Protective Effects of Riluzole on Dopamine Neurons

No abstract is available for this paper.

• Publication year

  2000

• Venue

  Journal of Neurochemistry

• Publication date

  2000-12-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1046/j.1471-4159.2000.0752259.xPMID 11080177
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Animal Models of Action Tremor

  2008cited by this paper
• Neuroprotection — rationale for pharmacological modulation of Na+-channels

  2005cited by this paper
• 6-Hydroxydopamine toxicity towards human SH-SY5Y dopaminergic neuroblastoma cells: independent of mitochondrial energy metabolism

  2000cited by this paper
• The protective effect of riluzole in the MPTP model of Parkinson's disease in mice is not due to a decrease in MPP(+) accumulation.

  2000influential reference
• Catechol-O-methyltransferase inhibition attenuates levodopa toxicity in mesencephalic dopamine neurons.

  2000cited by this paper
• 1-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (salsolinol) is toxic to dopaminergic neuroblastoma SH-SY5Y cells via impairment of cellular energy metabolism.

  2000influential reference
• Antioxidative and Proapoptotic Effects of Riluzole on Cultured Cortical Neurons

  1999influential reference
• Effect of riluzole on the neurological and neuropathological changes in an animal model of cardiac arrest-induced movement disorder.

  1999cited by this paper
• HEK-293 cells expressing the human dopamine transporter are susceptible to low concentrations of 1-methyl-4-phenylpyridine (MPP+) via impairment of energy metabolism.

  1999influential reference
• Prospects for new restorative and neuroprotective treatments in Parkinson's disease

  1999cited by this paper
• HEK-293 cells expressing the human dopamine transporter are susceptible to low concentrations of 1-methyl-4-phenylpyridine (MPP+) via impairment of energy metabolism.

  1999influential reference
• The role of excitotoxicity in neurodegenerative disease: implications for therapy.

  1999influential reference
• The role of excitotoxicity in neurodegenerative disease: implications for therapy.

  1999cited by this paper
• DATATOP: a decade of neuroprotective inquiry. Parkinson Study Group. Deprenyl And Tocopherol Antioxidative Therapy Of Parkinsonism.

  1998cited by this paper
• Riluzole delayed appearance of parkinsonian motor abnormalities in a chronic MPTP monkey model.

  1998influential reference
• DATATOP: A decade of neuroprotective inquiry

  1998cited by this paper
• Mechanisms of MPTP toxicity.

  1998influential reference
• Invited Review Free radicals and the pathobiology of brain dopamine systems

  1998influential reference
• Riluzole reduces incidence of abnormal movements but not striatal cell death in a primate model of progressive striatal degeneration.

  1997cited by this paper
• Differential action of riluzole on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels.

  1997cited by this paper
• Riluzole promotes survival of rat motoneurons in vitro by stimulating trophic activity produced by spinal astrocyte monolayers.

  1997influential reference
• Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II.

  1996cited by this paper
• Neuroprotective effects of riluzole on a model of Parkinson's disease in the rat.

  1996influential reference
• Comparison of the neurotoxicity of dihydroxyphenylalanine stereoisomers in cultured dopamine neurons.

  1996influential reference
• Riluzole, a Novel Neuroprotective Agent, Attenuates Both Neurologic Motor and Cognitive Dysfunction Following Experimental Brain Injury in the Rat

  1996cited by this paper
• Riluzole Anesthesia: Use-Dependent Block of Presynaptic Glutamate Fibers

  1996cited by this paper
• Dose-ranging study of riluzole in amyotrophic lateral sclerosis

  1996cited by this paper
• Volume‐sensitive chloride channels blocked by neuroprotective drugs in human glial cells (U‐138MG)

  1996cited by this paper
• Effect of riluzole on quinolinate-induced neuronal damage in rats: comparison with blockers of glutamatergic neurotransmission.

  1995influential reference
• Protective effect of riluzole on excitatory amino acid-mediated neurotoxicity in motoneuron-enriched cultures.

  1995influential reference
• Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron/astrocyte cocultures to kainic acid

  1995cited by this paper
• Riluzole prevents MPTP-induced parkinsonism in the rhesus monkey: a pilot study.

  1995influential reference
• Pharmacological protection against the cytotoxicity induced by 6-hydroxydopamine and H2O2 in chromaffin cells.

