Negative selection in hepatic tumor promotion in relation to cancer risk assessment.

No abstract is available for this paper.

• Publication year

  1995

• Venue

  Toxicology

• Publication date

  1995-09-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/0300-483X(95)03051-GPMID 7482557
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dioxins: model chemicals for assessing receptor-mediated toxicity.

  1995cited by this paper
• Carbon tetrachloride suppresses T-cell-dependent immune responses by induction of transforming growth factor-beta 1.

  1994cited by this paper
• Relative Sensitivities of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Induced Cyp1a-1 and Cyp1a-2 Gene Expression and Immunotoxicity in Female B6C3F1 Mice

  1994cited by this paper
• Regulation of mannose 6-phosphate/insulin-like growth factor-II receptors and transforming growth factor beta during liver tumor promotion with phenobarbital.

  1994cited by this paper
• Effect of some peroxisome proliferators on transforming growth factor-beta 1 gene expression and insulin-like growth factor II/mannose-6-phosphate receptor gene expression in rat liver.

  1994cited by this paper
• Computer simulation of cell growth governed by stochastic processes: application to clonal growth cancer models.

  1994cited by this paper
• Complete cDNA sequence of a human dioxin-inducible mRNA identifies a new gene subfamily of cytochrome P450 that maps to chromosome 2.

  1994cited by this paper
• Relative sensitivities of 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced Cyp1a-1 and Cyp1a-2 gene expression and immunotoxicity in female B6C3F1 mice.

  1994cited by this paper
• How important is the protein phosphorylation pathway in the toxic expression of dioxin-type chemicals?

  1994cited by this paper
• Dose response for TCDD promotion of hepatocarcinogenesis in rats initiated with DEN: histologic, biochemical, and cell proliferation endpoints.

  1993cited by this paper
• Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF-beta activities.

  1993cited by this paper
• Betaglycan presents ligand to the TGF beta signaling receptor.

  1993cited by this paper
• Betaglycan presents ligand to the TGFβ signaling receptor

  1993cited by this paper
• Human insulin-like growth factor type I and type II receptors are not imprinted.

  1993cited by this paper
• Requirement for transglutaminase in the activation of latent transforming growth factor-beta in bovine endothelial cells

  1993cited by this paper
• Functional polymorphism in the parental imprinting of the human IGF2R gene.

  1993cited by this paper
• Modeling receptor-mediated processes with dioxin: implications for pharmacokinetics and risk assessment.

  1993cited by this paper
• A physiologically based pharmacokinetic model for 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD) in the rat: tissue distribution and CYP1A induction.

  1993cited by this paper
• Influence of Orotic Acid on Multistage Hepatocarcinogenesis in the Rat: Resistance of Hepatocytes from Nodules to the Mitoinhibitory Effects of Orotic Acid

  1993cited by this paper
• The insulin–like growth factor type–2 receptor gene is imprinted in the mouse but not in humans

  1993cited by this paper
• A mechanistic model of effects of dioxin on gene expression in the rat liver.

  1993cited by this paper
• Response of phenobarbital- and ciprofibrate-exposed hepatocytes to growth factors in type I collagen gels.

  1993cited by this paper
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and -beta 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control.

  1992cited by this paper
• Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

  1992cited by this paper
• Hepatocyte growth factor/hepatopoietin A is expressed in fat‐storing cells from rat liver but not myofibroblast‐like cells derived from fat‐storing cells

  1992cited by this paper
• Dose-response relationships for chronic exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a rat tumor promotion model: quantification and immunolocalization of CYP1A1 and CYP1A2 in the liver.

  1992cited by this paper
• Dioxin Induces Expression of c-fos and c-jun Proto-Oncogenes and a Large Increase in Transcription Factor AP-1

  1992cited by this paper
• Effects of Ca2+ on the kinetics of phosphate release in skeletal muscle.

  1992cited by this paper
• TGF beta signals through a heteromeric protein kinase receptor complex.

  1992cited by this paper
• cDNA cloning and structure of mouse putative Ah receptor.

  1992cited by this paper
• Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor

  1992cited by this paper
• Plasma levels of HGF in rats treated with tumor promoters.

  1992cited by this paper
• Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase.

  1992cited by this paper
• Chemical cross-linking of the cytosolic and nuclear forms of the Ah receptor in hepatoma cell line 1c1c7.

  1992cited by this paper
• Classification of members of the Ah gene battery

  1992cited by this paper
• Expression cloning and characterization of the TGF-beta type III receptor.

  1991cited by this paper
• Cellular activation of latent transforming growth factor beta requires binding to the cation-independent mannose 6-phosphate/insulin-like growth factor type II receptor.

