Inhibition of Contraction and Myosin Light Chain Phosphorylation in Guinea‐Pig Smooth Muscle by p21‐Activated Kinase 1

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Physiology

• Publication date

  2003-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1113/jphysiol.2002.033167PMID 12692179PMCID PMC2342940
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Agonist-induced changes in the phosphorylation of the myosin- binding subunit of myosin light chain phosphatase and CPI17, two regulatory factors of myosin light chain phosphatase, in smooth muscle.

  2003cited by this paper
• Phosphorylation of the myosin phosphatase targeting subunit and CPI‐17 during Ca2+ Sensitization in Rabbit Smooth Muscle

  2003cited by this paper
• Phosphorylation of CPI17 and myosin binding subunit of type 1 protein phosphatase by p21-activated kinase.

  2002influential reference
• PAK5, a New Brain-Specific Kinase, Promotes Neurite Outgrowth in N1E-115 Cells

  2002cited by this paper
• AR and ER interaction with a p21-activated kinase (PAK6).

  2002cited by this paper
• Thiophosphorylation‐induced Ca2+ sensitization of guinea‐pig ileum contractility is not mediated by Rho‐associated kinase

  2001cited by this paper
• p21-activated kinase 1 participates in tracheal smooth muscle cell migration by signaling to p38 Mapk.

  2001cited by this paper
• Angiotensin II-induced Stimulation of p 21-activated Kinase and c-Jun NH 2-terminal Kinase Is Mediated by Rac 1 and Nck *

  2001cited by this paper
• Angiotensin II-induced Stimulation of p21-activated Kinase and c-Jun NH2-terminal Kinase Is Mediated by Rac1 and Nck*

  2001cited by this paper
• Regulation by GDI of RhoA/Rho-kinase-induced Ca2+ sensitization of smooth muscle myosin II.

  2001influential reference
• The Mechanism of PAK Activation

  2001cited by this paper
• Expression of CPI‐17 and myosin phosphatase correlates with Ca2+ sensitivity of protein kinase C‐induced contraction in rabbit smooth muscle

  2001cited by this paper
• Phosphorylation of Caldesmon by p21-activated Kinase

  2000cited by this paper
• Endothelial cell retraction is induced by PAK2 monophosphorylation of myosin II.

  2000cited by this paper
• Phosphorylation of Myosin Light Chain Kinase by p21-activated Kinase PAK2*

  2000influential reference
• Signal transduction by G‐proteins, Rho‐kinase and protein phosphatase to smooth muscle and non‐muscle myosin II

  2000cited by this paper
• Regulation of cross-bridge cycling by Ca2+ in smooth muscle.

  1999cited by this paper
• p21-Activated Kinase 1 (Pak1) Regulates Cell Motility in Mammalian Fibroblasts

  1999cited by this paper
• Inhibition of myosin light chain kinase by p21-activated kinase.

  1999influential reference
• Inhibitory Phosphorylation Site for Rho-associated Kinase on Smooth Muscle Myosin Phosphatase*

  1999cited by this paper
• Identification of Kinase-Phosphatase Signaling Modules Composed of p70 S6 Kinase-Protein Phosphatase 2A (PP2A) and p21-activated Kinase-PP2A*

  1999cited by this paper
• Different Molecular Mechanisms for Rho Family GTPase-dependent, Ca2+-independent Contraction of Smooth Muscle*

  1998influential reference
• Clostridium difficile toxin B inhibits carbachol‐induced force and myosin light chain phosphorylation in guinea‐pig smooth muscle: role of Rho proteins

  1998cited by this paper
• Membrane targeting of p21‐activated kinase 1 (PAK1) induces neurite outgrowth from PC12 cells

  1998influential reference
• PAK4, a novel effector for Cdc42Hs, is implicated in the reorganization of the actin cytoskeleton and in the formation of filopodia

  1998cited by this paper
• Phosphorylation of non-muscle myosin II regulatory light chain by p21-activated kinase (gamma-PAK).

  1998influential reference
• Angiotensin II stimulates p21-activated kinase in vascular smooth muscle cells: role in activation of JNK.

  1998influential reference
• Myosin light chain kinases

  1997cited by this paper
• Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells.

  1997cited by this paper
• Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes

  1997cited by this paper
• Cyclic GMP Causes Ca2+ Desensitization in Vascular Smooth Muscle by Activating the Myosin Light Chain Phosphatase*

  1997influential reference
• Exogenous caldesmon promotes relaxation of guinea-pig skinned taenia coli smooth muscles: inhibition of cooperative reattachment of latch bridges?

