The AKT axis as a therapeutic target in autoimmune diseases.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Endocrine, Metabolic & Immune Disorders - Drug Targets

• Publication date

  2009-05-31

• Fields of study

  Medicine

• Identifiers
  DOI 10.2174/187153009788452417PMID 19519464
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• No references are available for this paper.

• Disease-modifying strategies: Targeting protein kinases in multiple sclerosis and other autoimmune disorders.

  2025cites this paper
• Programmed Cell Death in Rheumatoid Arthritis

  2025cites this paper
• Signaling mechanisms involved in the regulation of remyelination in multiple sclerosis: a mini review

  2023cites this paper
• Resveratrol induces autophagy impeding BAFF-stimulated B-cell proliferation and survival by inhibiting the Akt/mTOR pathway.

  2022cites this paper
• Discovery and pre-clinical characterization of a selective PI3Kδ inhibitor, LL-00071210 in rheumatoid arthritis.

  2022cites this paper
• Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.

  2022cites this paper
• Cell type- and state- resolved immune transcriptomic profiling identifies glucocorticoid-responsive molecular defects in multiple sclerosis T cells

  2022cites this paper
• Exercise-driven exacerbation of inflammation: contribution of animal models of rheumatoid arthritis and spondyloarthritis

  2022cites this paper
• Downregulation of miR-125a-5p and miR-218-5p in Peripheral Blood Mononuclear Cells of Patients with Relapsing-Remitting Multiple Sclerosis

  2021cites this paper
• The PI3Kδ inhibitor parsaclisib ameliorates pathology and reduces autoantibody formation in preclinical models of systemic lupus erythematosus and Sjӧgren's syndrome.

  2021cites this paper
• Xanthohumol protect cognitive performance in diabetic model rats by inhibiting protein kinase B/nuclear factor kappa-B pathway

  2021cites this paper
• The expanding role of CDR1‐AS in the regulation and development of cancer and human diseases

  2020cites this paper
• Sex-Based Differences in the Cytokine Production and Intracellular Signaling Pathways in Patients With Rheumatoid Arthritis

  2020cites this paper
• Photobiomodulation with 630-nm LED radiation inhibits the proliferation of human synoviocyte MH7A cells possibly via TRPV4/PI3K/AKT/mTOR signaling pathway

  2020cites this paper
• Gene mutations in the PI3K/Akt signaling pathway were related to immune thrombocytopenia pathogenesis

  2020cites this paper
• IFN-γ and TNF-α Gene Polymorphisms in Multiple Sclerosis Patients in Northwest Iran.

  2020cites this paper
• CD226 Attenuates Treg Proliferation via Akt and Erk Signaling in an EAE Model

  2020cites this paper
• Benzoylaconitine inhibits production of IL-6 and IL-8 via MAPK, Akt, NF-κB signaling in IL-1β-induced human synovial cells.

  2019cites this paper
• Elevated expression of ciRS-7 in peripheral blood mononuclear cells from rheumatoid arthritis patients

  2019cites this paper
• Sulfasalazine alters microglia phenotype by competing endogenous RNA effect of miR‐136‐5p and long non‐coding RNA HOTAIR in cuprizone‐induced demyelination

  2018cites this paper
• Role of the mTOR pathway in minor salivary gland changes in Sjogren’s syndrome and systemic sclerosis

  2018cites this paper
• The Akt pathway in oncology therapy and beyond (Review)

  2018cites this paper
• Fengshi Gutong Capsule Attenuates Osteoarthritis by Inhibiting MAPK, NF-κB, AP-1, and Akt Pathways

  2018cites this paper
• AB0109 Autophagy inhibitor regulates apoptosis and proliferation of synovial fibroblasts through the inhibition of pi3k/akt pathway in collagen-induced arthritis rat model

  2017cites this paper
• Inflammation and its Disease Consequences

  2017cites this paper
• Gambogic acid suppresses inflammation in rheumatoid arthritis rats via PI3K/Akt/mTOR signaling pathway.

