The clinical and cellular basis of contact lens-related corneal infections

Microbial keratitis (MK) is the most visually devastating complication associated with contact lens wear. Pseudomonas aeruginosa (PA) is highly invasive in the corneal epithelium and is responsible for more than half of the reported cases of contact lens-related MK. To protect against Pseudomonas-mediated MK, the corneal epithelium has evolved overlapping defense mechanisms that function to protect the ocular surface from microbial invasion. Research has shown that contact lens wear disrupts these protective mechanisms through breakdown of normal homeostatic surface renewal as well as damaging the corneal surface, exposing underlying cell membrane receptors that bind and internalize PA through the formation of lipid rafts. Human clinical trials have shown that initial adherence of PA with resulting increased risk for microbial infection is mediated in part by contact lens oxygen transmissibility. Recently, chemical preserved multipurpose solutions (MPS) have been implicated in increasing PA adherence to corneal epithelial cells, in addition to inducing significant levels of toxic staining when used in conjunction with specific silicone hydrogel lenses. This review summarizes what is currently known about the relationship between contact lenses, the corneal epithelium, MPS, and infection.

• Publication year

  2008

• Venue

  Clinical Ophthalmology

• Publication date

  2008-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.2147/OPTH.S3249PMID 19277209PMCID 2652884
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Contact lens-associated microbial keratitis.

  2008cited by this paper
• Risk factors and causative organisms in microbial keratitis in daily disposable contact lens wear

  2008cited by this paper
• The effect of nonpreserved care solutions on 12 months of daily and extended silicone hydrogel contact lens wear.

  2008cited by this paper
• Effects of Multipurpose Solutions on Corneal Epithelial Tight Junctions

  2008cited by this paper
• A Series of Evaluations of MPS and Silicone Hydrogel Lens Combinations

  2007cited by this paper
• Microbial Keratitis Pathogens and Antibiotic Susceptibilities: A 5-Year Review of Cases at an Urban County Hospital in North Texas

  2007cited by this paper
• Host Resistance to Lung Infection Mediated by Major Vault Protein in Epithelial Cells

  2007cited by this paper
• Solution Toxicity in Soft Contact Lens Daily Wear Is Associated With Corneal Inflammation

  2007influential reference
• The Glenn A. Fry award lecture 2005. The pathogenesis of contact lens-related keratitis.

  2006cited by this paper
• The Pathogenesis of Contact Lens-Related Keratitis

  2006cited by this paper
• Regulation of Pseudomonas aeruginosa internalization after contact lens wear in vivo and in serum-free culture by ocular surface cells.

  2006cited by this paper
• Cytotoxicity and antimicrobial activity of six multipurpose soft contact lens disinfecting solutions 1

  2006cited by this paper
• Prolonged Hypoxia Induces Lipid Raft Formation and Increases Pseudomonas Internalization in vivo After Contact Lens Wear and Lid Closure

  2006cited by this paper
• Microbial Keratitis: Predisposing Factors and Morbidity

  2006cited by this paper
• Internalization of Pseudomonas aeruginosa is mediated by lipid rafts in contact lens-wearing rabbit and cultured human corneal epithelial cells.

  2005cited by this paper
• Corneal Staining and Subjective Symptoms With Multipurpose Solutions as a Function of Time

  2005cited by this paper
• Characterization of growth and differentiation in a telomerase-immortalized human corneal epithelial cell line.

  2005cited by this paper
• The Incidence of Contact Lens Related Microbial Keratitis in Australia

  2005cited by this paper
• The incidence of microbial keratitis among wearers of a 30-day silicone hydrogel extended-wear contact lens.

  2005cited by this paper
• Risk factors for the development of corneal infiltrative events associated with contact lens wear.

  2005cited by this paper
• Localization of Cystic Fibrosis Transmembrane Conductance Regulator to Lipid Rafts of Epithelial Cells Is Required for Pseudomonas aeruginosa-Induced Cellular Activation 1

  2004cited by this paper
• Hypoxia increases corneal cell expression of CFTR leading to increased Pseudomonas aeruginosa binding, internalization, and initiation of inflammation.

  2004cited by this paper
• Effects of Contact Lens Care Solutions on Surface Exfoliation and Bacterial Binding to Corneal Epithelial Cells1

  2003cited by this paper
• Vertical movement of epithelial basal cells toward the corneal surface during use of extended-wear contact lenses.

  2003cited by this paper
• Effects of eyelid closure and disposable and silicone hydrogel extended contact lens wear on rabbit corneal epithelial proliferation.

  2003cited by this paper
• Adaptive effects of 30-night wear of hyper-O(2) transmissible contact lenses on bacterial binding and corneal epithelium: a 1-year clinical trial.

  2002cited by this paper
• Effect of Eyelid Closure and Overnight Contact Lens Wear on Viability of Surface Epithelial Cells in Rabbit Cornea

  2002cited by this paper
• Annexin V binding to rabbit corneal epithelial cells following overnight contact lens wear or eyelid closure.

  2002cited by this paper
• Effects of daily and overnight wear of a novel hyper oxygen-transmissible soft contact lens on bacterial binding and corneal epithelium: a 13-month clinical trial.

  2002cited by this paper
• Corneal epithelial homeostasis following daily and overnight contact lens wear.