  1991cited by this paper
• Liver tumor promotion: Effect of phenobarbital on EGF and protein kinase C signal transduction and transforming growth factor-β1 expression

  1991cited by this paper
• Targets for dioxin: genes for plasminogen activator inhibitor-2 and interleukin-1 beta.

  1991cited by this paper
• Liver tumor promoter phenobarbital: a biphasic modulator of hepatocyte proliferation.

  1991cited by this paper
• The mouse insulin-like growth factor type-2 receptor is imprinted and closely linked to the Tme locus

  1991cited by this paper
• Structure and expression of the membrane proteoglycan betaglycan, a component of the TGF-beta receptor system.

  1991cited by this paper
• Cloning of a factor required for activity of the Ah (dioxin) receptor.

  1991cited by this paper
• Ovarian hormones enhance 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated increases in cell proliferation and preneoplastic foci in a two-stage model for rat hepatocarcinogenesis.

  1991cited by this paper
• The pro domain of pre-pro-transforming growth factor beta 1 when independently expressed is a functional binding protein for the mature growth factor.

  1990cited by this paper
• TCDD-induced altered expression of growth factors may have a role in producing cleft palate and enhancing the incidence of clefts after coadministration of retinoic acid and TCDD.

  1990cited by this paper
• Flow cytometric analysis of lymphocyte subpopulations in the spleen and thymus of mice exposed to an acute immunosuppressive dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

  1990cited by this paper
• Comparative genetic mechanisms of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced tumors.

  1990cited by this paper
• Drug metabolism. Growth signal pathways.

  1990cited by this paper
• Expression of hepatocyte growth factor gene in endothelial and Kupffer cells of damaged rat livers, as revealed by in situ hybridization.

  1990cited by this paper
• Genetics of circadian rhythms.

  1990cited by this paper
• The transforming growth factor-beta family.

  1990cited by this paper
• TGF-β1 binding protein: A component of the large latent complex of TGF-β1 with multiple repeat sequences

  1990cited by this paper
• Growth signal pathways

  1990cited by this paper
• TGF-beta 1 binding protein: a component of the large latent complex of TGF-beta 1 with multiple repeat sequences.

  1990cited by this paper
• Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action.

  1990cited by this paper
• Analysis of photoaffinity-labeled aryl hydrocarbon receptor heterogeneity by two-dimensional gel electrophoresis.

  1990cited by this paper
• The specific DNA binding activity of the dioxin receptor is modulated by the 90 kd heat shock protein.

  1990cited by this paper
• Hepatic enzymic zonation: A reevaluation of the concept of the liver acinus

  1989cited by this paper
• Interactions of recombinant and platelet transforming growth factor-beta 1 precursor with the insulin-like growth factor II/mannose 6-phosphate receptor.

  1989cited by this paper
• Transforming growth factor beta 1: importance of glycosylation and acidic proteases for processing and secretion.

  1989cited by this paper
• Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation.

  1988cited by this paper
• Association of the Ah receptor with the 90-kDa heat shock protein.

  1988cited by this paper
• Physicochemical characterization of the nuclear form of Ah receptor from mouse hepatoma cells exposed in culture to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

  1988cited by this paper
• Identification of mannose 6-phosphate in two asparagine-linked sugar chains of recombinant transforming growth factor-beta 1 precursor.

  1988cited by this paper
• Molecular events in the processing of recombinant type 1 pre-pro-transforming growth factor beta to the mature polypeptide

  1988cited by this paper
• Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin

  1988cited by this paper
• An antibody that blocks insulin-like growth factor (IGF) binding to the type II IGF receptor is neither an agonist nor an inhibitor of IGF-stimulated biologic responses in L6 myoblasts.

  1987cited by this paper
• A method to quantitate the relative initiating and promoting potencies of hepatocarcinogenic agents in their dose-response relationships to altered hepatic foci.

  1987cited by this paper
• Direct demonstration of rapid insulin-like growth factor II Receptor internalization and recycling in rat adipocytes. Insulin stimulates 125I-insulin-like growth factor II degradation by modulating the IGF-II receptor recycling process.

  1985cited by this paper
• Promotion mechanism of phenobarbital and partial hepatectomy in DENA hepatocarcinogenesis cell kinetics effect.

  1983cited by this paper
• Stimulation of DNA synthesis and cell proliferation in the liver of rats fed a choline-devoid diet and their suppression by phenobarbital.

  1982cited by this paper
• 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity.

  1982cited by this paper
• Quantitative evaluation of the promotion by 2,3,7,8-tetrachlorodibenzo-p-dioxin of hepatocarcinogenesis from diethylnitrosamine.

  1980cited by this paper
• Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats.

  1978cited by this paper
• New principle for the analysis of chemical carcinogenesis

  1976cited by this paper
• Models of carcinogenesis as an escape from mitotic inhibitors.

