Morphological and molecular basis of ovarian serous carcinoma

D. Rosen,Zhihong Zhang,Weiwei Shan,Jinsong Liu

Published 2010 in Journal of Biomedical Research

ABSTRACT

Serous carcinoma is the most common type of epithelial ovarian cancer. In this review, we provide a comprehensive picture of ovarian serous cancers from multiple aspects: the first part of this review summarizes the morphological, histological, and immunological signatures of ovarian serous carcinoma; subsequently, we review the history of the evolvement of different grading systems used in ovarian serous cancer; in the end, we focus on characterizing the genetics that underlie the 2-tiered pathways through which ovarian serous cancers are believed to arise: the low-grade and the high-grade pathways.

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