Medulloblastoma: experimental models and reality

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Acta Neuropathologica

• Publication date

  2017-07-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00401-017-1753-3PMID 28725965
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2014influential reference
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• Treatment of early childhood medulloblastoma by postoperative chemotherapy alone.

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  2001influential reference
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