Role of CCR7 in facilitating direct allosensitization and regulatory T-cell function in high-risk corneal transplantation.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Investigative Ophthalmology and Visual Science

• Publication date

  2010-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1167/iovs.09-3952PMID 19797201PMCID PMC2868459
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Levels of Foxp3 in Regulatory T Cells Reflect Their Functional Status in Transplantation1

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  2009cited by this paper
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  2007influential reference
• Tolerogenic dendritic cells and the quest for transplant tolerance

  2007cited by this paper
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  2006cited by this paper
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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003cited by this paper
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  2003cited by this paper
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  2002influential reference
• Cutting Edge: CD4+CD25+ Alloantigen-Specific Immunoregulatory Cells That Can Prevent CD8+ T Cell-Mediated Graft Rejection: Implications for Anti-CD154 Immunotherapy1

  2002cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  1999influential reference
• Role of CD4+ T cells in immunobiology of orthotopic corneal transplants in mice.

  1999cited by this paper
• Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice.

  1999cited by this paper
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  1999cited by this paper
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  1997cited by this paper
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  year unknowncited by this paper

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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
• [HLA matching in keratoplasty: lessons learned from lamellar techniques].

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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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