Critical factors for optimizing the 5-fluorouracil-folinic acid association in cancer chemotherapy.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Annals of Oncology

• Publication date

  1996-03-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/OXFORDJOURNALS.ANNONC.A010573PMID 8740793
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Factors that influence the therapeutic activity of 5-fluorouracil [6RS]leucovorin combinations in colon adenocarcinoma xenografts

  2004cited by this paper
• Thymidylate synthase mRNA level in adenocarcinoma of the stomach: a predictor for primary tumor response and overall survival.

  1996cited by this paper
• Response to fluorouracil therapy in cancer patients: the role of tumoral dihydropyrimidine dehydrogenase activity.

  1995cited by this paper
• Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors.

  1995cited by this paper
• Sequential methotrexate, 5‐fluorouracil (5‐FU), and high dose leucovorin versus 5‐FU and high dose leucovorin versus 5‐FU alone for advanced colorectal cancer. A multi‐institutional randomized trial

  1995cited by this paper
• Thymidylate synthase and drug resistance.

  1995cited by this paper
• Efficacy of adjuvant fluorouracil and folinic acid in colon cancer

  1995influential reference
• Phase II trial of cisplatin, fluorouracil, and pure folinic acid for locally advanced head and neck cancer: a pharmacokinetic and clinical survey.

  1995cited by this paper
• The effect of dose and interval between 5-fluorouracil and leucovorin on the formation of thymidylate synthase ternary complex in human cancer cells.

  1995cited by this paper
• Wide range for optimal concentration of folinic acid in fluorouracil modulation--experimental data on human tumour cell lines.

  1994cited by this paper
• Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil.

  1994cited by this paper
• Folinic acid and 5-fluorouracil as adjuvant chemotherapy in colon cancer.

  1994influential reference
• A role for dihydropyrimidine dehydrogenase and thymidylate synthase in tumour sensitivity to fluorouracil.

  1994cited by this paper
• Relationship between fluorouracil systemic exposure and tumor response and patient survival.

  1994cited by this paper
• Cisplatin, fluorouracil, and leucovorin augmented by interferon alfa-2b in head and neck cancer: a clinical and pharmacologic analysis.

  1993cited by this paper
• Ternary complex formation and reduced folate in surgical specimens of human adenocarcinoma tissues

  1993cited by this paper
• Decreased folylpolyglutamate synthetase expression: a novel mechanism of fluorouracil resistance.

  1993cited by this paper
• Intracellular metabolism of 5-formyl tetrahydrofolate in human breast and colon cell lines.

  1992influential reference
• Novel mechanism(s) of resistance to 5-fluorouracil in human colon cancer (HCT-8) sublines following exposure to two different clinically relevant dose schedules.

  1992cited by this paper
• Elevation of thymidylate synthase following 5-fluorouracil treatment is prevented by the addition of leucovorin in murine colon tumors.

  1992cited by this paper
• Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project.

  1992cited by this paper
• Influence of sex and age on fluorouracil clearance.

  1992cited by this paper
• Effects of diastereoisomers of 5-formyltetrahydrofolate on cellular growth, sensitivity to 5-fluoro-2'-deoxyuridine, and methylenetetrahydrofolate polyglutamate levels in HCT-8 cells.

  1991influential reference
• Schedule-dependent enhancement of the cytotoxicity of fluoropyrimidines to human carcinoma cells in the presence of folinic acid.

  1991influential reference
• Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin.

  1991cited by this paper
• Clinical relevance of biochemical modulation of 5-fluorouracil.

  1991cited by this paper
• Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer.

  1991influential reference
• Clinical relevance of biochemical modulation of 5-fluorouracil

  1991cited by this paper
• Pharmacokinetics of leucovorin metabolites in human plasma as a function of dose administered orally and intravenously.

  1991cited by this paper
• Single amino acid substitution defines a naturally occurring genetic variant of human thymidylate synthase.

  1990cited by this paper
• Continuous infusion high-dose leucovorin with 5-fluorouracil and cisplatin for untreated stage IV carcinoma of the head and neck.

