The Bed Nucleus of the Stria Terminalis Is Critical for Anxiety-Related Behavior Evoked by CO2 and Acidosis

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Journal of Neuroscience

• Publication date

  2014-07-30

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1523/JNEUROSCI.1680-14.2014PMID 25080586PMCID PMC4115136
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The human ortholog of acid-sensing ion channel gene ASIC1a is associated with panic disorder and amygdala structure and function.

  2014cited by this paper
• BNST neurocircuitry in humans

  2014cited by this paper
• Localization and behaviors in null mice suggest that ASIC1 and ASIC2 modulate responses to aversive stimuli

  2014cited by this paper
• ASIC1a Activation Enhances Inhibition in the Basolateral Amygdala and Reduces Anxiety

  2014cited by this paper
• Carbon dioxide-sensing in organisms and its implications for human disease

  2013cited by this paper
• Dissecting the anticipation of aversion reveals dissociable neural networks.

  2013cited by this paper
• Glutamatergic Signaling from the Parabrachial Nucleus Plays a Critical Role in Hypercapnic Arousal

  2013cited by this paper
• Acid-sensing ion channels in pain and disease

  2013cited by this paper
• Diverging neural pathways assemble a behavioural state from separable features in anxiety

  2013cited by this paper
• Neuronal correlates of fear conditioning in the bed nucleus of the stria terminalis

  2013cited by this paper
• Interactions between transient and sustained neural signals support the generation and regulation of anxious emotion.

  2013cited by this paper
• Fear and panic in humans with bilateral amygdala damage

  2013cited by this paper
• Electrolytic lesions of the bed nucleus of the stria terminalis disrupt freezing and startle potentiation in a conditioned context.

  2011cited by this paper
• A genome-wide study of panic disorder suggests the amiloride-sensitive cation channel 1 as a candidate gene

  2011cited by this paper
• Threat of suffocation and defensive reflex activation.

  2011cited by this paper
• Phasic and sustained fear in humans elicits distinct patterns of brain activity

  2011cited by this paper
• Human bed nucleus of the stria terminalis indexes hypervigilant threat monitoring.

  2010cited by this paper
• Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety

  2010cited by this paper
• ASIC2 Subunits Target Acid-Sensing Ion Channels to the Synapse via an Association with PSD-95

  2009cited by this paper
• Acid-Sensing Ion Channel-1a in the Amygdala, a Novel Therapeutic Target in Depression-Related Behavior

  2009cited by this paper
• The Taste of Carbonation

  2009cited by this paper
• The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior.

  2009cited by this paper
• Role of the extended amygdala in short-duration versus sustained fear: a tribute to Dr. Lennart Heimer

  2008cited by this paper
• Defects in Breathing and Thermoregulation in Mice with Near-Complete Absence of Central Serotonin Neurons

  2008cited by this paper
• Restoring Acid-Sensing Ion Channel-1a in the Amygdala of Knock-Out Mice Rescues Fear Memory But Not Unconditioned Fear Responses

  2008cited by this paper
• Detection of Near-Atmospheric Concentrations of CO2 by an Olfactory Subsystem in the Mouse

  2007cited by this paper
• Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit.

  2007cited by this paper
• Acid-sensing ion channel 1a is a postsynaptic proton receptor that affects the density of dendritic spines

  2006cited by this paper
• Contributions of the amygdala to emotion processing: from animal models to human behavior.

  2005cited by this paper
• PSD-95 and Lin-7b Interact with Acid-sensing Ion Channel-3 and Have Opposite Effects on H+-gated Current*

  2004cited by this paper
• Interamygdaloid connection of basolateral nucleus through the anterior commissure in the rat.

  2004cited by this paper
• Lesions in the bed nucleus of the stria terminalis disrupt corticosterone and freezing responses elicited by a contextual but not by a specific cue-conditioned fear stimulus.

  2004influential reference
• The mouse brain in stereotaxic coordinates

  2003cited by this paper
• Temporary Inactivation of the Bed Nucleus of the Stria Terminalis But Not of the Amygdala Blocks Freezing Induced by Trimethylthiazoline, a Component of Fox Feces

  2003influential reference
• Acid-Sensing Ion Channel 1 Is Localized in Brain Regions with High Synaptic Density and Contributes to Fear Conditioning

  2003cited by this paper
• Carbon dioxide in the study of panic disorder: issues of definition, methodology, and outcome.

  2003cited by this paper
• 64 NEURAL CIRCUITRY OF ANXIETY AND STRESS DISORDERS

  2002cited by this paper
• BOLD fMRI identifies limbic, paralimbic, and cerebellar activation during air hunger.

  2002cited by this paper
• The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory.

