Evaluation of neurotoxic and neuroprotective pathways affected by antiepileptic drugs in cultured hippocampal neurons.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Toxicology in Vitro

• Publication date

  2013-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.tiv.2013.09.008PMID 24055897
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Toxicology in Vitro

  2014cited by this paper
• Steady‐state plasma and cerebrospinal fluid pharmacokinetics and tolerability of eslicarbazepine acetate and oxcarbazepine in healthy volunteers

  2013cited by this paper
• Valproic acid mediates the synaptic excitatory/inhibitory balance through astrocytes--a preliminary study.

  2012cited by this paper
• Eslicarbazepine acetate (BIA 2-093)

  2011influential reference
• Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers.

  2010cited by this paper
• Molecular and Therapeutic Potential and Toxicity of Valproic Acid

  2010cited by this paper
• Drug interactions involving the new second- and third-generation antiepileptic drugs

  2010cited by this paper
• Early effects of mood stabilizers on the Akt/GSK-3β signaling pathway and on cell survival and proliferation

  2009cited by this paper
• Efficacy and safety of eslicarbazepine acetate as adjunctive treatment in adults with refractory partial‐onset seizures: A randomized, double‐blind, placebo‐controlled, parallel‐group phase III study

  2009cited by this paper
• Eslicarbazepine Acetate

  2009cited by this paper
• Chronic Administration of Mood Stabilizers Upregulates BDNF and Bcl-2 Expression Levels in Rat Frontal Cortex

  2009cited by this paper
• Modifications of Antiepileptic Drugs for Improved Tolerability and Efficacy

  2008cited by this paper
• Dynamic seizure-related changes in extracellular signal-regulated kinase activation in a mouse model of temporal lobe epilepsy.

  2008cited by this paper
• Pharmacokinetics of eslicarbazepine acetate in patients with moderate hepatic impairment

  2008cited by this paper
• Antiepileptic drugs and brain maturation: fetal exposure to lamotrigine generates cortical malformations in rats.

  2008cited by this paper
• Antiepileptic drugs during pregnancy: What is known and which AEDs seem to be safest?

  2008cited by this paper
• Neuropsychological and Behavioral Effects of Antiepilepsy Drugs

  2007cited by this paper
• Inhibition of mitogen-activated protein kinase and stimulation of Akt kinase signaling pathways: Two approaches with therapeutic potential in the treatment of neurodegenerative disease.

  2007cited by this paper
• Novel anticonvulsant drugs.

  2007cited by this paper
• Simultaneous and enantioselective liquid chromatographic determination of eslicarbazepine acetate, S-licarbazepine, R-licarbazepine and oxcarbazepine in mouse tissue samples using ultraviolet detection.

  2007cited by this paper
• The c-jun kinase/stress-activated pathway: regulation, function and role in human disease.

  2007cited by this paper
• ERK activation causes epilepsy by stimulating NMDA receptor activity

  2007cited by this paper
• Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons

  2007influential reference
• Effects of Lamotrigine Alone and in Combination with MK-801, Phenobarbital, or Phenytoin on Cell Death in the Neonatal Rat Brain

  2007cited by this paper
• MAPK phosphatases — regulating the immune response

  2007cited by this paper
• New antiepileptic drugs that are second generation to existing antiepileptic drugs

  2006cited by this paper
• Valproate: past, present, and future.

  2006cited by this paper
• Single‐Dose and Steady‐State Pharmacokinetics of Eslicarbazepine Acetate (BIA 2–093) in Healthy Elderly and Young Subjects

  2005influential reference
• Protection with estradiol in developmental models of apoptotic neurodegeneration

  2005cited by this paper
• Comparative analysis of the effects of four mood stabilizers in SH-SY5Y cells and in primary neurons.

  2005cited by this paper
• The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials.

  2005cited by this paper
• Antiepileptic drugs and neuroprotection: current status and future roles.

  2005cited by this paper
• The neurobiology of antiepileptic drugs

  2004cited by this paper
• Role of extracellular signal regulated kinases 1 and 2 in neuronal survival.

  2004cited by this paper
• Neurotoxicity Induced by Antiepileptic Drugs in Cultured Hippocampal Neurons: A Comparative Study between Carbamazepine, Oxcarbazepine, and Two New Putative Antiepileptic Drugs, BIA 2‐024 and BIA 2‐093

  2004influential reference
• Histone deacetylase inhibition-mediated neuronal differentiation of multipotent adult neural progenitor cells.

  2004cited by this paper
• The neurobiology of antiepileptic drugs for the treatment of nonepileptic conditions

  2004cited by this paper
• Antiepileptic Drugs and Apoptosis in the Developing Brain

  2003cited by this paper
• Akt as a mediator of cell death

  2003cited by this paper
• Overtreatment in epilepsy: adverse consequences and mechanisms.

