A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures.

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Neuroscience

• Publication date

  2015-12-03

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.neuroscience.2015.09.073PMID 26450748
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Modulation of non‐NMDA receptor gating by auxiliary subunits

  2015cited by this paper
• Structure and gating of tetrameric glutamate receptors

  2015cited by this paper
• Retour aux sources: defining the structural basis of glutamate receptor activation

  2014cited by this paper
• Modulation of non-NMDA receptor gating by auxiliary subunits.

  2014cited by this paper
• Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.

  2014cited by this paper
• Structural mechanism of glutamate receptor activation and desensitization

  2014cited by this paper
• L‐Asp is a useful tool in the purification of the ionotropic glutamate receptor A2 ligand‐binding domain

  2014cited by this paper
• AMPA receptor positive allosteric modulators: a patent review

  2013cited by this paper
• The Wobbler Mouse Model of Amyotrophic Lateral Sclerosis (ALS) Displays Hippocampal Hyperexcitability, and Reduced Number of Interneurons, but No Presynaptic Vesicle Release Impairments

  2013cited by this paper
• The macromolecular crystallography beamline I911-3 at the MAX IV laboratory

  2013cited by this paper
• Neuron NeuroResource High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor Complexes

  2012cited by this paper
• Thermodynamics and structural analysis of positive allosteric modulation of the ionotropic glutamate receptor GluA2.

  2012influential reference
• Copper Inhibits NMDA Receptor-Independent LTP and Modulates the Paired-Pulse Ratio after LTP in Mouse Hippocampal Slices

  2011cited by this paper
• Potential therapeutic uses of BDNF in neurological and psychiatric disorders

  2011cited by this paper
• Overview of the CCP4 suite and current developments

  2011cited by this paper
• Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors.

  2010cited by this paper
• Glutamate Receptor Ion Channels: Structure, Regulation, and Function

  2010cited by this paper
• Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2.

  2009influential reference
• X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor

  2009cited by this paper
• Pharmacology of ampakine modulators: from AMPA receptors to synapses and behavior.

  2007cited by this paper
• Phaser crystallographic software

  2007cited by this paper
• Ampakines and the threefold path to cognitive enhancement.

  2006cited by this paper
• Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2.

  2005cited by this paper
• Mechanism of Positive Allosteric Modulators Acting on AMPA Receptors

  2005cited by this paper
• A Binding Site Tyrosine Shapes Desensitization Kinetics and Agonist Potency at GluR2

  2005cited by this paper
• Nootropic agents enhance the recruitment of fast GABAA inhibition in rat neocortex.

  2005cited by this paper
• Modulation of AMPA receptor kinetics differentially influences synaptic plasticity in the hippocampus.

  2004influential reference
• Receptor trafficking and synaptic plasticity

  2004cited by this paper
• International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology

  2003cited by this paper
• The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741.

  2003cited by this paper
• Structural basis for partial agonist action at ionotropic glutamate receptors

  2003cited by this paper
• GYKI 52466 , a 2 , 3 = Benzodiazepine , Is a Highly Selective , Noncompetitive Antagonist of AMPA / Kainate Receptor Responses

  2003cited by this paper
• Mechanism of glutamate receptor desensitization

  2002influential reference
• Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core.

  2002cited by this paper
• GYKI 52466 has positive modulatory effects on AMPA receptors.

  2001cited by this paper
• Positive Modulation of AMPA Receptors Increases Neurotrophin Expression by Hippocampal and Cortical Neurons

  2000influential reference
• The contributions of GluR2 to allosteric modulation of AMPA receptors.

  2000influential reference
• Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.

  2000cited by this paper
• AMPA receptor desensitization modulates synaptic responses induced by repetitive afferent stimulation in hippocampal slices.

  1998influential reference
• Systematic analysis of domain motions in proteins from conformational change: New results on citrate synthase and T4 lysozyme

  1998cited by this paper
• The waveform of synaptic transmission at hippocampal synapses is not determined by AMPA receptor desensitization.

  1998influential reference
• Preparative isolation of the eutomer of cyclothiazide by high-performance liquid chromatography on a cellulose-derived chiral stationary phase with toluene-acetone as the mobile phase

  1996cited by this paper
• AMPA Receptor Flip/Flop Mutants Affecting Deactivation, Desensitization, and Modulation by Cyclothiazide, Aniracetam, and Thiocyanate

  1996cited by this paper
• Asynchronous release of synaptic vesicles determines the time course of the AMPA receptor-mediated EPSC.

  1995cited by this paper
• A molecular determinant for submillisecond desensitization in glutamate receptors.

  1994cited by this paper
• Control of kinetic properties of AMPA receptor channels by nuclear RNA editing.

  1994cited by this paper
• Identification and characterisation of the isomers of cyclothiazide responsible for potentiating ampa current.

  1994cited by this paper
• Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A.

  1993cited by this paper
• Benzothiadiazides inhibit rapid glutamate receptor desensitization and enhance glutamatergic synaptic currents

  1993cited by this paper
• Factors regulating the magnitude of long-term potentiation induced by theta pattern stimulation.

  1992cited by this paper
• Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs.

  1992cited by this paper
• Learning‐related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long‐term potentiation

  1991cited by this paper
• Electronic Reprint Biological Crystallography Phenix : a Comprehensive Python-based System for Macromolecular Structure Solution

  year unknowncited by this paper

• Allosteric Modalities for Membrane-Bound Receptors: Insights from Drug Hunting for Brain Diseases.

  2019cites this paper
• Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders.

  2019cites this paper
• Excitatory-inhibitory imbalance in the brain of the wobbler mouse model of amyotrophic lateral sclerosis substantiated by riluzole and diazepam.

  2017cites this paper