Excitatory Amino Acid Transmission

This book represents the proceedings of a Satellite Symposium to the 30th Congress of the International Union of Physiological Sciences, held in Canada during July of 1986. It is the twenty-fourth volume of the neurology and neurobiology collection. The contents of the book are divided into seven sections, beginning with an overview of the field of excitatory amino acid transmission, and a discussion of its historical development and some of its future possibilities. The next two sections address the classification, activation, and interactions of receptors. Of particular interest are the biophysical models that are theorized from experiments testing the efficacy of various transmitter analogues. Several of the papers deal extensively with the interactions of these receptors with phencyclidine-like compounds and barbiturates. The final four sections focus on the various neurotransmitters. The first of these includes eleven papers on a variety of methods to identify and localize transmitters. Immunocytochemical techniques are particularly emphasized. The second of the final four sections addresses some of the clinical implications of excitatory amino acid transmission gone awry, as well as its role in normal function. This set of papers discusses the connection between these neurotransmitters and epilepsy, neuropsychiatric disorders, ischemic brain damage, and Alzheimer's disease. Finally, the third and fourth sections discuss subcortical and cortical synaptic transmitters and include papers demonstrating the specificity between certain neurotransmitters and particular pathways. The papers which comprise the book are concise and written in a review style. The collection includes good examples of immunocytochemical receptor localization, pharmacological receptor characterization, and electrophysiological recording from brain slices and patch clamp techniques. The papers are generally informative and the conclusions follow directly from the results. The book is well recommended as a reference source for research neuroscientists at the graduate or postdoctoral level. It might also be worthwhile for the ambitious clinician interested in this area of the neurosciences and the clinical implications of some of the latest findings.

• Publication year

  1987

• Venue

  The Yale Journal of Biology and Medicine

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers
  PMCID 2590372
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

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