Killing of Candida albicans by Histatin 5: Cellular Uptake and Energy Requirement

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Antonie van Leeuwenhoek

• Publication date

  2001-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1023/A:1012070600340PMID 11816973
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Candida albicans Mutants Deficient in Respiration Are Resistant to the Small Cationic Salivary Antimicrobial Peptide Histatin 5

  2000cited by this paper
• Salivary Histatin 5 Induces Non-lytic Release of ATP fromCandida albicans Leading to Cell Death*

  1999influential reference
• Histatin 3-Mediated Killing of Candida albicans: Effect of Extracellular Salt Concentration on Binding and Internalization

  1999influential reference
• The Cellular Target of Histatin 5 on Candida albicans Is the Energized Mitochondrion*

  1999cited by this paper
• Thirteen-Year Evolution of Azole Resistance in Yeast Isolates and Prevalence of Resistant Strains Carried by Cancer Patients at a Large Medical Center

  1998cited by this paper
• Candidacidal Activity of Salivary Histatins

  1998influential reference
• Synthetic histatin analogues with broad-spectrum antimicrobial activity.

  1997cited by this paper
• Studies of the mechanism of human salivary histatin-5 candidacidal activity with histatin-5 variants and azole-sensitive and -resistant Candida species

  1997cited by this paper
• An antimicrobial peptide, magainin 2, induced rapid flip-flop of phospholipids coupled with pore formation and peptide translocation.

  1996cited by this paper
• Candidacidal activity of human salivary histatin recombinant variants produced by site-directed mutagenesis.

  1996cited by this paper
• Candidacidal activity of recombinant human salivary histatin-5 and variants

  1996cited by this paper
• Oral Candida: Clearance, Colonization, or Candidiasis?

  1995cited by this paper
• Structure, function, and membrane integration of defensins.

  1995cited by this paper
• Translocation of a channel-forming antimicrobial peptide, magainin 2, across lipid bilayers by forming a pore.

  1995cited by this paper
• Structure–activity studies on magainins and other host defense peptides

  1995cited by this paper
• Recombinant histatins: functional domain duplication enhances candidacidal activity.

  1995cited by this paper
• Defensins: antimicrobial and cytotoxic peptides of mammalian cells.

  1993cited by this paper
• Anticandidal activity of major human salivary histatins

  1991cited by this paper
• Salivary histatin 5: dependence of sequence, chain length, and helical conformation for candidacidal activity.

  1990cited by this paper
• An assay of relative cell wall porosity in Saccharomyces cerevisiae, Kluyveromyces lactis and Schizosaccharomyces pombe

  1990cited by this paper
• Structural Relationship Between Human Salivary Histatins

  1990cited by this paper
• Primary Structure and Anticandidal Activity of the Major Histatin from Parotid Secretion of the Subhuman Primate, Macaca fascicularis

  1990cited by this paper
• Antimicrobial properties of peptides from Xenopus granular gland secretions

  1988cited by this paper
• Histatins, a novel family of histidine-rich proteins in human parotid secretion. Isolation, characterization, primary structure, and fungistatic effects on Candida albicans.

  1988cited by this paper
• A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast.

  1988cited by this paper
• Candida infections: an overview.

  1987cited by this paper
• Induction of petite mutation with acriflavine and elevated temperature in Candida albicans.

  1987cited by this paper
• Morphogenesis in Candida albicans.

  1985cited by this paper
• Growth-inhibitory and bactericidal effects of human parotid salivary histidine-rich polypeptides on Streptococcus mutans

  1984cited by this paper
• Fungistatic and fungicidal activity of human parotid salivary histidine-rich polypeptides on Candida albicans

  1984influential reference
• Candida and candidosis

  1979cited by this paper
• Polyacrylamide Gel Electrophoresis of Human Salivary Histidine-Rich-Polypeptides

  1977cited by this paper
• Histidine-rich-polypeptides in Macaque parotid saliva are not nuclear histones.