  1995influential reference
• Antagonism by riluzole of entry of calcium evoked by NMDA and veratridine in rat cultured granule cells: evidence for a dual mechanism of action

  1994cited by this paper
• An immunohistochemical study on α‐ketoglutarate dehydrogenase complex in Parkinson's disease

  1994cited by this paper
• An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease.

  1994cited by this paper
• Block of the rat brain IIA sodium channel alpha subunit by the neuroprotective drug riluzole.

  1994cited by this paper
• The Arachidonic Acid Cascade, Eicosanoids, and Signal Transduction a

  1994cited by this paper
• A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group.

  1994cited by this paper
• The neuroprotective agent riluzole inhibits release of glutamate and aspartate from slices of hippocampal area CA1.

  1993cited by this paper
• Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes.

  1993cited by this paper
• Suppressive effect of L‐dopa on dopamine cells remaining in the ventral tegmental area of rats previously exposed to the neurotoxin 6‐hydroxydopamine

  1993cited by this paper
• Mechanisms of excitotoxicity in neurologic diseases

  1992cited by this paper
• Mitochondrial function in Parkinson's disease

  1992cited by this paper
• The glutamate antagonist, MK-801, does not prevent dopaminergic cell death induced by the 1-methyl-4-phenylpyridinium ion (MPP+) in rat dissociated mesencephalic cultures.

  1992cited by this paper
• Platelet mitochondrial function in Parkinson's disease. The Royal Kings and Queens Parkinson Disease Research Group.

  1992cited by this paper
• MPTP mechanisms of neurotoxicity and their implications for Parkinson's disease.

  1991influential reference
• Riluzole specifically blocks inactivated Na channels in myelinated nerve fibre

  1991cited by this paper
• The AMPA receptor antagonist NBQX has antiparkinsonian effects in monoamine‐depleted rats and MPTP‐treated monkeys

  1991cited by this paper
• Protection of substantia nigra from MPP+ neurotoxicity by N-methyl-D-aspartate antagonists

  1991cited by this paper
• Toxicity of 1‐Methyl‐4‐Phenylpyridinium for Rat Dopaminergic Neurons in Culture: Selectivity and Irreversibility

  1990cited by this paper
• Toxicity of 6‐hydroxydopamine and dopamine for dopaminergic neurons in culture

  1990influential reference
• Deficiencies in complex I subunits of the respiratory chain in Parkinson's disease.

  1989cited by this paper
• Transition Metals, Ferritin, Glutathione, and Ascorbic Acid in Parkinsonian Brains

  1989cited by this paper
• Mitochondrial complex I deficiency in Parkinson's disease.

  1989cited by this paper
• Basal Lipid Peroxidation in Substantia Nigra Is Increased in Parkinson's Disease

  1989cited by this paper
• Mitochondrial Complex I Deficiency in Parkinson's Disease

  1989cited by this paper
• Subcellular compartmentalization of 1-methyl-4-phenylpyridinium with catecholamines in adrenal medullary chromaffin vesicles may explain the lack of toxicity to adrenal chromaffin cells.

  1987cited by this paper
• Ion motive ATPases. II. Energy coupling and work output

  1987cited by this paper
• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) cause rapid ATP depletion in isolated hepatocytes.

  1986cited by this paper
• Presence and regulation of tyrosinase activity in human neuroblastoma cell variants in vitro.

  1985cited by this paper
• Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.

  1985cited by this paper
• Serum factor supporting long-term survival of rat central neurons in culture.

  1983cited by this paper
• Participation of active oxygen species in 6-hydroxydopamine toxicity to a human neuroblastoma cell line.

  1982influential reference
• Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site.

  1982cited by this paper
• Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

  1979cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• Phosphorylation state of cytosolic and mitochondrial adenine nucleotides and of pyruvate dehydrogenase in isolated rat liver cells.

