Protective effects of TRH and its analogues against various cytotoxic agents in retinoic acid (RA)-differentiated human neuroblastoma SH-SY5Y cells.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Neuropeptides

• Publication date

  2010-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.npep.2010.08.004PMID 20869113
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2010influential reference
• Indirubin-3'-monoxime inhibits beta-amyloid-induced neurotoxicity in neuroblastoma SH-SY5Y cells.

  2009influential reference
• Effects of TRH and its analogues on primary cortical neuronal cell damage induced by various excitotoxic, necrotic and apoptotic agents.

  2009influential reference
• Effects of all-trans-retinoic acid on human SH-SY5Y neuroblastoma as in vitro model in neurotoxicity research.

  2009cited by this paper
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  2009cited by this paper
• Okadaic acid protects human neuroblastoma SH-SY5Y cells from 1-methyl-4-phenylpyridinium ion-induced apoptosis.

  2009cited by this paper
• Apoptosis and in vitro Alzheimer’s disease neuronal models

  2009cited by this paper
• Neurotoxins and neurotoxic species implicated in neurodegeneration

  2009cited by this paper
• Kynurenic acid protects against the homocysteine-induced impairment of endothelial cells

  2009cited by this paper
• Modulation of neurotoxicant‐induced increases in intracellular calcium by phytoestrogens differ for amyloid beta peptide (Aβ) and 1‐methyl‐4‐phenyl‐pyridine (MPP+)

  2009influential reference
• Mechanisms of neurodegeneration in Huntington’s disease

  2008cited by this paper
• Caffeine activates the PI3K/Akt pathway and prevents apoptotic cell death in a Parkinson's disease model of SH-SY5Y cells.

  2008cited by this paper
• MAPKs as mediators of cell fate determination: an approach to neurodegenerative diseases.

  2008cited by this paper
• Chemistry and biology of thyrotropin-releasing hormone (TRH) and its analogs.

  2008cited by this paper
• The Role of the Thyrotropin-Releasing Hormone (TRH) Neuron as a Metabolic Sensor

  2008cited by this paper
• Effects of neurosteroids on hydrogen peroxide‐ and staurosporine‐induced damage of human neuroblastoma SH‐SY5Y cells

  2008influential reference
• The BCL-2 protein family: opposing activities that mediate cell death

  2008cited by this paper
• Oxidative and nitrative protein modifications in Parkinson's disease.

  2008cited by this paper
• Differences between normal and alpha-synuclein overexpressing SH-SY5Y neuroblastoma cells after Abeta(1-42) and NAC treatment.

  2008cited by this paper
• Role of homocysteine in the treatment of Parkinson's disease

  2008cited by this paper
• The attenuating effect of memantine on staurosporine-, salsolinol- and doxorubicin-induced apoptosis in human neuroblastoma SH-SY5Y cells.

  2008influential reference
• Synergistic induction of ER stress by homocysteine and beta-amyloid in SH-SY5Y cells.

  2008influential reference
• Neurosteroids enhance the viability of staurosporine and doxorubicin treated differentiated human neuroblastoma SH-SY5Y cells.

  2008influential reference
• Monoamine oxidase‐A modulates apoptotic cell death induced by staurosporine in human neuroblastoma cells

  2007cited by this paper
• Homocysteine and Parkinson's disease: a dangerous liaison?

  2007cited by this paper
• Neuroprotection: challenges and opportunities.

  2007cited by this paper
• Bcl‐2 overexpression delays caspase‐3 activation and rescues cerebellar degeneration in prion‐deficient mice that overexpress amino‐terminally truncated prion

  2007cited by this paper
• Implication of PTEN in production of reactive oxygen species and neuronal death in in vitro models of stroke and Parkinson's disease.

  2007cited by this paper
• Animal models of Huntington's disease.

  2007cited by this paper
• An analog of thyrotropin-releasing hormone (TRH) is neuroprotective against glutamate-induced toxicity in fetal rat hippocampal neurons in vitro.

  2007cited by this paper
• The role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric diseases

  2007cited by this paper
• Inhibitory effects of 1,25-dihydroxyvitamin D3 and its low-calcemic analogues on staurosporine-induced apoptosis.

  2007cited by this paper
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  2007cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Galpha(s) sensitizes human SH-SY5Y cells to apoptosis independently of the protein kinase A pathway.

  2006influential reference
• Effect of erythropoietin on staurosporine-induced apoptosis and differentiation of SH-SY5Y neuroblastoma cells.

  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Gαs sensitizes human SH‐SY5Y cells to apoptosis independently of the protein kinase A pathway

  2006influential reference
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  2006cited by this paper
• Neuroprotective effects of novel small peptides in vitro and after brain injury.

  2005influential reference
• Homocysteine and brain atrophy.

  2005cited by this paper
• Thyrotropin-releasing hormone (protirelin) inhibits potassium-stimulated glutamate and aspartate release from hippocampal slices in vitro.

  2005cited by this paper
• Regulation of neuronal cell death and neurodegeneration by members of the Bcl-2 family: therapeutic implications.

