The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Neurochemistry International

• Publication date

  2008-09-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.neuint.2008.06.003PMID 18590784PMCID PMC2613265
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Neurosecretases provide strategies to treat sporadic and familial Alzheimer disorders.

  2008cited by this paper
• Role of calpain and caspase in beta-amyloid-induced cell death in rat primary septal cultured neurons.

  2008cited by this paper
• Calpain-mediated mGluR1alpha truncation: a key step in excitotoxicity.

  2007cited by this paper
• N-terminal Cleavage of GSK-3 by Calpain

  2007cited by this paper
• Calpain-Mediated mGluR1α Truncation: A Key Step in Excitotoxicity

  2007cited by this paper
• Calpain inhibitors, a treatment for alzheimer’s disease

  2007cited by this paper
• Kainate induces AKT, ERK and cdk5/GSK3beta pathway deregulation, phosphorylates tau protein in mouse hippocampus.

  2007cited by this paper
• Calpastatin levels affect calpain activation and calpain proteolytic activity in APP transgenic mouse model of Alzheimer's disease.

  2007cited by this paper
• Beta-amyloid disrupted synaptic vesicle endocytosis in cultured hippocampal neurons.

  2007influential reference
• Inhibition of calpain-mediated cell death by a novel peptide inhibitor.

  2006cited by this paper
• Microtubule-associated protein MAP1A, MAP1B, and MAP2 proteolysis during soluble amyloid beta-peptide-induced neuronal apoptosis. Synergistic involvement of calpain and caspase-3.

  2006cited by this paper
• Microtubule-associated Protein MAP1A, MAP1B, and MAP2 Proteolysis during Soluble Amyloid β-Peptide-induced Neuronal Apoptosis

  2006cited by this paper
• β-Amyloid-induced Dynamin 1 Degradation Is Mediated by N-Methyl-D-Aspartate Receptors in Hippocampal Neurons*

  2006cited by this paper
• Mu-calpain is functionally required for alpha-processing of Alzheimer's beta-amyloid precursor protein.

  2005cited by this paper
• μ-Calpain is functionally required for α-processing of Alzheimer’s β-amyloid precursor protein

  2005cited by this paper
• Beta-amyloid-induced dynamin 1 depletion in hippocampal neurons. A potential mechanism for early cognitive decline in Alzheimer disease.

  2005cited by this paper
• The Generation of a 17 kDa Neurotoxic Fragment: An Alternative Mechanism by which Tau Mediates β-Amyloid-Induced Neurodegeneration

  2005cited by this paper
• Spectrin and calpain: a ‘target’ and a ‘sniper’ in the pathology of neuronal cells

  2005cited by this paper
• Cortical Synaptic Integration In Vivo Is Disrupted by Amyloid-β Plaques

  2004cited by this paper
• Alzheimer's disease pathogenesis and therapeutic interventions.

  2004cited by this paper
• Critical Role of Calpain-mediated Cleavage of Calcineurin in Excitotoxic Neurodegeneration*

  2004cited by this paper
• Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques.

  2004cited by this paper
• Calpain mediates calcium-induced activation of the erk1,2 MAPK pathway and cytoskeletal phosphorylation in neurons: relevance to Alzheimer's disease.

  2004cited by this paper
• The calpain inhibitor MDL 28170 prevents inflammation‐induced neurofilament light chain breakdown in the spinal cord and reduces thermal hyperalgesia

  2004cited by this paper
• Benzoylalanine-derived ketoamides carrying vinylbenzyl amino residues: discovery of potent water-soluble calpain inhibitors with oral bioavailability.

  2003influential reference
• The calpain system.

  2003cited by this paper
• Tau is essential to beta -amyloid-induced neurotoxicity.

  2002cited by this paper
• Tau is essential to β-amyloid-induced neurotoxicity

  2002cited by this paper
• Proapoptotic effects of tau cleavage product generated by caspase-3.

  2001cited by this paper
• Neurotoxicity induces cleavage of p35 to p25 by calpain

  2000cited by this paper
• μ-Calpain activation, DNA fragmentation, and synergistic effects of caspase and calpain inhibitors in protecting hippocampal neurons from ischemic damage ☆

  2000cited by this paper
• Inhibition of tau phosphorylating protein kinase cdk5 prevents β‐amyloid‐induced neuronal death

  1999cited by this paper
• Activation of the L voltage-sensitive calcium channel by mitogen-activated protein (MAP) kinase following exposure of neuronal cells to beta-amyloid. MAP kinase mediates beta-amyloid-induced neurodegeneration.

  1999cited by this paper
• Culturing nerve cells

  1998cited by this paper
• Postischemic treatment with calpain inhibitor MDL 28170 ameliorates brain damage in a gerbil model of global ischemia.