  2017cites this paper
• Apoptosis in response to heat stress is positively associated with heat-shock protein 90 expression in chicken myocardial cells in vitro

  2017cites this paper
• Circulating IL-27 Is Elevated in Rheumatoid Arthritis Patients

  2016cites this paper
• Protective effect of kaempferol, a flavonoid widely present in varieties of edible plants, on IL-1β-induced inflammatory response via inhibiting MAPK, Akt, and NF-κB signalling in SW982 cells

  2016cites this paper
• Gq-Coupled Receptors in Autoimmunity

  2016cites this paper
• The Small Molecule Inhibitor of Protein Kinase Revolution for the Treatment of Rheumatoid Arthritis

  2015cites this paper
• Beneficial Effects of Hydrogen-Rich Saline on Early Burn-Wound Progression in Rats

  2015cites this paper
• Epithelial Mesenchymal Transition: a double-edged sword

  2015cites this paper
• Oxidative Stress – A Major Player in the Pathophysiology of Systemic Lupus Erythematosus

  2014cites this paper
• Plasmocytoid dendritic cell deficit of early response to toll-like receptor 7 agonist stimulation in multiple sclerosis patients.

  2014cites this paper
• Targeting Insulin-Like Growth Factor 1 Leads to Amelioration of Inflammatory Demyelinating Disease

  2014cites this paper
• The Potential Roles of Bisphenol A (BPA) Pathogenesis in Autoimmunity

  2014cites this paper
• Activation of PI3K/Akt/mTOR signaling pathway triggered by PTEN downregulation in the pathogenesis of Crohn's disease

  2013cites this paper
• Hypoxia Enhances Chondrogenesis and Prevents Terminal Differentiation through PI3K/Akt/FoxO Dependent Anti-Apoptotic Effect

  2013cites this paper
• Anti-arthritic effects of clematichinenoside (AR-6) on PI3K/Akt signaling pathway and TNF-α associated with collagen-induced arthritis

  2013cites this paper
• Intracellular Signaling Pathways in Rheumatoid Arthritis.

  2013cites this paper
• Utilisation d'anticorps agonistes anti-cd83 pour le traitement de maladies auto-immunes

  2012cites this paper
• Inhibition of Heat Shock Protein 90 Reduces Inflammatory Signal Transduction in Murine J774 Macrophage Cells and Lessens Disease in Autoimmune MRL/lpr Mice: What in vitro, in vivo, and in silico Models Reveal

  2012cites this paper
• Acute myeloid leukemia developing in patients with autoimmune diseases

  2012cites this paper
• Increased production of circulating soluble co-stimulatory molecules CTLA-4, CD28 and CD80 in patients with rheumatoid arthritis.

  2012cites this paper
• Influence of pregnancy on the adipocytokine and peroxisome proliferator-activated receptor pathways in peripheral blood mononuclear cells from healthy donors and rheumatoid arthritis patients.

  2012cites this paper
• IL-15 positively regulates IL-21 production in celiac disease mucosa

  2012cites this paper
• A comparison of epithelial-to-mesenchymal transition and re-epithelialization.

  2012cites this paper
• HSP90 inhibition by 17-DMAG reduces inflammation in J774 macrophages through suppression of Akt and nuclear factor-κB pathways

  2012cites this paper
• Role of BI-1 (TEGT)-mediated ERK1/2 activation in mitochondria-mediated apoptosis and splenomegaly in BI-1 transgenic mice.

  2012cites this paper
• Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/lpr mouse model of systemic lupus erythematosus

  2012cites this paper
• Transglutaminase 2 expression is enhanced synergistically by interferon‐γ and tumour necrosis factor‐α in human small intestine

  2012cites this paper
• New organ-specific pharmacological strategies interfering with signaling pathways in inflammatory disorders/autoimmune disorders

  2011cites this paper
• Negative Regulation of TH17 Differentiation

  2011cites this paper
• The role of cytokines in Guillain–Barré syndrome

  2011cites this paper
• Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity

  2010cites this paper
• Suppression of Autoimmune Arthritis by Small Molecule Inhibitors of the JAK/STAT Pathway

  2010cites this paper
• GnRH signaling, the gonadotrope and endocrine control of fertility.

  2010cites this paper
• Immune dysfunction in autism: A pathway to treatment

  2010cites this paper
• Epigallocatechin-3-gallate (EGCG) attenuates inflammation in MRL/lpr mouse mesangial cells

  2010cites this paper