Monomethylarsonous acid destroys a tetrathiolate zinc finger much more efficiently than inorganic arsenite: mechanistic considerations and consequences for DNA repair inhibition.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Chemical Research in Toxicology

• Publication date

  2008-01-26

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1021/tx7003135PMID 18220366
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Reaction of the XPA zinc finger with S-nitrosoglutathione.

  2008cited by this paper
• Quantitative electrospray ionization mass spectrometry of zinc finger oxidation: the reaction of XPA zinc finger with H(2)O(2).

  2007cited by this paper
• Role of protons in the thermodynamic contribution of a Zn(II)-Cys4 site toward metalloprotein stability.

  2007cited by this paper
• Preferential binding of human XPA to the mitomycin C-DNA interstrand crosslink and modulation by arsenic and cadmium.

  2007cited by this paper
• Arsenic binding to human metallothionein.

  2006cited by this paper
• Arsenite binding to synthetic peptides: The effect of increasing length between two cysteines

  2006cited by this paper
• Arsenic Exposure Is Associated with Decreased DNA Repair in Vitro and in Individuals Exposed to Drinking Water Arsenic

  2006cited by this paper
• Dissociation of arsenite‐peptide complexes: Triphasic nature, rate constants, half‐lives, and biological importance

  2006cited by this paper
• On the Competition for Available Zinc*

  2005cited by this paper
• Stability of arsenic metabolites, arsenic triglutathione [As(GS)3] and methylarsenic diglutathione [CH3As(GS)2], in rat bile.

  2005cited by this paper
• Role of glutathione in reduction of arsenate and of gamma-glutamyltranspeptidase in disposition of arsenite in rats.

  2005cited by this paper
• Arsenite binding to synthetic peptides based on the Zn finger region and the estrogen binding region of the human estrogen receptor-alpha.

  2005cited by this paper
• Combined ion-mobility and mass-spectrometry investigations of metallothionein complexes using a tandem mass spectrometer with a segmented second quadrupole

  2005cited by this paper
• A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species.

  2004cited by this paper
• Interaction of selenium compounds with zinc finger proteins involved in DNA repair.

  2004cited by this paper
• Current aspects in metal genotoxicity

  2004cited by this paper
• Co(II) and Cd(II) substitute for Zn(II) in the zinc finger derived from the DNA repair protein XPA, demonstrating a variety of potential mechanisms of toxicity.

  2004cited by this paper
• Low dose exposure to sodium arsenite synergistically interacts with UV radiation to induce mutations and alter DNA repair in human cells.

  2004cited by this paper
• Equilibrium characterization of the As(III)-cysteine and the As(III)-glutathione systems in aqueous solution.

  2004cited by this paper
• Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review.

  2004cited by this paper
• Arsenite and its biomethylated metabolites interfere with the formation and repair of stable BPDE-induced DNA adducts in human cells and impair XPAzf and Fpg.

  2003cited by this paper
• FAST TRACK DECREASED DNA REPAIR GENE EXPRESSION AMONG INDIVIDUALS EXPOSED TO ARSENIC IN UNITED STATES DRINKING WATER

  2003cited by this paper
• Mechanism of nickel assault on the zinc finger of DNA repair protein XPA.

  2003cited by this paper
• Interaction of trivalent arsenicals with metallothionein.

  2003cited by this paper
• Case studies--arsenic.

  2003cited by this paper
• Methylated trivalent arsenicals as candidate ultimate genotoxic forms of arsenic: Induction of chromosomal mutations but not gene mutations

  2003cited by this paper
• The metabolism of inorganic arsenic oxides, gallium arsenide, and arsine: a toxicochemical review.

  2003cited by this paper
• Interactions of arsenic with human metallothionein-2.

  2002cited by this paper
• Arsenic inhibits the repair of DNA damage induced by benzo(a)pyrene.

  2002cited by this paper
• Pharmacokinetics, metabolism, and carcinogenicity of arsenic.

  2001cited by this paper
• Nitric oxide is involved in arsenite inhibition of pyrimidine dimer excision.

  2001cited by this paper
• Arsenite is a cocarcinogen with solar ultraviolet radiation for mouse skin: an animal model for arsenic carcinogenesis.

  2001cited by this paper
• Monomethylarsonous acid (MMA(III)) and arsenite: LD(50) in hamsters and in vitro inhibition of pyruvate dehydrogenase.