  1990cited by this paper
• Relationship between dose rate of [6RS]Leucovorin administration, plasma concentrations of reduced folates, and pools of 5,10-methylenetetrahydrofolates and tetrahydrofolates in human colon adenocarcinoma xenografts.

  1990cited by this paper
• Biological Modification of protracted infusion of 5-fluorouracil with weekly leucovorin

  1990cited by this paper
• Prospective randomized comparison of fluorouracil versus fluorouracil and high-dose continuous infusion leucovorin calcium for the treatment of advanced measurable colorectal cancer in patients previously unexposed to chemotherapy.

  1990cited by this paper
• The Modulation of Fluorouracil With Leucovorin in Metastatic Colorectal Carcinoma A Prospective Randomized Phase III Trial

  1990influential reference
• Site-directed mutagenesis of mouse thymidylate synthase: alteration of Arg44 to Val44 in a conserved loop guarding the active site has striking effects on catalysis and nucleotide binding.

  1990cited by this paper
• Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer.

  1989cited by this paper
• Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma.

  1989influential reference
• A prospective randomized comparison of continuous infusion fluorouracil with a conventional bolus schedule in metastatic colorectal carcinoma: a Mid-Atlantic Oncology Program Study.

  1989cited by this paper
• Pharmacokinetics of diastereoisomers of (6R,S)-folinic acid (leucovorin) in humans during constant high-dose intravenous infusion.

  1989cited by this paper
• The modulation of fluorouracil with leucovorin in metastatic colorectal carcinoma: a prospective randomized phase III trial. Gastrointestinal Tumor Study Group.

  1989cited by this paper
• Lack of interference by the unnatural isomer of 5-formyltetrahydrofolate with the effects of the natural isomer in leucovorin preparations.

  1989cited by this paper
• A randomized trial of fluorouracil and folinic acid in patients with metastatic colorectal carcinoma.

  1988cited by this paper
• Characteristics of thymidylate synthase purified from a human colon adenocarcinoma.

  1988cited by this paper
• Fluorouracil: biochemistry and pharmacology.

  1988cited by this paper
• Plasma and tumor tissue pharmacology of high-dose intravenous leucovorin calcium in combination with fluorouracil in patients with advanced colorectal carcinoma.

  1988cited by this paper
• Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells.

  1988cited by this paper
• Thymidylate synthase gene amplification in a colon tumor resistant to fluoropyrimidine chemotherapy.

  1987cited by this paper
• A prospective randomized trial of 5-fluorouracil versus 5-fluorouracil and high-dose leucovorin versus 5-fluorouracil and methotrexate in previously untreated patients with advanced colorectal carcinoma.

  1987cited by this paper
• Sensitivity of human, murine, and rat cells to 5-fluorouracil and 5'-deoxy-5-fluorouridine in relation to drug-metabolizing enzymes.

  1986cited by this paper
• Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil and high-dose folinic acid.

  1986cited by this paper
• Studies on the polyglutamate specificity of thymidylate synthase from fetal pig liver.

  1984cited by this paper
• Human leukemic cells resistant to 5-fluoro-2'-deoxyuridine contain a thymidylate synthetase with lower affinity for nucleotides.

  1983cited by this paper
• Clinical trial of cisplatin and 5-FU infusion as initial treatment for advanced squamous cell carcinoma of the head and neck.

  1982cited by this paper
• Regulation of folylpoly-gamma-glutamate synthesis in mammalian cells. In vivo and in vitro synthesis of pteroylpoly-gamma-glutamates by Chinese hamster ovary cells.

  1982cited by this paper
• Thymidylate synthetase - a target enzyme in cancer chemotherapy.

  1977cited by this paper
• The identification of the forms of folate found in the liver, kidney and intestine of the monkey and their biosynthesis from exogenous pteroylglutamate (folic acid).

  1974cited by this paper
• TREATMENT OF ADVANCED CANCER WITH 5-FLUOROURACIL.