  1977cited by this paper
• Polybase induced lysis of yeast spheroplasts

  1975cited by this paper
• Effect of Some Proteins on the Yeast Cell Membrane

  1967cited by this paper

• The Membrane Activity of the Amphibian Temporin B Peptide Analog TB_KKG6K Sheds Light on the Mechanism That Kills Candida albicans

  2022cites this paper
• Saliva and Its Importance in Sjögren’s Syndrome

  2021cites this paper
• Oral Candidiasis: A Disease of Opportunity

  2020cites this paper
• Microbial interactions and immunity response in oral Candida species.

  2020cites this paper
• Salivary Histatin 1 and 2 Are Targeted to Mitochondria and Endoplasmic Reticulum in Human Cells

  2020cites this paper
• The role of natural salivary defences in maintaining a healthy oral microbiota.

  2019cites this paper
• The power of saliva: Antimicrobial and beyond

  2019cites this paper
• Antifungal Activity of Mammalian Serum Amyloid A1 against Candida albicans

  2019cites this paper
• A Novel Mutant of rLj-RGD3 (rLj-112) Suppressed the Proliferation and Metastasis of B16 Cells through the EGFR Signaling Pathway

  2019cites this paper
• Salivary polypeptide/hyaluronic acid multilayer coatings act as "fungal repellents" and prevent biofilm formation on biomaterials.

  2018cites this paper
• Miniaturized Digestion and Extraction of Surface Proteins from Candida albicans following Treatment with Histatin 5 for Mass Spectrometry Analysis

  2016cites this paper
• Antimicrobial Peptides as a Strategy to Combat Fungal Biofilms.

  2016cites this paper
• Mass Spectrometric Analyses of Surface Proteins from Candida albicans After Treatment with Histatin 5

  2015cites this paper
• In Vitro Identification of Histatin 5 Salivary Complexes

  2015cites this paper
• Salivary peptidomic as a tool to disclose new potential antimicrobial peptides.

  2015cites this paper
• Human Antimicrobial Peptides and Proteins

  2014cites this paper
• Histatin 5 binds to Porphyromonas gingivalis hemagglutinin B (HagB) and alters HagB-induced chemokine responses

  2014cites this paper
• Nanoscale Adhesion Forces between Enamel Pellicle Proteins and Hydroxyapatite

  2014cites this paper
• Candidacidal mechanism of the arenicin-3-derived peptide NZ17074 from Arenicola marina

  2014cites this paper
• How Does It Kill?: Understanding the Candidacidal Mechanism of Salivary Histatin 5

  2014cites this paper
• Evaluating the copper-binding properties of the antifungal peptide histatin 5

  2014cites this paper
• Two Functional Motifs Define the Interaction, Internalization and Toxicity of the Cell-Penetrating Antifungal Peptide PAF26 on Fungal Cells

  2013cites this paper
• Impaired Histatin-5 Levels and Salivary Antimicrobial Activity against C. albicans in HIV Infected Individuals.

  2013cites this paper
• Antimicrobial peptides: The natural proteins and the future application for treatment of infectious diseases

  2013cites this paper
• Human salivary cystatin SA exhibits antimicrobial effect against Aggregatibacter actinomycetemcomitans.

  2012cites this paper
• Identification and characterization of histatin 1 salivary complexes by using mass spectrometry

  2012cites this paper
• Coprisin-induced antifungal effects in Candida albicans correlate with apoptotic mechanisms.

  2012cites this paper
• Investigating the Therapeutic Potential of Salivary Proteins for Oral Diseases

  2012cites this paper
• Chemical Genomic Screening of a Saccharomyces cerevisiae Genomewide Mutant Collection Reveals Genes Required for Defense against Four Antimicrobial Peptides Derived from Proteins Found in Human Saliva

  2012cites this paper
• Histatin 5 attenuates IL-8 dendritic cell response to P. gingivalis hemagglutinin B

  2011cites this paper
• Influence of histatin 5 on Candida albicans mitochondrial protein expression assessed by quantitative mass spectrometry.

  2011cites this paper
• Context Mediates Antimicrobial Efficacy of Kinocidin Congener Peptide RP-1

  2011cites this paper
• Protection of the oral mucosa by salivary histatin-5 against Candida albicans in an ex vivo murine model of oral infection.

