Presence of tetrahydroisoquinoline, a parkinsonism-related compound, in foods.

No abstract is available for this paper.

• Publication year

  1989

• Venue

  Journal of Chromatography A

• Publication date

  Unknown publication date

• Fields of study

  Agricultural and Food Sciences, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0378-4347(00)82740-1PMID 2584300
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Presence of tetrahydroisoquinoline and 1-methyl-tetrahydro-isoquinoline in foods: compounds related to Parkinson's disease.

  1988cited by this paper
• An endogenous substance of the brain, tetrahydroisoquinoline, produces parkinsonism in primates with decreased dopamine, tyrosine hydroxylase and biopterin in the nigrostriatal regions.

  1988cited by this paper
• Migration of tetrahydroisoquinoline, a possible parkinsonian neurotoxin, into monkey brain from blood as proved by gas chromatography-mass spectrometry.

  1988cited by this paper
• TETRAHYDROISOQUINOLINE AND 1-METHYL-TETRAHYDROISOQUINOLINE ARE PRESENT IN THE HUMAN BRAIN: RELATION TO PARKINSON’S DISEASE

  1987cited by this paper
• Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains.

  1987cited by this paper
• The effects of pyridinium salts, structurally related compounds of 1-methyl-4-phenylpyridinium ion (MPP+), on tyrosine hydroxylation in rat striatal tissue slices.

  1986cited by this paper
• Tetrahydroisoquinoline and 1-methyl-tetrahydroisoquinoline as novel endogenous amines in rat brain.

  1986cited by this paper
• Early and late effects of systemically administered 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on tyrosine hydroxylase activity in vitro and on tyrosine hydroxylation in tissue slices of mouse striatum.

  1986cited by this paper
• Inhibition of tyrosine hydroxylation in rat striatal tissue slices by 1-methyl-4-phenylpyridinium ion.

  1985cited by this paper
• Inhibition of tyrosine hydroxylation in tissue slices of the rat striatum by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

  1985cited by this paper
• Dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine in mice.

  1984cited by this paper
• Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism

  1984cited by this paper
• Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis.

  1983cited by this paper
• A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

  1983cited by this paper
• Ueber tertiäre und quaternäre Tetrahydroisochinolinbasen; ein Beitrag zur Stereochemie des Stickstoffs

  1901cited by this paper

• Quantitative Determination of Endogenous Tetrahydroisoquinolines, Potential Parkinson's Disease Biomarkers, in Mammals.

  2022cites this paper
• Salsolinol—neurotoxic or Neuroprotective?

  2019cites this paper
• In vitro neurotoxicity of salsolinol is attenuated by the presynaptic protein α-synuclein.

  2018cites this paper
• Antidepressant-like effect of 1,2,3,4-tetrahydroisoquinoline and its methyl derivative in animal models of depression

  2017cites this paper
• Current Status, Gaps, and Weaknesses of the Mechanism of Selective Dopaminergic Toxicity of MPTP/MPP+

  2017cites this paper
• N-methyltetrahydropyridines and pyridinium cations as toxins and comparison with naturally-occurring alkaloids.

  2016cites this paper
• The effect of peripheral chronic salsolinol administration on fat pad adipocytes morphological parameters.

  2016cites this paper
• Effects of 1,2,3,4-Tetrahydroisoquinoline Derivatives on Dopaminergic Spontaneous Discharge in Substantia Nigra Neurons in Rats

  2015cites this paper
• 1,2,3,4-Tetrahydroisoquinoline produces an antidepressant-like effect in the forced swim test and chronic mild stress model of depression in the rat: Neurochemical correlates.

  2014cites this paper
• Salsolinol, an Endogenous Compound Triggers a Two-Phase Opposing Action in the Central Nervous System

  2014cites this paper
• 1-Methyl-1,2,3,4-Tetrahydroisoquinoline, an Endogenous Amine with Unexpected Mechanism of Action: New Vistas of Therapeutic Application

  2013cites this paper
• Two Faces of 1,2,3,4-Tetrahydroisoquinoline Mode of Action in the Mammalian Brain: Is It an Endogenous Neurotoxin or a Neuromodulator?

  2012cites this paper
• 1-Methyl-1,2,3,4-Tetrahydroisoquinoline: A Potent Neuroprotecting Agent

  2012cites this paper
• Dietary inhibitors of monoamine oxidase A

  2011cites this paper
• A guide to neurotoxic animal models of Parkinson's disease.

