Versatile Chemical Derivatizations to Design Glycol Chitosan-Based Drug Carriers

Glycol chitosan (GC) and its derivatives have been extensively investigated as safe and effective drug delivery carriers because of their unique physiochemical and biological properties. The reactive functional groups such as the amine and hydroxyl groups on the GC backbone allow for easy chemical modification with various chemical compounds (e.g., hydrophobic molecules, crosslinkers, and acid-sensitive and labile molecules), and the versatility in chemical modifications enables production of a wide range of GC-based drug carriers. This review summarizes the versatile chemical modification methods that can be used to design GC-based drug carriers and describes their recent applications in disease therapy.

• Publication year

  2017

• Venue

  Molecules

• Publication date

  2017-10-01

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.3390/molecules22101662PMID 28981451PMCID 6151466
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Rolling circle transcription-based polymeric siRNA nanoparticles for tumor-targeted delivery.

  2017cited by this paper
• Synthesis, Characterization and In Vitro Evaluation of a Novel Glycol Chitosan-EDTA Conjugate to Inhibit Aminopeptidase-Mediated Degradation of Thymopoietin Oligopeptides

  2017cited by this paper
• Synergistic anti-tumor effects of bevacizumab and tumor targeted polymerized VEGF siRNA nanoparticles.

  2017cited by this paper
• Chemical Glycobiology.

  2016cited by this paper
• Reduction-responsive core-crosslinked micelles based on a glycol chitosan–lipoic acid conjugate for triggered release of doxorubicin

  2016cited by this paper
• In Situ Visualization of Lipid Raft Domains by Fluorescent Glycol Chitosan Derivatives.

  2016cited by this paper
• Characterization of glycol chitosan grafted with low molecular weight polyethylenimine as a gene carrier for human adipose-derived mesenchymal stem cells.

  2016cited by this paper
• Bioreducible PEI-functionalized glycol chitosan: A novel gene vector with reduced cytotoxicity and improved transfection efficiency.

  2016cited by this paper
• Novel glycol chitosan-based polymeric gene carrier synthesized by a Michael addition reaction with low molecular weight polyethylenimine.

  2016cited by this paper
• Tumor microenvironment and intracellular signal-activated nanomaterials for anticancer drug delivery

  2016cited by this paper
• Intravascular optical imaging of high-risk plaques in vivo by targeting macrophage mannose receptors

  2016cited by this paper
• Bioinspired tuning of glycol chitosan for 3D cell culture

  2016cited by this paper
• Co-delivery of VEGF and Bcl-2 dual-targeted siRNA polymer using a single nanoparticle for synergistic anti-cancer effects in vivo.

  2015cited by this paper
• A Collaborative Assembly Strategy for Tumor-Targeted siRNA Delivery.

  2015cited by this paper
• Selective redox-responsive drug release in tumor cells mediated by chitosan based glycolipid-like nanocarrier.

  2015cited by this paper
• Cancer-targeted MDR-1 siRNA delivery using self-cross-linked glycol chitosan nanoparticles to overcome drug resistance.

  2015influential reference
• Self-assembled glycol chitosan nanoparticles for disease-specific theranostics.

  2014cited by this paper
• Ginsenoside compound K-bearing glycol chitosan conjugates: synthesis, physicochemical characterization, and in vitro biological studies.

  2014cited by this paper
• Chemical tumor-targeting of nanoparticles based on metabolic glycoengineering and click chemistry.

  2014cited by this paper
• Acid pH-activated glycol chitosan/fullerene nanogels for efficient tumor therapy.

  2014influential reference
• TNF-α gene silencing using polymerized siRNA/thiolated glycol chitosan nanoparticles for rheumatoid arthritis.

  2014cited by this paper
• Glycol Chitosan-Based Fluorescent Theranostic Nanoagents for Cancer Therapy

  2014cited by this paper
• Stimuli-responsive nanocarriers for drug delivery.

  2013cited by this paper
• Cancer cell-specific photoactivity of pheophorbide a-glycol chitosan nanoparticles for photodynamic therapy in tumor-bearing mice.

  2013influential reference
• Enhanced drug-loading and therapeutic efficacy of hydrotropic oligomer-conjugated glycol chitosan nanoparticles for tumor-targeted paclitaxel delivery.

  2013influential reference
• Acidity generated by the tumor microenvironment drives local invasion.

