CD437, a synthetic retinoid, induces apoptosis in human respiratory epithelial cells via caspase-independent mitochondrial and caspase-8-dependent pathways both up-regulated by JNK signaling pathway.

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Experimental Cell Research

• Publication date

  2005-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.YEXCR.2005.02.005PMID 15922728
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Retinoids induce Fas(CD95) ligand cell surface expression via RARγ and nur77 in T cells

  2004cited by this paper
• Retinoid targets for apoptosis induction

  2003cited by this paper
• HA95 and LAP2β mediate a novel chromatin–nuclear envelope interaction implicated in initiation of DNA replication

  2003cited by this paper
• Identification and Characterization of a Cell Cycle and Apoptosis Regulatory Protein-1 as a Novel Mediator of Apoptosis Signaling by Retinoid CD437*

  2003cited by this paper
• The apoptotic action of the retinoid CD437/AHPN: diverse effects, common basis.

  2003cited by this paper
• NuMA and nuclear lamins behave differently in Fas-mediated apoptosis

  2003cited by this paper
• JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis.

  2003cited by this paper
• The synthetic retinoid CD437 selectively induces apoptosis in human lung cancer cells while sparing normal human lung epithelial cells.

  2002cited by this paper
• Elucidation of Molecular Events Mediating Induction of Apoptosis by Synthetic Retinoids Using a CD437-resistant Ovarian Carcinoma Cell Line*

  2002cited by this paper
• Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

  2002cited by this paper
• Membrane perturbations induced by the apoptotic Bax protein.

  2002cited by this paper
• [Are mitochondria targets of anticancer drugs responsible for apoptosis?].

  2002cited by this paper
• Role of Bcl-2 Family Members in Caspase-Independent Apoptosis during Chlamydia Infection

  2002cited by this paper
• Active Caspase-8 Translocates into the Nucleus of Apoptotic Cells to Inactivate Poly(ADP-ribose) Polymerase-2*

  2002cited by this paper
• Proteome analysis of nuclear matrix proteins during apoptotic chromatin condensation

  2002cited by this paper
• Overexpression of Helicard, a CARD-containing helicase cleaved during apoptosis, accelerates DNA degradation.

  2002cited by this paper
• Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria.

  2002cited by this paper
• Cyclin B and E2F-1 expression in prostate carcinoma cells treated with the novel retinoid CD437 are regulated by the ubiquitin-mediated pathway.

  2002cited by this paper
• Induction of apoptosis of human B-CLL and ALL cells by a novel retinoid and its nonretinoidal analog.

  2002cited by this paper
• Adenine nucleotide translocator mediates the mitochondrial membrane permeabilization induced by lonidamine, arsenite and CD437

  2001cited by this paper
• Induction of Egr-1 expression by the retinoid AHPN in human lung carcinoma cells is dependent on activated ERK1/2

  2001cited by this paper
• Retinoic acid receptor-independent mechanism of apoptosis of melanoma cells by the retinoid CD437 (AHPN)

  2001cited by this paper
• Synthetic retinoid CD437 promotes rapid apoptosis in malignant human epidermal keratinocytes and G1 arrest in their normal counterparts

  2001cited by this paper
• Electronics, People, and the Art of Publication

  2001cited by this paper
• Proliferation-dependent induction of apoptosis by the retinoid CD437 in p53-mutated keratinocytes

  2001cited by this paper
• Synthetic retinoid CD437 induces apoptosis of esophageal squamous HET-1A cells through the caspase-3-dependent pathway.

  2001cited by this paper
• Retinoid-related molecules induce cytochrome c release and apoptosis through activation of c-Jun NH(2)-terminal kinase/p38 mitogen-activated protein kinases.

  2001cited by this paper
• Pro-caspase-8 Is Predominantly Localized in Mitochondria and Released into Cytoplasm upon Apoptotic Stimulation*

  2001cited by this paper
• Effects of retinoic acid receptor-selective agonists on human nasal epithelial cell differentiation.

  2001cited by this paper
• Effects of a novel synthetic retinoid on malignant glioma in vitro: inhibition of cell proliferation, induction of apoptosis and differentiation.

  2001cited by this paper
• Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

  2000cited by this paper
• Dual mechanisms of action of the retinoid CD437: nuclear retinoic acid receptor-mediated suppression of squamous differentiation and receptor-independent induction of apoptosis in UMSCC22B human head and neck squamous cell carcinoma cells.

  2000cited by this paper
• Differential effects of several retinoid receptor-selective ligands on squamous differentiation and apoptosis in airway epithelial cells

  2000cited by this paper
• Implication of multiple mechanisms in apoptosis induced by the synthetic retinoid CD437 in human prostate carcinoma cells

  2000cited by this paper
• Augmentation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by the synthetic retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) through up-regulation of TRAIL receptors in human lung cancer cells.

