Scribble Scaffolds a Signalosome for Active Forgetting.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Neuron

• Publication date

  2016-06-15

• Fields of study

  Biology, Medicine, Psychology

• Identifiers
  DOI 10.1016/j.neuron.2016.05.010PMID 27263975PMCID PMC4926877
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Forgetting of long-term memory requires activation of NMDA receptors, L-type voltage-dependent Ca2+ channels, and calcineurin

  2016cited by this paper
• Identification of Genes That Promote or Inhibit Olfactory Memory Formation in Drosophila

  2015cited by this paper
• Sleep Facilitates Memory by Blocking Dopamine Neuron-Mediated Forgetting.

  2015cited by this paper
• Forgetting is regulated via Musashi-mediated translational control of the Arp2/3 complex.

  2014cited by this paper
• Hippocampal Neurogenesis Regulates Forgetting During Adulthood and Infancy

  2014cited by this paper
• The neuronal architecture of the mushroom body provides a logic for associative learning

  2014cited by this paper
• Homeostatic signaling and the stabilization of neural function.

  2013cited by this paper
• Scribble controls NGF-mediated neurite outgrowth in PC12 cells.

  2013cited by this paper
• Layered reward signaling through octopamine and dopamine in Drosophila

  2012cited by this paper
• A GAL4-driver line resource for Drosophila neurobiology.

  2012cited by this paper
• Analysis of functional neuronal connectivity in the Drosophila brain.

  2012cited by this paper
• Visualizing Long-Term Memory Formation in Two Neurons of the Drosophila Brain

  2012cited by this paper
• Dopamine is required for learning and forgetting in Drosophila.

  2012cited by this paper
• Serotonin–mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila

  2011cited by this paper
• Light-Induced Structural and Functional Plasticity in Drosophila Larval Visual System

  2011cited by this paper
• The Benefit of Forgetting in Thinking and Remembering

  2011cited by this paper
• The Planar Polarity Protein Scribble1 Is Essential for Neuronal Plasticity and Brain Function

  2010cited by this paper
• Forgetting is regulated through Rac activity in Drosophila.

  2010cited by this paper
• The leading edge during dorsal closure as a model for epithelial plasticity: Pak is required for recruitment of the Scribble complex and septate junction formation

  2010cited by this paper
• Forgetting and small G protein Rac

  2010cited by this paper
• A neural circuit mechanism integrating motivational state with memory expression in Drosophila.

  2009cited by this paper
• Scribble interacts with beta-catenin to localize synaptic vesicles to synapses.

  2009cited by this paper
• Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

  2009cited by this paper
• Dynamics of learning-related cAMP signaling and stimulus integration in the Drosophila olfactory pathway.

  2009cited by this paper
• Neuronal assemblies of the Drosophila mushroom body

  2008cited by this paper
• Scrib regulates PAK activity during the cell migration process.

  2008cited by this paper
• Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.

  2008cited by this paper
• Sequential use of mushroom body neuron subsets during drosophila odor memory processing.

  2007cited by this paper
• The Carnegie Protein Trap Library: A Versatile Tool for Drosophila Developmental Studies

  2007cited by this paper
• Drosophila α/β Mushroom Body Neurons Form a Branch-Specific, Long-Term Cellular Memory Trace after Spaced Olfactory Conditioning

  2006cited by this paper
• Drosophila alpha/beta mushroom body neurons form a branch-specific, long-term cellular memory trace after spaced olfactory conditioning.

  2006cited by this paper
• Exclusive Consolidated Memory Phases in Drosophila

  2004cited by this paper
• The psychology and neuroscience of forgetting.

  2004cited by this paper
• Nckβ Interacts with Tyrosine-Phosphorylated Disabled 1 and Redistributes in Reelin-Stimulated Neurons

  2003cited by this paper
• Rethinking interference theory: Executive control and the mechanisms of forgetting.

  2003cited by this paper
• Spatiotemporal Rescue of Memory Dysfunction in Drosophila

  2003cited by this paper
• The staufen/pumilio pathway is involved in Drosophila long-term memory.

  2003cited by this paper
• Two-photon calcium imaging reveals an odor-evoked map of activity in the fly brain.

