associated Sialorrhea

  2023cites this paper
• Recognition and management of clozapine adverse effects: A systematic review and qualitative synthesis

  2022cites this paper
• Patients' and primary carers' views on clozapine treatment for schizophrenia: A cross-sectional study in Qatar

  2022cites this paper
• Prevalence of clozapine-induced sialorrhea and its effect on quality of life

  2022cites this paper
• Drooling in Parkinson's disease and current treatment options

  2022cites this paper
• Amitriptyline for clozapine-induced hypersalivation: A case series.

  2022cites this paper
• Japanese Society of Neuropsychopharmacology: “Guideline for Pharmacological Therapy of Schizophrenia”

  2021cites this paper
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  2020cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Mental Health Issues and Special Care Patients.

  2016cites this paper
• Predisposing factors , physiopathology , and etiology

  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• Adverse Effects of Clozapine in Older Patients: Epidemiology, Prevention and Management

  2013cites this paper
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  2013cites this paper
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  2012cites this paper
• Amisulpride improved debilitating clozapine-induced sialorrhea.

  2011influential citation
• Saliva and the Control of Its Secretion

  2011cites this paper
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  2011cites this paper
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• Clozapine: Agonistic and Antagonistic Salivary Secretory Actions

  2010cites this paper
• N-Desmethylclozapine exerts dual and opposite effects on salivary secretion in the rat.

  2010cites this paper
• Antipsychotics and their Side Effects: Sialorrhea

  2010cites this paper
• Antipsychotic side effects and monitoring implications

  2010cites this paper
• A student practice experience focusing on the intellectually disabled

  2010cites this paper
• Update on the management of symptoms in schizophrenia: focus on amisulpride

  2009cites this paper
• Treatment of clozapine-induced hypersalivation with ipratropium bromide: a randomized, double-blind, placebo-controlled crossover study.

  2009cites this paper
• Clozapine-induced sialorrhea alleviated by bupropion--a case report.

  2009cites this paper
• Comparing the Effects of High-Dose Vitamin E With Those of Placebo on Insulin Resistance in Patients With Schizophrenia Treated With Olanzapine

  2009cites this paper
• Comparing the Effects of High-Dose Vitamin E With Those of Placebo on Insulin Resistance in Patients With Schizophrenia Treated With Olanzapine

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  2009cites this paper
• Comparing the effects of high-dose vitamin E with those of placebo on insulin resistance in patients with schizophrenia treated with olanzapine.

  2009cites this paper
• Botulinum toxin B as an effective and safe treatment for neuroleptic-induced sialorrhea

  2009cites this paper
• Amisulpride treatment for clozapine-induced sialorrhea.

  2009cites this paper
• Comparing the Effects of High-Dose Vitamin E With Those of Placebo on Insulin Resistance in Patients With Schizophrenia Treated With Olanzapine

  2009cites this paper
• Comparing the Effects of High-Dose Vitamin E With Those of Placebo on Insulin Resistance in Patients With Schizophrenia Treated With Olanzapine

  2009cites this paper
• Side effects of clozapine and some other psychoactive drugs.

  2008cites this paper
• Life-threatening clozapine-induced gastrointestinal hypomotility: an analysis of 102 cases.

  2008cites this paper
• Sialorrhoea and Drooling in Patients with Parkinson’s Disease

  2008cites this paper
• An Overview of Antipsychotics: Mechanisms of Action

  year unknowncites this paper