Functional diversification of two UGT80 enzymes required for steryl glucoside synthesis in Arabidopsis

Summary Plants have two UDP-glc:sterol glucosyltransferase enzymes that synthesize sugar-conjugated forms of sterols known as steryl glucosides. We provide evidence for their specialized roles in the production of diverse sterol-derived compounds.

• Publication year

  2014

• Venue

  Journal of Experimental Botany

• Publication date

  2014-10-14

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1093/jxb/eru410PMID 25316063PMCID 4265157
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Role of Arabidopsis ABCG9 and ABCG31 ATP Binding Cassette Transporters in Pollen Fitness and the Deposition of Steryl Glycosides on the Pollen Coat[W]

  2014cited by this paper
• Steryl Glucoside and Acyl Steryl Glucoside Analysis of Arabidopsis Seeds by Electrospray Ionization Tandem Mass Spectrometry

  2012cited by this paper
• Deciphering the Molecular Functions of Sterols in Cellulose Biosynthesis

  2012cited by this paper
• GABI-Kat SimpleSearch: new features of the Arabidopsis thaliana T-DNA mutant database

  2011cited by this paper
• MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods.

  2011cited by this paper
• The Arabidopsis thaliana ACBP3 regulates leaf senescence by modulating phospholipid metabolism and ATG8 stability.

  2010cited by this paper
• The functions of steryl glycosides come to those who wait: Recent advances in plants, fungi, bacteria and animals.

  2010influential reference
• Overexpression of Arabidopsis Acyl-CoA Binding Protein ACBP3 Promotes Starvation-Induced and Age-Dependent Leaf Senescence[W][OA]

  2010cited by this paper
• Extensive in vivo metabolite-protein interactions revealed by large-scale systematic analyses.

  2010cited by this paper
• Mutations in UDP-Glucose:Sterol Glucosyltransferase in Arabidopsis Cause Transparent Testa Phenotype and Suberization Defect in Seeds1[C][W][OA]

  2009cited by this paper
• Insights into the Role of Specific Lipids in the Formation and Delivery of Lipid Microdomains to the Plasma Membrane of Plant Cells1[W]

  2006cited by this paper
• Genome-wide profiling of stored mRNA in Arabidopsis thaliana seed germination: epigenetic and genetic regulation of transcription in seed.

  2005cited by this paper
• Biosynthesis and accumulation of sterols.

  2004cited by this paper
• Genome-Wide Insertional Mutagenesis of Arabidopsis thaliana

  2003cited by this paper
• Sitosterol-β-glucoside as Primer for Cellulose Synthesis in Plants

  2002cited by this paper
• Sitosterol-beta-glucoside as primer for cellulose synthesis in plants.

  2002cited by this paper
• A Conserved Domain of the Arabidopsis GNOM Protein Mediates Subunit Interaction and Cyclophilin 5 Binding

  2000cited by this paper
• Cloning and Functional Expression of UGT Genes Encoding Sterol Glucosyltransferases from Saccharomyces cerevisiae, Candida albicans, Pichia pastoris, andDictyostelium discoideum *

  1999cited by this paper
• Sterol glycosides and acylglycosides

  1999cited by this paper
• Characterization of tt15, a novel transparent testa mutant of Arabidopsis thaliana (L.) Heynh.

  1999cited by this paper
• The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence.

  1997influential reference
• UDP-glucose:sterol glucosyltransferase: cloning and functional expression in Escherichia coli/

  1997cited by this paper
• Purification of a Membrane-Bound UDP-Glucose:Sterol [beta]-D-Glucosyltransferase Based on Its Solubility in Diethyl Ether

  1994cited by this paper
• Phospholipid-Dependence of Plant UDP-Glucose Sterol beta-d-Glucosyl Transferase : IV. Reconstitution into Small Unilamellar Vesicles.

  1989cited by this paper
• A revised medium for rapid growth and bio assays with tobacco tissue cultures

  1962influential reference
• A rapid method of total lipid extraction and purification.

  1959cited by this paper

• Phytosterols: Structural variations, biosynthetic pathways, and their biological roles.

  2026cites this paper
• Transcriptome and metabolome reveal the accumulation of secondary metabolites in different species of Dioscorea

  2025cites this paper
• Sterols in plant biology – Advances in studying membrane dynamics

  2025cites this paper
• Potential Utility of Bacillus amyloliquefaciens SFB-1 as a Biocontrol Agent for Sweetpotato Black Rot Caused by Ceratocystis fimbriata

  2024cites this paper
• The transcription factor ERF110 promotes cold tolerance by directly regulating sugar and sterol biosynthesis in citrus.

  2024cites this paper
• Investigation of the potential regulation of the UDP-glycosyltransferase genes on rice grain size and abiotic stress response.

  2024cites this paper
• Insights into functional divergence, catalytic versatility and specificity of small molecule glycosyltransferases.

  2024cites this paper
• The interaction networks of small rubber particle proteins in the latex of Taraxacum koksaghyz reveal diverse functions in stress responses and secondary metabolism

  2024cites this paper
• Advances in the Biosynthesis and Molecular Evolution of Steroidal Saponins in Plants

  2023cites this paper
• Sterol 3-beta-Glucosyltransferase TRANSPARENT TESTA15 Controls Seed Development and Flavanol Accumulation through its Role in Vacuole Biogenesis and Maintenance in Arabidopsis

  2023cites this paper
• Increase in steryl glycoside levels and stimulation of lipid raft formation in azuki bean epicotyls under hypergravity conditions.

