SCIENCE@home

Polymeric Nanoparticles as Promising Novel Carriers for Drug Delivery: An Overview

Meenakshi Dadwal

Published 2014 in Journal of advanced pharmacy education and research

ABSTRACT

INTRODUCTION Over the past few decades, there has been a considerable research interest in the area of drug delivery using nanoparticles as carriers for small and large molecules. Polymeric nanoparticulate systems from biodegradable and biocompatible polymers are interesting options for controlled drug delivery and drug targeting. Polymeric nanoparticles are particulate dispersions or solid particles with size in the range of 10-1000 nm. The drug is dissolved, entrapped, encapsulated or attached to a nanoparticle matrix. They have been used in vivo to protect the drug entity in the systemic circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to the site of action. Various polymers have been used in delivery research as they can effectively deliver the drug to a target site and thus increase the therapeutic benefit, while minimizing side effects. [1] Polymer-based nanoparticles effectively carry drugs, proteins, and DNA to target cells and organs. Their nanometer-size promotes effective permeation through cell membranes and stability in the blood stream. Depending upon the method of preparation nanoparticles, nanospheres or nanocapsules can be obtained. Nanospheres have a monolithic-type structure (matrix) in which drugs are dispersed or adsorbed onto their surfaces or encapsulated within the particles. Nanocapsules are the vesicular system in which the drug is confined to a cavity consisting of an inner liquid core surrounded by a polymeric membrane. In this case the active substance is usually dissolved in the inner core, but may also be adsorbed to the capsule surface [Figure 1]. [2]

PUBLICATION RECORD

  • Publication year

    2014

  • Venue

    Journal of advanced pharmacy education and research

  • Publication date

    Unknown publication date

  • Fields of study

    Not labeled

  • Identifiers
    DOI 10.51847/isuzpup
  • External record

    Open on Semantic Scholar

  • Source metadata

    Semantic Scholar

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-45 of 45 references · Page 1 of 1

CITED BY

Showing 1-8 of 8 citing papers · Page 1 of 1