  1997cited by this paper
• The effects of caldesmon extraction on mechanical properties of skinned smooth muscle fibre preparations

  1996cited by this paper
• A Drosophila homolog of the Rac- and Cdc42-activated serine/threonine kinase PAK is a potential focal adhesion and focal complex protein that colocalizes with dynamic actin structures

  1996cited by this paper
• Cloning and Characterization of a Dictyostelium Myosin I Heavy Chain Kinase Activated by Cdc42 and Rac*

  1996cited by this paper
• Identification and Molecular Cloning of a p21cdc42/rac1-activated Serine/Threonine Kinase That Is Rapidly Activated by Thrombin in Platelets (*)

  1995cited by this paper
• Molecular Cloning of a New Member of the p21-Cdc42/Rac-activated Kinase (PAK) Family (*)

  1995cited by this paper
• A novel mechanism for the Ca(2+)-sensitizing effect of protein kinase C on vascular smooth muscle: inhibition of myosin light chain phosphatase

  1994cited by this paper
• A brain serine/threonine protein kinase activated by Cdc42 and Rac1

  1994cited by this paper
• Caldesmon and a 20-kDa actin-binding fragment of caldesmon inhibit tension development in skinned gizzard muscle fiber bundles.

  1993cited by this paper
• The protein kinase homologue Ste20p is required to link the yeast pheromone response G‐protein beta gamma subunits to downstream signalling components.

  1992cited by this paper
• Regulation of vascular smooth muscle tone by caldesmon.

  1992cited by this paper
• Effects of antibodies to myosin light chain kinase on contractility and myosin phosphorylation in chemically permeabilized smooth muscle.

  1991influential reference
• Differential skinning of smooth muscle: a new approach to excitation-contraction coupling.

  1991cited by this paper
• Ion-specific and general ionic effects on contraction of skinned fast- twitch skeletal muscle from the rabbit

  1991cited by this paper
• Myosin light chain and caldesmon phosphorylation in arterial muscle stimulated with endothelin-1.

  1990cited by this paper
• Protein phosphatase composition in the smooth muscle of guinea-pig ileum studied with okadaic acid and inhibitor 2.

  1989influential reference
• Caldesmon inhibits skeletal actomyosin subfragment-1 ATPase activity and the binding of myosin subfragment-1 to actin.

  1987cited by this paper
• Ca2+-induced hydrophobic site on calmodulin: application for purification of calmodulin by phenyl-Sepharose affinity chromatography.

  1982cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• highlighted topics Signal Transduction in Smooth Muscle Invited Review: Regulation of myosin phosphorylation in smooth muscle

  year unknowncited by this paper

• Regulation of Vascular Tone of Preglomerular Renal Vasculature by Caldesmon.

  2026cites this paper
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  2022cites this paper
• Changes in Skeletal Muscle PAK1 Levels Regulate Tissue Crosstalk to Impact Whole Body Glucose Homeostasis

  2022cites this paper
• Caldesmon ablation in mice causes umbilical herniation and alters contractility of fetal urinary bladder smooth muscle

  2021cites this paper
• Epac-mediated relaxation in murine basilar arteries depends on membrane permeability of cyclic nucleotide analogues and endothelial aging.

  2020influential citation
• MicroRNA Regulatory Pathways in the Control of the Actin–Myosin Cytoskeleton

  2020influential citation
• Invadopodia are chemosensing protrusions that guide cancer cell extravasation to promote brain tropism in metastasis

  2019cites this paper
• The Role of PAK Signaling in Synaptic Transmission and Plasticity and Social Memory in Mice

  2019cites this paper
• Group I Paks support muscle regeneration and counteract cancer‐associated muscle atrophy

  2018cites this paper
• Nicotine facilitates VSMC dysfunction through a miR-200b/RhoGDIA/cytoskeleton module

  2017cites this paper
• Redox regulation of the actin cytoskeleton and its role in the vascular system

  2017cites this paper
• Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability.

  2017cites this paper
• GENETIC DISSECTION OF THE Vav 2-Rac 1 SIGNALING AXIS IN VASCULAR SMOOTH MUSCLE CELLS by

  2016cites this paper
• Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives

  2016cites this paper
• p21‐Activated kinase (Pak) regulates airway smooth muscle contraction by regulating paxillin complexes that mediate actin polymerization

  2016influential citation
• P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate

  2016cites this paper
• Regulation of pulmonary endothelial barrier function by kinases.

  2016cites this paper
• Mechanisms of Vascular Smooth Muscle Contraction and the Basis for Pharmacologic Treatment of Smooth Muscle Disorders

  2016cites this paper
• Functions of Drosophila Pak (p21-activated kinase) in Morphogenesis: A Mechanistic Model based on Cellular, Molecular, and Genetic Studies

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• p21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 Pathway

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• Genetic Dissection of the Vav2-Rac1 Signaling Axis in Vascular Smooth Muscle Cells

  2014cites this paper
• p21-Activated protein kinases and their emerging roles in glucose homeostasis.

  2014cites this paper
• The small GTPase Rac1 is required for smooth muscle contraction

  2014cites this paper
• Participation of group I p21-activated kinases in neuroplasticity.