  1976cited by this paper

• From Brain to Muscle: The Role of Muscle Tissue in Neurodegenerative Disorders

  2024cites this paper
• Unsupervised machine learning identifies distinct ALS molecular subtypes in post-mortem motor cortex and blood expression data

  2023cites this paper
• Formulating treatment of major psychiatric disorders: algorithm targets the dominantly affected brain cell-types

  2023cites this paper
• Muscle Involvement in Amyotrophic Lateral Sclerosis: Understanding the Pathogenesis and Advancing Therapeutics

  2023cites this paper
• Unsupervised machine learning identifies distinct molecular and phenotypic ALS subtypes in post-mortem motor cortex and blood expression data

  2023cites this paper
• Cure of Alzheimer’s Dementia Requires Addressing All of the Affected Brain Cell Types

  2023cites this paper
• Supplementary Pharmacotherapy for the Behavioral Abnormalities Caused by Stressors in Humans, Focused on Post-Traumatic Stress Disorder (PTSD)

  2023cites this paper
• Synthesis of Benzothiazole Linked Triazole Conjugates and Their Evaluation Against Cholinesterase Enzymes

  2022cites this paper
• Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents

  2022cites this paper
• New Quinoline-2-one/thiazolium bromide Derivatives; Synthesis, Characterization and Mechanism of Formation

  2021cites this paper
• Synthesis and Antinociceptive Effect of Some Thiazole-Piperazine Derivatives: Involvement of Opioidergic System in the Activity

  2021cites this paper
• New quinolin-3-yl-N-hydrazinecarbothioamides in the synthesis of thiazoles and thiazines

  2021cites this paper
• Linc00514 promotes breast cancer metastasis and M2 polarization of tumor-associated macrophages via Jagged1-mediated notch signaling pathway

  2020cites this paper
• Downregulated long non-coding RNA LINC01093 in liver fibrosis promotes hepatocyte apoptosis via increasing ubiquitination of SIRT1.

  2020cites this paper
• Neuroprotective effects of Riluzole and Curcumin in human astrocytes and spinal cord white matter hypoxia.

  2020cites this paper
• Silver nanoparticles induce protective autophagy via Ca2+/CaMKKβ/AMPK/mTOR pathway in SH-SY5Y cells and rat brains

  2019cites this paper
• Riluzole Selective Antioxidant Effects in Cell Models Expressing Amyotrophic Lateral Sclerosis Endophenotypes

  2019cites this paper
• Oxidative Stress Effects of Soluble Sulfide on Human Hepatocyte Cell Line LO2

  2019cites this paper
• A pharmaco-metabolomics approach in a clinical trial of ALS: Identification of predictive markers of progression

  2018cites this paper
• Prophylactic Riluzole Attenuates Oxidative Stress Damage in Spinal Cord Distraction

  2018cites this paper
• Riluzole But Not Melatonin Ameliorates Acute Motor Neuron Degeneration and Moderately Inhibits SOD1-Mediated Excitotoxicity Induced Disrupted Mitochondrial Ca2+ Signaling in Amyotrophic Lateral Sclerosis

  2017cites this paper
• Aspergillus fumigatus‐induced early inflammatory response in pulmonary microvascular endothelial cells: Role of p38 MAPK and inhibition by silibinin

  2017cites this paper
• PA6 Stromal Cell Co-Culture Enhances SH-SY5Y and VSC4.1 Neuroblastoma Differentiation to Mature Phenotypes

  2016cites this paper
• Neurotropic growth factors and glycosaminoglycan based matrices to induce dopaminergic tissue formation.

  2015cites this paper
• Thiazole: a promising heterocycle for the development of potent CNS active agents.

  2015cites this paper
• Action potentials as indicators of metabolic perturbations for temporal proteomic analysis

  2014cites this paper
• Exploring Cross-Talk Between Oxidative Damage and Excitotoxicity and the Effects of Riluzole in the Rat Cortex After Exposure to Methylmercury

  2014cites this paper
• Role of miR-146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro

  2014cites this paper
• S[+] Apomorphine is a CNS penetrating activator of the Nrf2-ARE pathway with activity in mouse and patient fibroblast models of amyotrophic lateral sclerosis☆

  2013cites this paper
• Design and synthesis of (4E)-4-(4-substitutedbenzylideneamino)-3-substituted-2,3-dihydro-2-thioxothiazole-5-carbonitrile as novel A2A receptor antagonists.

  2013cites this paper
• An imbalance between excitatory and inhibitory neurotransmitters in amyotrophic lateral sclerosis revealed by use of 3-T proton magnetic resonance spectroscopy.

  2013cites this paper
• Methylparaben protects 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells and improved behavioral impairments in mouse model of Parkinson's disease.

  2013cites this paper
• Neuroprotective effects of riluzole in early phase Parkinson's disease on clinically relevant parameters in the marmoset MPTP model.