  2001cited by this paper
• Differential effects of toxic metal compounds on the activities of Fpg and XPA, two zinc finger proteins involved in DNA repair.

  2000cited by this paper
• Interference by toxic metal compounds with isolated zinc finger DNA repair proteins.

  2000cited by this paper
• Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells

  2000cited by this paper
• Monomethylarsonous acid (MMA(III)) is more toxic than arsenite in Chang human hepatocytes.

  2000cited by this paper
• Extended X-ray absorption fine structure evidence for a single metal binding domain in Xenopus laevis nucleotide excision repair protein XPA.

  1999cited by this paper
• Structural features of the minimal DNA binding domain (M98-F219) of human nucleotide excision repair protein XPA.

  1998cited by this paper
• Interaction of arsenic(III) with nucleotide excision repair in UV-irradiated human fibroblasts.

  1997cited by this paper
• The DNA damage-recognition problem in human and other eukaryotic cells: the XPA damage binding protein.

  1997cited by this paper
• Effect of arsenic and cadmium on the persistence of mutagen‐induced DNA lesions in human cells

  1996cited by this paper
• Interactions of rat red blood cell sulfhydryls with arsenate and arsenite.

  1995cited by this paper
• Delay of the excision of UV light-induced DNA adducts is involved in the coclastogenicity of UV light plus arsenite.

  1994cited by this paper
• Reduction and binding of arsenate and dimethylarsinate by glutathione: a magnetic resonance study.

  1994cited by this paper
• Transfer of arsenite from glutathione to dithiols: a model of interaction.

  1993cited by this paper
• Reactions of arsenic(III) and arsenic(V) species with glutathione.

  1993cited by this paper
• Effect of arsenite on the DNA repair of UV-irradiated Chinese hamster ovary cells.

  1992cited by this paper
• Analysis of a human DNA excision repair gene involved in group A xeroderma pigmentosum and containing a zinc-finger domain

  1990cited by this paper
• Cellular uptake and metabolic reduction of pentavalent to trivalent arsenic as determinants of cytotoxicity and morphological transformation.

  1987cited by this paper
• Inhibition of human excision DNA repair by inorganic arsenic and the co-mutagenic effect in V79 Chinese hamster cells.

  1986cited by this paper
• The reaction of methylarsenicals with thiols: Some biological implications

  1984cited by this paper
• Enhancement of UV-mutagenesis by low concentrations of arsenite in E. coli.

  1981cited by this paper

• Arsenite Impairs BRCA1-Dependent DNA Double-Strand Break Repair, a Mechanism Potentially Contributing to Genomic Instability

  2023cites this paper
• Effect of Long-Term Low-Dose Arsenic Exposure on DNA Methylation and Gene Expression in Human Liver Cells

  2023cites this paper
• Mechanisms of genotoxicity and proteotoxicity induced by the metalloids arsenic and antimony

  2023cites this paper
• Elucidating arsenic-bound proteins in the protein data bank: data mining and amino acid cross-validation through Raman spectroscopy

  2023cites this paper
• Heavy metals as risk factors for human diseases - a Bayesian network approach.

  2022cites this paper
• The Duality of Arsenic Metabolism: Impact on Human Health.

  2022cites this paper
• Electrospray-Induced Mass Spectrometry Is Not Suitable for Determination of Peptidic Cu(II) Complexes

  2021cites this paper
• Mode of action-based risk assessment of genotoxic carcinogens

  2020cites this paper
• The Reactions of H2O2 and GSNO with the Zinc Finger Motif of XPA. Not A Regulatory Mechanism, But No Synergy with Cadmium Toxicity

  2020cites this paper
• The role of H3K9me2‐regulated base excision repair genes in the repair of DNA damage induced by arsenic in HaCaT cells and the effects of Ginkgo biloba extract intervention

  2020cites this paper
• Biotransformation of arsenic and toxicological implication of arsenic metabolites

  2020cites this paper
• miR-145 via targeting ERCC2 is involved in arsenite-induced DNA damage in human hepatic cells.

  2018cites this paper
• Prevalence of exposure of heavy metals and their impact on health consequences

  2018cites this paper
• Methylarsenic compounds [MAK Value Documentation, 2014]

  2018cites this paper
• Metal binding properties, stability and reactivity of zinc fingers

  2018cites this paper
• Arsenic trioxide preferentially binds to the ring finger protein PML: understanding target selection of the drug.

