Elevated tissue Cr levels, increased plasma oxidative markers, and global hypomethylation of blood DNA in male Sprague‐Dawley rats exposed to potassium dichromate in drinking water

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Environmental Toxicology

• Publication date

  2016-09-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1002/tox.22117PMID 25846368
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• High concentrations of hexavalent chromium in drinking water alter iron homeostasis in F344 rats and B6C3F1 mice.

  2014influential reference
• RETRACTED: Role of DNA Methylation in Cell Cycle Arrest Induced by Cr (VI) in Two Cell Lines

  2013cited by this paper
• Oxidative DNA damage and global DNA hypomethylation are related to folate deficiency in chromate manufacturing workers.

  2012cited by this paper
• Global DNA hypomethylation in cancer: review of validated methods and clinical significance

  2012cited by this paper
• Oxidative stress and metal carcinogenesis.

  2012cited by this paper
• Chromium (VI) Can Activate and Impair Antioxidant Defense System

  2011cited by this paper
• Comparison of the Effects of Hexavalent Chromium in the Alimentary Canal of F344 Rats and B6C3F1 Mice Following Exposure in Drinking Water: Implications for Carcinogenic Modes of Action

  2011influential reference
• Oral ingestion of hexavalent chromium through drinking water and cancer mortality in an industrial area of Greece - An ecological study

  2011cited by this paper
• Chromium in Drinking Water: Sources, Metabolism, and Cancer Risks

  2011cited by this paper
• Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium

  2011influential reference
• Reactive oxygen species (ROS)--induced genetic and epigenetic alterations in human carcinogenesis.

  2011cited by this paper
• Aberrant DNA methylation of some tumor suppressor genes in lung cancers from workers with chromate exposure

  2011cited by this paper
• Exposure to hexavalent chromium resulted in significantly higher tissue chromium burden compared with trivalent chromium following similar oral doses to male F344/N rats and female B6C3F1 mice.

  2010cited by this paper
• Cancer Mortality in Chinese Populations Surrounding an Alloy Plant with Chromium Smelting Operations

  2009cited by this paper
• Metal-induced carcinogenesis, oxidative stress and hypoxia signalling.

  2009cited by this paper
• Oxidative stress, DNA damage, and antioxidant enzyme activity induced by hexavalent chromium in Sprague‐Dawley rats

  2009cited by this paper
• Lack of genotoxic effects in hematopoietic and gastrointestinal cells of mice receiving chromium(VI) with the drinking water.

  2008influential reference
• Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms

  2008cited by this paper
• Cancer Mortality in a Chinese Population Exposed to Hexavalent Chromium in Drinking Water

  2008cited by this paper
• Toxicology and carcinogenesis studies of sodium dichromate dihydrate (Cas No. 7789-12-0) in F344/N rats and B6C3F1 mice (drinking water studies).

  2008influential reference
• Hexavalent Chromium Is Carcinogenic to F344/N Rats and B6C3F1 Mice after Chronic Oral Exposure

  2008influential reference
• Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium.

  2008cited by this paper
• Oxidative stress, DNA methylation and carcinogenesis.

  2008cited by this paper
• Genesis of hexavalent chromium from natural sources in soil and groundwater

  2007cited by this paper
• The reduced expression and aberrant methylation of p16(INK4a) in chromate workers with lung cancer.

  2005cited by this paper
• Expression of Base Excision DNA Repair Genes Is a Sensitive Biomarker for in Vivo Detection of Chemical-induced Chronic Oxidative Stress

  2004cited by this paper
• Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2).

  2004cited by this paper
• Genetic and DNA-methylation changes induced by potassium dichromate in Brassica napus L.

  2004cited by this paper
• Expression of Base Excision DNA Repair Genes is a Sensitive Biomarker for In Vivo Detection of Chemical-Induced Chronic Oxidative Stress

  2004cited by this paper
• Relevance of DNA methylation in the management of cancer.

  2003cited by this paper
• Redox sensor function of metallothioneins.

  2002cited by this paper
• Chromate-induced epimutations in mammalian cells.

  2002cited by this paper
• [Oxidative DNA damage].

  2001influential reference
• Rats retain chromium in tissues following chronic ingestion of drinking water containing hexavalent chromium

  2000cited by this paper
• [Chromium pollution of soil and water in Jinzhou].

  1987cited by this paper

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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
• Geniposide alleviated hydrogen peroxide-induced apoptosis of human hepatocytes via altering DNA methylation.

  2023cites this paper
• Mechanisms of chromate carcinogenesis by chromatin alterations.

  2023cites this paper
• An Update Overview on Mechanistic Data and Biomarker Levels in Cobalt and Chromium-Induced Neurodegenerative Diseases

  2023cites this paper
• Epigenetic and epitranscriptomic mechanisms of chromium carcinogenesis.

  2023cites this paper
• Low-dose hexavalent chromium(VI) exposure promotes prostate cancer cell proliferation by activating MAGEB2-AR signal pathway.

  2022cites this paper
• The role of ageing and oxidative stress in intervertebral disc degeneration

  2022cites this paper
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  2022cites this paper
• Dynamic Alteration Profile and New Role of RNA m6A Methylation in Replicative and H2O2-Induced Premature Senescence of Human Embryonic Lung Fibroblasts

  2022cites this paper
• The Role of Oxidative Stress in Intervertebral Disc Degeneration

  2022cites this paper
• Children Environmentally Exposed to Agrochemicals in Rural Areas Present Changes in Oxidative Status and DNA Damage

  2021cites this paper
• Assessment of Mechanistic Data for Hexavalent Chromium-Induced Rodent Intestinal Cancer Using the Key Characteristics of Carcinogens

  2021cites this paper
• The Effect of Global DNA Methylation on PDCD5 Expression in the PBMC of Occupational Chromate Exposed Workers

  2021cites this paper
• Hexavalent Chromium Disrupts Chromatin Architecture.

  2021cites this paper
• Redox sensitive miR-27a/b/Nrf2 signaling in Cr(VI)-induced carcinogenesis.

  2021cites this paper
• The role of nutrition and epigenetics in environmental toxicology

  2020cites this paper
• Novel DNA methylation biomarkers for hexavalent chromium exposure: an epigenome-wide analysis.

  2020cites this paper
• DNA methylation modifications induced by hexavalent chromium

  2019cites this paper
• Highlight Article: Chromium exposure disrupts chromatin architecture upsetting the mechanisms that regulate transcription

  2019cites this paper
• Body burdens of heavy metals associated with epigenetic damage in children living in the vicinity of a municipal waste incinerator.

  2019cites this paper
• Mechanisms of Chromium-Induced Toxicity.

  2019cites this paper
• Cr(VI)-induced methylation and down-regulation of DNA repair genes and its association with markers of genetic damage in workers and 16HBE cells.

  2018cites this paper
• Concentration of chromium in whole blood and erythrocytes showed different relationships with serum apolipoprotein levels in Cr(VI) exposed subjects.

  2018cites this paper
• ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases

  2016cites this paper
• Explorer ROS , Cell Senescence , and Novel Molecular Mechanisms in Aging and Age-Related Diseases

  2016cites this paper
• Methylation levels of P16 and TP53 that are involved in DNA strand breakage of 16HBE cells treated by hexavalent chromium.

  2016cites this paper
• Mitochondrial DNA hypomethylation in chrome plating workers.

  2016cites this paper