  2012cites this paper
• Amyotrophic lateral sclerosis: new insights into underlying molecular mechanisms and opportunities for therapeutic intervention.

  2012cites this paper
• Effects of Mechanical Force on Cytoskeleton Structure and Calpain-Induced Apoptosis in Rat Dorsal Root Ganglion Neurons In Vitro

  2012cites this paper
• Lipid nanoparticles for drug targeting to the brain.

  2012cites this paper
• Effect of glutamate and riluzole on manganese-induced apoptotic cell signaling in neuronally differentiated mouse P19 Cells.

  2012cites this paper
• Antioxidation and protection against H 2 O 2 induced oxidative stress on normal human hepatocytes cell line (LO2) by extracts and three compounds from the root of Isatis Indigotica

  2012cites this paper
• Neurotoxic injury pathways in differentiated mouse motor neuron-neuroblastoma hybrid (NSC-34D) cells in vitro--limited effect of riluzole on thapsigargin, but not staurosporine, hydrogen peroxide and homocysteine neurotoxicity.

  2012cites this paper
• Riluzole prevents morphine-induced apoptosis in rat cerebral cortex

  2011cites this paper
• G0/G1 Phase Arrest and Apoptosis Induced by Manganese Chloride on Cultured Rat Astrocytes and Protective Effects of Riluzole

  2011cites this paper
• Dose-dependent modulation of apoptotic processes by fluoxetine in maturing neuronal cells: an in vitro study

  2011cites this paper
• The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors.

  2011cites this paper
• L-DOPA: a scapegoat for accelerated neurodegeneration in Parkinson's disease?

  2011influential citation
• Riluzole, neuroprotection and amyotrophic lateral sclerosis.

  2010cites this paper
• SH-SY5Y human neuroblastoma cell line: in vitro cell model of dopaminergic neurons in Parkinson's disease.

  2010cites this paper
• Involvement of Src‐suppressed C kinase substrate in experimental autoimmune encephalomyelitis: A link between release of astrocyte proinflammatory factor and oligodendrocyte apoptosis

  2010cites this paper
• Brain-targeted solid lipid nanoparticles containing riluzole: preparation, characterization and biodistribution.

  2010cites this paper
• Intracerebroventricular administration of riluzole prevents morphine-induced apoptosis in the lumbar region of the rat spinal cord

  2010cites this paper
• Pre‐synaptic glutamate‐induced activation of DA release in the striatum after partial nigral lesion

  2010cites this paper
• Involvement of Src-Suppressed C Kinase Substrate in Neuronal Death Caused by the Lipopolysaccharide-Induced Reactive Astrogliosis

  2010cites this paper
• Protective effect of 5-hydroxymethylfurfural derived from processed Fructus Corni on human hepatocyte LO2 injured by hydrogen peroxide and its mechanism.

  2010cites this paper
• Terminally differentiated SH-SY5Y cells provide a model system for studying neuroprotective effects of dopamine agonists

  2009cites this paper
• A star-PEG-heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases.

  2009cites this paper
• Effects of various nitric oxide synthase inhibitors on AlCl3-induced neuronal injury in rats

  2009cites this paper
• Neuroprotective effect of naphtha[1,2-d]thiazol-2-amine in an animal model of Parkinson's disease

  2009cites this paper
• Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture.

  2009cites this paper
• The effects of riluzole on neurological, brain biochemical, and histological changes in early and late term of sepsis in rats.

  2009cites this paper
• Optical Analysis of [Ca 2+ ]i and Mitochondrial Signaling Pathways: Implications for the Selective Vulnerability of Motoneurons in Amyotrophic Lateral Sclerosis (ALS)

  2009cites this paper
• The effect of 7-nitroindazole on aluminium toxicity in the rat brain.

  2008cites this paper
• Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity.

  2008cites this paper
• Amyotrophic lateral sclerosis: from current developments in the laboratory to clinical implications.

  2008cites this paper
• Stage-dependent vulnerability of fetal mesencephalic neuroprogenitors towards dopaminergic neurotoxins.

  2008cites this paper
• Driving GDNF expression: the green and the red traffic lights.

  2008cites this paper
• Riluzole in the Treatment of Mood and Anxiety Disorders

  2008cites this paper
• Pretreatment with near-infrared light via light-emitting diode provides added benefit against rotenone- and MPP+-induced neurotoxicity.