  2002cited by this paper
• Intranuclear localization of apoptosis‐inducing factor (AIF) and large scale dna fragmentation after traumatic brain injury in rats and in neuronal cultures exposed to peroxynitrite

  2002cited by this paper
• Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy.

  2002cited by this paper
• Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection.

  2002cited by this paper
• Antiepileptic drugs and apoptotic neurodegeneration in the developing brain

  2002influential reference
• Drug‐induced Apoptotic Neurodegeneration in the Developing Brain

  2002cited by this paper
• The novel anticonvulsant BIA 2-093 inhibits transmitter release during opening of voltage-gated sodium channels: a comparison with carbamazepine and oxcarbazepine.

  2002cited by this paper
• Basic Pharmacology of Valproate

  2002cited by this paper
• Essential role of the mitochondrial apoptosis-inducing factor in programmed cell death

  2001cited by this paper
• Ten years of protein kinase B signalling: a hard Akt to follow.

  2001cited by this paper
• Neurotoxic/neuroprotective profile of carbamazepine, oxcarbazepine and two new putative antiepileptic drugs, BIA 2-093 and BIA 2-024.

  2000cited by this paper
• Persistent Activation of ERK Contributes to Glutamate-induced Oxidative Toxicity in a Neuronal Cell Line and Primary Cortical Neuron Cultures*

  2000cited by this paper
• Neuronal death enhanced by N-methyl-D-aspartate antagonists.

  2000cited by this paper
• Neuroprotection by MAPK/ERK kinase inhibition with U0126 against oxidative stress in a mouse neuronal cell line and rat primary cultured cortical neurons.

  2000cited by this paper
• Different mechanisms of protection against apoptosis by valproate and Li+.

  1999cited by this paper
• Neuroprotection by Brain-derived Neurotrophic Factor Is Mediated by Extracellular Signal-regulated Kinase and Phosphatidylinositol 3-Kinase*

  1999cited by this paper
• Enzyme concentration as an important factor in the in vitro testing of the stereospecificity of the enzymatic hydrolysis of organophosphorus compounds.

  1999cited by this paper
• Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives.

  1999cited by this paper
• Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine.

  1998cited by this paper
• A common anticonvulsant binding site for phenytoin, carbamazepine, and lamotrigine in neuronal Na+ channels.

  1998cited by this paper
• New Antiepileptic Drugs in Epileptology

  1998cited by this paper
• Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

  1997cited by this paper
• Requirement for phosphatidylinositol-3 kinase in the prevention of apoptosis by nerve growth factor.

  1995cited by this paper
• Carbamazepine Clinical Pharmacology: A Review

  1995cited by this paper
• Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurones

  1995cited by this paper
• Carbamazepine induction of apoptosis in cultured cerebellar neurons: effects of N-methyl-D-aspartate, aurintricarboxylic acid and cycloheximide.

  1995cited by this paper
• Optimized survival of hippocampal neurons in B27‐supplemented neurobasal™, a new serum‐free medium combination

  1993influential reference
• Valproic acid

  1980cited by this paper

• In vitro models of valproic acid to assess neurodevelopmental toxicity: A scoping review

  2025cites this paper
• Mood Stabilizers (Lamotrigine, Lithium, and Valproic Acid) Decrease Bipolar Disease Model (Ouabain)‐Induced Oxidative Stress and Apoptosis Through the Inhibition of the TRPM2 Channel in Neuronal Cells

  2025cites this paper
• May anti‐seizure medications alter brain structure in temporal lobe epilepsy? A prospective study

  2024cites this paper
• 1H‐MRS reveals metabolic alterations in generalized tonic‐clonic seizures before and after treatment

  2021cites this paper
• Passive Addiction and Teratogenic Effects

  2018cites this paper
• Protective Role of UCP2 in Oxidative Stress and Apoptosis during the Silent Phase of an Experimental Model of Epilepsy Induced by Pilocarpine

  2018cites this paper
• Evaluation of the effects of antiepileptic drugs on folic acid uptake by human placental choriocarcinoma cells.

  2017cites this paper
• Valproic acid promotes neuronal differentiation and GABAergic interneuron formation in primary hippocampal stem cells

  2017cites this paper
• Neurodevelopmental Effects of Antiepileptic Drugs

  2017cites this paper
• Short-term use of antiepileptic drugs is neurotoxic to the immature brain

  2015cites this paper
• Calidad de vida relacionada con la salud en niños con epilepsia de un hospital mexicano

  2014cites this paper
• [Health-related quality of life in children with epilepsy in a Mexican hospital].

  2014cites this paper