  2023cites this paper
• Recent progress in molecular genetics and omics-driven research in seed biology.

  2023cites this paper
• Characterization of UDP-glycosyltransferase family members reveals how major flavonoid glycoside accumulates in the roots of Scutellaria baicalensis

  2022cites this paper
• A novel sterol glycosyltransferase catalyses steroidal sapogenin 3-O glucosylation from Paris polyphylla var. yunnanensis

  2022cites this paper
• Tomato STEROL GLYCOSYLTRANSFERASE 1 Silencing Unveils a Major Role of Steryl Glycosydes in Plant and Fruit Development

  2022cites this paper
• UGT72, a Major Glycosyltransferase Family for Flavonoid and Monolignol Homeostasis in Plants

  2022cites this paper
• Characterization of Three Paris polyphylla Glycosyltransferases from Different UGT Families for Steroid Functionalization.

  2022cites this paper
• Phytosterol metabolism in plants and algae, time to dive into the unknown

  2022cites this paper
• Structure-function relationship of terpenoid glycosyltransferases from plants.

  2021cites this paper
• ERECTA signaling regulates plant immune responses via chromatin-mediated promotion of WRKY33 binding to target genes.

  2021cites this paper
• UGT86C11 is a novel plant UDP-glycosyltransferase involved in labdane diterpene biosynthesis

  2021cites this paper
• Molecular cloning and functional characterization of UGTs from Glycyrrhiza uralensis flavonoid pathway.

  2021cites this paper
• Sterol Glucosyltransferases Tailor Polysaccharide Accumulation in Arabidopsis Seed Coat Epidermal Cells

  2021cites this paper
• Molecular Cloning and Functional Characterization of a Sterol 3-O-Glucosyltransferase Involved in Biosynthesis of Steroidal Saponins in Trigonella foenum-graecum

  2021cites this paper
• Leaf Lipid Alterations in Response to Heat Stress of Arabidopsis thaliana

  2020cites this paper
• Dissecting cholesterol and phytosterol biosynthesis via mutants and inhibitors.

  2020cites this paper
• Highlights to phytosterols accumulation and equilibrium in plants: Biosynthetic pathway and feedback regulation.

  2020cites this paper
• Gene expression and evolution of Family-1 UDP-glycosyltransferases—insights from an aquatic flowering plant (sacred lotus)

  2020cites this paper
• Temporal dynamics of QTL effects on vegetative growth in Arabidopsis thaliana

  2020cites this paper
• Transcriptome analysis of the endangered Notopterygium incisum: Cold-tolerance gene discovery and identification of EST-SSR and SNP markers

  2019influential citation
• Inactivation of UDP-Glucose Sterol Glucosyltransferases Enhances Arabidopsis Resistance to Botrytis cinerea

  2019cites this paper
• Phylogenomic analysis of UDP-dependent glycosyltransferases provides insights into the evolutionary landscape of glycosylation in plant metabolism.

  2019cites this paper
• Exploring the functional significance of sterol glycosyltransferase enzymes.

  2018cites this paper
• The enzymatic biosynthesis of acylated steroidal glycosides and their cytotoxic activity

  2018cites this paper
• Transcriptomic Analysis of Seed Coats in Yellow-Seeded Brassica napus Reveals Novel Genes That Influence Proanthocyanidin Biosynthesis

  2017cites this paper
• Emerging roles for conjugated sterols in plants.

  2017cites this paper
• Genome-wide analysis of UDP-glycosyltransferase super family in Brassica rapa and Brassica oleracea reveals its evolutionary history and functional characterization

  2017cites this paper
• AoAtg26, a putative sterol glucosyltransferase, is required for autophagic degradation of peroxisomes, mitochondria, and nuclei in the filamentous fungus Aspergillus oryzae

  2017cites this paper
• Tomato UDP-Glucose Sterol Glycosyltransferases: A Family of Developmental and Stress Regulated Genes that Encode Cytosolic and Membrane-Associated Forms of the Enzyme

  2017influential citation
• Population structure and genetic basis of the agronomic traits of upland cotton in China revealed by a genome‐wide association study using high‐density SNPs

  2017cites this paper
• Positioning of the SCRAMBLED receptor requires UDP-Glc:sterol glucosyltransferase 80B1 in Arabidopsis roots

  2017cites this paper
• Kinetic studies on recombinant UDP-glucose: sterol 3-O-β-glycosyltransferase from Micromonospora rhodorangea and its bioconversion potential

  2016cites this paper
• Glucosylceramides are critical for cell-type differentiation and organogenesis, but not for cell viability in Arabidopsis.

  2015cites this paper
• Effect of freeze and heat stress on sgt knockout mutant of Arabidopsis thaliana Characterization of Arabidopsis sterol glycosyltransferase TTG 15 / UGT 80 B 1 role during freeze and heat stress

  2015cites this paper
• Characterization of Arabidopsis sterol glycosyltransferase TTG15/UGT80B1 role during freeze and heat stress

  2015cites this paper
• Production and Optimization of Para-Hydroxybenzoic Acid (pHBA) in Algae Using Metabolic Engineering and Genomics Approaches

  year unknowncites this paper