  2013cited by this paper
• Chitosan-based nanocarriers with pH and light dual response for anticancer drug delivery.

  2013influential reference
• Multifunctional Nanoparticles: Cost Versus Benefit of Adding Targeting and Imaging Capabilities

  2012cited by this paper
• Facilitated intracellular delivery of peptide-guided nanoparticles in tumor tissues.

  2012cited by this paper
• Targeted polymeric therapeutic nanoparticles: design, development and clinical translation.

  2012cited by this paper
• Photodynamic therapy using glycol chitosan grafted fullerenes.

  2012influential reference
• Tumor-homing poly-siRNA/glycol chitosan self-cross-linked nanoparticles for systemic siRNA delivery in cancer treatment.

  2012cited by this paper
• Molecular mechanism and physiological functions of clathrin-mediated endocytosis

  2011cited by this paper
• Molecular targeting of atherosclerotic plaques by a stabilin-2-specific peptide ligand.

  2011cited by this paper
• Chitosan and chitosan derivatives in drug delivery and tissue engineering

  2011influential reference
• Comparative study of photosensitizer loaded and conjugated glycol chitosan nanoparticles for cancer therapy.

  2011cited by this paper
• Photodynamic therapy with fullerenes in vivo: reality or a dream?

  2011cited by this paper
• Macrophages in the pathogenesis of atherosclerosis.

  2011cited by this paper
• A smart polysaccharide/drug conjugate for photodynamic therapy.

  2011cited by this paper
• Bio and nanotechnological strategies for tumor-targeted gene therapy.

  2010cited by this paper
• Tumor-homing glycol chitosan/polyethylenimine nanoparticles for the systemic delivery of siRNA in tumor-bearing mice.

  2010cited by this paper
• A self-organized 3-diethylaminopropyl-bearing glycol chitosan nanogel for tumor acidic pH targeting: in vitro evaluation.

  2010cited by this paper
• Stability and cellular uptake of polymerized siRNA (poly-siRNA)/polyethylenimine (PEI) complexes for efficient gene silencing.

  2010cited by this paper
• Tumor targeting efficiency of bare nanoparticles does not mean the efficacy of loaded anticancer drugs: importance of radionuclide imaging for optimization of highly selective tumor targeting polymeric nanoparticles with or without drug.

  2010cited by this paper
• Copper-free click chemistry in living animals

  2010cited by this paper
• Targeted delivery of low molecular drugs using chitosan and its derivatives.

  2010cited by this paper
• A novel fluorescent probe for the detection of myeloperoxidase activity in atherosclerosis-associated macrophages

  2009cited by this paper
• The potential of glycol chitosan nanoparticles as carrier for low water soluble drugs.

  2009cited by this paper
• Tumor specificity and therapeutic efficacy of photosensitizer-encapsulated glycol chitosan-based nanoparticles in tumor-bearing mice.

  2009cited by this paper
• Programmed assembly of 3-dimensional microtissues with defined cellular connectivity

  2009cited by this paper
• Hydrotropic oligomer-conjugated glycol chitosan as a carrier of paclitaxel: synthesis, characterization, and in vivo biodistribution.

  2009influential reference
• MATERIAL FOR : Cell-Selective Metabolic Labeling of Proteins

  2009cited by this paper
• Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles.

  2008cited by this paper
• Self-assembled glycol chitosan nanoparticles for the sustained and prolonged delivery of antiangiogenic small peptide drugs in cancer therapy.

  2008influential reference
• Chitosan-modifications and applications: Opportunities galore

  2008cited by this paper
• Antitumor efficacy of cisplatin-loaded glycol chitosan nanoparticles in tumor-bearing mice.

  2008influential reference
• Polysaccharides-based nanoparticles as drug delivery systems.

  2008cited by this paper
• Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties.

  2008cited by this paper
• A new atherosclerotic lesion probe based on hydrophobically modified chitosan nanoparticles functionalized by the atherosclerotic plaque targeted peptides.

  2008cited by this paper
• Hydrophobically modified glycol chitosan nanoparticles-encapsulated camptothecin enhance the drug stability and tumor targeting in cancer therapy.

  2008influential reference
• Nanocarriers as an emerging platform for cancer therapy.

  2007cited by this paper
• The promise of chitosan microspheres in drug delivery systems

  2007cited by this paper
• Pathways of clathrin-independent endocytosis

  2007cited by this paper
• Structure, depolymerization, and cytocompatibility evaluation of glycol chitosan.

