The X protein of hepatitis B virus binds to the F box protein Skp2 and inhibits the ubiquitination and proteasomal degradation of c‐Myc

No abstract is available for this paper.

• Publication year

  2006

• Venue

  FEBS Letters

• Publication date

  2006-01-23

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2005.12.034PMID 16376880
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Transgenic mice.

  2006cited by this paper
• The SCF ubiquitin ligase: insights into a molecular machine

  2004cited by this paper
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  2004cited by this paper
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• c-Fos Is a Mediator of the c-Myc-induced Apoptotic Signaling in Serum-deprived Hepatoma Cells via the p38 Mitogen-activated Protein Kinase Pathway*

  2004cited by this paper
• Inhibition of Cellular Proteasome Activities Enhances Hepadnavirus Replication in an HBX-Dependent Manner

  2004cited by this paper
• Hepatitis B Virus Core Protein Stimulates the Proteasome-Mediated Degradation of Viral X Protein

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• Viruses and the 26S proteasome: hacking into destruction.

  2003cited by this paper
• Hepatocellular carcinoma in a hepatitis B ‘x’ transgenic mouse model: A sequential pathological evaluation

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• Skp2 regulates Myc protein stability and activity.

  2003cited by this paper
• The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription.

  2003cited by this paper
• The ubiquitin-proteasome proteolytic pathway: destruction for the sake of construction.

  2002cited by this paper
• In Vivo Interference with Skp1 Function Leads to Genetic Instability and Neoplastic Transformation

  2002cited by this paper
• Viruses and apoptosis

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• Skp2 is oncogenic and overexpressed in human cancers

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• A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition

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• Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis

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• Strategies in subversion: de‐regulation of the mammalian cell cycle by viral gene products

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• The Human Immunodeficiency Virus Type 1 Vpu Protein Inhibits NF-κB Activation by Interfering with βTrCP-mediated Degradation of IκB*

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• Rhabdoviruses and the Cellular Ubiquitin-Proteasome System: a Budding Interaction

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• The human immunodeficiency virus type 1 Vpu protein inhibits NF-kappa B activation by interfering with beta TrCP-mediated degradation of Ikappa B.

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• Proteasomal turnover of p21Cip1 does not require p21Cip1 ubiquitination.

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• Latent Membrane Protein 2A of Epstein-Barr Virus Binds WW Domain E3 Protein-Ubiquitin Ligases That Ubiquitinate B-Cell Tyrosine Kinases

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• Hepatitis B Virus X Protein Is both a Substrate and a Potential Inhibitor of the Proteasome Complex

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• Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome

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• The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice

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• A truncated mutant (residues 58-140) of the hepatitis B virus X protein retains transactivation function.

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• The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53.

  1993cited by this paper
• Full-length and truncated versions of the hepatitis B virus (HBV) X protein (pX) transactivate the cmyc protooncogene at the transcriptional level.

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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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• HERC5 E3 ligase mediates ISGylation of hepatitis B virus X protein to promote viral replication.

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• The Hepatitis B Virus Interactome: A Comprehensive Overview

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• Identification of Hepatitis B virus etiologic antigens, HBx and Pre-S2, in Diffuse Large B-cell Lymphoma.

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• HBx acts as an oncogene and promotes the invasion and metastasis of hepatocellular carcinoma both in vivo and vitro.

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• Relationship between HBx expression and the pathogenesis of CLD and ( HCC ) : A model

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• The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis

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• Interplay of Wnt β-catenin pathway and miRNAs in HBV pathogenesis leading to HCC.

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• Viral deubiquitinases: role in evasion of anti-viral innate immunity

  2017cites this paper
• Cell cycle‐dependent regulation of cytoglobin by Skp2

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• Hepatocyte Factor JMJD5 Regulates Hepatitis B Virus Replication through Interaction with HBx

  2016cites this paper
• Hepatitis B virus X protein activates Notch signaling by its effects on Notch1 and Notch4 in human hepatocellular carcinoma.

  2016cites this paper
• Hepatitis B virus X protein enhances Myc stability by inhibiting SCFSkp2 ubiquitin E3 ligase-mediated Myc ubiquitination and contributes to oncogenesis

  2016cites this paper
• Hepatitis B virus and microRNAs: Complex interactions affecting hepatitis B virus replication and hepatitis B virus-associated diseases.

  2015cites this paper
• The HBx oncoprotein of hepatitis B virus potentiates cell transformation by inducing c-Myc-dependent expression of the RNA polymerase I transcription factor UBF

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• The G1 phase E3 ubiquitin ligase TRUSS that gets deregulated in human cancers is a novel substrate of the S-phase E3 ubiquitin ligase Skp2

  2015influential citation
• Hepatitis B virus X protein activates Notch signaling by its effects on Notch 1 and Notch 4 in human hepatocellular carcinoma

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• The Smad7–Skp2 complex orchestrates Myc stability, impacting on the cytostatic effect of TGF-&bgr;

  2014cites this paper
• Using proteomics to identify the HBx interactome in hepatitis B virus: how can this inform the clinic?

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• Human Oncogenic Viruses and Cancer

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• Hepatitis B Virus HBx Protein Interactions with the Ubiquitin Proteasome System

  2014cites this paper
• Retracted: HBx Elevates Oncoprotein AEG-1 Expression to Promote Cell Migration by Downregulating miR-375 and miR-136 in Malignant Hepatocytes

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• Running Title: Role of MLL1 in specifying E2F1 paradox

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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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• Mechanisms of HBx Mediated Liver Cancer: Multiple Pathways and Opportunities

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  2010cites this paper
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  2007cites this paper
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