  2003cited by this paper
• Scribble is essential for olfactory behavior in Drosophila melanogaster.

  2003cited by this paper
• Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase.

  2003cited by this paper
• Regulation of Synaptic Plasticity and Synaptic Vesicle Dynamics by the PDZ Protein Scribble

  2002cited by this paper
• Protein phosphatase 1 is a molecular constraint on learning and memory

  2002cited by this paper
• Recruitment of scribble to the synaptic scaffolding complex requires GUK-holder, a novel DLG binding protein.

  2002cited by this paper
• Correlates of sleep and waking in Drosophila melanogaster.

  2000cited by this paper
• Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.

  2000cited by this paper
• Localization of apical epithelial determinants by the basolateral PDZ protein Scribble

  2000cited by this paper
• Learning Performance of Normal and MutantDrosophila after Repeated Conditioning Trials with Discrete Stimuli

  2000cited by this paper
• Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis.

  1999cited by this paper
• The organization of extrinsic neurons and their implications in the functional roles of the mushroom bodies in Drosophila melanogaster Meigen.

  1998cited by this paper
• Tripartite mushroom body architecture revealed by antigenic markers.

  1998cited by this paper
• Neuroblast ablation in Drosophila P[GAL4] lines reveals origins of olfactory interneurons.

  1997cited by this paper
• DAMB, a novel dopamine receptor expressed specifically in Drosophila mushroom bodies.

  1996cited by this paper
• Subdivision of the Drosophila mushroom bodies by enhancer-trap expression patterns.

  1995cited by this paper
• Distinct morphogenetic functions of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion.

  1994cited by this paper
• Genetic dissection of consolidated memory in Drosophila.

  1994cited by this paper

• Dopamine neuron specific RNA-sequencing reveals Neprilysin 1 acts downstream of the cohesin complex to suppress learning.

  2026cites this paper
• Molecular Underpinnings of Memory Persistence and Forgetting

  2025influential citation
• What could evolve in the evolution of memory?

  2025cites this paper
• Striatal Gradient in Value-Decay Explains Regional Differences in Dopamine Patterns and Reinforcement Learning Computations

  2025cites this paper
• A temporally restricted function of the dopamine receptor Dop1R2 during memory formation

  2025cites this paper
• Rapid memory shift between different synaptic ensembles promotes forgetting in Drosophila.

  2025cites this paper
• Anesthesia-triggered dopaminergic bursts actively induce forgetting: a paradigm shift in understanding cold-shock amnesia

  2025cites this paper
• Neuronal Actin Remodeling and Its Role in Higher Nervous Activity

  2025cites this paper
• Roles of feedback and feed-forward networks of dopamine subsystems: insights from Drosophila studies

  2024cites this paper
• Accelerated protein retention expansion microscopy using microwave radiation

  2024cites this paper
• Feeding a rich diet supplemented with the translation inhibitor cycloheximide decreases lifespan and ovary size in Drosophila

  2024cites this paper
• Active forgetting and neuropsychiatric diseases

  2024influential citation
• Loss of the polarity protein Par3 promotes dendritic spine neoteny and enhances learning and memory

  2024cites this paper
• Overexpression of the limk1 Gene in Drosophila melanogaster Can Lead to Suppression of Courtship Memory in Males

  2024cites this paper
• Accelerated protein retention expansion microscopy using microwave radiation

  2024cites this paper
• Feeding a rich diet supplemented with the translation inhibitor cycloheximide decreases lifespan and ovary size in Drosophila

  2024cites this paper
• The Role of LIM Kinase 1 in Memory Processes

  2024cites this paper
• Skewing information flow through pre- and postsynaptic plasticity in the mushroom bodies of Drosophila

  2024influential citation
• Learning and memory using Drosophila melanogaster: a focus on advances made in the fifth decade of research

  2023cites this paper
• Role of LIM-Kinase 1 in Memory Processes

  2023cites this paper
• Differential second messenger signaling via dopamine neurons bidirectionally regulates memory retention

  2023cites this paper
• Incorporating neuro-inspired adaptability for continual learning in artificial intelligence

  2023cites this paper
• Time-dependent inhibition of Rac1 in the VTA enhances long-term aversive memory: implications in active forgetting mechanisms

  2023influential citation
• Multiple Attention Modules-based Knowledge Tracing

  2023influential citation
• Roles of Rac1-Dependent Intrinsic Forgetting in Memory-Related Brain Disorders: Demon or Angel

  2023cites this paper
• Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory

  2023cites this paper
• LIM-kinase 1 effects on memory abilities and male courtship song in Drosophila depend on the neuronal type

  2023cites this paper
• Spontaneous recovery of reward memory through active forgetting of extinction memory.

