MYELOID NEOPLASIA The TAK 1-NFk B axis as therapeutic target for AML

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Not labeled

• Identifiers

  No identifiers available.

• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity.

  2014cited by this paper
• IKK-dependent activation of NF-κB contributes to myeloid and lymphoid leukemogenesis by BCR-ABL1.

  2014cited by this paper
• A Pan-BCL2 inhibitor renders bone-marrow-resident human leukemia stem cells sensitive to tyrosine kinase inhibition.

  2013cited by this paper
• Bortezomib sensitivity of acute myeloid leukemia CD34(+) cells can be enhanced by targeting the persisting activity of NF-κB and the accumulation of MCL-1.

  2013cited by this paper
• Mechanism and in vitro pharmacology of TAK1 inhibition by (5Z)-7-Oxozeaenol.

  2013influential reference
• Selective killing of candidate AML stem cells by antibody targeting of IL1RAP.

  2013cited by this paper
• Targeting IRAK1 as a therapeutic approach for myelodysplastic syndrome.

  2013influential reference
• Epigenetic roles of MLL oncoproteins are dependent on NF-κB.

  2013cited by this paper
• Positive transforming growth factor-β activated kinase-1 expression has an unfavorable impact on survival in T3N1-3M0 esophageal squamous cell carcinomas.

  2013cited by this paper
• BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells.

  2013cited by this paper
• TAK1 (MAP3K7) Signaling Regulates Hematopoietic Stem Cells through TNF-Dependent and -Independent Mechanisms

  2012cited by this paper
• Noncanonical NF‐κB Signaling Regulates Hematopoietic Stem Cell Self‐Renewal and Microenvironment Interactions

  2012cited by this paper
• Inhibition of transforming growth factor-β-activated kinase-1 blocks cancer cell adhesion, invasion, and metastasis

  2012cited by this paper
• RNA sequencing of pancreatic circulating tumour cells implicates WNT signaling in metastasis

  2012cited by this paper
• TAK1 kinase signaling regulates embryonic angiogenesis by modulating endothelial cell survival and migration.

  2012cited by this paper
• A Proteomics and Transcriptomics Approach to Identify Leukemic Stem Cell (LSC) Markers*

  2012cited by this paper
• Overexpression of IL-1 receptor accessory protein in stem and progenitor cells and outcome correlation in AML and MDS.

  2012cited by this paper
• Cancer stem cell definitions and terminology: the devil is in the details

  2012cited by this paper
• Cancer stem cells: impact, heterogeneity, and uncertainty.

  2012cited by this paper
• Essential role of TAK1 in regulating mantle cell lymphoma survival.

  2012cited by this paper
• TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers.

  2012cited by this paper
• HemaExplorer: a database of mRNA expression profiles in normal and malignant haematopoiesis

  2012cited by this paper
• Stem cell gene expression programs influence clinical outcome in human leukemia

  2011cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• TNF-α/Fas-RIP-1-induced cell death signaling separates murine hematopoietic stem cells/progenitors into 2 distinct populations.

  2011cited by this paper
• Gene expression profiling in the leukemic stem cell-enriched CD34+ fraction identifies target genes that predict prognosis in normal karyotype AML

  2011cited by this paper
• Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells.

  2010cited by this paper
• TAK1 Is Required for Survival of Mouse Fibroblasts Treated with TRAIL, and Does So by NF-κB Dependent Induction of cFLIPL

  2010cited by this paper
• FLT3-ITD up-regulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD–specific STAT5 activation

  2010cited by this paper
• Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells, and enhances drug resistance.

  2010cited by this paper
• Mcl1 haploinsufficiency protects mice from Myc-induced acute myeloid leukemia.

  2010cited by this paper
• Survival-Related Profile, Pathways, and Transcription Factors in Ovarian Cancer

  2009cited by this paper
• Sensitive in vivo imaging of T cells using a membrane-bound Gaussia princeps luciferase

  2009cited by this paper
• Ex vivo assays to study self-renewal and long-term expansion of genetically modified primary human acute myeloid leukemia stem cells.

  2009cited by this paper
• Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).

  2008cited by this paper
• Stems cells and the pathways to aging and cancer.

  2008cited by this paper
• lumi: a pipeline for processing Illumina microarray

  2008cited by this paper
• TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice

  2008cited by this paper
• TAK1 Regulates Reactive Oxygen Species and Cell Death in Keratinocytes, Which Is Essential for Skin Integrity*

  2008cited by this paper
• Activated intrinsic apoptosis pathway is a key related prognostic parameter in acute myeloid leukemia.

  2007cited by this paper
• Deregulation of apoptosis in acute myeloid leukemia.

  2007cited by this paper
• Establishing long-term cultures with self-renewing acute myeloid leukemia stem/progenitor cells.

  2007cited by this paper
• Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression.

  2006cited by this paper
• Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members.

  2006cited by this paper
• Targeting NF-kappaB in hematologic malignancies.

  2006cited by this paper
• Constitutive activation of NF-kappa B is not sufficient to disturb normal steady-state hematopoiesis.

  2006cited by this paper
• c-Myc rapidly induces acute myeloid leukemia in mice without evidence of lymphoma-associated antiapoptotic mutations.

  2005cited by this paper
• Bioconductor: open software development for computational biology and bioinformatics

  2004cited by this paper
• Constitutive NF-κB DNA-binding activity in AML is frequently mediated by a Ras/PI3-K/PKB-dependent pathway

  2004cited by this paper
• Phase I Study of Bortezomib in Refractory or Relapsed Acute Leukemias

  2004cited by this paper
• A Resorcylic Acid Lactone, 5Z-7-Oxozeaenol, Prevents Inflammation by Inhibiting the Catalytic Activity of TAK1 MAPK Kinase Kinase*

  2003cited by this paper
• Preferential induction of apoptosis for primary human leukemic stem cells

  2002cited by this paper
• Nuclear factor-kappaB is constitutively activated in primitive human acute myelogenous leukemia cells.

  2001cited by this paper
• Singular value decomposition for genome-wide expression data processing and modeling.

  2000cited by this paper
• IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.

  1997cited by this paper
• The spontaneous expression of interleukin-1 beta and interleukin-6 is associated with spontaneous expression of AP-1 and NF-kappa B transcription factor in acute myeloblastic leukemia cells.

  1995cited by this paper
• Stimulation of NF-kappa B-mediated transcription by mutant derivatives of the latent membrane protein of Epstein-Barr virus

  1995cited by this paper

• No citing papers are available for this paper.