Diabetic conditions downregulate the expression of CD2AP in podocytes via PI3‐K/Akt signalling

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Diabetes/Metabolism Research Reviews

• Publication date

  2015-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/dmrr.2562PMID 24846128
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Regulation of CD2-associated protein influences podocyte endoplasmic reticulum stress-mediated apoptosis induced by albumin overload.

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• Effects of 22-Oxa-Calcitriol on Podocyte Injury in Adriamycin-Induced Nephrosis

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• Downregulation of CD2‐associated protein impaired the physiological functions of podocytes

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  2006cited by this paper
• Expression profile of nephrin, podocin, and CD2AP in Chinese children with MCNS and IgA nephropathy

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• Glomerular expression of transforming growth factor–β (TGF-β) isoforms in mice lacking CD2-associated protein

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• Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes.

  2005cited by this paper
• Interactions of the integrin subunit beta1A with protein kinase B/Akt, p130Cas and paxillin contribute to regulation of radiation survival.

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• A Novel Role for the Adaptor Molecule CD2-associated Protein in Transforming Growth Factor-β-induced Apoptosis*

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• Nephrin and CD2AP Associate with Phosphoinositide 3-OH Kinase and Stimulate AKT-Dependent Signaling

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• CD2-Associated Protein Haploinsufficiency Is Linked to Glomerular Disease Susceptibility

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• CD2-associated protein and the kidney

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• Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin.

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• CD2AP and p130Cas localize to different F-actin structures in podocytes.

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• CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere.

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• The lipid–podocyte axis: emerging clues in membranous nephropathy pathogenesis

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• Modes of podocyte death in diabetic kidney disease: an update

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• Renal cell markers: lighthouses for managing renal diseases.

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• Experimental study on renoprotective effect of intermedin on diabetic nephropathy.

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• Long non-coding RNA TTC28-AS1 attenuates high glucose-induced damage in HK-2 cells depending on the regulation of miR-320a/CD2AP axis

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• The Role of Podocytes and Podocyte-Associated Biomarkers in Diagnosis and Treatment of Diabetic Kidney Disease

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• The effects of microRNA-126 reduced inflammation and apoptosis of diabetic nephropathy through PI3K/AKT signalling pathway by VEGF

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• MicroRNA-22 alleviates inflammation in ischemic stroke via p38 MAPK pathways

  2019cites this paper
• Ginseng Total Saponin Attenuates Podocyte Apoptosis Induced by Diabetic Conditions Through the Recovery of CD2-Associated Protein

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• Die Rolle der Gerüstproteine in der Regulation der Schlitzmembran

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• Potential signaling pathway and molecular mechanism of CD2AP associated with proteinuria in glomerular disease

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• Urinary podocyte-associated mRNA levels correlate with proximal tubule dysfunction in early diabetic nephropathy of type 2 diabetes mellitus

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• Lack of serum‐ and glucocorticoid‐inducible kinase 3 leads to podocyte dysfunction

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• The Roles of CD2AP and SHIP2 in Insulin Resistance and Podocyte Apoptosis

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• Montelukast improves the changes of cytoskeletal and adaptor proteins of human podocytes by interleukin-13

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• Effect of the knockdown of Cabin1 on p53 in glomerular podocyte

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• CD2-associated protein/phosphoinositide 3-kinase signaling has a preventive role in angiotensin II-induced podocyte apoptosis.

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• Rapid Identification of Potential Drugs for Diabetic Nephropathy Using Whole-Genome Expression Profiles of Glomeruli

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• GLCCI1 is a novel component associated with the PI3K signaling pathway in podocyte foot processes

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• CIN85 Deficiency Prevents Nephrin Endocytosis and Proteinuria in Diabetes

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• Exploring the Interaction Between Cindr and JNK Signaling in Drosophila

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• Lack of CD2AP disrupts Glut4 trafficking and attenuates glucose uptake in podocytes

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• Renal Lipotoxicity-Associated Inflammation and Insulin Resistance Affects Actin Cytoskeleton Organization in Podocytes

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• Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance.

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• Roles of adaptor proteins in podocyte biology.

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