  2018cites this paper
• The Flop Side of Using Heavy Metal(oids)s in the Traditional Medicine: Toxic Insults and Injury to Human Health

  2018cites this paper
• Kinetics and thermodynamics of zinc(II) and arsenic(III) binding to XPA and PARP-1 zinc finger peptides.

  2016cites this paper
• Modifications of H3K9me2, H3K36me3 and H4K20me2 may be involved in arsenic-induced genetic damage.

  2016cites this paper
• Inhibition of poly(ADP-ribose)polymerase-1 and DNA repair by uranium.

  2016cites this paper
• MECHANISMS OF LOW DOSE ARSENIC LYMPHOID STEM CELL IMMUNOTOXICITY AND POTENTIAL INTERACTIONS WITH DIBENZO[def, p]CHRYSENE (DBC)

  2015cites this paper
• Medical Countermeasures—Chelation Therapy

  2015cites this paper
• Arsenic Interaction with Zinc Finger Motifs

  2015cites this paper
• Molecular Mechanisms in Arsenic Toxicity

  2015cites this paper
• Reduced cellular DNA repair capacity after environmentally relevant arsenic exposure. Influence of Ogg1 deficiency.

  2015cites this paper
• Sulforaphane inhibits damage-induced poly (ADP-ribosyl)ation via direct interaction of its cellular metabolites with PARP-1.

  2015cites this paper
• Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation

  2015influential citation
• Heavy metals in wild house mice from coal-mining areas of Colombia and expression of genes related to oxidative stress, DNA damage and exposure to metals.

  2014cites this paper
• Risk of laryngeal and nasopharyngeal cancer associated with arsenic and cadmium in the Tunisian population.

  2014cites this paper
• Differential Binding of Monomethylarsonous Acid Compared to Arsenite and Arsenic Trioxide with Zinc Finger Peptides and Proteins

  2014cites this paper
• Risk of laryngeal and nasopharyngeal cancer associated with arsenic and cadmium in the Tunisian population

  2014cites this paper
• Arsenic exposure disrupts the normal function of the FA/BRCA repair pathway.

  2014cites this paper
• Nutzen-Risiko-Bewertung von Mineralstoffen und Spurenelementen

  2014cites this paper
• Melanocytes and keratinocytes have distinct and shared responses to ultraviolet radiation and arsenic.

  2014cites this paper
• The reaction of arsenite with proteins relies on solution conditions.

  2014cites this paper
• Monomethylated trivalent arsenic species disrupt steroid receptor interactions with their DNA response elements at non‐cytotoxic cellular concentrations

  2014cites this paper
• Metal interaction with redox regulation: an integrating concept in metal carcinogenesis?

  2013cites this paper
• Fish micronucleus assay to assess genotoxic potential of arsenic at its guideline exposure in aquatic environment

  2013cites this paper
• Nutzen-Risiko-Bewertung von Mineralstoffen und Spurenelementen : Biochemische, physiologische und toxikologische Aspekte

  2013cites this paper
• Die Bedeutung des Transkriptionsfaktors MTF-1 für die Aufnahme, Zytotoxizität und Genotoxizität von anorganischem Arsenit

  2013cites this paper
• Mouse micronucleus assay as a surrogate to assess genotoxic potential of arsenic at its human reference dose.

  2013cites this paper
• 3.28 – Metal Carcinogens

  2013cites this paper
• On the design of zinc-finger models with cyclic peptides bearing a linear tail.

  2013cites this paper
• Arsenic. Can this toxic metalloid sustain life?

  2013cites this paper
• Double-edged effects of arsenic compounds: anticancer and carcinogenic effects.

  2013cites this paper
• Inhibition of nucleotide excision repair by arsenic

  2013cites this paper
• Arsenic Binding to Proteins

  2013cites this paper
• Reduction of arsenite-enhanced ultraviolet radiation-induced DNA damage by supplemental zinc.

  2013cites this paper
• Epigenetic Histone Changes in the Toxicologic Mode of Action of Arsenic

  2012cites this paper
• Genotoxic potential of arsenic at its reference dose.