  2000cited by this paper
• Identification of a unique binding protein specific for a novel retinoid inducing cellular apoptosis

  2000cited by this paper
• S-phase arrest and apoptosis induced in normal mammary epithelial cells by a novel retinoid.

  2000cited by this paper
• Induction of apoptosis in ovarian carcinoma cells by AHPN/CD437 is mediated by retinoic acid receptors

  2000cited by this paper
• Bid Induces the Oligomerization and Insertion of Bax into the Outer Mitochondrial Membrane

  2000cited by this paper
• Isolation and characterization of an acute promyelocytic leukemia cell line selectively resistant to the novel antileukemic and apoptogenic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid.

  2000cited by this paper
• Review: nuclear lamins--structural proteins with fundamental functions.

  2000cited by this paper
• The Novel Synthetic Retinoid 6-(3-adamantyl-4-hydroxyphenyl)-2-naphthalene Carboxylic Acid (CD437) Causes Apoptosis in Acute Promyelocytic Leukemia Cells Through Rapid Activation of Caspases

  1999cited by this paper
• In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RARα protein and the PML retargeting on PML-nuclear bodies

  1999cited by this paper
• Activation of the p38 and JNK/SAPK mitogen-activated protein kinase pathways during apoptosis is mediated by a novel retinoid.

  1999cited by this paper
• Mechanisms of apoptosis induced by the synthetic retinoid CD437 in human non-small cell lung carcinoma cells

  1999cited by this paper
• Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

  1999cited by this paper
• Synthetic retinoid CD437 induces S‐phase arrest and apoptosis in human prostate cancer cells LNCaP and PC‐3

  1999cited by this paper
• Roles of LAP2 Proteins in Nuclear Assembly and DNA Replication: Truncated LAP2β Proteins Alter Lamina Assembly, Envelope Formation, Nuclear Size, and DNA Replication Efficiency in Xenopus laevis Extracts

  1999cited by this paper
• The novel retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene carboxylic acid can trigger apoptosis through a mitochondrial pathway independent of the nucleus.

  1999cited by this paper
• The RARgamma selective agonist CD437 inhibits gastric cell growth through the mechanism of apoptosis.

  1999cited by this paper
• Differential responses of normal, premalignant, and malignant human bronchial epithelial cells to receptor-selective retinoids.

  1999cited by this paper
• Involvement of cyclin-dependent kinase activities in CD437-induced apoptosis.

  1999cited by this paper
• Inhibition of cell proliferation and induction of apoptosis by the retinoid AHPN in human lung carcinoma cells.

  1998cited by this paper
• Growth-inhibitory effects of the synthetic retinoid CD437 against ovarian carcinoma models in vitro and in vivo

  1998cited by this paper
• Molecular Determinants of AHPN (CD437)-Induced Growth Arrest and Apoptosis in Human Lung Cancer Cell Lines

  1998cited by this paper
• Mitochondria and apoptosis.

  1998cited by this paper
• Regulated Targeting of BAX to Mitochondria

  1998cited by this paper
• Caspase-independent cell death induced by anti-CD2 or staurosporine in activated human peripheral T lymphocytes.

  1998cited by this paper
• Movement of Bax from the Cytosol to Mitochondria during Apoptosis

  1997cited by this paper
• Bcl-XLExpression and Its Downregulation by a Novel Retinoid in Breast Carcinoma Cells

  1997cited by this paper
• Bcl-X(L) expression and its downregulation by a novel retinoid in breast carcinoma cells.

  1997cited by this paper
• Induction of apoptosis by retinoids and retinoic acid receptor gamma-selective compounds in mouse thymocytes through a novel apoptosis pathway.

  1997cited by this paper
• Induction of apoptosis in human non‐small cell lung carcinoma cells by the novel synthetic retinoid CD437

  1997cited by this paper
• Specific Activation of Retinoic Acid Receptors (RARs) and Retinoid X Receptors Reveals a Unique Role for RARγ in Induction of Differentiation and Apoptosis of S91 Melanoma Cells*

  1997cited by this paper
• Cytosol-to-membrane redistribution of Bax and Bcl-X(L) during apoptosis.

  1997cited by this paper
• Retinoid induced apoptosis in leukemia cells through a retinoic acid nuclear receptor-independent pathway.

  1997cited by this paper
• Differential effects of synthetic nuclear retinoid receptor-selective retinoids on the growth of human non-small cell lung carcinoma cells.

  1997cited by this paper
• Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

  1997cited by this paper
• Cleavage of the nuclear matrix protein NuMA during apoptosis.