  1998cited by this paper
• m-Calpain (calcium-activated neutral proteinase) in Alzheimer's disease brains.

  1998cited by this paper
• Calpain-mediated regulation of NMDA receptor structure and function.

  1998cited by this paper
• Selective phosphorylation of adult tau isoforms in mature hippocampal neurons exposed to fibrillar A beta.

  1997cited by this paper
• A dynamin GTPase mutation causes a rapid and reversible temperature-inducible locomotion defect in C. elegans.

  1997cited by this paper
• The C-terminal domain of glutamate receptor subunit 1 is a target for calpain-mediated proteolysis.

  1996cited by this paper
• Calcium Influx into Human Neuroblastoma Cells Induces ALZ‐50 Immunoreactivity: Involvement of Calpain‐Mediated Hydrolysis of Protein Kinase C

  1996cited by this paper
• β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding

  1995cited by this paper
• Calpain Inhibitor AK295 Protects Neurons From Focal Brain Ischemia: Effects of Postocdusion Intra-arterial Administration

  1994cited by this paper
• Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease.

  1994cited by this paper
• Induction of mutant dynamin specifically blocks endocytic coated vesicle formation

  1994cited by this paper
• Widespread activation of calcium-activated neutral proteinase (calpain) in the brain in Alzheimer disease: a potential molecular basis for neuronal degeneration.

  1993cited by this paper
• Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity.

  1993cited by this paper
• Molecular characterization of the minimal protease resistant tau unit of the Alzheimer's disease paired helical filament.

  1993cited by this paper
• Seminars in medicine of the Beth Israel Hospital, Boston. beta-Amyloid and the pathogenesis of Alzheimer's disease.

  1991cited by this paper
• β-Amyloid and the pathogenesis of alzheimer's disease

  1991cited by this paper
• Microtubule formation and neurite growth in cerebellar macroneurons which develop in vitro: evidence for the involvement of the microtubule-associated proteins, MAP-1a, HMW-MAP2 and Tau.

  1989cited by this paper
• Alzheimerʼs disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein

  1988cited by this paper
• The carboxyl third of tau is tightly bound to paired helical filaments.

  1988cited by this paper
• The ultrastructural localization of calcium‐activated protease “calpain” in rat brain

  1988cited by this paper
• Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.

  1986cited by this paper
• Neurofibrillary tangles of Alzheimer disease share antigenic determinants with the axonal microtubule-associated protein tau (tau)

  1986cited by this paper
• The distribution of tau in the mammalian central nervous system

  1985cited by this paper
• Brain fodrin: substrate for calpain I, an endogenous calcium-activated protease.

  1984cited by this paper
• An Efficient Synthesis of Optically Active α-(t-Butoxycarbonylamino)-aldehydes from α-Amino Acids

  1983cited by this paper
• Growth of a rat neuroblastoma cell line in serum-free supplemented medium.

  1979influential reference
• Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

  1979cited by this paper
• Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

  1970influential reference

• Annexin A6 membrane repair protein protects against amyloid-induced dystrophic neurites and tau phosphorylation in Alzheimer’s disease model mice

  2025cites this paper
• Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome

  2025cites this paper
• Calpain Inhibitors as Potential Therapeutic Modulators in Neurodegenerative Diseases

  2022cites this paper
• DNA vaccines targeting amyloid-β oligomer ameliorate cognitive deficits of aged APP/PS1/tau triple-transgenic mouse models of Alzheimer’s disease

  2022cites this paper
• Revisiting the grammar of Tau aggregation and pathology formation: how new insights from brain pathology are shaping how we study and target Tauopathies.

  2021cites this paper
• The formation of small aggregates contributes to the neurotoxic effects of tau45-230.

  2021cites this paper
• DNA Vaccination Target on Amyloid Oligomer also Reduce tau Pathology and Improve Synaptic Function in Aged 3xTg-AD Mice

  2020influential citation
• Improved synaptic and cognitive function in aged 3 × Tg-AD mice with reduced amyloid-β after immunotherapy with a novel recombinant 6Aβ15-TF chimeric vaccine.

  2018cites this paper
• Involvement of calpain in the neuropathogenesis of Alzheimer’s disease

  2018cites this paper
• Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer's Disease: 2-(3-Phenyl-1H-pyrazol-1-yl)-nicotinamides.