  1976cited by this paper
• Reduction and enhancement by phenobarbital of hepatocarcinogenesis induced in the rat by 2-acetylaminofluorene.

  1971cited by this paper

• Chemically-Induced Hepatocarcinogenesis

  2016cites this paper
• Expression of CYP1A1 and CYP1A2 in the liver and kidney of rabbits after prolonged infusion of propofol.

  2016cites this paper
• Mode of action and dose–response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study

  2014cites this paper
• Modeling Drug- and Chemical-Induced Hepatotoxicity with Systems Biology Approaches

  2012cites this paper
• Multiscale Integration of Toxicokinetic and Toxicodynamic Processes: From Cell and Tissue to Organ and “Whole Body” Models

  2011cites this paper
• Characterizing and predicting carcinogenicity and mode of action using conventional and toxicogenomics methods.

  2010cites this paper
• Chapter 99 – The Safety Assessment of Piperonyl Butoxide

  2010cites this paper
• Primary Liver Cancer: Chemical Carcinogenesis

  2009cites this paper
• Tissue‐Level Modeling of Xenobiotic Metabolism in Liver: An Emerging Tool for Enabling Clinical Translational Research

  2009cites this paper
• Use of short-term transcriptional profiles to assess the long-term cancer-related safety of environmental and industrial chemicals.

  2009cites this paper
• Differential expression of genes associated with cell proliferation and apoptosis induced by okadaic acid during the transformation process of BALB/c 3T3 cells.

  2008cites this paper
• A comparison of transcriptomic and metabonomic technologies for identifying biomarkers predictive of two-year rodent cancer bioassays.

  2007cites this paper
• Response to Comments by Caldwell et al. on Article “Applying Mode-of-Action and Pharmacokinetic Considerations in Contemporary Cancer Risk Assessments: An Example with Trichloroethylene”

  2006cites this paper
• Probing the control elements of the CYP1A1 switching module in H4IIE hepatoma cells.

  2005cites this paper
• Regional Induction of CYP1A1 in Rat Liver Following Treatment with Mixtures of PCB 126 and PCB 153

  2004cites this paper
• Applying Mode-of-Action and Pharmacokinetic Considerations in Contemporary Cancer Risk Assessments: An Example with Trichloroethylene

  2004cites this paper
• Single cell analysis of switch-like induction of CYP1A1 in liver cell lines.

  2004cites this paper
• Induction of CYP1A1 in primary rat hepatocytes by 3,3',4,4',5-pentachlorobiphenyl: evidence for a switch circuit element.

  2004cites this paper
• Human respiratory tract cancer risks of inhaled formaldehyde: dose-response predictions derived from biologically-motivated computational modeling of a combined rodent and human dataset.

  2004cites this paper
• Stochastic simulation of hepatic preneoplastic foci development for four chlorobenzene congeners in a medium-term bioassay.

  2003cites this paper
• The Use of Quantitative Histological and Molecular Data for Risk Assessment and Biologically Based Model Development

  2002cites this paper
• Dose-related effects of the peroxisome proliferator methylclofenapate in rat liver.

  2002cites this paper
• A clonal growth model: time-course simulations of liver foci growth following penta- or hexachlorobenzene treatment in a medium-term bioassay.

  2001influential citation
• Under What Conditions Is Trichloroethylene Likely To Be a Carcinogen in Humans?

  2001cites this paper
• CHAPTER 64 – The Safety Assessment of Piperonyl Butoxide

  2001cites this paper
• The functions of cytokines and their uses in toxicology

  2001cites this paper
• Critical effect sizes in toxicological risk assessment: a comprehensive and critical evaluation.

  2001cites this paper
• Species differences in hepatic peroxisome proliferation, cell replication and transforming growth factor-beta1 gene expression in the rat, Syrian hamster and guinea pig.

  2000cites this paper
• Trichloroacetate Tissue Dosimetry and PPAR alpha-Mediated Liver Cancer Induction by Trichioroethylene and Perchioroethylene

  2000cites this paper
• Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on initiation and promotion of GST-P-positive foci in rat liver: A quantitative analysis of experimental data using a stochastic model.

  2000cites this paper
• Potentiation of epidermal growth factor-induced DNA synthesis in rat hepatocytes by phenobarbitone: possible involvement of oxidative stress and kinase activation.

  2000cites this paper
• A physiologically based pharmacodynamic analysis of hepatic foci within a medium-term liver bioassay using pentachlorobenzene as a promoter and diethylnitrosamine as an initiator.

  2000cites this paper
• EGF receptors of hepatocytes from rats treated with phenobarbital are sensitized to down-regulation by phenobarbital in culture.