  2012cites this paper
• Possible Positive Selection for an Arsenic-Protective Haplotype in Humans

  2012influential citation
• Darinaparsin: Solid Tumor Hypoxic Cytotoxin and Radiosensitizer

  2012cites this paper
• Cancer Therapy : Preclinical Darinaparsin : Solid Tumor Hypoxic Cytotoxin and Radiosensitizer

  2012cites this paper
• Environmental arsenic exposure and DNA methylation of the tumor suppressor gene p16 and the DNA repair gene MLH1: effect of arsenic metabolism and genotype.

  2012cites this paper
• Synthesis of a fluorescently labeled compound for the detection of arsenic-induced apoptotic HL60 cells.

  2012cites this paper
• Arsenite Interacts Selectively with Zinc Finger Proteins Containing C3H1 or C4 Motifs*

  2011cites this paper
• Zinc finger proteins as templates for metal ion exchange and ligand reactivity. Chemical and biological consequences.

  2011cites this paper
• Arsenic-induced oxidative stress and its reversibility.

  2011cites this paper
• Arsenic exposure and toxicology: a historical perspective.

  2011cites this paper
• Electrospray Mass Spectrometry of Arsenic Compounds and Thiol–Arsenic Complexes

  2011cites this paper
• The Role of Oxidative Stress in Carcinogenesis Induced by Metals and Xenobiotics

  2010cites this paper
• Antimony impairs nucleotide excision repair: XPA and XPE as potential molecular targets.

  2010cites this paper
• Biophysical analysis of the interaction of toxic metal ions and oxidants with the zinc finger domain of XPA.

  2010cites this paper
• Genotoxicity of metal ions: chemical insights.

  2010cites this paper
• ARSENIC INHIBITS THE SEALING OF UV-INDUCED CHROMOSOMAL DNA NICKS DURING NUCLEOTIDE EXCISION REPAIR BY INHIBITING DNA LIGASE III (cid:2)

  2010cites this paper
• Identification of arsenite-and arsenic diglutathione-binding proteins in human hepatocarcinoma cells.

  2010cites this paper
• Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines.

  2010cites this paper
• Cytogenetic insights into DNA damage and repair of lesions induced by a monomethylated trivalent arsenical.

  2010cites this paper
• Organoarsenicals. Uptake, metabolism, and toxicity.

  2010cites this paper
• Arsenite and its mono- and dimethylated trivalent metabolites enhance the formation of benzo[a]pyrene diol epoxide-DNA adducts in Xeroderma pigmentosum complementation group A cells.

  2009cites this paper
• Darinaparsin: a novel organic arsenical with promising anticancer activity

  2009cites this paper
• Zinc finger proteins as templates for metal ion exchange: Substitution effects on the C-finger of HIV nucleocapsid NCp7 using M(chelate) species (M=Pt, Pd, Au).

  2009cites this paper
• Trivalent methylated arsenical-induced phosphatidylserine exposure and apoptosis in platelets may lead to increased thrombus formation.

  2009cites this paper
• Inhibition of Poly(ADP-ribose) Polymerase-1 by Arsenite Interferes with Repair of Oxidative DNA Damage*

  2009cites this paper
• Darinaparsin:anovelorganic arsenicalwithpromising anticanceractivity

  2009cites this paper
• Physiological levels of glutathione enhance Zn(II) binding by a Cys4 zinc finger.

  2009cites this paper
• Effects of arsenic on maternal and fetal health.

  2009cites this paper
• Biomarkers of oxidative stress and damage in human populations exposed to arsenic.

  2009cites this paper
• Impact of arsenic on nucleotide excision repair: XPC function, protein level, and gene expression.

  2009cites this paper
• Coordination dynamics of zinc in proteins.

  2009cites this paper
• Comparative functional genomic analysis identifies distinct and overlapping sets of genes required for resistance to monomethylarsonous acid (MMAIII) and arsenite (AsIII) in yeast.

  2009cites this paper
• Monomethylarsenite competes with Zn2+ for binding sites in the glucocorticoid receptor.

  2008cites this paper
• Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms

  2008cites this paper
• PROKARYOTIC ARSENIC RESISTANCE-STUDIES IN BACILLUS SUBTILIS EMIL AALTONEN

  2008cites this paper
• Prokaryotic Arsenic Resistance - Studies in Bacillus subtilis

  2008cites this paper