Essentiality is an emergent property of metabolic network wiring

No abstract is available for this paper.

• Publication year

  2007

• Venue

  FEBS Letters

• Publication date

  2007-05-29

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2007.04.067PMID 17493616
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2005influential reference
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  2005influential reference
• Comparison of network-based pathway analysis methods.

  2004cited by this paper
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  2004cited by this paper
• Genome-scale microbial in silico models: the constraints-based approach.

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  2003cited by this paper
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