Biochemical and biological effects of KN-93, an inhibitor of calmodulin-dependent protein kinase II, on the initial events of mouse egg activation induced by ethanol.

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Journal of Reproduction and Fertility

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1530/JRF.0.1150151PMID 10341733
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• KN-62, l-[N,O-Bis(5-isoquinolinesulfonyl)-N-methyl-~-tyrosyl]-4- phenylpiperazine, a Specific Inhibitor of Ca2”/Calmodulin-dependent Protein Kinase II*

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  1998cited by this paper
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• Heparin inhibits Ca2+/calmodulin-dependent kinase II activation and c-fos induction in mesangial cells.

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• Expression of Rab3A in the cortical region in mouse metaphase II eggs.

  1998cited by this paper
• CaMK-II inhibition reduces cyclin D1 levels and enhances the association of p27kip1 with Cdk2 to cause G1 arrest in NIH 3T3 cells.

  1998cited by this paper
• Ca2+ oscillations in the activation of the egg and development of the embryo in mammals.

  1998cited by this paper
• Unique protein kinase C profile in mouse oocytes: lack of calcium‐dependent conventional isoforms suggested by rtPCR and Western blotting

  1997cited by this paper
• Protein kinase C is required for the disappearance of MPF upon artificial activation in mouse eggs.

  1997cited by this paper
• Activation of protein kinase C after fertilization is required for remodeling the mouse egg into the zygote

  1997cited by this paper
• Study of protein kinase C antagonists on cortical granule exocytosis and cell‐cycle resumption in fertilized mouse eggs

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• In vitro exocytosis in sea urchin eggs requires a synaptobrevin-related protein.

  1997cited by this paper
• Involvement of Rabphilin-3A in cortical granule exocytosis in mouse eggs

  1996cited by this paper
• Effects of calcium-BAPTA buffers and the calmodulin antagonist W-7 on mouse egg activation.

  1996cited by this paper
• The synaptic vesicle cycle: a cascade of protein–protein interactions

  1995cited by this paper
• G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase).

  1995cited by this paper
• The exit of mouse oocytes from meiotic M-phase requires an intact spindle during intracellular calcium release.

  1995cited by this paper
• Calmodulin-dependent protein kinase II is required for G1/S progression in HeLa cells.

  1995cited by this paper
• Calmodulin-dependent protein kinase II is activated transiently in ethanol-stimulated mouse oocytes.

  1995cited by this paper
• The effect of KN-62, Ca2+/calmodulin dependent protein kinase II inhibitor on cell cycle.

  1994cited by this paper
• Involvement of inositol 1,4,5-trisphosphate-mediated Ca2+ release in early and late events of mouse egg activation.

  1994cited by this paper
• Phosphorylation of Rabphilin-3A by calmodulin-dependent protein kinase II.

  1994cited by this paper
• Competence to undergo normal, fertilization-induced cortical activation develops after metaphase I of meiosis in mouse oocytes.

  1994cited by this paper
• Ca2+ is involved through type II calmodulin-dependent protein kinase in cyclin degradation and exit from metaphase.

  1994cited by this paper
• Calcium, calmodulin and cell cycle regulation

  1994cited by this paper
• The metaphase II arrest in mouse oocytes is controlled through microtubule‐dependent destruction of cyclin B in the presence of CSF.

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• Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell.

  1993cited by this paper
• Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs

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• Protein kinase C-dependent and independent events in mouse egg activation

  1993cited by this paper
• Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93.

  1993cited by this paper
• Neuronal Ca2+/calmodulin-dependent protein kinases.

  1992cited by this paper
• Meiosis, egg activation, and nuclear envelope breakdown are differentially reliant on Ca2+, whereas germinal vesicle breakdown is Ca2+ independent in the mouse oocyte

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• Cytoskeleton and molecular mechanisms in neurotransmitter release by neurosecretory cells.

  1992cited by this paper
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  1992cited by this paper
• The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells.

  1991cited by this paper
• KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

  1990cited by this paper
• The regulation and cellular functions of phosphatidylcholine hydrolysis.

  1990cited by this paper
• Effects of protein kinase C stimulation and free Ca2+ rise in mammalian egg activation.

  1989cited by this paper
• Quantitative studies of changes in cortical granule number and distribution in the mouse oocyte during meiotic maturation.

  1988cited by this paper
• How calcium may cause exocytosis in sea urchin eggs

  1987cited by this paper
• Parthenogenetic activation of mouse oocytes in vitro with ethanol and benzyl alcohol.

  1983cited by this paper
• Calmodulin confers calcium sensitivity on secretory exocytosis

  1982cited by this paper
• Free Ca2+ increases in exponential phases during mouse oocyte activation

  1981cited by this paper
• Ultrastructural localization of lectin-binding sites on the zonae pellucidae and plasma membranes of mammalian eggs

  1975cited by this paper

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• Fertilization 2: Polyspermic Fertilization.

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• The birth of quail chicks after intracytoplasmic sperm injection

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• Phospho-Regulation Pathways During Egg Activation in Drosophila melanogaster

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• Molecular changes during egg activation.

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• Nature And Regulation Of Protein Phosphorylation Changes During Egg Activation In Drosophila Melanogaster

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• Protein phosphorylation changes reveal new candidates in the regulation of egg activation and early embryogenesis in D. melanogaster.

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• Degree of Cortical Granule Exocytosis in in vitro- matured Porcine Oocytes Induced by Different Artificial Stimulators

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• CaMKII activation is a novel effector of alcohol’s neurotoxicity in neural crest stem/progenitor cells

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• Oocyte maturation failure: a syndrome of bad eggs.

  2010cites this paper
• GENETIC AND MOLECULAR ANALYSIS OF CALCIUM SIGNALING PATHWAYS AND THE PRAGE GENE IN DROSOPHILA EGG ACTIVATION

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• The Role of the Ca2+-dependent protein kinase, CaMK-II, in Heart and Kidney Development in the Zebrafish, Danio rerio

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• Transitioning from egg to embryo: Triggers and mechanisms of egg activation

  2008cites this paper
• Short Title: MARCKS mediates cortical granules exocytosis

  2008cites this paper
• The roles of Ca2+, downstream protein kinases, and oscillatory signaling in regulating fertilization and the activation of development.

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• Cellular scaffolds in mammalian eggs.

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• KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser.

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