  2011cites this paper
• Lack of association of dairy food, calcium, and vitamin D intake with the risk of Parkinson's disease: a case-control study in Japan.

  2011cites this paper
• TETRAHYDROISOQUINOLINE NEUROTOXINS AND PARKINSON DISEASE

  2010cites this paper
• A possible physiological role for cerebral tetrahydroisoquinolines

  2009cites this paper
• Review on apoptosis vs. necrosis of substantia nigrapars compacta in parkinson’s disease

  2009cites this paper
• Treatment with 1,2,3,4,-tetrahydroisoquinoline affects glutamate release in the striatum but not the binding of [^3H]MK-801 to NMDA receptors in the dopaminergic structures of the rat brain

  2009cites this paper
• Localization of N‐methyl‐norsalsolinol within rodent and human brain

  2008cites this paper
• Regional distribution of tetrahydroisoquinoline derivatives in rodent, human, and parkinson’s disease brain

  2008cites this paper
• Progressive Supranuclear Palsy and Corticobasal Degeneration

  2007cites this paper
• Consumption of dairy products and risk of Parkinson's disease.

  2007cites this paper
• Synthesis and neurotoxicity of tetrahydroisoquinoline derivatives for studying Parkinson's disease.

  2005cites this paper
• Consumption of milk and calcium in midlife and the future risk of Parkinson disease

  2005cites this paper
• Coenzyme Q10 Stabilizes Mitochondria in Parkinson’s Disease

  2005cites this paper
• Treatment with 1,2,3,4-tetrahydroisoquinolone affects the levels of nitric oxide, S-nitrosothiols, glutathione and the enzymatic activity of gamma-glutamyl transpeptidase in the dopaminergic structures of rat brain.

  2005cites this paper
• 1,2,3,4-Tetrahydroisoquinoline protects terminals of dopaminergic neurons in the striatum against the malonate-induced neurotoxicity.

  2005cites this paper
• Disposition of 1,2,3,4,-tetrahydroisoquinoline in the brain of male Wistar and Dark Agouti rats.

  2004cites this paper
• Inhibition of rodent brain monoamine oxidase and tyrosine hydroxylase by endogenous compounds - 1,2,3,4-tetrahydro-isoquinoline alkaloids.

  2004cites this paper
• Update on epidemiological aspects of progressive supranuclear palsy

  2003cites this paper
• Oxidative DNA damage and glioma cell death induced by tetrahydropapaveroline.

  2003cites this paper
• The interaction of tetrahydroisoquinoline derivatives with antinociceptive action of morphine and oxotremorine in mice

  2003cites this paper
• 1-Benzyl-1,2,3,4-tetrahydroisoquinoline (1BnTIQ), an endogenous neurotoxin, induces dopaminergic cell death through apoptosis.

  2003cites this paper
• Diet and Parkinson's disease: A potential role of dairy products in men

  2002cites this paper
• Parkinson's disease.

  2002cites this paper
• Role of noradrenergic system in the mechanism of action of endogenous neurotoxin 1,2,3,4-tetrahydroisoquinoline: biochemical and functional studies.

  2002cites this paper
• Effect of acute administration of 1,2,3,4-tetrahydroisoquinoline on the levels of glutathione and reactive oxygen species, and on the enzymatic activity of gamma-glutamyl transpeptidase in dopaminergic structures of rat brain.

  2001cites this paper
• Antidopaminergic effects of 1,2,3,4-tetrahydroisoquinoline and salsolinol

  2000cites this paper
• R- und S-Salsolinol-Spiegel in Plasma und Liquor cerebrospinalis bei unbehandelten Parkinson-Patienten

  1999cites this paper
• Effect of acute and chronic administration of 1,2,3,4-tetrahydroisoquinoline on muscle tone, metabolism of dopamine in the striatum and tyrosine hydroxylase immunocytochemistry in the substantia nigra, in rats.

  1999cites this paper
• Isoquinoline derivatives as endogenous neurotoxins in the aetiology of Parkinson's disease.

  1998cites this paper
• Determination of biological markers for alcohol abuse.

  1998cites this paper
• Salsolinol and norsalsolinol in human urine samples.

  1997cites this paper
• Isoquinoline neurotoxins in the brain and Parkinson's disease.

  1997cites this paper
• Inhibition of [3H]dopamine uptake into striatal synaptosomes by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

  1996cites this paper
• Effect of Dopamine, Dimethoxyphenylethylamine, Papaverine, and Related Compounds on Mitochondrial Respiration and Complex I Activity

  1996cites this paper
• Interaction of 1,2,3,4-tetrahydroisoquinoline with some components of cigarette smoke: potential implications for Parkinson's Disease.

