Recent Analytical Trends in Lipidomics ; Techniques and Applications in Clinical Medicine

Lipidomics is an emerging field of biomedical research which includes complex lipidome analysis. Basically it is the lipidome whichis the comprehensive and quantitative description of a set of lipid species present in an organism. Lipidomics encompasses the comprehensive analysis of molecular lipid species, including their quantitation and metabolic pathways. The wide diversity of native lipids and their modifications make lipidomic analyses challenging and difficult. The method of choice for sensitive detection and quantitation of molecular lipid species is mass spectrometry, either by direct infusion or coupled with liquid chromatography. Although lipidomics allows for high-throughput analysis, low-abundant lipid species are not properly detected. Previous separation of lipid species by liquid chromatography increases ionization efficiency and is better suited for quantifying low abundant and isomeric lipid species. This article reviews the recent trends in this emerging field.

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