  2017cites this paper
• association with the cytoskeleton and membrane-bound organelles : functional implications in neurodegeneration

  2017cites this paper
• Cholesterol in the Pathogenesis of Alzheimer’s, Parkinson’s Diseases and Autism: Link to Synaptic Dysfunction

  2017cites this paper
• Dual Mechanism of Toxicity for Extracellular Injection of Tau Oligomers versus Monomers in Human Tau Mice

  2017cites this paper
• Dynamin Functions and Ligands: Classical Mechanisms Behind

  2017cites this paper
• Chronic traumatic encephalopathy‐integration of canonical traumatic brain injury secondary injury mechanisms with tau pathology

  2017cites this paper
• Methods related to studying tau fragmentation.

  2017cites this paper
• A Novel Aβ B-Cell Epitope Vaccine (rCV01) for Alzheimer’s Disease Improved Synaptic and Cognitive Functions in 3 × Tg-AD Mice

  2016cites this paper
• A novel recombinant 6Aβ15-THc-C chimeric vaccine (rCV02) mitigates Alzheimer’s disease-like pathology, cognitive decline and synaptic loss in aged 3 × Tg-AD mice

  2016cites this paper
• MOL # 105064 Title: Dynamin Functions and Ligands: Classical Mechanisms Behind Running title: Dynamin Function and Ligands

  2016cites this paper
• Oligomeric α‐synuclein and β‐amyloid variants as potential biomarkers for Parkinson's and Alzheimer's diseases

  2016cites this paper
• Peripherally administered sera antibodies recognizing amyloid-β oligomers mitigate Alzheimer's disease-like pathology and cognitive decline in aged 3× Tg-AD mice.

  2016cites this paper
• The Neurotoxic Tau45-230 Fragment Accumulates in Upper and Lower Motor Neurons in Amyotrophic Lateral Sclerosis Subjects

  2016cites this paper
• Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer's disease

  2015cites this paper
• A role for cell cycle protein E2F1 in HIV-induced neurotoxicity

  2015cites this paper
• Synaptic Therapy in Alzheimer’s Disease: A CREB-centric Approach

  2015cites this paper
• Neuronal degeneration, synaptic defects, and behavioral abnormalities in tau₄₅₋₂₃₀ transgenic mice.

  2014cites this paper
• Platelets as potential link between diabetes and Alzheimer's disease.

  2014cites this paper
• Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes. Update 2014

  2014cites this paper
• Featured Articles Increased cerebrospinal fluid calpain activity and microparticle levels in Alzheimer's disease

  2014cites this paper
• Cognitive Enhancers (Nootropics). Part 2: Drugs Interacting with Enzymes

  2013cites this paper
• β-Amyloid Carrying the Dutch Mutation Has Diverse Effects on Calpain-Mediated Toxicity in Hippocampal Neurons

  2012cites this paper
• The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo.

  2012cites this paper
• Calpain inhibitor A-705253 mitigates Alzheimer's disease-like pathology and cognitive decline in aged 3xTgAD mice.

  2012cites this paper
• Calpain inhibition as a potential treatment of Alzheimer's disease.

  2012cites this paper
• Calpain Dysregulation in Alzheimer's Disease

  2012cites this paper
• Aβ toxicity in primary cultured neurons.

  2011cites this paper
• Calpain-Mediated Tau Cleavage: A Mechanism Leading to Neurodegeneration Shared by Multiple Tauopathies

  2011cites this paper
• Alzheimer's Disease and Frontotemporal Dementia

  2011influential citation
• Other Mechanisms of Neurodegeneration

  2011cites this paper
• Calpain inhibitors: a survey of compounds reported in the patent and scientific literature

  2011cites this paper
• Post-translational modifications of tau protein: implications for Alzheimer's disease.

  2011cites this paper
• Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation

  2011cites this paper
• Implicating Calpain in Tau-Mediated Toxicity In Vivo

  2011cites this paper
• Cleavage of Tau by calpain in Alzheimer's disease: the quest for the toxic 17 kD fragment.

  2011cites this paper
• Calpains: attractive targets for the development of synthetic inhibitors.

  2010cites this paper
• Inhibition of calpain prevents NMDA‐induced cell death and β‐amyloid‐induced synaptic dysfunction in hippocampal slice cultures

  2010cites this paper
• Dual vulnerability of tau to calpains and caspase-3 proteolysis under neurotoxic and neurodegenerative conditions

  2010cites this paper
• RESEARCH PAPER Inhibition of calpain prevents NMDA-induced cell death and b-amyloid-induced synaptic dysfunction in hippocampal slice cultures

  2010cites this paper
• Effect of Lipids on the Activity of Calpain in Subcellular Fractions Obtained from the Rat Brain

  2009cites this paper
• Calcium in the initiation, progression and as an effector of Alzheimer’s disease pathology

  2009cites this paper
• Capsaicin promotes the amyloidogenic route of brain amyloid precursor protein processing.

  2009cites this paper
• New approaches to the treatment of frontotemporal lobar degeneration

  2008cites this paper