  2023cites this paper
• Anesthesia Resistant Memories in Drosophila, a Working Perspective

  2022cites this paper
• Genetics and Molecular Biology of Memory Suppression

  2022cites this paper
• Genetic dissection of mutual interference between two consecutive learning tasks in Drosophila

  2022influential citation
• Active forgetting requires Sickie function in a dedicated dopamine circuit in Drosophila

  2022cites this paper
• Behavioral Forgetting of Olfactory Learning Is Mediated by Interneuron-Regulated Network Plasticity in Caenorhabditis elegans

  2022cites this paper
• Characterization of reproductive proteins in the Mexican fruit fly points towards the evolution of novel functions

  2022cites this paper
• The signaling pathway of levamisole-sensitive-acetylcholine receptors involved in short-term forgetting of Caenorhabditis elegans

  2022cites this paper
• Forgetting as a form of adaptive engram cell plasticity

  2022cites this paper
• The Making of Long-Lasting Memories: A Fruit Fly Perspective

  2021cites this paper
• Forgetting Unwanted Memories: Active Forgetting and Implications for the Development of Psychological Disorders

  2021cites this paper
• Neuropeptide F inhibits dopamine neuron interference of long-term memory consolidation in Drosophila.

  2021cites this paper
• Bidirectional role of dopamine in learning and memory-active forgetting.

  2021cites this paper
• Rho Signaling in Synaptic Plasticity, Memory, and Brain Disorders

  2021cites this paper
• Early loss of Scribble affects cortical development, interhemispheric connectivity and psychomotor activity

  2021cites this paper
• Memory suppressor genes: Modulating acquisition, consolidation, and forgetting.

  2021cites this paper
• Clock neurons gate memory extinction in Drosophila.

  2021cites this paper
• Subcellular information processing in the olfactory system

  2020cites this paper
• An expanded particle swarm optimization based on multi-exemplar and forgetting ability

  2020cites this paper
• The Drosophila Mushroom Body: From Architecture to Algorithm in a Learning Circuit.

  2020cites this paper
• The Role of Rac GTPase in Dendritic Spine Morphogenesis and Memory

  2020cites this paper
• miR-92a Suppresses Mushroom Body-Dependent Memory Consolidation in Drosophila

  2020cites this paper
• Rac1 Impairs Forgetting-Induced Cellular Plasticity in Mushroom Body Output Neurons

  2020influential citation
• It's about time: Delay-dependent forgetting of item- and contextual-information

  2020cites this paper
• Dopamine-based mechanism for transient forgetting

  2020cites this paper
• Drosophila Running title : Drosophila olfactory processing

  2020cites this paper
• Neuronal mechanisms underlying innate and learned olfactory processing in Drosophila.

  2019cites this paper
• Come Fly with Me: an overview of dopamine receptors in Drosophila melanogaster.

  2019cites this paper
• Dopamine D1 and D2 Receptors Differentially Regulate Rac1 and Cdc42 Signaling in the Nucleus Accumbens to Modulate Behavioral and Structural Plasticity After Repeated Methamphetamine Treatment.

  2019cites this paper
• Engrams, Neurogenesis, and Forgetting

  2019cites this paper
• Cellular Adaptation Relies on Regulatory Proteins Having Episodic Memory

  2019cites this paper
• Early loss of Scribble affects cortical development and interhemispheric connectivity resulting in psychomotor dysregulation

  2019cites this paper
• Stromalin Constrains Memory Acquisition by Developmentally Limiting Synaptic Vesicle Pool Size.

