Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP‐1 analogues

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Journal of Controlled Release

• Publication date

  2013-04-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.jconrel.2013.12.013PMID 24370893PMCID PMC3929184
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Oral delivery of bioencapsulated exendin-4 expressed in chloroplasts lowers blood glucose level in mice and stimulates insulin secretion in beta-TC6 cells.

  2013cited by this paper
• Ganglioside GM1-mediated Transcytosis of Cholera Toxin Bypasses the Retrograde Pathway and Depends on the Structure of the Ceramide Domain*

  2013cited by this paper
• Exenatide once weekly versus liraglutide once daily in patients with type 2 diabetes (DURATION-6): a randomised, open-label study.

  2013cited by this paper
• Lipid sorting by ceramide structure from plasma membrane to ER for the cholera toxin receptor ganglioside GM1.

  2012cited by this paper
• Peptides as therapeutics with enhanced bioactivity.

  2012cited by this paper
• Converting peptides into drug leads by lipidation.

  2012cited by this paper
• Low molecular weight (1 kDa) polyethylene glycol conjugation markedly enhances the hypoglycemic effects of intranasally administered exendin-4 in type 2 diabetic db/db mice.

  2012cited by this paper
• Discovery of Dual-Action Membrane-Anchored Modulators of Incretin Receptors

  2011cited by this paper
• Discovery and characterization of taspoglutide, a novel analogue of human glucagon‐like peptide‐1, engineered for sustained therapeutic activity in type 2 diabetes

  2011cited by this paper
• Pharmacological Characterization of Human Incretin Receptor Missense Variants

  2010cited by this paper
• Subcellular targeting strategies for drug design and delivery

  2010cited by this paper
• A new orally available glucagon-like peptide-1 receptor agonist, biotinylated exendin-4, displays improved hypoglycemic effects in db/db mice.

  2009cited by this paper
• Liraglutide

  2009cited by this paper
• The recycling and transcytotic pathways for IgG transport by FcRn are distinct and display an inherent polarity

  2009cited by this paper
• Ganglioside GM1 Binding Peptides: A Potential Adjuvant for Transcutaneous Immunization

  2009cited by this paper
• Membrane-tethered ligands are effective probes for exploring class B1 G protein-coupled receptor function

  2009cited by this paper
• Pharmacokinetics and pharmacodynamics of exenatide following alternate routes of administration.

  2008cited by this paper
• Targeting Incretins in Type 2 Diabetes: Role of GLP-1 Receptor Agonists and DPP-4 Inhibitors.

  2008cited by this paper
• Effects of Once-Weekly Dosing of a Long-Acting Release Formulation of Exenatide on Glucose Control and Body Weight in Subjects With Type 2 Diabetes

  2008cited by this paper
• Preparation, characterization, and application of biotinylated and biotin-PEGylated glucagon-like peptide-1 analogues for enhanced oral delivery.

  2008cited by this paper
• PEGylation improves the hypoglycaemic efficacy of intranasally administered glucagon‐like peptide‐1 in type 2 diabetic db/db mice

  2008cited by this paper
• Enhancement of oral drug absorption-effect of lipid conjugation on the enzymatic stability and intestinal permeability of l-Glu-l-Trp-NH(2).

  2007cited by this paper
• Structure-activity and protraction relationship of long-acting glucagon-like peptide-1 derivatives: importance of fatty acid length, polarity, and bulkiness.

  2007cited by this paper
• Nicotinamide nucleotide transhydrogenase: a link between insulin secretion, glucose metabolism and oxidative stress.

  2006cited by this paper
• The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes.

  2006cited by this paper
• Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route.

  2006cited by this paper
• Chapter 54 – Mucosal Adjuvants

  2005cited by this paper
• A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness.

  2005cited by this paper
• Sorting of Furin in Polarized Epithelial and Endothelial Cells: Expression Beyond the Golgi Apparatus

  2004cited by this paper
• Effect on glycemic control of exenatide (synthetic exendin-4) additive to existing metformin and/or sulfonylurea treatment in patients with type 2 diabetes.

  2003cited by this paper
• Structure, organization, and function of glycosphingolipids in membrane

  2003cited by this paper
• Uptake and metabolism of exogenous glycosphingolipids by cultured cells.

  2001cited by this paper
• The glucagon-like peptides.

  1999cited by this paper
• Basolateral Sorting of Furin in MDCK Cells Requires a Phenylalanine-Isoleucine Motif Together with an Acidic Amino Acid Cluster

  1999cited by this paper
• Processing of Human Intestinal Prolactase to an Intermediate Form by Furin or by a Furin-like Proprotein Convertase*

  1998cited by this paper
• Furin: a mammalian subtilisin/Kex2p-like endoprotease involved in processing of a wide variety of precursor proteins.

  1997cited by this paper
• A Review and Predictive Models of Gang ioside Uptake by Biological Membranes

  1993cited by this paper
• Absorption of Polyethylene Glycols 600 Through 2000: The Molecular Weight Dependence of Gastrointestinal and Nasal Absorption

  1990cited by this paper
• Preparation

  1986cited by this paper
• Characterization and quantitative determination of gangliosides and neutral glycosphingolipids in human liver.

  1982cited by this paper
• Covalent attachment of immunoglobulins to liposomes via glycosphingolipids.

  1981cited by this paper
• A simple method for the isolation and purification of total lipides from animal tissues.

  1957cited by this paper

• Palmitoylated caveolin-1 enables endosome sorting of complex sphingolipids

  2025cites this paper
• Sorting of complex sphingolipids within the cellular endomembrane systems

  2025cites this paper
• Biochemotaxis‐Oriented Engineering Bacteria Expressing GLP‐1 Enhance Diabetes Therapy by Regulating the Balance of Immune

  2024cites this paper
• Editorial: Pharmacology of gangliosides

  2024cites this paper
• Progress and limitations of oral peptide delivery as a potentially transformative therapy

  2022cites this paper
• Structural basis for acyl chain control over glycosphingolipid sorting and vesicular trafficking

  2021cites this paper
• Intestinal permeation enhancers: Lessons learned from studies using an organ culture model.

  2020cites this paper
• Conjugation of peptides to short-acyl-chain ceramides for delivery across mucosal cell barriers.

  2020cites this paper
• Probing paracellular -versus transcellular tissue barrier permeability using a gut mucosal explant culture system

  2019cites this paper
• Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids

  2018cites this paper
• Analysis of carbohydrates and glycoconjugates by matrix-assisted laser desorption/ionization mass spectrometry: An update for 2013-2014.

  2018cites this paper
• Advances in micro- and nanotechnologies for the GLP-1-based therapy and imaging of pancreatic beta-cells

  2018cites this paper
• Membrane Transport across Polarized Epithelia.

  2017cites this paper
• Pathways of protein and lipid receptor-mediated transcytosis in drug delivery

  2017cites this paper
• Modification of Ganglioside Content of Human Gastric Epithelial Cell Membrane Decreases Helicobacter pylori Adhesion

  2017cites this paper
• Acylation of Therapeutic Peptides: Interaction with Lipid Membranes and its Implications in Oral Delivery

  2016cites this paper
• Chemically modified peptides and proteins - critical considerations for oral delivery

  2016cites this paper
• Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues.

  2016cites this paper
• A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production[S]

  2015cites this paper
• Novel Delivery Systems for Improving the Clinical Use of Peptides

  2015cites this paper
• May 08, 2020 Acylation of Glucagon-like peptide-2 Interaction with lipid membranes and in

  2014cites this paper