Fentanyl-Induced Brain Hypoxia Triggers Brain Hyperglycemia and Biphasic Changes in Brain Temperature

No abstract is available for this paper.

• Publication year

  2018

• Venue

  Neuropsychopharmacology

• Publication date

  2018-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1038/npp.2017.181PMID 28849778PMCID PMC5809788
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A review: Fentanyl and non-pharmaceutical fentanyls.

  2017cited by this paper
• Deadly chemistry.

  2017cited by this paper
• Intravenous Heroin Induces Rapid Brain Hypoxia and Hyperglycemia that Precede Brain Metabolic Response

  2017cited by this paper
• Rapid Physiological Fluctuations in Nucleus Accumbens Oxygen Levels Induced by Arousing Stimuli: Relationships with Changes in Brain Glucose and Metabolic Neural Activation

  2017cited by this paper
• Interpreting BOLD: towards a dialogue between cognitive and cellular neuroscience

  2016cited by this paper
• Robust Brain Hyperglycemia during General Anesthesia: Relationships with Metabolic Brain Inhibition and Vasodilation

  2016cited by this paper
• Clinically Relevant Pharmacological Strategies That Reverse MDMA-Induced Brain Hyperthermia Potentiated by Social Interaction

  2016cited by this paper
• Relationship between Nonmedical Prescription-Opioid Use and Heroin Use.

  2016cited by this paper
• Compulsive-Like Responding for Opioid Analgesics in Rats with Extended Access

  2015cited by this paper
• Parsing Glucose Entry into the Brain: Novel Findings Obtained with Enzyme-Based Glucose Biosensors

  2014cited by this paper
• The reinstatement model of drug relapse: recent neurobiological findings, emerging research topics, and translational research

  2013cited by this paper
• Microdialysis-coupled enzymatic microreactor for in vivo glucose monitoring in rats.

  2013cited by this paper
• Effects of Anesthetic Agents on Brain Blood Oxygenation Level Revealed with Ultra-High Field MRI

  2012cited by this paper
• Rapid fluctuations in extracellular brain glucose levels induced by natural arousing stimuli and intravenous cocaine: fueling the brain during neural activation.

  2012cited by this paper
• Opiate versus psychostimulant addiction: the differences do matter

  2011cited by this paper
• Respiratory, cerebrovascular and cardiovascular responses to isocapnic hypoxia.

  2011cited by this paper
• The neurovascular unit in brain function and disease

  2011cited by this paper
• New Opioids: Expensive Distractions or Important Additions to Practice?

  2010cited by this paper
• Glial and neuronal control of brain blood flow

  2010cited by this paper
• Brain temperature homeostasis: physiological fluctuations and pathological shifts.

  2010cited by this paper
• Opioids and the control of respiration.

  2008cited by this paper
• General anesthesia as a factor affecting impulse activity and neuronal responses to putative neurotransmitters.

  2006cited by this paper
• Neural systems of reinforcement for drug addiction: from actions to habits to compulsion

  2005cited by this paper
• Confounding effects of anesthesia on functional activation in rodent brain: a study of halothane and alpha-chloralose anesthesia.

  2005cited by this paper
• Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats.

  2005cited by this paper
• Nucleus accumbens shell and core dopamine: differential role in behavior and addiction.

  2002cited by this paper
• The neural basis of functional brain imaging signals.

  2002cited by this paper
• Effects of anesthesia on functional activation of cerebral blood flow and metabolism

  2001cited by this paper
• COGNITIVE NEUROSCIENCE: Heroin-induced neuronal activation in rat brain assessed by functional MRI

  2000cited by this paper
• A review of the use of fentanyl analgesia in the management of acute pain in adults.

  1999cited by this paper
• Effect of anesthesia on cerebral tissue oxygen and cardiopulmonary parameters in rats.

  1997cited by this paper
• Extracellular glucose concentration in mammalian brain: continuous monitoring of changes during increased neuronal activity and upon limitation in oxygen supply in normo-, hypo-, and hyperglycemic animals

  1994cited by this paper
• A deadly chemistry

  1993cited by this paper
• Extracellular Brain Glucose Levels Reflect Local Neuronal Activity: A Microdialysis Study in Awake, Freely Moving Rats

  1992cited by this paper
• Opioids and respiration.

  1989cited by this paper
• Activation of cholinergic mechanisms in the medulla oblongata reverse intravenous opioid-induced respiratory depression.

  1987cited by this paper
• A psychomotor stimulant theory of addiction.

  1987cited by this paper
• Effects of Phenobarbital on Cerebral Blood Flow and Metabolism in Young and Aged Rats

  1986cited by this paper
• The Rat Brain in Stereotaxic Coordinates

  1983influential reference
• The Rat Brain in Stereotaxic Coordinates

  1983cited by this paper
• Centrally mediated bradycardia and hypotension induced by narcotic analgesics: dextromoramide and fentanyl.

  1974cited by this paper
• Recent studies of cerebral blood flow and cerebral metabolism in man.