  2019cites this paper
• Dopamine Neurotransmission in the Ventral Tegmental Area Promotes Active Forgetting of Cocaine-Associated Memory

  2019cites this paper
• Different roles of Rac1 in the acquisition and extinction of methamphetamine-associated contextual memory in the nucleus accumbens

  2019cites this paper
• Dopamine and the Temporal Dependence of Learning and Memory

  2019cites this paper
• Drosophila Tau Negatively Regulates Translation and Olfactory Long-Term Memory, But Facilitates Footshock Habituation and Cytoskeletal Homeostasis

  2019influential citation
• Genetic dissection of active forgetting in labile and consolidated memories in Drosophila

  2019cites this paper
• Wilm’s tumor 1 promotes memory flexibility

  2019cites this paper
• Nitric oxide acts as a cotransmitter in a subset of dopaminergic neurons to diversify memory dynamics

  2019cites this paper
• Inhibition of Rac1-dependent forgetting alleviates memory deficits in animal models of Alzheimer’s disease

  2019cites this paper
• Altered Actin Filament Dynamics in the Drosophila Mushroom Bodies Lead to Fast Acquisition of Alcohol Consumption Preference

  2019cites this paper
• Loss of Function of Phosphodiesterase 11A4 Shows that Recent and Remote Long-Term Memories Can Be Uncoupled.

  2019cites this paper
• The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis.

  2018cites this paper
• The polarity protein Angiomotin p130 controls dendritic spine maturation

  2018cites this paper
• Neural, Cellular and Molecular Mechanisms of Active Forgetting

  2018cites this paper
• Scribble: A master scaffold in polarity, adhesion, synaptogenesis, and proliferation

  2018cites this paper
• A retrieval-specific mechanism of adaptive forgetting in the mammalian brain

  2018cites this paper
• Dopamine Neurons Mediate Learning and Forgetting through Bidirectional Modulation of a Memory Trace.

  2018cites this paper
• Ex vivo Whole-cell Recordings in Adult Drosophila Brain.

  2018cites this paper
• Crosstalk between Rac1-mediated actin regulation and ROS production.

  2018cites this paper
• Active Protection: Learning-Activated Raf/MAPK Activity Protects Labile Memory from Rac1-Independent Forgetting.

  2018cites this paper
• The polarity protein Angiomotin p130 controls dendritic spine maturation

  2018cites this paper
• Regulation of cellular and PCP signalling by the Scribble polarity module.

  2017cites this paper
• Genetic Architecture of Natural Variation Underlying Adult Foraging Behavior That Is Essential for Survival of Drosophila melanogaster

  2017cites this paper
• Reciprocal synapses between mushroom body and dopamine neurons form a positive feedback loop required for learning

  2017influential citation
• The Biology of Forgetting-A Perspective.

  2017cites this paper
• The neuronal protein Neurexin directly interacts with the Scribble–Pix complex to stimulate F-actin assembly for synaptic vesicle clustering

  2017cites this paper
• Fruit Flies Can Teach Us How We Forget

  2017cites this paper
• Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX

  2017cites this paper
• Two Components of Aversive Memory in Drosophila, Anesthesia-Sensitive and Anesthesia-Resistant Memory, Require Distinct Domains Within the Rgk1 Small GTPase

  2017cites this paper
• Dopaminergic rules of engagement for memory in Drosophila.

  2017cites this paper
• Crystal structures of Scribble PDZ 1 and PDZ 3 with b-PIX Lim et al . 1 Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor b-PIX

  2017cites this paper
• Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans

  2017influential citation
• The Persistence and Transience of Memory.

  2017cites this paper
• Wilm’s tumor 1 promotes memory flexibility

  2017cites this paper
• Structure, biochemistry, and biology of PAK kinases.

  2017cites this paper
• Behavioral Modulation by Spontaneous Activity of Dopamine Neurons

  2017cites this paper
• Losing Connections, Losing Memory: AMPA Receptor Endocytosis as a Neurobiological Mechanism of Forgetting

  2016influential citation
• Hippocampal Activation of Rac1 Regulates the Forgetting of Object Recognition Memory.

  2016cites this paper
• A temporally restricted function of the Dopamine receptor Dop1R2 1 during memory formation 2

  year unknowncites this paper