  2008cites this paper
• Resveratrol induces apoptosis, influences IL-6 and exerts immunomodulatory effect on mouse lymphocytic leukemia both in vitro and in vivo.

  2007cites this paper
• Protective Effect of (±) Isoborneol Against 6-OHDA-Induced Apoptosis in SH-SY5Y Cells

  2007cites this paper
• Chapter 8 – Genes and Oxidative Stress in Sporadic and Familial Parkinsonism: cDNA Microarray Studies

  2007cites this paper
• Excitotoxicity.

  2007cites this paper
• Methylphenidate exerts no neurotoxic, but neuroprotective effects in vitro

  2006influential citation
• Specific regulation of rat glial cell line‐derived neurotrophic factor gene expression by riluzole in C6 glioma cells

  2006cites this paper
• 7-nitroindazole, a selective neuronal nitric oxide synthase inhibitore in vivo, prevents kainate-induced intrahippocampal neurotoxicity

  2005cites this paper
• Involvement of proinflammatory factors, apoptosis, caspase-3 activation and Ca2+ disturbance in microglia activation-mediated dopaminergic cell degeneration.

  2005cites this paper
• Riluzole restores motor activity in rats with post-traumatic peripheral neuropathy.

  2004cites this paper
• Dopaminergic neurotoxicity of homocysteine and its derivatives in primary mesencephalic cultures.

  2004cites this paper
• Activity of protein phosphatase calcineurin is decreased in sporadic and familial amyotrophic lateral sclerosispatients

  2004cites this paper
• Dopamine Agonist 3-PPP Fails to Protect Against MPTP-Induced Toxicity

  2004cites this paper
• Is levodopa toxic?

  2004cites this paper
• Glycogen synthase kinase 3β (GSK3β) mediates 6‐ hydroxydopamine‐induced neuronal death

  2004cites this paper
• Glycogen synthase kinase 3beta (GSK3beta) mediates 6-hydroxydopamine-induced neuronal death.

  2004cites this paper
• Glycogen synthase kinase 3 β ( GSK 3 β ) mediates 6-hydroxydopamine-induced neuronal death

  2004cites this paper
• Neuroprotektive Strategien bei neurodegenerativen Erkrankungen — was haben wir gelernt?

  2003cites this paper
• Functional characterization of dopaminergic neurons derived from rodent mesencephalic progenitor cells.

  2003cites this paper
• 7-nitroindazole reduces nitrite concentration in rat brain after intrahippocampal kainate-induced seizure.

  2003cites this paper
• Neuroprotective Strategies in Parkinson’s Disease

  2003cites this paper
• Catechol-O-methyltransferase inhibition protects against 3,4-dihydroxyphenylalanine (DOPA) toxicity in primary mesencephalic cultures: new insights into levodopa toxicity.

  2003cites this paper
• Effect of chronic treatment with riluzole on the nigrostriatal dopaminergic system in weaver mutant mice.

  2002cites this paper
• Expression of mutant &agr;-synucleins enhances dopamine transporter-mediated MPP+ toxicity in vitro

  2002cites this paper
• Parkinson-Syndrome: Klinische Symptomatik, Differenzialdiagnose und Verlauf

  2002cites this paper
• A double-blind, placebo-controlled and longitudinal study of riluzole in early Parkinson's disease.

  2002cites this paper
• Effect of Riluzole on serum amino acids in patients with amyotrophic lateral sclerosis

  2002cites this paper
• Selective dopaminergic neurotoxicity of isoquinoline derivatives related to Parkinson's disease: studies using heterologous expression systems of the dopamine transporter.

  2002cites this paper
• Nitric oxide production in the rat brain after kainate-induced seizure

  2002cites this paper
• Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells.

  2001cites this paper
• Neuroprotective effect of riluzole in MPTP-treated mice.

  2001cites this paper
• Sequential Treatment of SH‐SY5Y Cells with Retinoic Acid and Brain‐Derived Neurotrophic Factor Gives Rise to Fully Differentiated, Neurotrophic Factor‐Dependent, Human Neuron‐Like Cells

  2000cites this paper
• Comprehensive Invited Review Amyotrophic Lateral Sclerosis: From Current Developments in the Laboratory to Clinical Implications

  year unknowncites this paper