  1996cites this paper
• Procedures for MS analysis of clinically relevant compounds.

  1995cites this paper
• Role of mitochondria in the etiology and pathogenesis of Parkinson's disease.

  1995cites this paper
• Inhibition of complex I by isoquinoline derivatives structurally related to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

  1995cites this paper
• Presence of N-methyl-norsalsolinol in the CSF: correlations with dopamine metabolites of patients with Parkinson's disease.

  1995cites this paper
• Mass spectrometry in Parkinson's disease.

  1995cites this paper
• Detection of 1-phenyl-N-methyl-1,2,3,4-tetrahydroisoquinoline and 1-phenyl-1,2,3,4-tetrahydroisoquinoline in human brain by gas chromatography-tandem mass spectrometry.

  1995cites this paper
• Inhibition of type A monoamine oxidase by 2(N)-methyl-6,7-dihydroxyisoquinolinium ions.

  1994cites this paper
• Endogenous MPTP-Like Amines in the Brain: Isoquinolines

  1994cites this paper
• Studies on the pathogenesis of Parkinson's disease in Japan.

  1994cites this paper
• Etiopathogenesis

  1994cites this paper
• Potential parkinsonian protoxicants within and without.

  1994cites this paper
• Contributory mechanisms in the causation of neurodegenerative disorders.

  1993cites this paper
• Gas chromatographic-mass spectrometric screening procedure for the identification of formaldehyde-derived tetrahydro-beta-carbolines in human urine.

  1993cites this paper
• Gas chromatographic-mass spectrometric screening procedure for the identification of formaldehyde-derived tetrahydroisoquinolines in human urine.

  1993cites this paper
• Presence of methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines, derivatives of the neurotoxin isoquinoline, in parkinsonian lumbar CSF.

  1992cites this paper
• Endogenous synthesis of N-methylsalsolinol, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, in rat brain during in vivo microdialysis with salsolinol, as demonstrated by gas chromatography-mass spectrometry.

  1992cites this paper
• N‐Methylation of Dopamine‐Derived 6,7‐Dihydroxy‐1,2,3,4‐Tetrahydroisoquinoline, (R)‐Salsolinol, in Rat Brains: In Vivo Microdialysis Study

  1992cites this paper
• Nicotine, Parkinson's and Alzheimer's Disease

  1992cites this paper
• Selective inhibition of complex I by N-methylisoquinolinium ion and N-methyl-1,2,3,4-tetrahydroisoquinoline in isolated mitochondria prepared from mouse brain.

  1992cites this paper
• Can tetrahydroisoquinoline (TIQ) or N-methyl-TIQ produce parkinsonism?

  1991cites this paper
• Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains.

  1991cites this paper
• Parkinson’s Disease. From Clinical Aspects to Molecular Basis

  1991cites this paper
• Drug disposition in the mammalian eye and brain: a comparison of mechanisms.

  1991cites this paper
• Tetrahydroisoquinoline and its derivatives: the occurrence and the metabolism in the brain, and the effects on catecholamine metabolism

  1991cites this paper
• Relationship between TIQs and Parkinson’s disease

  1991cites this paper
• Epidemiology of Parkinson’s disease-interplaying genes and environmental factors

  1991cites this paper
• High-performance liquid chromatographic determination of 1,2,3,4-tetrahydroisoquinoline in rat brain with fluorescence detection.

  1991cites this paper
• 7 – Naturally Occurring Toxicants and Food Constituents of Toxicological Interest

  1991cites this paper
• Risk Factors to Parkinson’s Disease; Heritability and Life Styles

  1990cites this paper
• Biosynthesis of N-Methylisoquinolinium Ion, a Potent Inhibitor of Catecholamine Metabolism, from 1,2,3,4-Tetrahydroisoquinoline Through N-Methyl-1,2,3,4-Tetrahydroisoquinoline in Human Brain

  1990cites this paper
• Endogenous synthesis of N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of N-methylisoquinolinium ion, in the brains of primates with parkinsonism after systemic administration of 1,2,3,4-tetrahydroisoquinoline.

  1990cites this paper
• Parkinsoism Produced by an Endogenous Substance, Tetrahydroisoquinoline, in Monkeys and Mice

  1990cites this paper
• Parkinsonism in monkeys produced by chronic administration of an endogenous substance of the brain, tetrahydroisoquinoline: the behavioral and biochemical changes.

  1990cites this paper