  2014cites this paper
• Smooth Muscle Specific Rac1 Deficiency Induces Hypertension by Preventing p116RIP3‐Dependent RhoA Inhibition

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  2014cites this paper
• Involvement of Rho GTPases and their regulators in the pathogenesis of hypertension

  2014cites this paper
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  2013cites this paper
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  2013cites this paper
• Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.

  2013cites this paper
• Small G proteins in the cardiovascular system: physiological and pathological aspects.

  2013cites this paper
• Activation of Rac by Asef2 promotes myosin II-dependent contractility to inhibit cell migration on type I collagen

  2013cites this paper
• Kinetics of myosin light chain kinase activation of smooth muscle myosin in an in vitro model system.

  2013cites this paper
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• Etude du rôle des intégrines liant la laminine dans le développement et la tumorigenèse mammaires

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• The characteristics of genistin-induced inhibitory effects on intestinal motility

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• Rap1 potentiates endothelial cell junctions by spatially controlling myosin II activity and actin organization

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• Decreased myosin phosphatase target subunit 1(MYPT1) phosphorylation via attenuated rho kinase and zipper‐interacting kinase activities in edematous intestinal smooth muscle

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• Regulación de la plasticidad astrocitaria por ibuprofeno y FGF2

  2011cites this paper
• Control of mammary myoepithelial cell contractile function by α3β1 integrin signalling

  2011cites this paper
• Biochemistry of smooth muscle myosin light chain kinase.

  2011cites this paper
• Kinase-related protein/telokin inhibits Ca2+-independent contraction in Triton-skinned guinea pig taenia coli.

  2010cites this paper
• A transcriptional cross–talk between RhoA and c–Myc inhibits the RhoA/Rock–dependent cytoskeleton

  2010cites this paper
• The role of Rho protein signaling in hypertension

  2010cites this paper
• Characterization of tightly associated smooth muscle myosin-myosin light-chain kinase-calmodulin complexes.

  2009cites this paper
• Regulation of smooth muscle contraction by small GTPases.

  2009cites this paper
• Rac and Cdc 42 : Functional Antagonism to Rho and the Emerging Importance of Actin Cytoskeleton Dynamics for Smooth Muscle Contraction

  2009cites this paper
• p21-Activated Kinase 1 Participates in Vascular Remodeling In Vitro and In Vivo

  2009cites this paper
• p 21-Activated Kinase 1 Participates in Vascular Remodeling In Vitro and In Vivo

  2009cites this paper
• Rac-mediated macropinocytosis is a critical route for naked plasmid DNA transfer in mice.

  2009cites this paper
• Migration of airway smooth muscle cells.

  2008cites this paper
• Smooth-Muscle Myosin II

  2008cites this paper
• Tumorhead distribution to cytoplasmic membrane of neural plate cells is positively regulated by Xenopus p21-activated kinase 1 (X-PAK1).

  2007cites this paper
• p21-Activated kinase-1 and its role in integrated regulation of cardiac contractility.

  2007cites this paper
• Regulation of Cardiac Contraction p 21-Activated kinase-1 and its role in integrated regulation of cardiac contractility

  2007cites this paper
• Mechanisms of vascular smooth muscle cell migration.

  2007cites this paper
• Regulation of the crossbridge cycle in vascular smooth muscle by cAMP signalling

  2006cites this paper
• Signaling for contraction and relaxation in smooth muscle of the gut.

  2006cites this paper
• Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathway.

  2006cites this paper
• Urocortin-Induced Decrease in Ca2+ Sensitivity of Contraction in Mouse Tail Arteries Is Attributable to cAMP-Dependent Dephosphorylation of MYPT1 and Activation of Myosin Light Chain Phosphatase

  2006cites this paper
• CHAPTER 19 – Cellular Physiology of Gastrointestinal Smooth Muscle

  2006cites this paper
• The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A.

  2005cites this paper
• Is myosin phosphorylation sufficient to regulate smooth muscle contraction?

  2005cites this paper
• Novel p21-activated kinase-dependent protrusions characteristically formed at the edge of transformed cells.

  2004cites this paper
• Application of pak inhibitor for arthropathy treatment

  2004cites this paper
• Role of p21 activated kinase in zebrafish lateral line development.

  2004influential citation
• Formin Homology Domain Protein (FHOD1) Is a Cyclic GMP-dependent Protein Kinase I-binding Protein and Substrate in Vascular Smooth Muscle Cells*

  2004cites this paper
• p21-activated Kinase Regulates Endothelial Permeability through Modulation of Contractility*

  2004cites this paper
• Lessons from old and new kinases.

  2004cites this paper
• Lessons From Old and New Kinases

  2004cites this paper
• Lessons From Old and New Kinases

  2004cites this paper
• Regulation of myosin phosphorylation and myofilament Ca2+ sensitivity in vascular smooth muscle.

  2004cites this paper
• The Small GTPase Cdc42 Regulates Actin Polymerization and Tension Development during Contractile Stimulation of Smooth Muscle*

  2004cites this paper
• Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase.

  2003cites this paper
• Jcb: Article

  year unknowncites this paper