Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Diabetologia

• Publication date

  2014-02-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00125-013-3085-8PMID 24162585PMCID PMC3918745
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• PTEN controls β‐cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a

  2013cited by this paper
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  2010cited by this paper
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  2009cited by this paper
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  2009cited by this paper
• Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus.

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  2008cited by this paper
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• IGF-I mediates regeneration of endocrine pancreas by increasing beta cell replication through cell cycle protein modulation in mice

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  2008influential reference
• Regulation of pancreatic beta-cell function by the forkhead protein FoxO1.

  2007cited by this paper
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• Total insulin and IGF-I resistance in pancreatic beta cells causes overt diabetes.

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• Very slow turnover of beta-cells in aged adult mice.

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  2005cited by this paper
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  2004cited by this paper
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  2004cited by this paper
• β cell replication is the primary mechanism for maintaining postnatal β cell mass

  2004cited by this paper
• Pancreatic-specific inactivation of IGF-I gene causes enlarged pancreatic islets and significant resistance to diabetes.

  2004cited by this paper
• PTEN Induces Cell Cycle Arrest by Decreasing the Level and Nuclear Localization of Cyclin D1

  2003cited by this paper
• β-cell–specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter β-cell mass

  2002cited by this paper
• Activation of phosphatidylinositol 3-kinase contributes to insulin-like growth factor I-mediated inhibition of pancreatic beta-cell death.

  2002cited by this paper
• β cell expression of IGF-I leads to recovery from type 1 diabetes

  2002cited by this paper
• beta-cell-specific deletion of the Igf1 receptor leads to hyperinsulinemia and glucose intolerance but does not alter beta-cell mass.

  2002cited by this paper
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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Transgenic overexpression of hepatocyte growth factor in the beta-cell markedly improves islet function and islet transplant outcomes in mice.

  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
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