Pentoxifylline Ameliorates Renal Tumor Necrosis Factor Expression, Sodium Retention, and Renal Hypertrophy in Diabetic Rats

No abstract is available for this paper.

• Publication year

  2004

• Venue

  American Journal of Nephrology

• Publication date

  2004-05-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1159/000079121PMID 15205554
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Suppression of tumor necrosis factor-alpha and inducible nitric oxide synthase gene expression by THI 52, a new synthetic naphthyl-benzylisoquinoline alkaloid.

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• Urinary tumor necrosis factor contributes to sodium retention and renal hypertrophy during diabetes.

  2003cited by this paper
• Activation of tubular epithelial cells in diabetic nephropathy.

  2002cited by this paper
• Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetes.

  2001cited by this paper
• Sodium sensitivity related to albuminuria appearing before hypertension in type 2 diabetic patients.

  2001cited by this paper
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  2001cited by this paper
• Transforming growth factor beta contributes to progressive diabetic nephropathy.

  2000cited by this paper
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  2000cited by this paper
• Putative pathophysiological role of growth factors and cytokines in experimental diabetic kidney disease

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Urinary protein excretion and serum tumor necrosis factor in diabetic patients with advanced renal failure: effects of pentoxifylline administration.

  1999cited by this paper
• Potassium supplementation increases sodium excretion and nitric oxide production in hypertensive Dahl rats.

  1999cited by this paper
• Advanced glycation end products-cytokine-nitric oxide sequence pathway in the development of diabetic nephropathy: aminoguanidine ameliorates the overexpression of tumour necrosis factor-α and inducible nitric oxide synthase in diabetic rat glomeruli

  1999cited by this paper
• Tumor necrosis factor-alpha: molecular-biological aspects minireview.

  1999cited by this paper
• Glomerular ultrafiltration of IGF-I may contribute to increased renal sodium retention in diabetic nephropathy.

  1999cited by this paper
• Pentoxifylline increases gut ketogenesis following trauma and hemorrhagic shock.

  1998cited by this paper
• Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats.

  1998cited by this paper
• Comparison of tumour necrosis factor and endothelin-1 between essential and renal hypertensive patients

  1998cited by this paper
• On the prognosis of IDDM patients with large kidneys.

  1998cited by this paper
• Effect of GH/IGF-I deficiency on long-term renal changes and urinary albumin excretion in diabetic dwarf rats.

  1997cited by this paper
• Salt. A perpetrator of hypertensive target organ disease?

  1997cited by this paper
• Quantitative morphology of the rat kidney during diabetes mellitus and insulin treatment

  1997cited by this paper
• Salt Restriction Reduces Hyperfiltration, Renal Enlargement, and Albuminuria in Experimental Diabetes

  1997cited by this paper
• Neutralization of TGF-β by Anti-TGF-β Antibody Attenuates Kidney Hypertrophy and the Enhanced Extracellular Matrix Gene Expression in STZ-Induced Diabetic Mice

  1996cited by this paper
• Modulation of glucose production by indomethacin and pentoxifylline in healthy humans.

  1996cited by this paper
• Renal fate of circulating advanced glycated end products (AGE): evidence for reabsorption and catabolism of AGE-peptides by renal proximal tubular cells

  1996cited by this paper
• Pentoxifylline reduces proteinuria in insulin-dependent and non insulin-dependent diabetic patients.

  1995cited by this paper
• Tamm-Horsfall glycoprotein in streptozotocin diabetic rats: a study of kidney in situ hybridization, immunohistochemistry, and urinary excretion

  1995cited by this paper
• Pentoxifylline inhibits basal glucose production in humans.

  1994cited by this paper
• Inhibition of endogenous TNF formation by pentoxifylline.

  1993cited by this paper
• mRNA Expression of Growth Factors in Glomeruli From Diabetic Rats

  1993cited by this paper
• Possible role of tumor necrosis factor and interleukin-1 in the development of diabetic nephropathy.

  1991cited by this paper
• Exchangeable Sodium and Renin in Hypertensive Diabetic Patients With and Without Nephropathy

  1985cited by this paper
• The Stages in Diabetic Renal Disease: With Emphasis on the Stage of Incipient Diabetic Nephropathy

  1983cited by this paper
• Evaluation of sodium and potassium balance in rats.

  1972cited by this paper

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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
• Diabetic nephropathy: Pathogenesis to cure.

  2022cites this paper
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  2020cites this paper
• The role of the TNF-α gene -308 G/A polymorphism in the development of diabetic nephropathy: An updated meta-analysis.

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  2020cites this paper
• Pathogenic Pathways and Therapeutic Approaches Targeting Inflammation in Diabetic Nephropathy

  2020cites this paper
• Inflammatory Targets in Diabetic Nephropathy

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  2020cites this paper
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  2019cites this paper
• Potential drug–drug interactions associated with clinical and laboratory findings at hospital admission

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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• 6. Diabetic Nephropathy

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• Pathogenic perspectives for the role of inflammation in diabetic nephropathy.

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• Pathophysiology of Diabetic Nephropathy: Involvement of Multifaceted Signalling Mechanism

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  2008cites this paper
• Fisiopatología de la nefropatía diabética

  2008cites this paper
• Role of inflammation in diabetic nephropathy.

  2008cites this paper
• The pathogenesis of diabetic nephropathy

  2008cites this paper
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  2008cites this paper
• The effects of pentoxifylline into the kidneys of rats in a model of unilateral hindlimb ischemia/reperfusion injury.

  2008cites this paper
• The role of inflammatory cytokines in diabetic nephropathy.

  2008cites this paper
• [Perspectives and usefulness of inflammatory biomarkers within the context of chronic renal disease].

  2007cites this paper
• Effect of TNF-α inhibition on urinary albumin excretion in experimental diabetic rats

  2007cites this paper
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  2007cites this paper
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  2007cites this paper
• Effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats.

  2007cites this paper
• Diabetes, Inflammation, Proinflammatory Cytokines, and Diabetic Nephropathy

  2006cites this paper
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  2006cites this paper
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  2006cites this paper
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  2006cites this paper
• The role of TNF-alpha in diabetic nephropathy: pathogenic and therapeutic implications.

  2006cites this paper
• The role of TNF-α in diabetic nephropathy: Pathogenic and therapeutic implications

  2006cites this paper
• Role of inflammation in diabetic complications.

  2005cites this paper
• Tumor necrosis factor-alpha gene expression in diabetic nephropathy: relationship with urinary albumin excretion and effect of angiotensin-converting enzyme inhibition.

  2005cites this paper
• Role of inflammation in diabetic complications

  2005cites this paper
• The role of inflammation as a pathogenic factor in the development of renal disease in diabetes

  2005cites this paper
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  year unknowncites this paper