  1947cited by this paper
• Recent studies of cerebral blood flow and cerebral metabolism in man.

  1947cited by this paper

• Safety profile of fentanyl with different routes of administration: a disproportionality analysis using the EudraVigilance database.

  2026cites this paper
• Decoding behavioral economics vs. traditional dose response functions in rodent intravenous drug self-administration procedures.

  2026cites this paper
• Divergent Ventilatory Responses during Opioid-Induced Respiratory Depression in Response to Repeated Fentanyl Use.

  2025cites this paper
• The role of central versus peripheral opioid receptors in fentanyl-induced brain hypoxia.

  2025cites this paper
• Effect of general hyperthermia and local cooling on fentanyl tolerance in rats

  2025cites this paper
• Fentanyl and Alcohol Co-Exposure Induce Robust, Sustained Hyperlocomotion and Neural Circuit Disruption in Larval Zebrafish

  2025cites this paper
• Fentanyl abuse and its implication on health and society

  2025cites this paper
• Peripheral opioid receptor antagonism alleviates fentanyl-induced cardiorespiratory depression and is devoid of aversive behavior

  2025cites this paper
• Comparison of fentanyl-induced brain oxygen responses following intravenous and intraperitoneal injections in rats.

  2025cites this paper
• The Rise of Fentanyl: Molecular Aspects and Forensic Investigations

  2025cites this paper
• Oxidative Stress, Hypoxia and Cellular Metabolism: Unraveling the Effects of Fentanyl on Lung Cancer Cells

  2025cites this paper
• Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice

  2024cites this paper
• The genetic landscape of pediatric postural orthostatic tachycardia syndrome

  2024cites this paper
• Oxygen fluctuations in the brain and periphery induced by intravenous fentanyl: effects of dose and drug experience.

  2024cites this paper
• Respiratory Depression Associated with Opioids: A Narrative Review

  2024cites this paper
• Hypoxic Effects of Heroin and Fentanyl and Their Basic Physiological Mechanisms.

  2024cites this paper
• Exploring the Psychological Side of Fentanyl: A Scoping Review to Disclose the Psychosocial Dimensions of Illicitly Manufactured Fentanyl Users.

  2024cites this paper
• Ventilatory Effects of Fentanyl, Heroin, and d-Methamphetamine, Alone and in Mixtures in Male Rats Breathing Normal Air 

  2023cites this paper
• Basic metabolic and vascular effects of ketamine and its interaction with fentanyl.

  2023cites this paper
• The pattern of brain oxygen response induced by intravenous fentanyl limits the time window of therapeutic efficacy of naloxone.

  2023cites this paper
• Xylazine effects on opioid-induced brain hypoxia

  2023cites this paper
• Combined treatment with naloxone and the alpha2 adrenoceptor antagonist atipamezole reversed brain hypoxia induced by a fentanyl-xylazine mixture in a rat model

  2023cites this paper
• Electroanalysis of Fentanyl and Its New Analogs: A Review

  2022cites this paper
• Fentanyl Induces Novel Conditioned Place Preference in Adult Zebrafish, Disrupts Neurotransmitter Homeostasis, and Triggers Behavioral Changes

  2022cites this paper
• Acute Toxic Effects of the New Psychoactive Substance “Voodoo” among Patients presented to the Poison Control Center of Ain Shams University Hospitals (PCC-ASUH), Egypt, during 2017

  2021cites this paper
• A vicious cycle of neuropathological, cognitive and behavioural sequelae of repeated opioid overdose.

  2021cites this paper
• Does a Hypoxic Injury from a Non-fatal Overdose Lead to an Alzheimer Disease?

  2020cites this paper
• Cocaine added to heroin fails to affect heroin-induced brain hypoxia.

  2020cites this paper
• Reasons to avoid fentanyl.

  2020cites this paper
• The Challenge Posed by New Synthetic Opioids: Pharmacology and Toxicology

  2019cites this paper
• Respiratory depression and brain hypoxia induced by opioid drugs: Morphine, oxycodone, heroin, and fentanyl

  2019cites this paper
• The rising crisis of illicit fentanyl use, overdose, and potential therapeutic strategies

  2019cites this paper
• Interactions of benzodiazepines with heroin: respiratory depression, temperature effects, and behavior.

  2019cites this paper
• Changes in brain oxygen and glucose induced by oxycodone: Relationships with brain temperature and peripheral vascular tone

  2018cites this paper
• Inflow of oxygen and glucose in brain tissue induced by intravenous norepinephrine: relationships with central metabolic and peripheral vascular responses.

  2018cites this paper
• Drug Interactions With New Synthetic Opioids

  2018cites this paper
• Central and Peripheral Mechanisms Underlying Physiological and Drug-Induced Fluctuations in Brain Oxygen in Freely-Moving Rats

  2018cites this paper
• Heroin Contaminated with Fentanyl Dramatically Enhances Brain Hypoxia and Induces Brain Hypothermia

  2017cites this paper