Coexistence of t(2;14;11)(p16.1;q32;q23) and t(14;19)(q32;q13.3) chromosome translocations in a patient with chronic lymphocytic leukemia

Rationale: With combination of multiple techniques, we have successfully characterized unique, complex chromosomal changes in a patient with chronic lymphocytic leukemia (CLL), a lymphoproliferative disorder. Diagnoses: The diagnosis was based on white blood cell, flow cytometry, and immunophenotypes and confirmed by karyotype, fluorescence in situ hybridization, and array comparative genomic hybridization from the patient's blood culture. Interventions: The patient was given fludarabine, cyclophosphamide and rituximab (FCR) for 6 cycles. Outcomes: After completion of 6 cycles of FCR, the computed tomography scans of the neck/chest/abdomen/pelvic showed that the patient in CR. During the 10-month follow-up, the patient's clinical course remained uneventful. Lessons: The translocation t(14;19) identified in this patient is a recurrent translocation found in patients with chronic B-cell lymphoproliferative disorders and the 3-way translocation involving chromosomes 2, 14, and 11 may play a role as an enhancer.

• Publication year

  2017

• Venue

  Medicine

• Publication date

  2017-12-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/MD.0000000000009169PMID 29390452PMCID 5758154
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Chronic lymphocytic leukaemia.

  2018cited by this paper
• Chronic lymphocytic leukaemia.

  2016cited by this paper
• Incidence rates of chronic lymphocytic leukemia in US states are associated with residential radon levels.

  2016cited by this paper
• Rare double-hit with two translocations involving IGH both, with BCL2 and BCL3, in a monoclonal B-cell lymphoma/leukemia

  2015cited by this paper
• Concurrent rearrangements of BCL2, BCL3, and BCL11A genes in atypical chronic lymphocytic leukemia

  2014cited by this paper
• Chronic lymphocytic leukemia with a FGFR3 translocation: case report and literature review of an uncommon cytogenetic event.

  2014cited by this paper
• Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma

  2014cited by this paper
• Acquisition of t(11;14) in a patient with chronic lymphocytic leukemia carrying both t(14;19)(q32;q13.1) and +12

  2013cited by this paper
• Molecular pathogenesis of chronic lymphocytic leukemia.

  2012cited by this paper
• High‐risk clonal evolution in chronic B‐lymphocytic leukemia: single‐center interphase fluorescence in situ hybridization study and review of the literature

  2012cited by this paper
• Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia.

  2011cited by this paper
• The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia

  2008cited by this paper
• A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation

  2007cited by this paper
• Chromosomal translocations independently predict treatment failure, treatment-free survival and overall survival in B-cell chronic lymphocytic leukemia patients treated with cladribine

  2007cited by this paper
• Translocations as a mechanism for homozygous deletion of 13q14 and loss of the ATM gene in a patient with B-cell chronic lymphocytic leukemia.

  2007cited by this paper
• Chromosomal translocations are associated with poor prognosis in chronic lymphocytic leukemia.

  2006cited by this paper
• Molecular pathogenesis of chronic lymphocytic leukemia.

  2006cited by this paper
• miR-15 and miR-16 induce apoptosis by targeting BCL2.

  2005cited by this paper
• Overlapping deletion regions at 11q23 in myelodysplastic syndrome and chronic lymphocytic leukemia, characterized by a novel BAC probe set.

  2004cited by this paper
• Genomic aberrations and survival in chronic lymphocytic leukemia.

  2000cited by this paper
• Inactivation of ataxia telangiectasia mutated gene in B-cell chronic lymphocytic leukaemia.

  1999cited by this paper
• BCL3 rearrangements and t(14;19) in chronic lymphocytic leukemia and other B‐cell malignancies: A molecular and cytogenetic study

  1997influential reference
• BCL3 rearrangement and t(14;19)(q32;q13) in lymphoproliferative disorders

  1996influential reference
• Chronic lymphocytic leukemia.

  1995cited by this paper
• The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control.

  1990influential reference

• No citing papers are available for this paper.