  1997cited by this paper
• Lamin-binding Fragment of LAP2 Inhibits Increase in Nuclear Volume during the Cell Cycle and Progression into S Phase

  1997cited by this paper
• Rapid induction of apoptosis in human C33A cervical carcinoma cells by the synthetic retinoid 6‐[3‐(1‐adamantyl)hydroxyphenyl]‐2‐naphtalene carboxylic acid (CD437)

  1997cited by this paper
• Structure-function comparisons of the proapoptotic protein Bax in yeast and mammalian cells

  1996cited by this paper
• Treatment of melanoma cells with the synthetic retinoid CD437 induces apoptosis via activation of AP-1 in vitro, and causes growth inhibition in xenografts in vivo

  1996cited by this paper
• Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death

  1995cited by this paper
• Effects of various synthetic retinoids on proliferation and immunophenotype of human melanoma cells in vitro.

  1995cited by this paper
• Chromatin condensation during apoptosis is accompanied by degradation of lamin A+B, without enhanced activation of cdc2 kinase

  1994cited by this paper
• Identification of synthetic retinoids with selectivity for human nuclear retinoic acid receptor gamma.

  1992cited by this paper

• Simvastatin Induces Apoptosis in Medulloblastoma Brain Tumor Cells via Mevalonate Cascade Prenylation Substrates

  2019cites this paper
• Design, synthesis and biological evaluation of small molecules for controlling cellular development

  2016cites this paper
• Enhanced photodynamic therapy efficacy of methylene blue-loaded calcium phosphate nanoparticles.

  2015cites this paper
• The lipophilic bullet hits the targets: medicinal chemistry of adamantane derivatives.

  2013cites this paper
• Synthetic retinoid CD437 induces apoptosis and acts synergistically with TRAIL receptor-2 agonist in malignant melanoma.

  2012cites this paper
• Growth inhibition of a human colon carcinoma cell, COLO 201, by a natural product, Vitex agnus-castus fruits extract, in vivo and in vivo

  2012cites this paper
• Bioactive constituents and anti-proliferative properties of supercritical carbon dioxide Salvia miltiorrhiza extract in 3T3-L1 adipocytes

  2012cites this paper
• Retinoid pathway and cancer therapeutics.

  2010cites this paper
• The peptidomimetic, 1-adamantyl-substituted, and flex-het classes of retinoid-derived molecules: structure-activity relationships and retinoid receptor-independent anticancer activities.

  2010cites this paper
• Carbon black and titanium dioxide nanoparticles elicit distinct apoptotic pathways in bronchial epithelial cells

  2010cites this paper
• Chapter 102 – Using Retinoids to Increase Radioiodine Uptake in Thyroid Cancer: Role as Potential Redifferentiation Agents

  2009cites this paper
• Using Retinoids to Increase Radioiodine Uptake in Thyroid Cancer

  2009cites this paper
• Drugs targeting the mitochondrial pore act as citotoxic and cytostatic agents in temozolomide-resistant glioma cells

  2009cites this paper
• Characterization of natural killer cells in nonobese diabetic/severely compromised immunodeficient mice during pregnancy.

  2009cites this paper
• Effect of TLR3 and TLR7 activation in uterine NK cells from non-obese diabetic (NOD) mice.

  2009cites this paper
• Involvement of thioredoxin‐binding protein 2 in the antitumor activity of CD437

  2008cites this paper
• Comparison between synthetic retinoid CD437 and acitretin inhibiting melanoma A375 cell in vitro

  2008cites this paper
• T-cell Ubiquitin Ligand Affects Cell Death through a Functional Interaction with Apoptosis-inducing Factor, a Key Factor of Caspase-independent Apoptosis*

  2007cites this paper
• Characterization of apoptotic pathway associated with caspase-independent excision of DNA loop domains.

  2007cites this paper
• Mitochondrial membrane permeabilization in cell death.

  2007cites this paper
• Mechanism of 4-HPR-induced apoptosis in glioma cells: evidences suggesting role of mitochondrial-mediated pathway and endoplasmic reticulum stress.

  2006cites this paper
• The permeability transition pore complex in cancer cell death

  2006cites this paper
• Mechanisms of doxycycline-induced cytotoxicity on human bronchial epithelial cells.

  2006cites this paper
• Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis

  2006cites this paper
• Regulation of Nur77 nuclear export by c-Jun N-terminal kinase and Akt

  2006cites this paper
• Molecular Mechanisms of Apoptosis Induced by Ajoene in 3T3‐L1 Adipocytes

  2006cites this paper
• Activation of mitogen-activated protein kinases is essential for hydrogen peroxide -induced apoptosis in retinal pigment epithelial cells

  2006cites this paper
• A Drosophila ortholog of the human MRJ modulates polyglutamine toxicity and aggregation.

  2006cites this paper