  2010cites this paper
• Susceptibility of Candida biofilms to histatin 5 and fluconazole

  2010cites this paper
• Salivary peptidomics

  2010cites this paper
• The dual trend in histatins research

  2009cites this paper
• A novel antifungal analog peptide derived from protaetiamycine

  2009cites this paper
• A Novel Immune Evasion Strategy of Candida albicans: Proteolytic Cleavage of a Salivary Antimicrobial Peptide

  2009cites this paper
• Fungicidal effect of antimicrobial peptide arenicin-1.

  2009cites this paper
• Salivary histatin‐5 and oral fungal colonisation in HIV+ individuals

  2009cites this paper
• Antimicrobial peptides: to membranes and beyond

  2009cites this paper
• Implication du farnesol et des cellules épithéliales gingivales dans le contrôle de la candidose buccale

  2009cites this paper
• Enhanced Susceptibility to Antifungal Oligopeptides in Yeast Strains Overexpressing ABC Multidrug Efflux Pumps

  2008cites this paper
• 7 Antimicrobiële peptiden (AMP’s) in speeksel

  2008cites this paper
• Proteomic and metabolic characterization of a Candida albicans mutant resistant to the antimicrobial peptide MUC7 12-mer.

  2008cites this paper
• The Antimicrobial Peptide Histatin-5 Causes a Spatially Restricted Disruption on the Candida albicans Surface, Allowing Rapid Entry of the Peptide into the Cytoplasm

  2008cites this paper
• Estudos estruturais de histatina-5 e seu análogo, TOAC0-histatina-5: interação com metais e sistemas biomiméticos

  2008cites this paper
• 2,5-dimethyl-4-hydroxy-3(2H)-furanone (DMHF); antimicrobial compound with cell cycle arrest in nosocomial pathogens.

  2007cites this paper
• Energy Depletion Protects Candida albicans against Antimicrobial Peptides by Rigidifying Its Cell Membrane*

  2007cites this paper
• Candicidal action of resveratrol isolated from grapes on human pathogenic yeast C. albicans.

  2007cites this paper
• S-phase accumulation of Candida albicans by anticandidal effect of amentoflavone isolated from Selaginella tamariscina.

  2007cites this paper
• Duke University Dissertation Template

  2007cites this paper
• Synthetic Histidine-Rich Peptides Inhibit Candida Species and Other Fungi In Vitro: Role of Endocytosis and Treatment Implications

  2006cites this paper
• Biological activity of Tat (47-58) peptide on human pathogenic fungi.

  2006cites this paper
• Candida glabrata is unusual with respect to its resistance to cationic antifungal proteins

  2005cites this paper
• Characterisation of a novel miniaturised bubble column bioreactor for high throughput cell cultivation

  2005cites this paper
• Candidacidal effects of two antimicrobial peptides: histatin 5 causes small membrane defects, but LL-37 causes massive disruption of the cell membrane.

  2005cites this paper
• Reactive oxygen species play no role in the candidacidal activity of the salivary antimicrobial peptide histatin 5.

  2004cites this paper
• The TRK1 Potassium Transporter Is the Critical Effector for Killing of Candida albicans by the Cationic Protein, Histatin 5*

  2004cites this paper
• Immunopathogenesis of Oropharyngeal Candidiasis in Human Immunodeficiency Virus Infection

  2004cites this paper
• Interactions of histatin 5 and histatin 5-derived peptides with liposome membranes: surface effects, translocation and permeabilization.

  2004cites this paper
• Salivary Proteins: Protective and Diagnostic Value in Cariology?

  2004cites this paper
• Respiratory inhibition of isolated mammalian mitochondria by salivary antifungal peptide histatin-5.

  2003cites this paper
• Candida albicans Ssa1/2p Is the Cell Envelope Binding Protein for Human Salivary Histatin 5*

  2003cites this paper
• Internalisation and Degradation of Histatin 5 by Candida albicans

  2003cites this paper
• Current Awareness on yeast

  2002cites this paper
• Histatin-derived peptides: potential agents to treat localised infections

  2002cites this paper
• Histatin 5 and derivatives. Their localization and effects on the ultra-structural level.

  2002cites this paper
• The human salivary peptide histatin 5 exerts its antifungal activity through the formation of reactive oxygen species

  2001cites this paper