  2000cites this paper
• Analysis of rat liver foci growth with a quantitative two-cell model after treatment with 2,4,5,3',4'-pentachlorobiphenyl.

  2000cites this paper
• Comparison of the effects of some CYP3A and other enzyme inducers on replicative DNA synthesis and cytochrome P450 isoforms in rat liver.

  1998cites this paper
• Mechanistic modeling of rodent liver tumor promotion at low levels of exposure: an example related to dose-response relationships for 2,3,7,8-tetrachlorodibenzo-p-dioxin

  1998cites this paper
• Dichloroacetate and trichloroacetate promote clonal expansion of anchorage-independent hepatocytes in vivo and in vitro.

  1998cites this paper
• Nonresponsiveness to 2,3,7,8-tetrachlorodibenzo-p-dioxin of transforming growth factor beta1 and CYP 1A1 gene expression in rat liver fat-storing cells.

  1998cites this paper
• A short-term assessment of tumor-promotion activity in the livers of rats treated with two genotoxic methylating agents: dimethylnitrosamine and methylnitrosourea.

  1998cites this paper
• The traditional toxicologic paradigm is correct: dose influences mechanism.

  1998cites this paper
• Induction and localization of cytochrome P450 1B1 (CYP1B1) protein in the livers of TCDD-treated rats: detection using polyclonal antibodies raised to histidine-tagged fusion proteins produced and purified from bacteria.

  1998cites this paper
• The use of biochemical and molecular parameters to estimate dose-response relationships at low levels of exposure.

  1998cites this paper
• Differences in kinetics of induction and reversibility of TCDD-induced changes in cell proliferation and CYP1A1 expression in female Sprague-Dawley rat liver.

  1998cites this paper
• Differences in phenotype and cell replicative behavior of hepatic tumors induced by dichloroacetate (DCA) and trichloroacetate (TCA).

  1997cites this paper
• Comparison of the Hepatic and Renal Effects of 1,4-Dichlorobenzene in the Rat and Mouse

  1997cites this paper
• Implementation of EPA Revised Cancer Assessment Guidelines: Incorporation of Mechanistic and Pharmacokinetic Data.

  1997cites this paper
• Hepatic foci in rats after diethylnitrosamine initiation and 2,3,7,8-tetrachlorodibenzo-p-dioxin promotion: evaluation of a quantitative two-cell model and of CYP 1A1/1A2 as a dosimeter.

  1997cites this paper
• Effect of piperonyl butoxide on cell replication and xenobiotic metabolism in the livers of CD-1 mice and F344 rats.

  1997cites this paper
• The relative susceptibility of animals and humans to the carcinogenic hazard posed by exposure to 2,3,7,8-TCDD: an analysis using standard and internal measures of dose.

  1997cites this paper
• A multicompartment geometric model of the liver in relation to regional induction of cytochrome P450s.

  1997cites this paper
• Cancer and non‐cancer risk assessment should be harmonized

  1997cites this paper
• Comparison of the hepatic and renal effects of 1,4-dichlorobenzene in the rat and mouse.

  1997cites this paper
• Inhibition of gap junctional intercellular communication by barbiturates in long-term primary cultured rat hepatocytes is correlated with liver tumour promoting activity.

  1996cites this paper
• Activation of hepatic NF-kappaB by phenobarbital in rats.

  1996cites this paper
• Phenobarbital selectively promotes initiated cells with reduced TGF beta receptor levels.

  1996cites this paper
• Growth modulation of hepatocytes and rat liver epithelial cells (WB-F344) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).

  1996cites this paper
• The linearized multistage model and the future of quantitative risk assessment

  1996cites this paper
• SHORT COMMUNICATION: Phenobarbital selectively promotes initiated cells with reduced TGFβ receptor levels

  1996cites this paper
• 2,3,7,8-tetrachlorodibenzo-p-dioxin inhibits DNA synthesis in rat primary hepatocytes

  1995cites this paper
• Mechanisms of liver tumor promotion

  1995cites this paper
• Use of quantitative modelling in methylene chloride risk assessment.

  1995cites this paper
• Development of physiologically based pharmacokinetic and physiologically based pharmacodynamic models for applications in toxicology and risk assessment.

  1995cites this paper
• Considering pharmacokinetic and mechanistic information in cancer risk assessments for environmental contaminants: examples with vinyl chloride and trichloroethylene.

  1995cites this paper
• 2,3,7,8-Tetrachlorodibenzo-p-dioxin inhibits DNA synthesis in rat primary hepatocytes.

  1995cites this paper
• What do we Mean by Dose

  1995cites this paper
• Tissue-Level Modeling of Xenobiotic Metabolism in Liver: An Emerging Tool for Enabling Clinical Translational Research

  year unknowncites this paper