  1964cited by this paper
• FLUORINATED PYRIMIDINES. XIX. SOME BIOLOGICAL EFFECTS OF 5-TRIFLUOROMETHYLURACIL AND 5-TRIFLUOROMETHYL-2'-DEOXYURIDINE ON ESCHERICHIA COLI AND BACTERIOPHAGE T4B.

  1963cited by this paper

• British Oncology Pharmacy Association Delphi consensus guidelines: Co-infusion of trometamol-containing calcium folinate (Leucovorin) with systemic anti-cancer treatments

  2024cites this paper
• Drug-drug interactions in clinical practice: a literature review and SWOT analysis

  2024cites this paper
• A RETROSPECTIVE AND PROSPECTIVE STUDY FOR ADVERSE DRUG REACTION OF CANCER CHEMOTHERAPY IN BREAST CANCER

  2022cites this paper
• Phase II trial of S-1 plus leucovorin in patients with advanced gastric cancer and clinical prediction by S-1 pharmacogenetic pathway

  2016cites this paper
• Prognostic value of biomarkers in metastatic colorectal cancer patients.

  2015cites this paper
• Anaphylactic reaction associated with intravenous administration of folinic acid in a patient with colon cancer.

  2011cites this paper
• Tissue Levels of Reduced Folates in Patients with Colorectal Carcinoma After Infusion of Folinic Acid at Various Dose Levels

  2008cites this paper
• Meta analysis of advanced cancer survival data using lognormal parametric fitting: a statistical method to identify effective treatment protocols.

  2007cites this paper
• Mechanisms of Resistance to Anticancer Agents

  2005cites this paper
• The Oral Fluorinated Pyrimidines

  2004cites this paper
• Combination of 5-fluorouracil and irinotecan on modulation of thymidylate synthase and topoisomerase I expression and cell cycle regulation in human colon cancer LoVo cells: clinical relevance.

  2002cites this paper
• Impact of the oxaliplatin-5 fluorouracil-folinic acid combination on respective intracellular determinants of drug activity

  2002cites this paper
• Anaphylactic shock secondary to intravenous administration of folinic acid: a first report.

  2002cites this paper
• Phase II Study of Combined 5‐Fluorouracil/ Ginkgo biloba Extract (GBE 761 ONC) Therapy in 5‐Fluorouracil Pretreated Patients with Advanced Colorectal Cancer

  2001cites this paper
• Response to 5-fluorouracil of orthotopically xenografted human colon cancers with a microsatellite instability: influence of P53 status.

  2000cites this paper
• Standard dose (Mayo regimen) 5-fluorouracil and low dose folinic acid: prohibitive toxicity?

  2000cites this paper
• Phase II Study with 5-Fluorouracil and Ginkgo biloba Extract (GBE 761 ONC) in Patients with Pancreatic Cancer

  1999cites this paper
• Thymidylate synthase level as the main predictive parameter for sensitivity to 5-fluorouracil, but not for folate-based thymidylate synthase inhibitors, in 13 nonselected colon cancer cell lines.

  1999cites this paper
• 5-Fluorouracil in colorectal cancer: rationale and clinical results of frequently used schedules.

  1998cites this paper
• Bolus injection (2-4 min) versus short-term (10-20 min) infusion of 5-fluorouracil in patients with advanced colorectal cancer: a prospective randomised trial. Nordic Gastrointestinal Tumour Adjuvant Therapy Group.

  1998cites this paper
• Cyclophosphamide, methotrexate, and chronic oral tegafur modulated by folinic acid in the treatment of patients with advanced breast carcinoma

  1998cites this paper
• Protracted treatment with tegafur and low dose oral leucovorin in patients with advanced colorectal carcinoma

  1998cites this paper
• Intermittent Continuous Infusion of Fluorouracil and Low-Dose Oral Leucovorin in Pretreated Breast Cancer: A Pilot Study

  1997cites this paper
• Adjuvant chemotherapy in colorectal cancer with high-dose leucovorin and fluorouracil: impact on disease-free survival and overall survival.

  1997cites this paper
• High- versus low-dose levo-leucovorin as a modulator of 5-fluorouracil in advanced colorectal cancer: A ‘GISCAD’ phase III study

  1997cites this paper