  2002cited by this paper
• The Mouse Brain in Stereotaxic Coordinates

  2001cited by this paper
• Neuroimaging of cerebral activations and deactivations associated with hypercapnia and hunger for air.

  2001cited by this paper
• Brain responses associated with consciousness of breathlessness (air hunger).

  2001cited by this paper
• Neuroanatomical hypothesis of panic disorder, revised.

  2000cited by this paper
• A proton-gated cation channel involved in acid-sensing

  1997cited by this paper
• Role of the Hippocampus, the Bed Nucleus of the Stria Terminalis, and the Amygdala in the Excitatory Effect of Corticotropin-Releasing Hormone on the Acoustic Startle Reflex

  1997influential reference
• Relief of the 'air hunger' of breathholding. A role for pulmonary stretch receptors.

  1996cited by this paper
• False suffocation alarms, spontaneous panics, and related conditions. An integrative hypothesis.

  1993cited by this paper
• Different projections of the central amygdaloid nucleus mediate autonomic and behavioral correlates of conditioned fear

  1988influential reference
• Effects of vasodilatation and acidosis on the blood-brain barrier.

  1988influential reference
• Stability of cerebrospinal fluid pH in chronic acid-base disturbances in blood.

  1965influential reference

• Lacking ASIC1a in ASIC4-positive amygdala/bed nucleus of the stria terminalis (BNST) neurons reduces anxiety and innate fear in mice

  2025cites this paper
• Blockade of acid-sensing ion channels 1a in the mice dorsal raphe nucleus inhibits panic-like responses: Role of 5-HT1A receptors in the dorsal periaqueductal gray.

  2025cites this paper
• Altered Interictal Bed Nucleus of Stria Terminalis Connectivity in Patients With Temporal Lobe Epilepsy.

  2025cites this paper
• Acid-sensing ion channels: structure, function, pharmacology and clinical significance.

  2025cites this paper
• ASIC1a channels in the locus coeruleus mediate hypercapnic acidosis detection and CO2-induced panic behavior.

  2025cites this paper
• A molecularly defined brain circuit module for regulating panic-like defensive state

  2025cites this paper
• Nutcracker mechanism in the thalamo-caudate groove: implications of stria terminalis and superior thalamostriate vein compression in the neurocognitive impairment of normal pressure hydrocephalus

  2025cites this paper
• Placebo Effects Are Small on Average in the 7.5% CO2 Inhalational Model of Generalized Anxiety

  2024cites this paper
• Deleterious effects of social isolation on neuroendocrine-immune status, and cancer progression in rats.

  2024cites this paper
• Can cognitive behavioral therapy improve vasomotor symptoms and recurrent depression in postmenopausal women?

  2024cites this paper
• Locus coeruleus noradrenaline depletion and its differential impact on CO2-induced panic and hyperventilation in male and female mice.

  2024cites this paper
• A pontomesencephalic PACAPergic pathway underlying panic-like behavioral and somatic symptoms in mice

  2024cites this paper
• The integrated brain network that controls respiration

  2023cites this paper
• Upregulation of carbonic anhydrase 1 beneficial for depressive disorder

  2023cites this paper
• We need to talk: The urgent conversation on chronic pain, mental health, prescribing patterns and the opioid crisis

  2023influential citation
• Subfornical organ interleukin 1 receptor: a novel regulator of spontaneous and conditioned fear associated behaviors in mice.

  2022cites this paper
• Chronic Ethanol Exposure Modulates Periaqueductal Gray to Extended Amygdala Dopamine Circuit

  2022cites this paper
• Neuroimmune mechanisms in fear and panic pathophysiology

  2022cites this paper
• Dyspnea.

  2022cites this paper
• Knockdown of Acid-sensing Ion Channel 1a in the PVN Promotes Metabolic Disturbances in Male Mice.

  2022cites this paper
• The subfornical organ regulates acidosis‐evoked fear by engaging microglial acid‐sensor TDAG8 and forebrain neurocircuits in male mice

  2022cites this paper
• Not Only COVID-19: Involvement of Multiple Chemosensory Systems in Human Diseases

  2022cites this paper
• Amygdala-driven apnea and the chemoreceptive origin of anxiety.

  2022cites this paper
• Presentation and management of anxiety in individuals with acute symptomatic or asymptomatic COVID-19 infection, and in the post-COVID-19 recovery phase

  2021cites this paper
• Disruption of Synaptic Transmission in the Bed Nucleus of the Stria Terminalis Reduces Seizure-Induced Death in DBA/1 Mice and Alters Brainstem E/I Balance

  2021cites this paper
• Psychophysiology

  2021cites this paper
• Post-acquisition CO2 Inhalation Enhances Fear Memory and Depends on ASIC1A

  2021influential citation
• Topography and motion of acid-sensing ion channel intracellular domains

  2021cites this paper
• Chemoreceptor mechanisms regulating CO2‐induced arousal from sleep

  2021cites this paper
• High Behavioral Sensitivity to Carbon Dioxide Associates with Enhanced Fear Memory and Altered Forebrain Neuronal Activation.