  2007cited by this paper
• Chitin and chitosan: Properties and applications

  2006cited by this paper
• Hydrophobically modified glycol chitosan nanoparticles as carriers for paclitaxel.

  2006influential reference
• N-acetyl histidine-conjugated glycol chitosan self-assembled nanoparticles for intracytoplasmic delivery of drugs: endocytosis, exocytosis and drug release.

  2006cited by this paper
• Self-assembled nanoparticles based on glycol chitosan bearing hydrophobic moieties as carriers for doxorubicin: in vivo biodistribution and anti-tumor activity.

  2006cited by this paper
• A new prostate carcinoma binding peptide (DUP-1) for tumor imaging and therapy.

  2005cited by this paper
• Self-assembled nanoparticles containing hydrophobically modified glycol chitosan for gene delivery.

  2005cited by this paper
• Chemistry in living systems

  2005cited by this paper
• Recent advances with liposomes as pharmaceutical carriers

  2005cited by this paper
• Chitin and chitosan: Chemistry, properties and applications

  2004cited by this paper
• Self-assembled nanoparticles based on glycol chitosan bearing 5beta-cholanic acid for RGD peptide delivery.

  2004cited by this paper
• A strain-promoted [3 + 2] azide-alkyne cycloaddition for covalent modification of biomolecules in living systems.

  2004cited by this paper
• Anticancer Drug Delivery with Transferrin Targeted Polymeric Chitosan Vesicles

  2004cited by this paper
• The dawning era of polymer therapeutics

  2003cited by this paper
• Biodistribution and anti-tumor efficacy of doxorubicin loaded glycol-chitosan nanoaggregates by EPR effect.

  2003cited by this paper
• Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities.

  2003cited by this paper
• The changing faces of glutathione, a cellular protagonist.

  2003cited by this paper
• Targeting of Apoptotic Macrophages and Experimental Atheroma With Radiolabeled Annexin V: A Technique With Potential for Noninvasive Imaging of Vulnerable Plaque

  2003cited by this paper
• In Vivo Imaging of Proteolytic Activity in Atherosclerosis

  2002cited by this paper
• Chemical Glycobiology

  2001cited by this paper
• Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.

  2000cited by this paper
• Porous chitosan scaffolds for tissue engineering.

  1999cited by this paper
• Preparation of chitosan self-aggregates as a gene delivery system.

  1998cited by this paper
• Chitosan and its use as a pharmaceutical excipient.

  1998cited by this paper
• Biological applications of fullerenes.

  1996cited by this paper
• Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

  1994cited by this paper
• A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

  1986cited by this paper

• Stabilization of chitosan-based nanomedicines in cancer therapy: a review.

  2025cites this paper
• Thioketal-linked glycol chitosan nanosystem for targeted and sustained drug delivery of mesalazine in inflammatory bowel disease.

  2025cites this paper
• Biocompatible Glycol Chitosan Microgels as Effective Drug Carriers

  2023cites this paper
• Chitosan-based nanoscale delivery systems in hepatocellular carcinoma: Versatile bio-platform with theranostic application.

  2023cites this paper
• Macrophage membrane-derived pH-responsive nanovesicles to target tumor cells with integrin α4β1 receptor

  2023cites this paper
• Hydrophobically modified PEGylated glycol chitosan nanoparticles: synthesis, characterisation and anticancer properties

  2021cites this paper
• A Brief Review on Hydrophobic Modifications of Glycol Chitosan into Amphiphilic Nanoparticles for Enhanced Drug Delivery

  2021cites this paper
• Antimicrobial Properties of Chitosan and Its Derivatives

  2021cites this paper
• Chitin and chitosan

  2021cites this paper
• Glycol chitosan-based renal docking biopolymeric nanomicelles for site-specific delivery of the immunosuppressant.

  2020cites this paper
• Deep Tumor Penetration of Doxorubicin-Loaded Glycol Chitosan Nanoparticles Using High-Intensity Focused Ultrasound

  2020cites this paper
• Chitosan-based nanomedicine for brain delivery: Where are we heading?

  2020cites this paper
• Tumor-targeting glycol chitosan nanocarriers: overcoming the challenges posed by chemotherapeutics

  2019cites this paper
• Polymer conjugation optimizes EDTA as a calcium-chelating agent that exclusively removes extrafibrillar minerals from mineralized collagen.

  2019cites this paper