  2005cited by this paper
• Novel Neuroprotective Tripeptides and Dipeptides

  2005influential reference
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  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• Activation of ERK1/2, JNK and PKB by hydrogen peroxide in human SH-SY5Y neuroblastoma cells: role of ERK1/2 in H2O2-induced cell death.

  2004influential reference
• Caspases, apoptosis and aging.

  2003cited by this paper
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  2003influential reference
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  2003influential reference
• Neuroprotective effects of the novel D3/D2 receptor agonist and antiparkinson agent, S32504, in vitro against 1-methyl-4-phenylpyridinium (MPP+) and in vivo against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a comparison to ropinirole.

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  2003influential reference
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  2003cited by this paper
• Akt as a mediator of cell death

  2003influential reference
• Cell death in Parkinson's disease

  2002cited by this paper
• Folic acid and homocysteine in age-related disease.

  2002cited by this paper
• Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease

  2002cited by this paper
• Insulin‐like growth factor‐1 protects peroxynitrite‐induced cell death by preventing cytochrome c‐induced caspase‐3 activation

  2002cited by this paper
• Apoptotic molecules and MPTP-induced cell death.

  2002cited by this paper
• Thyrotropin releasing hormone (TRH) in the hippocampus of Alzheimer patients

  2002cited by this paper
• [TRH analogs at Gedeon Richter Ltd.: highlights of experimental and clinical efficacy of posatirelin].

  2002cited by this paper
• Transfection‐enforced Bcl‐2 overexpression and an anti‐Parkinson drug, rasagiline, prevent nuclear accumulation of glyceraldehyde‐3‐phosphate dehydrogenase induced by an endogenous dopaminergic neurotoxin, N‐methyl(R)salsolinol

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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
• Chemistry and biology.

  2000cited by this paper
• Differential effects of staurosporine and retinoic acid on the vulnerability of the SH‐SY5Y neuroblastoma cells: Involvement of Bcl‐2 and p53 proteins

  1999cited by this paper
• Thyrotropin-releasing hormone (TRH), a signal peptide of the central nervous system.

  1999cited by this paper
• Neuroprotective effect of thyrotropin-releasing hormone against excitatory amino acid-induced cell death in hippocampal slices.

  1999cited by this paper
• Chemistry and Biology

  1999influential reference
• Effects of pentylenetetrazole-induced kindling on thyrotropin-releasing hormone biosynthesis and receptors in rat brain.

  1999cited by this paper
• Prepro-thyrotropin-releasing hormone 178-199 exerts partial protection against cerebral ischemia in adult rats.

  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
• Structure-activity analyses of beta-amyloid peptides: contributions of the beta 25-35 region to aggregation and neurotoxicity.

  1995cited by this paper
• Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity

  1995cited by this paper
• Treatment with Thyrotropin-Releasing Hormone (TRH) in Patients with Traumatic Spinal Cord Injuries

  1995cited by this paper
• Effects of RGH-2202 on behavioral deficits after focal cerebral ischemia in rats.

  1995cited by this paper
• Differentiation of neuroblastoma enhances Bcl-2 expression and induces alterations of apoptosis and drug resistance.

  1995cited by this paper
• Staurosporine-induced neuronal apoptosis.

  1995cited by this paper
• Modeling of acute spinal cord injury in the rat: neuroprotection and enhanced recovery with methylprednisolone, U-74006F and YM-14673.

  1994cited by this paper
• Thyrotropin‐Releasing hormone gene expression and receptors are differentially modified in limbic foci by seizures

  1993cited by this paper
• L-homocysteic acid selectively activates N-methyl-D-aspartate receptors of rat retinal ganglion cells.

  1992cited by this paper
• Comparison of a Serotonin Antagonist, Opioid Antagonist, and TRH Analog for the Acute Treatment of Experimental Spinal Trauma

  1991cited by this paper
• Systemic administration of kainic acid produces elevations in TRH in rat central nervous system.

  1990cited by this paper
• A comparison of the locomotor effects induced by centrally injected TRH and TRH analogues.

  1984cited by this paper
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  1981cited by this paper

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  2020cites this paper
• Long non-coding RNA-p21 regulates MPP+-induced neuronal injury by targeting miR-625 and derepressing TRPM2 in SH-SY5Y cells.

  2019cites this paper
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  2018cites this paper
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  2018cites this paper
• The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

  2017cites this paper
• The ATM kinase inhibitor KU-55933 provides neuroprotection against hydrogen peroxide-induced cell damage via a γH2AX/p-p53/caspase-3-independent mechanism: Inhibition of calpain and cathepsin D.

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  2016cites this paper
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  2016cites this paper
• Protection by polyphenol extract from olive stones against apoptosis produced by oxidative stress in human neuroblastoma cells

  2016cites this paper
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  2015cites this paper
• Protective Effects of Bacopa Monnieri on Hydrogen Peroxide and Staurosporine: Induced Damage of Human Neuroblastoma SH-SY5Y Cells

  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2011cites this paper
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  year unknowncites this paper