Interactions of Human Myeloid Cells with Natural Killer Cell Subsets In Vitro and In Vivo

In both human and mouse it has been recently realized that natural killer (NK) cells do not emerge from the bone marrow with full functional competence but rather acquire functions in interaction with antigen-presenting cells (APCs), primarily dendritic cells (DCs). Here we review the mechanisms and the consequences of this NK-cell preactivation, as well as discuss new experimental models that now allow investigating these interactions for human NK cells and their response to human pathogens in vivo. These investigations will allow harnessing NK cells during vaccination for improved innate and adaptive immunity.

• Publication year

  2011

• Venue

  Journal of Biomedicine and Biotechnology

• Publication date

  2011-03-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2011/251679PMID 21541250PMCID 3085306
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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