  2020cites this paper
• The amygdala differentially regulates defensive behaviors evoked by CO2.

  2020influential citation
• Mechanisms and consequences of oxygen- and carbon dioxide-sensing in mammals.

  2020cites this paper
• Anesthesia, Analgesia, and Euthanasia

  2020cites this paper
• Understanding rat emotional responses to CO2

  2020cites this paper
• Hypoxie a hyperkapnie - jak fungujĂ­ chemoreceptory?

  2020cites this paper
• Effect of serotonin transporter genotype on carbon dioxide-induced fear-related behavior in mice

  2020cites this paper
• Off-Target Effects of Clozapine-N-Oxide on the Chemosensory Reflex Are Masked by High Stress Levels

  2019cites this paper
• Fluoxetine Modulates Spontaneous and Conditioned Behaviors to Carbon Dioxide (CO2) Inhalation and Alters Forebrain-Midbrain Neuronal Activation.

  2019cites this paper
• Acid-Sensing Ion Channels: Novel Mediators of Cerebral Vascular Responses.

  2019cites this paper
• Interoception, conditioning, and fear: The panic threesome.

  2019cites this paper
• Recruitment of central angiotensin II type 1 receptor associated neurocircuits in carbon dioxide associated fear

  2019influential citation
• Panic‐like escape response elicited in mice by exposure to CO2, but not hypoxia

  2018cites this paper
• Characterizing the Behavioral and Neural Mechanisms Underpinning Stress-Enhanced Fear Learning, a Rodent Model of Post-Traumatic Stress Disorder

  2018cites this paper
• A novel role for acid‐sensing ion channels in Pavlovian reward conditioning

  2018cites this paper
• Effects of acute restraint and unpredictable chronic mild stress on brain corticotrophin releasing factor mRNA in the elevated T‐maze

  2018cites this paper
• Differential behavioral sensitivity to carbon dioxide (CO2) inhalation in rats.

  2017cites this paper
• Distinct responses to predictable and unpredictable threat in anxiety pathologies: effect of panic attack.

  2017cites this paper
• ASIC1A in neurons is critical for fear‐related behaviors

  2017influential citation
• Dual-hormone stress reactivity predicts downstream war-zone stress-evoked PTSD.

  2017cites this paper
• Mechanics and Chemistry of Respiration in Health

  2017cites this paper
• Histone Modifications in a Mouse Model of Early Adversities and Panic Disorder: Role for Asic1 and Neurodevelopmental Genes

  2016cites this paper
• Effects of Voluntary Locomotion and Calcitonin Gene-Related Peptide on the Dynamics of Single Dural Vessels in Awake Mice

  2016cites this paper
• The Genetics of Stress-Related Disorders: PTSD, Depression, and Anxiety Disorders

  2016cites this paper
• Transient loss of consciousness during hypercapnia and hypoxia: Involvement of pathways associated with general anesthesia.

  2016cites this paper
• The RS685012 Polymorphism of ACCN2, the Human Ortholog of Murine Acid-Sensing Ion Channel (ASIC1) Gene, is Highly Represented in Patients with Panic Disorder

  2016influential citation
• Panic Anxiety in Humans with Bilateral Amygdala Lesions: Pharmacological Induction via Cardiorespiratory Interoceptive Pathways

  2016cites this paper
• Acid-sensing ion channel 1a contributes to hippocampal LTP inducibility through multiple mechanisms

  2016cites this paper
• Two aspects of ASIC function: Synaptic plasticity and neuronal injury.

  2015cites this paper
• Neural Control of Breathing and CO2 Homeostasis.

  2015influential citation
• Mechanical restriction of intracortical vessel dilation by brain tissue sculpts the hemodynamic response

  2015cites this paper
• ASIC1A in the bed nucleus of the stria terminalis mediates TMT-evoked freezing

  2015influential citation
• Implication du striatum et du pallidum ventral dans le traitement de l'information aversive : approche électrophysiologique et pharmacologique chez le primate non-humain

  2015cites this paper
• Environmental CO2 inhibits Caenorhabditis elegans egg-laying by modulating olfactory neurons and evokes widespread changes in neural activity

  2015cites this paper
• Neuroprotective strategies for traumatic brain injury

  2015cites this paper
• Neural circuits in anxiety and stress disorders: a focused review

  2015cites this paper
• Neural circuits in anxiety and stress disorders: a focused review

  2015cites this paper
• Acid-sensing ion channels: a novel therapeutic target for pain and anxiety.

  2014influential citation