  2002cited by this paper
• Asymptomatic Corneal Staining Associated with the Use of Balafilcon Silicone-Hydrogel Contact Lenses Disinfected with a Polyaminopropyl Biguanide-Preserved Care Regimen

  2002cited by this paper
• Microbial entry through caveolae: variations on a theme

  2002cited by this paper
• Effects of rigid and soft contact lens daily wear on corneal epithelium, tear lactate dehydrogenase, and bacterial binding to exfoliated epithelial cells.

  2001influential reference
• Co‐option of endocytic functions of cellular caveolae by pathogens

  2001cited by this paper
• Comparative cytotoxicity potential of soft contact lens care regimens.

  2001cited by this paper
• Proliferation rate of rabbit corneal epithelium during overnight rigid contact lens wear.

  2001influential reference
• Effects of low and hyper Dk rigid gas permeable contact lenses on Bcl-2 expression and apoptosis in the rabbit corneal epithelium.

  2001cited by this paper
• Bcl-2 expression in the human cornea.

  2001cited by this paper
• Caveolae as portals of entry for microbes.

  2001cited by this paper
• Intraocular lens implants and risk of endophthalmitis

  2000cited by this paper
• CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa.

  2000cited by this paper
• The effect of rigid gas permeable contact lens wear on proliferation of rabbit corneal and conjunctival epithelial cells.

  1999influential reference
• The application of in vivo confocal microscopy and tear LDH measurement in assessing corneal response to contact lens and contact lens solutions.

  1999cited by this paper
• Short-term hypoxia downregulates epithelial cell desquamation in vivo, but does not increase Pseudomonas aeruginosa adherence to exfoliated human corneal epithelial cells.

  1999influential reference
• The relationship between contact lens oxygen permeability and binding of Pseudomonas aeruginosa to human corneal epithelial cells after overnight and extended wear.

  1999influential reference
• Soft contact lens care systems and corneal staining in Hong Kong-Chinese.

  1998cited by this paper
• Epithelial cell polarity affects susceptibility to Pseudomonas aeruginosa invasion and cytotoxicity

  1997cited by this paper
• Functional rafts in cell membranes

  1997cited by this paper
• Adherence of Pseudomonas aeruginosa to shed rabbit corneal epithelial cells after overnight wear of contact lenses.

  1997cited by this paper
• Relationship between cytotoxicity and corneal epithelial cell invasion by clinical isolates of Pseudomonas aeruginosa

  1996cited by this paper
• Apoptosis in the corneal epithelium.

  1996cited by this paper
• Pseudomonas aeruginosa invades corneal epithelial cells during experimental infection

  1994cited by this paper
• The relation between contact lens oxygen transmissibility and binding of Pseudomonas aeruginosa to the cornea after overnight wear.

  1994influential reference
• Effects of rigid gas permeable contact lens extended wear on rabbit cornea assessed by LDH activity, MDH activity, and albumin levels in tear fluid.

  1993cited by this paper
• Morphologic effects of contact lens wear on the corneal surface.

  1992cited by this paper
• Tear Lactate Dehydrogenase Levels: A New Method to Assess Effects of Contact Lens Wear in Man

  1992cited by this paper
• Extended contact lens wear enhances Pseudomonas aeruginosa adherence to human corneal epithelium.

  1992cited by this paper
• Quantitative evaluation of the corneal epithelial barrier: effect of artificial tears and preservatives.

  1991cited by this paper
• The effects of contact lens wear on the morphology of corneal surface cells in the human.

  1990cited by this paper
• The relative risk of ulcerative keratitis among users of daily-wear and extended-wear soft contact lenses. A case-control study. Microbial Keratitis Study Group.

  1989cited by this paper
• A partial-thickness epithelial defect increases the adherence of Pseudomonas aeruginosa to the cornea.

  1989cited by this paper
• The incidence of ulcerative keratitis among users of daily-wear and extended-wear soft contact lenses.

  1989cited by this paper
• Investigation of sloughed corneal epithelial cells collected by non-invasive irrigation of the corneal surface.

  1986cited by this paper
• Contact lens-associated microbial keratitis.

  1986cited by this paper
• Corneal ulcers associated with daily-wear and extended-wear contact lenses.

  1986cited by this paper
• Effects of long-term extended contact lens wear on the human cornea.

  1985cited by this paper
• Critical oxygen levels to avoid corneal edema for daily and extended wear contact lenses.

  1984cited by this paper
• Effects of contact lens wear on mitosis of corneal epithelium and lactate content in aqueous humor of rabbit.

  1983cited by this paper

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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
• Cornea and ocular surface disease: application of cutting-edge optometric research.

  2014cites this paper
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  2014cites this paper
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  2013influential citation
• The role of protein tyrosine phosphorylation in the cell–cell junctions and intercellular permeability of post-confluent bovine corneal epithelial cells

  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
• Why does the healthy cornea resist Pseudomonas aeruginosa infection?

  2013cites this paper
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  2011cites this paper
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  2011cites this paper
• Pseudomonas genomes: diverse and adaptable.

  2011cites this paper
• Mechanical robustness of Pseudomonas aeruginosa biofilms.

  2011cites this paper
• Contact Lens-Related Corneal Ulcer: A Teaching Case Report

  2011cites this paper
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  2010cites this paper